KR930000129A - Fgf함유 뼈 대체물질 - Google Patents

Fgf함유 뼈 대체물질 Download PDF

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KR930000129A
KR930000129A KR1019920011102A KR920011102A KR930000129A KR 930000129 A KR930000129 A KR 930000129A KR 1019920011102 A KR1019920011102 A KR 1019920011102A KR 920011102 A KR920011102 A KR 920011102A KR 930000129 A KR930000129 A KR 930000129A
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South Korea
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bone substitute
bone
substitute according
porous
matrix
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KR1019920011102A
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English (en)
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니스 베르트홀트
딩겔다인 엘비라
바리그 헬무트
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원본미기재
메르크 파텐트 게젤샤프트 미트 베슈랭크터 하프퉁
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Publication of KR930000129A publication Critical patent/KR930000129A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/3094—Designing or manufacturing processes
    • A61F2002/30968—Sintering
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

내용 없음

Description

FGF 함유 뼈 대체물질
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (25)

  1. 다공성 매트릭스에 섬유아세포 성장인자의 생물학적 작용을 갖는 하나 이상의 폴리펩티드로 이루어지는 것을 특징으로 하는 뼈 대체물질.
  2. 제1항에 있어서, 염기성 섬유아세포 성장인자로 이루어지는 것을 특징으로 하는 뼈 대체물질.
  3. 제1항에 있어서, 산성 섬유아세포 성장인자로 이루어지는 것을 특징으로 하는 뼈 대체물질.
  4. 제2항 또는 제3항에 있어서, 재조합 방법에 의해 제조된 섬유아세포 성장 인자로 이루어지는 것을 특징으로하는 뼈 대체물질.
  5. 제2항 내지 제4항 중 어느 한 항에 있어서, 섬유아세포 성장인자의 뮤테인으로 이루어지는 것을 특징으로하는 뼈 대체물질.
  6. 제1항 내지 제5항 중 어느 한 항에 있어서, 폴리펩티드의 산-안정화된 형태로 이루어지는 것을 특징으로하는 뼈 대체물질.
  7. 제1항에 있어서, 폴리펩티드 1ng/㎤ 내지 1㎎/㎤, 바람직하게는 1 내지 100㎍g/㎤으로 이루어지는 것을 특징으로 하는 뼈 대체물질.
  8. 제1항 내지 제7항 중 어느 한 항에 있어서, 다공성 매트릭스가 미네랄에 의해, 바람직하게는 바이오 활성물질에 의해 형성되는 것을 특징으로 하는 뼈 대체물질.
  9. 제8항에 있어서, 다공성 미네랄 매트릭스가 본질적으로 칼슘 미네랄로 구성되는 것을 특징으로 하는 뼈 대체 물질.
  10. 제9항에 있어서, 다공성 미네랄 매트릭스가 본질적으로 인산 칼슘으로 구성되는 것을 특징으로 하는 뼈대체물질.
  11. 제9항에 있어서, 다공성 미네랄 매트릭스가 히드록시아파타이트, 인산 3칼슘 및 인산 4칼슘으로 이루어진 그룹으로부터 선택되는 하나이상의 화합물로 구성되는 것을 특징으로 하는 뼈 대체물질.
  12. 제9항 내지 제11항 중 어느 한 항에 있어서, 칼슘 미네랄을 천연 뼈로부터 얻는 것을 특징으로 하는 뼈대체물질.
  13. 제9항 내지 제12항 중 어느 한 항에 있서, 다공성 미네랄 매트릭스가 소결된 인산칼슘 세라믹인 것을 특징으로 하는 뼈 대체물질.
  14. 제12항에 있어서, 다공성 미네랄 매트릭스가 소결된 해면질 뼈 세라믹으로 구성되는 것을 특징으로 하는뼈 대체물질.
  15. 제1항 내지 제7항 중 어느 한 항에 있어서 다공성 매트릭스가 생리학적으로 허용가능한 금속물질로 형성되 는 것을 특징으로 하는 뼈 대체물질.
  16. 제1항에 있어서, 다공성 매트릭스가 생리학적으로 허용가능한 폴리머 물질로 형성되는 것을 특징으로 하는뼈 대체물질.
  17. 제1항 내지 제16항 중 어느 한 항에 있어서, 다공성 매트릭스가 임플랜트 성형품으로서 존재하는 것을 특징으로 하는 뼈 대체물질.
  18. 제1항 내지 제16항 중 어느 한 항에 있어서 다공성 매트릭스가 임플랜트 성형품의 표면 또는 표면코팅을 형성하는 것을 특징으로 하는 뼈 대체물질.
  19. 제1항 내지 제16항 중 어느 한 함에 있어서, 다공성 매트릭스가 분말 또는 그래뉼 형태로 존재하는 것을 특징으로 하는 뼈 대체물체.
  20. 제19항에 있어서, 다공성 미네랄 매트릭스가 분말 또는 그래뉼 형태로 존재하고 생리학적으로 허용가능한 폴리머 물질과 결합하여 성형품을 형성하는 것을 특징으로 하는 뼈 대체물질.
  21. 제19항에 있어서, 다공성 미네랄 매트릭스가 분말 또는 그래뉼 형태로 존재하고 골 시멘트 성분을 형성하는것을 특징으로 하는 뼈 대체물질.
  22. 제1항 내지 제21항에 있어서, 돌 이상의 별도의 성분으로 된 즉시 사용 임플랜테이션 세트 형태로 존재하고, 상기 성분중 하나는 다공성 매트릭스로 이루어지고, 다른 성분은 폴리펩티드 용액 또는 현탁액으로 이루어지는 것을 특징으로 하는 뼈 대체물질.
  23. 제22항에 있어서, 다공성 매트릭스로 이루어지는 성분이 임플랜트 성형품인 것을 특징으로 하는 뼈 대체물질.
  24. 제23항에 있어서, 임플랜트 성형품이 미네랄 물질, 바람직하기는 세라믹 물질로 구성되는 것을 특징으로하는 뼈 대체물질.
  25. 제24항에 있어서, 임플랜트 성형품이 소결된 뼈 세라믹으로 구성되는 것을 특징으로 하는 뼈 대체물질.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920011102A 1991-06-26 1992-06-25 Fgf함유 뼈 대체물질 KR930000129A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4121043A DE4121043A1 (de) 1991-06-26 1991-06-26 Knochenersatzmaterial mit fgf
DEP4121043.3 1991-06-26

