KR900003122A - 카테콜 유도체 - Google Patents

카테콜 유도체 Download PDF

Info

Publication number
KR900003122A
KR900003122A KR1019890011527A KR890011527A KR900003122A KR 900003122 A KR900003122 A KR 900003122A KR 1019890011527 A KR1019890011527 A KR 1019890011527A KR 890011527 A KR890011527 A KR 890011527A KR 900003122 A KR900003122 A KR 900003122A
Authority
KR
South Korea
Prior art keywords
piperidyl
dihydroxyphenyl
propionamide
iii
phenylpropyl
Prior art date
Application number
KR1019890011527A
Other languages
English (en)
Inventor
이쯔오 우시다
유코우 시나가와
도시미쯔 기시모토
다카시 오노
마사후미 아라타
Original Assignee
미즈노 시게루
닛본 타바코 산교 가부시기가이샤
하기와라 무미오
요시토미 세이야꾸 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 미즈노 시게루, 닛본 타바코 산교 가부시기가이샤, 하기와라 무미오, 요시토미 세이야꾸 가부시기가이샤 filed Critical 미즈노 시게루
Publication of KR900003122A publication Critical patent/KR900003122A/ko

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D211/00Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56Nitrogen atoms
    • C07D211/58Nitrogen atoms attached in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

내용 없음

Description

카테콜 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 하기 구조식의 카테콜 유도체 또는 이것의 약학적 허용 산 부가염.
    상기식에서 R1은 수소원자, 아실라디칼 또는 카르바모일 라디칼이며; R2는 수소원자, 저급알킬라디칼 또는 하기 구조의 아르알킬 라디칼이며;
    R3및 R4는 수소원자, 저급알콕시, 할로겐 원자, 저급알킬, 트리플루오로메틸 및 히드록실로 구성되는 그룹으로부터 선택되는 서로 동일한 혹은 상이한 치환체이며; m은 1 내지 4의 정수이며, n은 1 내지 4의 정수이다.
  2. 제1항에 있어서, 하기의 i)-xii)의 화합물들로 구성되는 그룹으로부터 선택되는 유도체 또는 이것의 약학적 허용 산 부가염.
    i)N-[1-(3-(4-페닐프로필)-4-피페리딜]-3-(3,4-디히드록시페닐)프로피온아미드. 하이드로클로라이드, ⅱ)N-[1-(3-(4-메톡시페닐)프로필)-4-피페리딜]-3-(3,4-디히드록시페닐)프로피온아미드. 하이드로클로라이드, ⅲ)N-[1-(3-(3,4-디메톡시페닐))-4-피페리딜]-3-(3,4-디히드록시페닐)프로피온아미드. 하이드로클로라이드, ⅳ)N-[1-(3-페닐프로필)-4-피페리딜]-3,4-디히드록시페닐아세트아미드,ⅴ)N-[1-(3-페닐프로필)-4-피페리딜]-3-디아세톡시페닐)프로피온아미드, ⅵ)N-[1-(3-페닐프로필)-4-(3,4-디히드록시페닐)부티르아미드, ⅶ)N-[1-(2-페닐에틸)-4-피페리딜]-3-(3,4-디히드록시페닐)프로피온아미드, ⅷ)N-[1-(4-페닐부틸)-4-피페리딜]-3-(3,4-디히드록시페닐)프로피온아미드, ⅸ)N-[1-(3-(4-클로로페닐)프로필)-4-피페리딜]-3-(3,4-디아세톡시페닐)프로피온아미드, ⅹ)N-[1-(3,3-디페닐)프로필)-4-피페리딜]-3-(3,4-디히드록시페닐)프로피온아미드, xi)N-[1-(2-(3,4-디메톡시페닐)에틸)-4-피페리딜]-3-(3,4-디히드록시페닐)프로피온아미드, xii)N-[1-(3-페닐프로필)-4-피페리딜]-(3,4-디히드록시페닐)부티르아미드.
  3. 치료학적 유효양의 제1항 또는 제2항의 카테콜 유도체와 약학적 허용 첨가제로 구성되는 변성 신경학적 장애를 예방 또는 치료하기 위한 약학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890011527A 1988-08-12 1989-08-12 카테콜 유도체 KR900003122A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP20000688 1988-08-12
JP63-200006 1988-08-12

Publications (1)

Publication Number Publication Date
KR900003122A true KR900003122A (ko) 1990-03-23

Family

ID=16417226

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890011527A KR900003122A (ko) 1988-08-12 1989-08-12 카테콜 유도체

Country Status (3)

Country Link
EP (1) EP0354568A3 (ko)
KR (1) KR900003122A (ko)
DK (1) DK386089A (ko)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100459917B1 (ko) * 2001-12-14 2004-12-03 (주)바이오뉴트리젠 페놀릭산 유도체 및 이를 포함하는 혈중 지질 농도 관련질환의 예방 및 치료용 조성물

