KR900003122A - 카테콜 유도체 - Google Patents
카테콜 유도체 Download PDFInfo
- Publication number
- KR900003122A KR900003122A KR1019890011527A KR890011527A KR900003122A KR 900003122 A KR900003122 A KR 900003122A KR 1019890011527 A KR1019890011527 A KR 1019890011527A KR 890011527 A KR890011527 A KR 890011527A KR 900003122 A KR900003122 A KR 900003122A
- Authority
- KR
- South Korea
- Prior art keywords
- piperidyl
- dihydroxyphenyl
- propionamide
- iii
- phenylpropyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (3)
- 하기 구조식의 카테콜 유도체 또는 이것의 약학적 허용 산 부가염.상기식에서 R1은 수소원자, 아실라디칼 또는 카르바모일 라디칼이며; R2는 수소원자, 저급알킬라디칼 또는 하기 구조의 아르알킬 라디칼이며;R3및 R4는 수소원자, 저급알콕시, 할로겐 원자, 저급알킬, 트리플루오로메틸 및 히드록실로 구성되는 그룹으로부터 선택되는 서로 동일한 혹은 상이한 치환체이며; m은 1 내지 4의 정수이며, n은 1 내지 4의 정수이다.
- 제1항에 있어서, 하기의 i)-xii)의 화합물들로 구성되는 그룹으로부터 선택되는 유도체 또는 이것의 약학적 허용 산 부가염.i)N-[1-(3-(4-페닐프로필)-4-피페리딜]-3-(3,4-디히드록시페닐)프로피온아미드. 하이드로클로라이드, ⅱ)N-[1-(3-(4-메톡시페닐)프로필)-4-피페리딜]-3-(3,4-디히드록시페닐)프로피온아미드. 하이드로클로라이드, ⅲ)N-[1-(3-(3,4-디메톡시페닐))-4-피페리딜]-3-(3,4-디히드록시페닐)프로피온아미드. 하이드로클로라이드, ⅳ)N-[1-(3-페닐프로필)-4-피페리딜]-3,4-디히드록시페닐아세트아미드,ⅴ)N-[1-(3-페닐프로필)-4-피페리딜]-3-디아세톡시페닐)프로피온아미드, ⅵ)N-[1-(3-페닐프로필)-4-(3,4-디히드록시페닐)부티르아미드, ⅶ)N-[1-(2-페닐에틸)-4-피페리딜]-3-(3,4-디히드록시페닐)프로피온아미드, ⅷ)N-[1-(4-페닐부틸)-4-피페리딜]-3-(3,4-디히드록시페닐)프로피온아미드, ⅸ)N-[1-(3-(4-클로로페닐)프로필)-4-피페리딜]-3-(3,4-디아세톡시페닐)프로피온아미드, ⅹ)N-[1-(3,3-디페닐)프로필)-4-피페리딜]-3-(3,4-디히드록시페닐)프로피온아미드, xi)N-[1-(2-(3,4-디메톡시페닐)에틸)-4-피페리딜]-3-(3,4-디히드록시페닐)프로피온아미드, xii)N-[1-(3-페닐프로필)-4-피페리딜]-(3,4-디히드록시페닐)부티르아미드.
- 치료학적 유효양의 제1항 또는 제2항의 카테콜 유도체와 약학적 허용 첨가제로 구성되는 변성 신경학적 장애를 예방 또는 치료하기 위한 약학적 조성물.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP20000688 | 1988-08-12 | ||
JP63-200006 | 1988-08-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR900003122A true KR900003122A (ko) | 1990-03-23 |
Family
ID=16417226
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019890011527A KR900003122A (ko) | 1988-08-12 | 1989-08-12 | 카테콜 유도체 |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP0354568A3 (ko) |
KR (1) | KR900003122A (ko) |
DK (1) | DK386089A (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100459917B1 (ko) * | 2001-12-14 | 2004-12-03 | (주)바이오뉴트리젠 | 페놀릭산 유도체 및 이를 포함하는 혈중 지질 농도 관련질환의 예방 및 치료용 조성물 |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5595872A (en) * | 1992-03-06 | 1997-01-21 | Bristol-Myers Squibb Company | Nucleic acids encoding microsomal trigyceride transfer protein |
KR20010012316A (ko) | 1997-05-08 | 2001-02-15 | 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 | 프로테아제 억제제 |
DE19924148A1 (de) * | 1999-05-26 | 2000-12-07 | Univ Heidelberg | Sphingomyelinasehemmer |
SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
GB0011838D0 (en) * | 2000-05-17 | 2000-07-05 | Astrazeneca Ab | Chemical compounds |
GB0104050D0 (en) | 2001-02-19 | 2001-04-04 | Astrazeneca Ab | Chemical compounds |
GB0107228D0 (en) | 2001-03-22 | 2001-05-16 | Astrazeneca Ab | Chemical compounds |
SE0103818D0 (sv) | 2001-11-15 | 2001-11-15 | Astrazeneca Ab | Chemical compounds |
SE0301369D0 (sv) | 2003-05-09 | 2003-05-09 | Astrazeneca Ab | Chemical compounds |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3334594A1 (de) * | 1983-09-24 | 1985-04-04 | Boehringer Ingelheim KG, 6507 Ingelheim | Basisch substituierte 2,4-dimethoxybenzamide, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung |
FR2552762B1 (fr) * | 1983-09-30 | 1986-07-25 | Delalande Sa | Nouveaux amides piperaziniques et homopiperaziniques derives de l'acide 3,4-dioxymethylene cinnamique, leur procede de preparation et leur application en therapeutique |
-
1989
- 1989-08-07 DK DK386089A patent/DK386089A/da not_active Application Discontinuation
- 1989-08-10 EP EP19890114800 patent/EP0354568A3/en not_active Withdrawn
- 1989-08-12 KR KR1019890011527A patent/KR900003122A/ko not_active Application Discontinuation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100459917B1 (ko) * | 2001-12-14 | 2004-12-03 | (주)바이오뉴트리젠 | 페놀릭산 유도체 및 이를 포함하는 혈중 지질 농도 관련질환의 예방 및 치료용 조성물 |
Also Published As
Publication number | Publication date |
---|---|
DK386089A (da) | 1990-02-13 |
EP0354568A2 (en) | 1990-02-14 |
EP0354568A3 (en) | 1991-09-11 |
DK386089D0 (da) | 1989-08-07 |
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WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |