DK0452858T3 - Til mærkning af proteiner og andre aminholdige forbindelser nyttige metalkomplekser af syreaddukter til dioximligander - Google Patents
Til mærkning af proteiner og andre aminholdige forbindelser nyttige metalkomplekser af syreaddukter til dioximliganderInfo
- Publication number
- DK0452858T3 DK0452858T3 DK91105987.1T DK91105987T DK0452858T3 DK 0452858 T3 DK0452858 T3 DK 0452858T3 DK 91105987 T DK91105987 T DK 91105987T DK 0452858 T3 DK0452858 T3 DK 0452858T3
- Authority
- DK
- Denmark
- Prior art keywords
- amine
- containing compounds
- metal complexes
- compounds useful
- acid adducts
- Prior art date
Links
- 150000001412 amines Chemical class 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000002372 labelling Methods 0.000 title abstract 2
- 239000002184 metal Substances 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 239000002253 acid Substances 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 150000001642 boronic acid derivatives Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
- C07F13/005—Compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6887—Antibody-chelate conjugates using chelates for therapeutic purposes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0478—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from non-cyclic ligands, e.g. EDTA, MAG3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2123/00—Preparations for testing in vivo
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/508,433 US5183653A (en) | 1990-04-13 | 1990-04-13 | Boronic acid adducts of metal dioxime complexes useful in labelling proteins and other amine-containing compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0452858T3 true DK0452858T3 (da) | 1997-11-17 |
Family
ID=24022730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91105987.1T DK0452858T3 (da) | 1990-04-13 | 1991-04-15 | Til mærkning af proteiner og andre aminholdige forbindelser nyttige metalkomplekser af syreaddukter til dioximligander |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5183653A (da) |
| EP (1) | EP0452858B1 (da) |
| JP (1) | JP2933740B2 (da) |
| AT (1) | ATE155474T1 (da) |
| CA (1) | CA2039218C (da) |
| DE (1) | DE69126816T2 (da) |
| DK (1) | DK0452858T3 (da) |
| ES (1) | ES2103755T3 (da) |
| GR (1) | GR3024598T3 (da) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6825169B1 (en) * | 1991-10-22 | 2004-11-30 | Trustees Of Tufts College | Inhibitors of dipeptidyl-aminopeptidase type IV |
| US5300280A (en) * | 1992-02-14 | 1994-04-05 | Mallinckrodt Medical, Inc. | Stabilized radiopharmaceutical kits |
| US5594151A (en) * | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexing reagents derived from aminosalicylic acid |
| US5744627A (en) * | 1994-01-28 | 1998-04-28 | Prolinx, Inc. | Boronic compound complexing reagents and complexes |
| US5623055A (en) * | 1994-01-28 | 1997-04-22 | Prolinx, Inc. | Phenylboronic acid complexes derived from aminosalicylic acid for bioconjugate preparation |
| US5847192A (en) * | 1994-01-28 | 1998-12-08 | Prolinx, Inc. | Boronic compound complexing reagents and complexes |
| US5594111A (en) * | 1994-01-28 | 1997-01-14 | Prolinx, Inc. | Phenylboronic acid complexes for bioconjugate preparation |
| US5837878A (en) * | 1994-01-28 | 1998-11-17 | Prolinx, Inc. | Boronic compound complexing reagents and highly stable complexes |
| US5777148A (en) * | 1994-01-28 | 1998-07-07 | Prolinx, Inc. | Boronic compound complexing reagents and highly stable complexes |
| US5852178A (en) * | 1994-01-28 | 1998-12-22 | Prolinx, Inc. | Phenylboronic acid complexing reagents for conjugating biologically active molecules |
| US6075126A (en) | 1996-08-05 | 2000-06-13 | Prolinx, Inc. | Phenyldiboronic acid reagents and complexes |
| US6156884A (en) * | 1996-08-05 | 2000-12-05 | Prolinx, Inc. | Bifunctional boronic compound complexing reagents and complexes |