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5595872A (en) * 1992-03-06 1997-01-21 Bristol-Myers Squibb Company Nucleic acids encoding microsomal trigyceride transfer protein
KR20010012316A (ko) 1997-05-08 2001-02-15 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 프로테아제 억제제
DE19924148A1 (de) * 1999-05-26 2000-12-07 Univ Heidelberg Sphingomyelinasehemmer
SE9902987D0 (sv) 1999-08-24 1999-08-24 Astra Pharma Prod Novel compounds
GB0011838D0 (en) * 2000-05-17 2000-07-05 Astrazeneca Ab Chemical compounds
GB0104050D0 (en) 2001-02-19 2001-04-04 Astrazeneca Ab Chemical compounds
GB0107228D0 (en) 2001-03-22 2001-05-16 Astrazeneca Ab Chemical compounds
SE0103818D0 (sv) 2001-11-15 2001-11-15 Astrazeneca Ab Chemical compounds
SE0301369D0 (sv) 2003-05-09 2003-05-09 Astrazeneca Ab Chemical compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3334594A1 (de) * 1983-09-24 1985-04-04 Boehringer Ingelheim KG, 6507 Ingelheim Basisch substituierte 2,4-dimethoxybenzamide, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung
FR2552762B1 (fr) * 1983-09-30 1986-07-25 Delalande Sa Nouveaux amides piperaziniques et homopiperaziniques derives de l'acide 3,4-dioxymethylene cinnamique, leur procede de preparation et leur application en therapeutique

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100459917B1 (ko) * 2001-12-14 2004-12-03 (주)바이오뉴트리젠 페놀릭산 유도체 및 이를 포함하는 혈중 지질 농도 관련질환의 예방 및 치료용 조성물

Also Published As

Publication number Publication date
DK386089A (da) 1990-02-13
EP0354568A2 (en) 1990-02-14
EP0354568A3 (en) 1991-09-11
DK386089D0 (da) 1989-08-07

Similar Documents

Publication Publication Date Title
FR2658818B1 (fr) Nouveaux derives a structure naphtalenique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
KR970704702A (ko) 치환된 피리미딘 화합물 및 그의 용도(Substituted Pyrimidine Compounds and Their Use)
FI881985A0 (fi) Foerfarande foer framstaellning av terapeutiskt verkande (s,s,s)-isomerer av substituerade acylderivat av 1,2,3,4-tetrahydroisokinolin-3-karboxylsyror.
KR970704435A (ko) 헤테로시클릭 화합물의 도파민-D 리간드로서의 용도(Use of Heterocyclic Compounds as Dopamines-D Ligands)
KR920008024A (ko) 퀴놀린 유도체
KR900003151A (ko) 화합물
KR900003122A (ko) 카테콜 유도체
KR930700106A (ko) 혈전증 치료제 및 포스포 디에스테라제 저해제
KR870010067A (ko) 신규의 디포스폰산 화합물, 이들의 제조 방법 및 이들을 함유하는 제약조성물
MY106247A (en) Anti-atherosclerotic diaryl compounds
PT695183E (pt) Utilizacao de tiazolidinodionas para o tratamento da aterosclerose e perturbacoes alimentares
KR890011596A (ko) 불면증 치료용 의약품의 제조에 있어서 1,4-이치환-피페리디닐 화합물의 용도
KR910000730A (ko) N-헤테로아릴-푸린-6-아민, 이의 제조방법 및 약제로서의 이의 용도
KR890016017A (ko) 치환된 1-(1h-이미다졸-4-일)알킬-벤즈아미드
KR960706476A (ko) 인터류킨-1 활성 억제제로서의 신규한 벤젠설포닐아민 유도체(Novel benzen-esulfonylimine derivatives as inhibitors of lL-1 action)
KR900001675A (ko) 기관지확장 작용을 갖는 화합물
KR910004557A (ko) 2,4,6-치환 페놀 유도체
DE3363553D1 (en) Substituted alpha-(ethyl)-alpha-(phenyl)-(omega-(dialkylamino)-alkoxy)-benzyl alcohols, their acid addition salts and quaternary salts, process for their preparation, as well as medicines containing these compounds
KR900016178A (ko) 2-치환 n,n'-디트리메톡시벤조일 피페라진, 그의 제조 방법 및 그를 함유하는 치료 조성물
EP0139440A3 (en) Pyridinium compounds
KR900011724A (ko) 특정 피롤릴페닐-치환된 하이드록삼산 유도체
KR900012925A (ko) 인돌 유도체
KR880002828A (ko) 디하이드로피리딘 유도체 및 이것의 약학적 조성말
ES8507468A1 (es) Procedimiento de obtencion de agentes de beta-bloqueantes conteniendo grupos ester con propiedades oftalmologicas
KR890008148A (ko) 새로운 세파로스포린 화합물 및 항균제

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid