KR920021986A - 유도성 발광을 활용하는 분석방법 - Google Patents

유도성 발광을 활용하는 분석방법 Download PDF

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KR920021986A
KR920021986A KR1019920008623A KR920008623A KR920021986A KR 920021986 A KR920021986 A KR 920021986A KR 1019920008623 A KR1019920008623 A KR 1019920008623A KR 920008623 A KR920008623 A KR 920008623A KR 920021986 A KR920021986 A KR 920021986A
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에프. 울만 에드윈
커라코시안 라어
에스. 피즈 죤
다닐로프 유리
비. 와그너 다니엘
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알란 엠. 크루비너
신텍스(유. 에스. 에이.)인코포레이티드
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Abstract

내용 없음.

Description

유도성 발광을 활용하는 분석방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 비타민 B12에 대한 분석 결과의 그래프 설명이다.
제2도는 디그옥신 (digoxin)에 대한 분석 결과의 그래프 설명이다.
제3도는 본 발명에 따른 HCG에 대한 분석 결과의 그래프 설명이다.

Claims (15)

  1. 분석물을 함유하는 것으로 생각되는 매질을 내재적 준안전성 종 (Speses) (이는 상기 매질중에서 확산 가능하며, 분석물의 존재로 인하여 상기의 내재적 준안정성 종에 근접한 상기 매질중의 물질과 바람직하게 반응할 수 있다)을 형성하도록 처리하고, 상기의 내재적 준안정성 종이 상기 물질과 반응(이의 반응을 상기 매질중의 분석물의 양을 나타낸다)했는가를 측정함을 특징으로 하여, 분석물을 측정하는 방법.
  2. 분석물을 함유하는 것으로 생각되는 매질을 (1) 특이적 결합쌍(sbp)원과 결합된 광감작제 및 (2) sbp원과 결합된 화학적 발광 화합물과 배합(여기에서, 광감작제를 활성화시키는 경우 화학적발광 화합물로부터 방사되는 빛의 양은 상기 매질중의 분석물의 양과 관련된다)함을 개선점으로 하여, 상기 매질을 분석물이 존재하는 경우 특이적 결합상 (specific binding pair ; sbp) 컴플렉스를 형성하도록 처리하고, 컴플렉스가 형성되었는가를 측정하는 단계를 특징으로 하여, 액체 매질중의 분석물을 검정하는 방법.
  3. 분석물 함유하는 것으로 생각되는 매질을, 분석물에 존재하는 경우 광감작제에 의해 발생되는 싱글렛(singlet)산소가 화학적발광 화합물을 활성화시킨 후 연속하여 빛을 발한 수 있도록 분석물로 인해 광감작제 및 화학적 발광 화합물을 인접되게 되는 조건하에서 처리하고, 빛 (이의 양은 상기 매질중의 분석물의 양과 관련된다)를 측정함을 특징으로 하여, 분석물을 측정하는 방법.
  4. 제3항에 있어서, 화학적발광 화합물이 올레핀 그룹 및 올레핀 그룹과 결합한 하나 이상의 전자 공여 치환체를 포함하는 방법.
  5. 제3항에 있어서, 화학적발광 화합물이 p-알킬리덴-N-메틸 아크리단, 에놀에테르 및 에나민으로 이루어진 그룹중에서 선택되는 방법.
  6. 제3항에 있어서, 적어도 광감작제 또는 화학적발광 화합물이 표면을 갖는 현탁성 입자와 결합되는 방법.
  7. 제3항에 있어서, 표면이 또한 근접하게 되고 현탁성 입자상에 있으며, 입자가 라텍스 입자, 지질 이중층, 오일 소적, 실리카 입자, 금속 졸 및 염료 미소결정으로 이루어진 그룹중에서 선택되는 방법.
  8. 제3항에 있어서, 광감작제가 메틸렌 블루, 로즈 벤갈, 포피린 및 프랄로시아닌으로 이루어진 그룹중에서 선택된 염료인 방법.