Publications (1)

Publication Number Publication Date
KR930000129A true KR930000129A (ko) 1993-01-15

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KR1019920011102A KR930000129A (ko) 1991-06-26 1992-06-25 Fgf함유 뼈 대체물질

Country Status (18)

Country Link
US (1) US6118043A (ko)
EP (1) EP0520237B1 (ko)
JP (2) JPH07171211A (ko)
KR (1) KR930000129A (ko)
AT (1) ATE176161T1 (ko)
AU (1) AU652839B2 (ko)
CA (1) CA2072244A1 (ko)
CZ (1) CZ281711B6 (ko)
DE (2) DE4121043A1 (ko)
ES (1) ES2128330T3 (ko)
HU (1) HUT65499A (ko)
IE (1) IE922067A1 (ko)
MX (1) MX9203253A (ko)
NO (1) NO922511L (ko)
PL (1) PL172728B1 (ko)
RU (1) RU2062622C1 (ko)
TW (1) TW293776B (ko)
ZA (1) ZA924780B (ko)

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KR100563476B1 (ko) * 1998-07-03 2006-03-27 이진용 골재생재료
WO2015034307A1 (ko) * 2013-09-09 2015-03-12 주식회사 본셀바이오텍 갑오징어뼈를 이용한 골이식재 및 이의 제조방법

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DE4121043A1 (de) 1993-01-07
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MX9203253A (es) 1994-03-31
HU9202123D0 (en) 1992-10-28
CA2072244A1 (en) 1992-12-27
IE922067A1 (en) 1992-12-30
DE59209624D1 (de) 1999-03-11
ATE176161T1 (de) 1999-02-15
AU652839B2 (en) 1994-09-08
PL295001A2 (en) 1992-12-28
JPH07171211A (ja) 1995-07-11
US6118043A (en) 2000-09-12
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RU2062622C1 (ru) 1996-06-27
TW293776B (ko) 1996-12-21
ZA924780B (en) 1993-04-28
JP2003093495A (ja) 2003-04-02
AU1854692A (en) 1993-01-07
CZ281711B6 (cs) 1996-12-11
NO922511D0 (no) 1992-06-25
ES2128330T3 (es) 1999-05-16

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