KR920700206A - 테트라-아자 마크로싸이클 화합물과 이들의 금속착화합물 - Google Patents

테트라-아자 마크로싸이클 화합물과 이들의 금속착화합물

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KR920700206A
KR920700206A KR1019890700624A KR890700624A KR920700206A KR 920700206 A KR920700206 A KR 920700206A KR 1019890700624 A KR1019890700624 A KR 1019890700624A KR 890700624 A KR890700624 A KR 890700624A KR 920700206 A KR920700206 A KR 920700206A
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formula
integer
compounds
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KR1019890700624A
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데이비드 파커
토마스 앤드류 밀리칸
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셀텍크 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65G—TRANSPORT OR STORAGE DEVICES, e.g. CONVEYORS FOR LOADING OR TIPPING, SHOP CONVEYOR SYSTEMS OR PNEUMATIC TUBE CONVEYORS
    • B65G49/00—Conveying systems characterised by their application for specified purposes not otherwise provided for
    • B65G49/05—Conveying systems characterised by their application for specified purposes not otherwise provided for for fragile or damageable materials or articles
    • B65G49/06—Conveying systems characterised by their application for specified purposes not otherwise provided for for fragile or damageable materials or articles for fragile sheets, e.g. glass
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Cephalosporin Compounds (AREA)
  • External Artificial Organs (AREA)
  • Saccharide Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

내용 없음

Description

테트라－아자 마크로싸이클 화합물과 이들의 금속착화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (18)

  1. 구조식(1)의 화합물과 이의 금속착화합물 및 염.
    여기에서, m과 n은 0이거나 1, 2또는 3인 정수로 각각은 서로 같거나 상이할 수 있으며; b는 0 또는 1, 2또는 3인 정수;R, R1, R2와 R3는 수소원자 또는 알킬, 알콕시알킬, －CO2H, －SO3H, －PO2H2나 아릴기로 각각은 서로 같거나 상이할수 있으며; L은 공유결합 또는 연결기이고, Z는 수소원자 또는 반응성 관능기로, L이 공유결합이면 Z는 반응성 관능기이다.
  2. 제1항에 있어서, q는 1 내지 6인 정수이고,R, R1, R2와 R3가 －CO2H기인 화합물.
  3. 제2항에 있어서, q는 1인 화합물.
  4. 전술한 어느 한 항에 있어서, L은 임의로 치환된 지방족 하이드로카르빌 사슬과, －O－또는 －S－로부터 선택된 하나 또는 그 이상의 이종 원자에 의하여 임의로 차단되거나 또는 하나 또는 그 이상의 －N(R5)－(여기에서 R5는 수소원자나 C1-6알킬기), －CON(R5)－, N(R5)CO－, 시클로지방족, 방향족 혹은 헤테로 방향족기들에 의하여 임의로 차단된 것인 화합물.
  5. 전술한 어느 한 항에 있어서, Z가 티올, 아미노, 카르복실, 하이드록실, 알데히드, 방향족 또는 헤테로방향족기와 반응할 수 있는 것인 화합물.
  6. 제5항에 있어서, Z는 할로겐 원자 또는 －SH, －NH2, 하이드라진 또는 그 유도체, －NCO, －NCS, －COR10(여기에서 R10은 할로겐원자 또는 N3, C1-6알콕시, C6-12아릴옥시, 이미딜옥시 혹은 이미다 조일옥시기이다.), 이미드, －Het1－C(Het2)=CH2(여기에서 Het1과 Het2는 같거나 상이할 수도 있는 질소함유 헤테로시클릭기 이거나, Het1은 질소 함유 헤테로시클릭기이고 Het2는 수소원자 이다.) 또는 구조식(여기에서 R11은 C1-4알킬기이다)으로 구성된 군으로부터 선택된 것인 화합물.
  7. 금속의 이온가가 +2가 또는 +3가이고 배위수가 6 또는 그 이상의 금속이 착화된 전술한 항에서 언급한 구조식(1)화합물의 금속착화합물.
  8. 제7항에 있어서, 금속이 구리, 납, 비스무스, 이트륨, 테르븀, 가돌리늄 또는 스탄듐인 화합물.