  9. 제3항에 있어서, 광감작제 및 화학적발광 화합물 각각이 이와 결합된 특이적 결합쌍(sbp)원을 갖고, sbp이 독립적으로 리간드, 수용체, 폴리뉴클레오타이드 및 폴리뉴클레오타이드 결합제로 이루어진 그릅중에서 선택되는 방법.
  10. (a) (1) 분석물을 함유하는 것으로 생각되는 매질, (2) 여기 상태에서 산소를 싱글렛 상태로 합성화시킬 수 있는 광감작제(이는 특이적 결합쌍(sbP)원과 결합된다), 및 (3) 화학적발광 화합물을 갖는 현탁성 입자 물질(이는 이에 결함된 sbP원을 갖는다)을 배합하고, (b) 배합물을 광감작제가 여기하도록 광으로 처리하며, (c) 매질로부터 방사되는 발광의 양(이는 매질중의 분석물의 양에 관련된다)에 대해 배합물을 조사함을 특징으로 하여, 분석물을 측정하는 방법.
  11. (a) (1) 분석물을 함유하는 것으로 생가되는 매질, (2) 제1sbp원과 결합된 광감작제 및 제2spb원과 결합된 화학적발광 화합물을 배합하고, (b) 배합물을 광감작제가 여기하도록 광으로 처리하며, (c) 매질로부터 발사되는 발광의 양(이는 매질중의 분석물의 양에 관련된다)에 대해 배합물을 조사함을 특징으로 하여, 분석물을 측정하는 방법.
  12. (a) (1) 분석물을 함유하는 것으로 생각되는 샘플, (2) 혼입된 화학적발광 화합물을 갖는 제1 현탁성 입자(이는 spb원이 결합되어 있다), 및 (3) 산소를 이의 싱글렛 상태로 활성화시킬 수 있는 광감작제가 혼입된 제2현탁성 입자(이는 특이적 결함쌍(sbp)원이 결합되어 있다)를 수성 매질중에서 배합하고, (b) 매질을 싱글렛 상태의 산소를 생성하도록 조사하며, (C) 매질로부터 방사되는 발광의 양(이는 매질중의 분석물의 양에 관련된다)을 측정함을 특징으로 하여, 분석물을 측정하는 방법.
  13. 제1sbp원과 결합된 화학적발광 화합물 및 여기 상태에서 산소를 이의 싱글렛 상태로 활성화시킬 수 있는, 제2 sbp원과 결합된 광감작제를 패키지형 배합물로 포함하는 키트.
  14. 제13항에 있어서, 패키지형 배합물이 (a) 화학적발광 화합물을 포함하는 현탁성 입자(이는 특이적 결합쌍(sbp)원이 결합되어 있다)를 포함하는 조성물, 및 (2) 상기 조성물에는 포함되지 않으며, 상기 상태에서 산소를 이의 싱글렛 상태로 활성화시킬 수 있는 광감작제를 포함하는 키트.
  15. 제14항에 있어서, 조성물이 광감작제를 포함하는 제2현탁성 입자(이는 sbp원이 결함되어 있다)를 포함하는 키트.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920008623A 1991-05-22 1992-05-21 Assay methods utilizing induced luminescence KR100246650B1 (en)

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Families Citing this family (141)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5578498A (en) * 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
GB9425138D0 (en) * 1994-12-12 1995-02-08 Dynal As Isolation of nucleic acid
DE69722918D1 (de) * 1996-02-19 2003-07-24 Schaffer Moshe Photoempfindliche zusammensetzung
US6420135B1 (en) * 1996-10-31 2002-07-16 Human Genome Sciences, Inc. Streptococcus pneumoniae polynucleotides and sequences
ATE239912T1 (de) * 1997-08-01 2003-05-15 Presens Prec Sensing Gmbh Verfahren und vorrichtung zur referenzierung von fluoreszenzintensitätssignalen
US6649362B2 (en) * 1997-09-08 2003-11-18 Medvet Science Pty. Ltd. Screening method for an agent having an effect on a sphingosine kinase signaling pathway
US6322980B1 (en) 1999-04-30 2001-11-27 Aclara Biosciences, Inc. Single nucleotide detection using degradation of a fluorescent sequence
US6514700B1 (en) * 1999-04-30 2003-02-04 Aclara Biosciences, Inc. Nucleic acid detection using degradation of a tagged sequence
US6627400B1 (en) 1999-04-30 2003-09-30 Aclara Biosciences, Inc. Multiplexed measurement of membrane protein populations
US7001725B2 (en) 1999-04-30 2006-02-21 Aclara Biosciences, Inc. Kits employing generalized target-binding e-tag probes
US6673550B2 (en) * 1999-04-30 2004-01-06 Aclara Biosciences, Inc. Electrophoretic tag reagents comprising fluorescent compounds
US7105310B1 (en) * 2000-07-19 2006-09-12 California Institute Of Technology Detection of biomolecules by sensitizer-linked substrates
AU6115300A (en) * 1999-07-19 2001-02-05 California Institute Of Technology Detection of biomolecules by sensitizer-linked substrates