| US6056941A (en) * | 1999-07-28 | 2000-05-02 | Bracco Research Usa | Kit for the preparation of technetium TC 99m teboroxime myocardial perfusion agent |
| US7211240B2 (en) * | 2002-03-01 | 2007-05-01 | Bracco International B.V. | Multivalent constructs for therapeutic and diagnostic applications |
| US8623822B2 (en) * | 2002-03-01 | 2014-01-07 | Bracco Suisse Sa | KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy |
| EP1587944A4 (en) | 2002-03-01 | 2007-03-21 | Dyax Corp | KDR AND VEGF / KDR BINDING PEPTIDES AND THEIR USE FOR DIAGNOSTIC AND THERAPEUTIC PURPOSES |
| US7261876B2 (en) | 2002-03-01 | 2007-08-28 | Bracco International Bv | Multivalent constructs for therapeutic and diagnostic applications |
| ES2398393T3 (es) | 2002-03-01 | 2013-03-15 | Dyax Corp. | Péptidos de unión a KDR y a VEGF/KDR y su uso en diagnóstico y terapia |
| US7794693B2 (en) * | 2002-03-01 | 2010-09-14 | Bracco International B.V. | Targeting vector-phospholipid conjugates |
| US7226577B2 (en) | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| US7390670B2 (en) * | 2003-02-20 | 2008-06-24 | Lumigen, Inc. | Signalling compounds and methods for detecting hydrogen peroxide |
| DK2949658T3 (da) | 2003-03-03 | 2018-10-01 | Dyax Corp | Peptider, som specifikt binder HGF-receptor (cMet) og anvendelser deraf |
| KR101106533B1 (ko) * | 2003-07-24 | 2012-01-20 | 브라코 이미징 에스.피.에이. | 안정한 방사성의약 조성물 및 제조 방법 |
| WO2008059489A2 (en) | 2006-11-13 | 2008-05-22 | Spectrum Dynamics Llc | Radioimaging applications of and novel formulations of teboroxime |
| JP5345945B2 (ja) | 2006-12-11 | 2013-11-20 | ブラッコ・イメージング・ソシエタ・ペル・アチオニ | フィブリン結合ペプチドおよびそのコンジュゲート |
| EP2147684A1 (en) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
| US20120045393A1 (en) | 2009-03-17 | 2012-02-23 | Linder Karen E | Lhrh-ii peptide analogs |
| US20150344523A1 (en) | 2014-05-05 | 2015-12-03 | California Institute Of Technology | Mutant akt-specific capture agents, compositions, and methods of using and making |
| US10598671B2 (en) | 2015-07-15 | 2020-03-24 | Indi Molecular, Inc. | IL-17F-specific capture agents, compositions, and methods of using and making |
| JP6991148B2 (ja) | 2016-02-09 | 2022-01-12 | ブラッコ・スイス・ソシエテ・アノニム | セレクチン標的化のための組み換えキメラタンパク質 |
| US20170319722A1 (en) | 2016-04-04 | 2017-11-09 | Indi Molecular, Inc. | Cd8-specific capture agents, compositions, and methods of using and making |
| EP3519425B1 (en) | 2016-09-29 | 2024-02-28 | Indi Molecular, Inc. | Compositions for detection, inhibition and imaging of indoleamine 2,3-dioxygenase 1 (ido1) and methods of making and using same |
| EP3535278A4 (en) | 2016-11-01 | 2020-06-24 | Ohio State Innovation Foundation | METHOD FOR IODING BIOMOLECULES |
| EP3638687A1 (en) | 2017-06-15 | 2020-04-22 | Indi Molecular, Inc. | Il-17f and il-17a-specific capture agents, compositions, and methods of using and making |
| US11638764B2 (en) | 2018-11-08 | 2023-05-02 | Indi Molecular, Inc. | Theranostic capture agents, compositions, and methods of using and making |
| WO2020186091A1 (en) | 2019-03-12 | 2020-09-17 | Indi Molecular, Inc. | Cross-linked epitopes and methods of use thereof |
| WO2020236952A1 (en) | 2019-05-20 | 2020-11-26 | Ohio State Innovation Foundation | Apohemoglobin-haptoglobin complexes and methods of using thereof |
| WO2020236969A1 (en) | 2019-05-20 | 2020-11-26 | Indi Molecular, Inc. | Compositions and methods relating to detection, inhibition, and imaging of indoleamine 2,3-dioxygenase 1 (ido1) |
| US11414460B2 (en) | 2019-07-19 | 2022-08-16 | Institute For Systems Biology | KRAS-specific capture agents, compositions, and methods of making and using |
| CN111377968B (zh) * | 2020-03-09 | 2023-07-25 | 中国医学科学院阜外医院 | 一类含芳基硼酸的99mTc(Ⅲ)配合物及其药盒配方和应用 |
| WO2022098743A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1) |
| WO2022098745A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, delivery systems, and methods useful in tumor therapy |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4705849A (en) * | 1985-04-15 | 1987-11-10 | E. R. Squibb & Sons, Inc. | Boronic acid adducts of technetium-99m dioxime complexes |