  9. 특허청구의 범위 제1항 내지 제7항에서 언급한 구조식(1)화합물의 이트륨착화합물.
  10. 전술한 어느 한항에 있어서, d가 1인 화합물.
  11. 구조식 (1a)화합물과 이의 금속착화합물 및 염.
    여기에서 R1, R2와 R3는 수소원자 또는 알킬, 알콕시알킬, －CO2H, －SO3H, －PO2H2혹은 아릴기로 서로 같거나 다를수 있으며; L은 공유결합 또는 연결기; Z는 수소원자 또는 반응성관능기로서 L이 공유결합이면 Z는 반응성 관능기이다.
  12. 제11항에 있어서, R1, R2와 R3는 각각이 －CO2H기인 화합물.
  13. 구조식(1)화합물이나 금속착화합물 및 이들의 염이 단백질, 펩타이드 혹은 탄수화물과 결합된 공액화합물(conjugated compound).
    여기에서, m과 n은 0 또는 1, 2 또는 3인 정수로 서로 같거나 다를수 있으며; d는 0 또는 1, 2 또는 3인 정수; q는 0 또는 1 내지 6인 정수; R, R1, R2와 R3는 수소원자 또는 알킬, 알콕시알킬, －CO2H, －SO3H, －PO2H2또는 아릴기로 서로 같거나 다를수 있으며; L은 공유결합 또는 연결기; Z는 수소원자 또는 반응성 관능기로, L이 공유결합이면 Z는 반응성 관능기이다.
  14. 구조식(2)의 공액화합물(conjugated compound)과 이의 금속착화합물 및 이들의 염.
    여기에서, m과 n은 0 또는 1, 2 또는 3인 정수로 서로 같거나 다를수 있으며, d는 0 또는 1, 2 또는 3인 정수; q는 0 또는 1내지 6인 정수이며, R, R1, R2와 R3는 수소원자 또는 알킬, 알콕시 알킬, －CO3H, －SO3H, －PO2H2또는 아릴기로 서로 같거나 다를수 있으며; L은 공유결합 또는 연결기; Z1는 반응성관능기의 잔기; W는 0또는 1인 정수; z는 그이상의 정수; Ab는 항체이다.
  15. 특허청구의 범위 1항기재의 구조식(1)화합물이나 이들의 금속착화합물 또는 이들의 염과 하나또는 그 이상의 약학적으로 유용한 담체들로 구성된 조성물.
  16. 특허청구의 범위 제14항 기재의 구조식(2)화합물이나 이들의 금속착화합물 또는 이들의 염과 하나 이상의 약학적으로 유용한 담체들로 구성된 조성물.
  17. 구조식(3)화합물(여기에서 m, n, d, L과 Z는 구조식(1)의 화합물의 기재와 같다)이나 이들의 금속 착화합물을 R1(CH2)qD(여기에서 D는 치환기이고 R1과 q는 구조식(1)화합물의 기재와 같다.)인 시약과 반응시킴을 특징으로 하는 특허청구의 번위 제1항기재의 구조식(1)화합물 이들의 금속착화합물의 제조방법.