US7160735B2 (en) * 2000-04-28 2007-01-09 Monogram Biosciences, Inc. Tagged microparticle compositions and methods
US7771929B2 (en) * 2000-04-28 2010-08-10 Monogram Biosciences, Inc. Tag library compounds, compositions, kits and methods of use
US20030207300A1 (en) * 2000-04-28 2003-11-06 Matray Tracy J. Multiplex analytical platform using molecular tags
US7537938B2 (en) * 2000-04-28 2009-05-26 Monogram Biosciences, Inc. Biomarker detection in circulating cells
US6632606B1 (en) 2000-06-12 2003-10-14 Aclara Biosciences, Inc. Methods for single nucleotide polymorphism detection
US7186568B1 (en) * 2000-06-26 2007-03-06 Lumigen Inc. Electrochemiluminescence from acridan compounds
DE10064827A1 (de) * 2000-12-22 2002-06-27 Dade Behring Marburg Gmbh Nachweisverfahren
WO2002076499A2 (en) * 2001-03-23 2002-10-03 Aphton Corporation Combination treatment of pancreatic cancer
US20090191232A1 (en) * 2001-05-04 2009-07-30 Gevas Philip C Combination therapy for the treatment of tumors
HUP0501021A3 (en) 2001-05-21 2006-06-28 Aclara Biosciences Inc Mountai Methods and compositions for analyzing proteins
CZ20033143A3 (en) * 2001-05-21 2004-04-14 Aclara Biosciences, Inc. Methods and compositions for analyzing proteins
AU2002344221A1 (en) * 2001-05-26 2002-12-09 Aclara Biosciences, Inc. Catalytic amplification of multiplexed assay signals
CA2448719A1 (en) * 2001-06-09 2002-12-19 Glsynthesis Inc. Lipid structures and uses thereof
US7045311B2 (en) * 2001-10-25 2006-05-16 Monogram Biosciences, Inc. Whole cell assay systems for cell surface proteases
JP2005538929A (ja) 2002-01-16 2005-12-22 ダイナル バイオテック エイエスエイ 単一サンプルからの核酸及びタンパク質の単離方法
KR20040108655A (ko) * 2002-03-05 2004-12-24 아클라라 바이오사이언시스 인코퍼레이티드 막-결합된 민감제를 사용하는 복합 분석법
WO2003085374A2 (en) * 2002-04-02 2003-10-16 Aclara Biosciences, Inc. Multiplexed assays using electrophoretically separated molecular tags
US20030199603A1 (en) * 2002-04-04 2003-10-23 3M Innovative Properties Company Cured compositions transparent to ultraviolet radiation
US20040229293A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui Surface receptor complexes as biomarkers
US7402397B2 (en) * 2002-05-21 2008-07-22 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20040229294A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB surface receptor complexes as biomarkers
US20040229380A1 (en) * 2002-05-21 2004-11-18 Po-Ying Chan-Hui ErbB heterodimers as biomarkers
US7105308B2 (en) 2002-07-25 2006-09-12 Monogram Biosciences, Inc. Detecting receptor oligomerization
US20040229299A1 (en) * 2002-05-21 2004-11-18 Badal M. Youssouf Intracellular complexes as biomarkers
US20050221349A1 (en) * 2002-05-30 2005-10-06 Stuart Wilson Methods of detecting target molecules and molecular interactions
US20040175765A1 (en) * 2002-07-05 2004-09-09 Sharat Singh Cell-screening assay and composition
WO2004010842A2 (en) * 2002-07-26 2004-02-05 Aclara Biosciences, Inc. Lipophilic electrophoretic probes
US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