| GB8603537D0 (en) * | 1986-02-13 | 1986-03-19 | Parker D | Conjugate compound |
| US4877868A (en) * | 1986-03-12 | 1989-10-31 | Neorx Corporation | Radionuclide antibody coupling |
| US4861869A (en) * | 1986-05-29 | 1989-08-29 | Mallinckrodt, Inc. | Coupling agents for joining radionuclide metal ions with biologically useful proteins |
| DE3728599A1 (de) * | 1986-12-10 | 1988-06-23 | Hoechst Ag | Verfahren zur herstellung einer mit technetium-99m-markierten organspezifischen substanz |
| US4871836A (en) * | 1987-10-13 | 1989-10-03 | E. R. Squibb & Sons, Inc. | Boronic acid adducts of rhenium and radioactive isotopes of rhenium dioxime complexes |
-
1990
- 1990-04-13 US US07/508,433 patent/US5183653A/en not_active Expired - Lifetime
-
1991
- 1991-03-27 CA CA002039218A patent/CA2039218C/en not_active Expired - Fee Related
- 1991-04-12 JP JP3079577A patent/JP2933740B2/ja not_active Expired - Fee Related
- 1991-04-15 DE DE69126816T patent/DE69126816T2/de not_active Expired - Fee Related
- 1991-04-15 EP EP91105987A patent/EP0452858B1/en not_active Expired - Lifetime
- 1991-04-15 AT AT91105987T patent/ATE155474T1/de not_active IP Right Cessation
- 1991-04-15 ES ES91105987T patent/ES2103755T3/es not_active Expired - Lifetime
- 1991-04-15 DK DK91105987.1T patent/DK0452858T3/da active
-
1997
- 1997-09-02 GR GR970402242T patent/GR3024598T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5183653A (en) | 1993-02-02 |
| CA2039218A1 (en) | 1991-10-14 |
| EP0452858B1 (en) | 1997-07-16 |
| CA2039218C (en) | 1999-03-30 |
| EP0452858A2 (en) | 1991-10-23 |
| GR3024598T3 (en) | 1997-12-31 |
| ATE155474T1 (de) | 1997-08-15 |
| EP0452858A3 (en) | 1992-04-15 |
| JPH05320182A (ja) | 1993-12-03 |
| DE69126816T2 (de) | 1998-02-12 |
| DE69126816D1 (de) | 1997-08-21 |
| ES2103755T3 (es) | 1997-10-01 |
| JP2933740B2 (ja) | 1999-08-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK0452858T3 (da) | Til mærkning af proteiner og andre aminholdige forbindelser nyttige metalkomplekser af syreaddukter til dioximligander | |
| DK285187A (da) | Metalchelatharpikser | |
| DK0629617T3 (da) | Heteroatombærende ligander og metalkomplekser deraf | |
| DK594588A (da) | Fremgangsmaade til fremstilling af et kimaerisk antistofmolekyle | |
| DE3588210D1 (de) | Biologisch nützliche Konjugate | |
| ATE79278T1 (de) | Markierung von traegermolekuelen mit metallionen. | |
| SE8400865L (sv) | Platinaforening samt forfarande for dess framstellning | |
| DK539589A (da) | Fremgangsmaade til fremstilling af 3-oxo-4-azasteroider | |
| DK169086D0 (da) | Boronsyreaddukter af technetium-99m-dioxim-komplekser | |
| DK568788D0 (da) | Boronsyreaddukter af rheniumdioximkomplekser | |
| DK0537611T3 (da) | Fremgangsmåde til fremstilling af substituerede N-(aryl)-1,2,4-triazolopyrimidin-2-sulfonamider | |
| PT82052B (de) | Tumorhemmende (1-benzyl-ethylendiamin)-platin(ii)-komplexe | |
| DK540181A (da) | Montagebord til optagelse af fladt formede arbejdsemner | |
| DE59101233D1 (de) | Halteklammer zur Befestigung von Bauteilen an Trägerplatten. | |
| ATE88901T1 (de) | Fluorkohlenstoffkette enthaltende antigene konjugate. | |
| DK0920413T3 (da) | Kompleksdannende reagens til boronforbindelser og tilsvarende komplekser | |
| BR9403827A (pt) | Composto, processo para sua preparação, e sua aplicação | |
| NO892189L (no) | Trijodbenzenforbindelser og kontrastmidler for radiografiinneholdende disse. | |
| ATE47858T1 (de) | Trihalo(amin)-gold(iii)-komplexe. | |
| DE69132772D1 (de) | Herstellung von Borsäurederivaten | |
| DK0915832T3 (da) | Kompleksdannende reagenser til boronforbindelser og højstabile komplekser | |
| DK0488778T3 (da) | Radioaktiv iodforbindelse til mærkning af antistof | |
| KR920004363U (ko) | 지게차용 운반대 | |
| DK0759901T3 (da) | Fremgangsmåde til fremstilling af N-Z-beskyttede N-alkylerede aminosyrer |