  18. 특허청구의 범위 제1항기재의 구조식(1)의 화합물을 항체 Ab와 반응시킴을 특징으로 하는 특허청구의 범위 제14항 기재의 구조식(2)의 공액화합물(conjugated compound)의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890700624A 1987-08-12 1988-08-12 테트라-아자 마크로싸이클 화합물과 이들의 금속착화합물 KR920700206A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB8719042 1987-08-12
GB878719042A GB8719042D0 (en) 1987-08-12 1987-08-12 Conjugate compounds
PCT/GB1988/000671 WO1989001476A1 (en) 1987-08-12 1988-08-12 Tetra-aza macrocycles and metal complexes thereof

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KR920700206A true KR920700206A (ko) 1992-02-19

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Country Link
US (1) US6774228B1 (ko)
EP (1) EP0328589B1 (ko)
JP (1) JPH02501141A (ko)
KR (1) KR920700206A (ko)
AT (1) ATE136302T1 (ko)
AU (1) AU629515B2 (ko)
CA (1) CA1341102C (ko)
DE (1) DE3855177T2 (ko)
DK (1) DK172789A (ko)
GB (1) GB8719042D0 (ko)
WO (1) WO1989001476A1 (ko)

Families Citing this family (131)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5422096A (en) * 1985-05-08 1995-06-06 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5271927A (en) * 1986-02-13 1993-12-21 Celltech Limited Antibody conjugates with macrocyclic ligands
US5132409A (en) * 1987-01-12 1992-07-21 Bracco Industria Chimica S.P.A. Macrocyclic chelating agents and chelates thereof
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
GB8719041D0 (en) * 1987-08-12 1987-09-16 Parker D Conjugate compounds
RU2059642C1 (ru) * 1987-12-24 1996-05-10 Бракко Индустрия Кимика С.п.А Хелаты гадолиния и способ их получения
AU630362B2 (en) * 1988-05-25 1992-10-29 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Macrocyclic chelates & methods of use thereof
EP0353450B1 (en) * 1988-06-24 1995-03-29 The Dow Chemical Company Macrocyclic bifunctional chelants, complexes thereof and their antibody conjugates
US5776894A (en) * 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
US5342936A (en) * 1989-02-10 1994-08-30 David Parker Tetra-aza macrocycles and processes for their preparation
WO1990009379A1 (en) * 1989-02-10 1990-08-23 Celltech Limited Aza-macrocycles and processes for their preparation
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents
US6139603A (en) * 1989-02-22 2000-10-31 L'air Liquide, Societe Anonyme Pour L'etude Et L'exploitation Des Procedes Georges Claude Process for recovering oxygen
DE3911816A1 (de) * 1989-04-11 1990-10-25 Hoechst Ag Substituierte 1,4,7,10-tetraazacyclotridecane, verfahren zu deren herstellung sowie verwendung derselben zur markierung von substanzen mit radionukliden
DK169306B1 (da) * 1989-06-14 1994-10-10 Af 18 Juni 1990 As Middel til fjernelse eller inaktivering af uønskede komponenter i blod eller andre ekstracellulære legemsvæsker samt fremgangsmåde til fremstilling af dextran-O-carbonyl-benzo-18-crown-6 og af dextran-hydroxyethylbenzo-18-crown-6
US5247077A (en) * 1989-06-23 1993-09-21 Celltech Limited Tri-aza macrocycles and processes for their preparation
DE69032761T2 (de) * 1989-08-28 1999-04-22 Gen Hospital Corp Hydroxy-aryl metallchelate für bildformung zur nmr diagnose
FR2654102B1 (fr) * 1989-11-09 1992-01-10 Air Liquide Procede de synthese de derives polyazotes cycliques.
US5236695A (en) * 1989-11-27 1993-08-17 Concat, Ltd. MRI image enhancement of bone and related tissue using complexes of paramagnetic cations and polyphosphonate ligands
GB9004017D0 (en) * 1990-02-22 1990-04-18 Krenning Eric P Improvements in or relating to organic compounds
US5684135A (en) * 1990-04-18 1997-11-04 Celltech Therapeutics Limited Conjugate compounds containing aza-macro-cycles and processes for their preparation
GB9008724D0 (en) * 1990-04-18 1990-06-13 Celltech Ltd Chemical compounds
DE69124132T2 (de) * 1990-04-18 1997-06-05 Celltech Therapeutics Ltd Tetra-aza-makrozyklen, Verfahren zu ihrer Herstellung und ihre Anwendung in NMR-Bildformung
JPH06340556A (ja) * 1990-06-18 1994-12-13 Dow Chem Co:The イメージング剤としての大環状アミノホスホン酸錯体の使用
GB9112536D0 (en) * 1991-06-11 1991-07-31 Celltech Ltd Chemical compounds
DE4237943C2 (de) * 1992-11-06 1997-10-23 Schering Ag Verfahren zur Herstellung von Metallkomplexen der N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,7,10-tetraazacyclododecan- und N-beta-Hydroxyalkyl-tri-N-carboxyalkyl-1,4,8,11-tetraazacyclotetradecan-Derivate