GB0229287D0 (en) * 2002-12-16 2003-01-22 Dna Res Innovations Ltd Polyfunctional reagents
US6900058B2 (en) * 2003-03-11 2005-05-31 Bionostics, Inc. Control solution for photometric analysis
WO2004088326A2 (en) * 2003-03-28 2004-10-14 Aphton Corporation Gastrin hormone immunoassays
US7402398B2 (en) * 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
US20050019939A1 (en) * 2003-07-25 2005-01-27 Dale Spall Combination marker for liquids and method identification thereof
CA2535510C (en) * 2003-08-11 2013-10-15 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
US20050130246A1 (en) * 2003-10-27 2005-06-16 Hossein Salimi-Moosavi Detecting human anti-therapeutic antibodies
US20050112586A1 (en) * 2003-11-24 2005-05-26 Roland Janzen Method and composition for stabilizing liquid reagents
CA2547351A1 (en) * 2003-12-01 2005-07-07 Dade Behring Marburg Gmbh Homogeneous detection method
US20050118727A1 (en) * 2003-12-01 2005-06-02 Carsten Schelp Conjugates and their use in detection methods
EP1730193A2 (en) * 2004-03-29 2006-12-13 Receptor Biologix, Inc. Monoclonal antibodies to gastrin hormone
US20050272108A1 (en) * 2004-05-21 2005-12-08 Bhanu Kalra Stabilized two component system for chemiluminescent assay in immunodiagnostics
US7316910B2 (en) * 2004-06-03 2008-01-08 Kinase Scientific, Llc Rapid test for hemolytic streptococcus
JP4786656B2 (ja) * 2004-06-09 2011-10-05 パーキンエルマー エルエーエス，インク． シデロホアおよび関連組成物を使用する標的分子検出の方法
WO2006032980A1 (en) * 2004-09-22 2006-03-30 Receptor Biologix, Inc. Monoclonal antibolies to progastrin
US7939267B2 (en) * 2004-11-04 2011-05-10 Laboratory Corporation Of America Holdings Detection of activation of endothelial cells as surrogate marker for angiogenesis
US7682839B2 (en) * 2005-03-14 2010-03-23 Lumigen, Inc. Methods using novel chemiluminescent labels
US20060205094A1 (en) * 2005-03-14 2006-09-14 Lumigen, Inc. Methods using novel chemiluminescent labels
US20060281104A1 (en) * 2005-06-13 2006-12-14 Macevicz Stephen C Leuco dye particles and uses thereof
US7919242B2 (en) * 2005-06-30 2011-04-05 Roche Molecular Systems, Inc. Light emission modifiers and their uses in nucleic acid detection, amplification and analysis
US20070037174A1 (en) * 2005-08-12 2007-02-15 Rampal Jang B Chemiluminescent generated fluorescent labeling
TWI273667B (en) * 2005-08-30 2007-02-11 Via Tech Inc Chip package and bump connecting structure thereof
EP1994407A4 (en) 2005-12-30 2009-05-20 Turun Yliopisto METHOD FOR DETERMINING THE CONCENTRATION, LOAD OR SIZE UNIT OF A SUBSTANCE
US7799534B2 (en) * 2006-05-09 2010-09-21 Beckman Coulter, Inc. Nonseparation assay methods
US7732153B2 (en) 2006-05-09 2010-06-08 Beckman Coulter, Inc. Nonseparation assay methods
BRPI0711388B1 (pt) * 2006-05-09 2021-02-23 Beckman Coulter, Inc método para detectar um analito em uma amostra em um procedimento de ensaio
BRPI0717416A2 (pt) 2006-09-21 2013-11-12 Prometheus Lab Inc Método para realizar um imunoensaio complexo de alta produtividade, e, arranjo
US9146233B2 (en) * 2006-11-13 2015-09-29 Perkinelmer Health Sciences, Inc. Detecting molecular interactions by fluorescence resonance energy transfer on a solid-phase support