US5310535A (en) * 1992-04-24 1994-05-10 The Dow Chemical Company Carboxamide modified polyamine chelators and radioactive complexes thereof for conjugation to antibodies
US5807535A (en) * 1992-07-31 1998-09-15 Australian Nuclear Science & Technology Organisation Metal complexes of hydroxyaryl containing aminocarboxylic acid chelating agents
PT590766E (pt) * 1992-07-31 2000-07-31 Australian Nuclear Science Tec Complexos metalicos de hidroxiarilo contendo agentes quelantes de acido aminocarboxilico
EP0588229A3 (en) * 1992-09-12 1994-06-15 Hoechst Ag Macrocyclic chelating agents for the preparation of technetium or rhenium complexes
CA2163232A1 (en) 1993-05-20 1994-12-08 Robert C. Brasch Macromolecular contrast media for mr imaging
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
TW319763B (ko) 1995-02-01 1997-11-11 Epix Medical Inc
GB9504910D0 (en) * 1995-03-10 1995-04-26 Nycomed Imaging As Compounds
US5874573A (en) 1995-06-26 1999-02-23 Concat, Inc. Compounds with chelation affinity and selectivity for first transition series elements: use in medical therapy
GB9812545D0 (en) 1998-06-10 1998-08-05 Celltech Therapeutics Ltd Biological products
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
DE69942782D1 (de) 1998-11-27 2010-10-28 Ucb Sa Zusammensetzungen und Verfahren zur Erhöhung der Knochenmineralisierung
US6565828B2 (en) * 2000-04-07 2003-05-20 Bristol-Myers Squibb Company Macrocyclic chelants for metallopharmaceuticals
GB0013810D0 (en) 2000-06-06 2000-07-26 Celltech Chiroscience Ltd Biological products
US6517814B2 (en) 2001-01-09 2003-02-11 Bristol-Myers Squibb Pharma Company Macrocyclic chelants useful for metallopharmaceuticals
JP2004530654A (ja) 2001-02-23 2004-10-07 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー アテローム硬化症および脆弱性プラークを画像診断するための標識マクロファージスカベンジャー受容体拮抗薬
DE10135356C1 (de) 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen
US7338651B2 (en) * 2001-09-04 2008-03-04 Texas Tech University System Multi-use multimodal imaging chelates
GB0124317D0 (en) 2001-10-10 2001-11-28 Celltech R&D Ltd Biological products
JP4418745B2 (ja) 2002-05-28 2010-02-24 ユセベ ファルマ ソシエテ アノニム 抗体ｐｅｇ位置異性体、それを含む組成物及びその使用
GB0303337D0 (en) 2003-02-13 2003-03-19 Celltech R&D Ltd Biological products
CN100418957C (zh) * 2003-07-08 2008-09-17 香港大学 三-n-烷基化的1,4,7,10-四氮杂环十二烷的合成
CA2581639C (en) 2004-09-30 2016-07-26 Molecular Devices Corporation Luminescent lanthanide complexes
ZA200804594B (en) 2005-12-09 2010-08-25 Ucb Pharma Sa Antibody molecules having specificity for human IL-6
JP2009529917A (ja) 2006-03-22 2009-08-27 ヴァイラル ロジック システムズ テクノロジー コーポレーション 標的ポリペプチドの同定方法および免疫学的疾患の治療のためのその使用
US8377448B2 (en) 2006-05-15 2013-02-19 The Board Of Trustees Of The Leland Standford Junior University CD47 related compositions and methods for treating immunological diseases and disorders
GB0620729D0 (en) 2006-10-18 2006-11-29 Ucb Sa Biological products
GB0807413D0 (en) 2008-04-23 2008-05-28 Ucb Pharma Sa Biological products
PL2398498T3 (pl) 2009-02-17 2019-03-29 Ucb Biopharma Sprl Cząsteczki przeciwciał swoiste wobec ludzkiego OX40
GB0904214D0 (en) 2009-03-11 2009-04-22 Ucb Pharma Sa Biological products
WO2011030107A1 (en) 2009-09-10 2011-03-17 Ucb Pharma S.A. Multivalent antibodies
GB0920127D0 (en) 2009-11-17 2009-12-30 Ucb Pharma Sa Antibodies
GB0920324D0 (en) 2009-11-19 2010-01-06 Ucb Pharma Sa Antibodies
GB201000467D0 (en) 2010-01-12 2010-02-24 Ucb Pharma Sa Antibodies
GB201000588D0 (en) 2010-01-14 2010-03-03 Ucb Pharma Sa Bacterial host strain
WO2011110604A1 (en) 2010-03-11 2011-09-15 Ucb Pharma, S.A. Pd-1 antibody
TW201134488A (en) 2010-03-11 2011-10-16 Ucb Pharma Sa PD-1 antibodies
US10472426B2 (en) 2010-03-25 2019-11-12 Ucb Biopharma Sprl Disulfide stabilized DVD-Ig molecules
GB201005064D0 (en) 2010-03-25 2010-05-12 Ucb Pharma Sa Biological products
GB201012599D0 (en) 2010-07-27 2010-09-08 Ucb Pharma Sa Process for purifying proteins
GB201014033D0 (en) 2010-08-20 2010-10-06 Ucb Pharma Sa Biological products
ES2632583T3 (es) 2011-01-14 2017-09-14 Ucb Biopharma Sprl Anticuerpo que se une a IL-17A e IL-17F
EP2546267A1 (en) 2011-07-13 2013-01-16 UCB Pharma S.A. Bacterial host strain expressing recombinant DsbC
MX2014002769A (es) 2011-09-16 2014-06-11 Ucb Pharma Sa Anticuerpos neutralizantes para las exotoxinas principales tcda y tcdb de clostridium difficile.
UA112203C2 (uk) 2011-11-11 2016-08-10 Юсб Фарма С.А. Злитий білок біоспецифічного антитіла, який зв'язується з ox40 людини та сироватковим альбуміном людини
GB201203051D0 (en) 2012-02-22 2012-04-04 Ucb Pharma Sa Biological products
GB201203071D0 (en) 2012-02-22 2012-04-04 Ucb Pharma Sa Biological products
GB201208370D0 (en) 2012-05-14 2012-06-27 Ucb Pharma Sa Antibodies
GB201223276D0 (en) 2012-12-21 2013-02-06 Ucb Pharma Sa Antibodies and methods of producing same
GB201315487D0 (en) 2013-08-30 2013-10-16 Ucb Pharma Sa Antibodies
GB201320066D0 (en) 2013-11-13 2013-12-25 Ucb Pharma Sa Biological products
GB201409558D0 (en) 2014-05-29 2014-07-16 Ucb Biopharma Sprl Method
GB201411320D0 (en) 2014-06-25 2014-08-06 Ucb Biopharma Sprl Antibody construct
GB201412658D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201412659D0 (en) 2014-07-16 2014-08-27 Ucb Biopharma Sprl Molecules
GB201506869D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method
GB201506870D0 (en) 2015-04-22 2015-06-03 Ucb Biopharma Sprl Method
WO2016176656A2 (en) 2015-04-30 2016-11-03 President And Fellows Of Harvard College Anti-ap2 antibodies and antigen binding agents to treat metabolic disorders
GB201508180D0 (en) 2015-05-13 2015-06-24 Ucb Biopharma Sprl Antibodies
US10316097B2 (en) 2015-05-27 2019-06-11 Ucb Biopharma Sprl Method for the treatment of epilepsy, epileptogenesis, seizures or convulsions by an anti-colony-stimulating factor 1 receptor (CSF-1R) antibody
BR112017028102A2 (pt) 2015-07-06 2018-09-04 Ucb Biopharma Sprl anticorpos de ligação à tau
GB201601075D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies molecules
GB201601073D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibodies
GB201601077D0 (en) 2016-01-20 2016-03-02 Ucb Biopharma Sprl Antibody molecule
MX2018005031A (es) 2015-10-27 2018-06-13 Ucb Biopharma Sprl Metodos de tratamiento con anticuerpos anti interleucina 17a/17f (il-17a/f).
GB201521382D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521389D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Method
GB201521391D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201521383D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl And Ucb Celltech Method
GB201521393D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Antibodies
GB201522394D0 (en) 2015-12-18 2016-02-03 Ucb Biopharma Sprl Antibodies
EP3463482B1 (en) 2016-06-07 2021-10-06 The Brigham and Women's Hospital, Inc. Methods relating to t peripheral helper cells in autoantibody-associated conditions
GB201610198D0 (en) 2016-06-10 2016-07-27 Ucb Biopharma Sprl Anti-ige antibodies
SG10201913858WA (en) 2016-08-26 2020-03-30 Agency Science Tech & Res Macrophage stimulating protein receptor (or ron - recepteur d' origine nantais) antibodies and uses thereof
GB201616596D0 (en) 2016-09-29 2016-11-16 Nascient Limited Epitope and antibodies
GB201621635D0 (en) 2016-12-19 2017-02-01 Ucb Biopharma Sprl Crystal structure
WO2018183366A1 (en) 2017-03-28 2018-10-04 Syndax Pharmaceuticals, Inc. Combination therapies of csf-1r or csf-1 antibodies and a t-cell engaging therapy
AU2018269039A1 (en) 2017-05-19 2019-12-19 Syndax Pharmaceuticals, Inc. Combination therapies
GB201802486D0 (en) 2018-02-15 2018-04-04 Ucb Biopharma Sprl Methods
AU2019361247A1 (en) 2018-10-16 2021-05-27 UCB Biopharma SRL Method for the treatment of Myasthenia Gravis
SG11202109545VA (en) 2019-03-26 2021-10-28 Aslan Pharmaceuticals Pte Ltd Treatment employing anti-il-13r antibody or binding fragment thereof
GB201919062D0 (en) 2019-12-20 2020-02-05 Ucb Biopharma Sprl Antibody
GB201919061D0 (en) 2019-12-20 2020-02-05 Ucb Biopharma Sprl Multi-specific antibody
GB201919058D0 (en) 2019-12-20 2020-02-05 Ucb Biopharma Sprl Multi-specific antibodies
GB202001447D0 (en) 2020-02-03 2020-03-18 Ucb Biopharma Sprl Antibodies
EP4229086A1 (en) 2020-10-15 2023-08-23 UCB Biopharma SRL Binding molecules that multimerise cd45
WO2022089767A1 (en) 2020-11-02 2022-05-05 UCB Biopharma SRL Use of anti-trem1 neutralizing antibodies for the treatment of motor neuron neurodegenerative disorders
EP4255925A1 (en) 2020-12-07 2023-10-11 UCB Biopharma SRL Antibodies against interleukin-22
US20240067758A1 (en) 2020-12-07 2024-02-29 UCB Biopharma SRL Multi-specific antibodies and antibody combinations
WO2022186773A1 (en) 2021-03-01 2022-09-09 Aslan Pharmaceuticals Pte Ltd TREATMENT OF ATOPIC DERMATITIS EMPLOYING ANTI-IL-13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF IN AN ALLERGIC POPULATION
WO2022186772A1 (en) 2021-03-01 2022-09-09 Aslan Pharmaceuticals Pte Ltd TREATMENT OF ATOPIC DERMATITIS EMPLOYING ANTI-IL-13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF
EP4067381A1 (en) 2021-04-01 2022-10-05 Julius-Maximilians-Universität Würzburg Novel tnfr2 binding molecules
CA3218933A1 (en) 2021-05-03 2022-11-10 UCB Biopharma SRL Antibodies
GB202111905D0 (en) 2021-08-19 2021-10-06 UCB Biopharma SRL Antibodies
WO2023048650A1 (en) 2021-09-27 2023-03-30 Aslan Pharmaceuticals Pte Ltd TREATMENT OF PRURITIS EMPLOYING ANTI-IL13Rα1 ANTIBODY OR BINDING FRAGMENT THEREOF
WO2023048651A1 (en) 2021-09-27 2023-03-30 Aslan Pharmaceuticals Pte Ltd Method for treatment of moderate to severe atoptic dematitis
GB202115122D0 (en) 2021-10-21 2021-12-08 Dualyx Nv Binding molecules targeting IL-2 receptor
TW202333784A (zh) 2021-10-29 2023-09-01 新加坡商亞獅康私人有限公司 抗ｉｌ１３ｒ抗體調配物
WO2023140780A1 (en) 2022-01-24 2023-07-27 Aslan Pharmaceuticals Pte Ltd. Method of treating inflammatory disease
WO2023163659A1 (en) 2022-02-23 2023-08-31 Aslan Pharmaceuticals Pte Ltd Glycosylated form of anti-il13r antibody
GB202210679D0 (en) 2022-07-21 2022-09-07 Dualyx Nv Binding molecules targeting il-12rb2
WO2024043837A1 (en) 2022-08-26 2024-02-29 Aslan Pharmaceuticals Pte Ltd High concentration anti-il13r antibody formulation
WO2024054157A1 (en) 2022-09-06 2024-03-14 Aslan Pharmaceuticals Pte Ltd Treatment for sleep loss or sleep disturbance in patients with dermatitis

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2803528C2 (de) * 1977-03-09 1984-10-18 Tabushi, Iwao, Kyoto Schwermetallionen-Adsorbens und dessen Verwendung zum Adsorbieren von Schwermetallionen
JPS53144592A (en) 1977-05-19 1978-12-15 Tabuse Iwao 122alkyll1*4*7*100tetrazacyclotridecane
US4432907A (en) 1979-09-10 1984-02-21 Analytical Radiation Corporation Diamine acid fluorescent chelates
US4671958A (en) 1982-03-09 1987-06-09 Cytogen Corporation Antibody conjugates for the delivery of compounds to target sites
US4472509A (en) 1982-06-07 1984-09-18 Gansow Otto A Metal chelate conjugated monoclonal antibodies
SU1098937A1 (ru) * 1983-03-25 1984-06-23 Ордена Ленина институт элементоорганических соединений им.А.Н.Несмеянова 1,4,7,10-Тетра/диоксифосфорилметил/-1,4,7,10-тетраазациклододекан в качестве комплексона дл св зывани катионов меди /п/,кобальта /п/,кадми /п/,свинца /п/ и лантана /ш/
CA1260827A (en) 1984-08-31 1989-09-26 Richard C. Siegel Antibody-metal ion complexes
US4659839A (en) 1984-10-10 1987-04-21 Mallinckrodt, Inc. Coupling agents for radiolabeled antibody fragments
ATE66469T1 (de) 1985-01-14 1991-09-15 Neorx Corp Metall-radionuklid markiertes protein fuer diagnose und therapie.
JPS61226751A (ja) 1985-03-30 1986-10-08 Konishiroku Photo Ind Co Ltd ハロゲン化銀写真感光材料用処理液及びその処理方法
US4678667A (en) 1985-07-02 1987-07-07 501 Regents of the University of California Macrocyclic bifunctional chelating agents
US4885363A (en) 1987-04-24 1989-12-05 E. R. Squibb & Sons, Inc. 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
EP0232751B1 (en) 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
GB8603537D0 (en) * 1986-02-13 1986-03-19 Parker D Conjugate compound
FR2596992B1 (fr) * 1986-04-11 1988-12-16 Guerbet Sa Sel de lysine du complexe gadolinium-dota et ses applications au diagnostic
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
GB8618443D0 (en) 1986-07-29 1986-09-03 Univ London Monoclonal antibodies
US5049667A (en) * 1987-04-14 1991-09-17 Guerbet S.A. Nitrogen-containing cyclic ligands
FR2614020B1 (fr) * 1987-04-14 1989-07-28 Guerbet Sa Nouveaux ligands cycliques azotes, complexes metalliques formes par ces ligands, compositions de diagnostic contenant ces complexes et procede de preparation des ligands.
DE3713842A1 (de) * 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
AU617338B2 (en) * 1987-07-16 1991-11-28 Nycomed As Aminopolycarboxylic acids and derivatives thereof
ATE137228T1 (de) 1987-07-16 1996-05-15 Nycomed Imaging As Aminocarbonsäure und derivate
GB8719042D0 (en) 1987-08-12 1987-09-16 Parker D Conjugate compounds
JPH02500566A (ja) * 1987-08-17 1990-03-01 プラント・ジェネティック・システムズ・エヌ・ブイ バチルス・スリンギエンシスからのｄｎａ配列で形質転換された植物
AU630362B2 (en) * 1988-05-25 1992-10-29 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Macrocyclic chelates & methods of use thereof
US4923985A (en) * 1988-05-25 1990-05-08 The United States Of America As Represented By The Department Of Health & Human Services Process for synthesizing macrocyclic chelates
US5053503A (en) * 1989-02-17 1991-10-01 Centocor Chelating agents
DE10135356C1 (de) * 2001-07-20 2003-04-17 Schering Ag Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen

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