EP2109689A4 (en) * 2007-02-07 2010-02-10 Perscitus Biosciences Llc DETECTION OF THE PROXIMITY OF A MOLECULE
US7674406B2 (en) * 2007-06-14 2010-03-09 Bindra Perminder S Chemiluminescent compositions and methods of making and using thereof
RU2519647C2 (ru) * 2007-07-13 2014-06-20 Нестек С.А. Выбор лекарственных средств для терапии рака легких с помощью матриц на основе антител
US20100240070A1 (en) * 2007-11-07 2010-09-23 Beckman Coulter, Inc. Nonseparation Assay Methods Using Peroxide Generating Enzymes
CA2711843C (en) * 2007-12-20 2018-11-13 Laboratory Corporation Of America Holdings Her-2 diagnostic methods
CA2716826C (en) 2008-02-25 2017-05-09 Prometheus Laboratories Inc. Drug selection for breast cancer therapy using antibody-based arrays
SG177252A1 (en) 2008-12-01 2012-03-29 Lab Corp America Holdings METHODS AND ASSAYS FOR MEASURING p95 AND/OR p95 IN A SAMPLE AND ANTIBODIES SPECIFIC FOR p95
CA2749846C (en) 2009-01-15 2018-08-07 Laboratory Corporation Of America Holdings Methods of determining patient response by measurement of her-3
WO2010095033A1 (en) 2009-02-20 2010-08-26 Perkinelmer Biosignal, Inc. Multiplex assay methods and compositions
CA2753596A1 (en) * 2009-02-27 2010-09-02 Beckman Coulter, Inc. Non separation assays with selective signal inhibitors
MX2011009019A (es) 2009-02-27 2011-09-29 Beckman Coulter Inc Ensayos homogeneos de fase de solucion.
US9347947B2 (en) * 2009-03-12 2016-05-24 Siemens Healthcare Diagnostics Inc. Immunoassays employing non-particulate chemiluminescent reagent
WO2010121066A2 (en) * 2009-04-15 2010-10-21 Cornell Research Foundation, Inc. Silica nanoparticles incorporating chemiluminescent and absorbing active molecules
US7964119B2 (en) * 2009-05-12 2011-06-21 Mega Glow, LLC. Chemiluminescent powders and methods of making and using thereof
US8658066B2 (en) 2009-05-12 2014-02-25 Mega Glow, Llc Chemiluminescent powders and methods of making and using thereof
ES2627909T3 (es) 2009-07-15 2017-08-01 Diatech Holdings, Inc. Selección de fármacos para el tratamiento del cáncer gástrico usando matrices basadas en anticuercuerpos
TW201113523A (en) * 2009-08-31 2011-04-16 Mbio Diagnostics Inc Integrated sample preparation and analyte detection
US8153442B2 (en) * 2009-10-21 2012-04-10 Siemens Healthcare Diagnostics Inc. Stabilization of signal generation in particles used in assays
US20110306148A1 (en) 2010-06-14 2011-12-15 Siemens Healthcare Diagnostics Inc. Composition for use as an assay reagent
EP2399971A1 (en) 2010-06-25 2011-12-28 Mega Glow, Inc Chemiluminescent compositons and methods of making and using thereof
US8778614B2 (en) 2010-08-24 2014-07-15 Enzo Life Sciences, Inc. Assays for detecting modified compounds
US9995681B2 (en) * 2010-09-28 2018-06-12 Authentix, Inc. Determining the quantity of a taggant in a liquid sample
US9719995B2 (en) 2011-02-03 2017-08-01 Pierian Holdings, Inc. Drug selection for colorectal cancer therapy using receptor tyrosine kinase profiling
JP6468838B2 (ja) 2011-05-19 2019-02-13 ラボラトリー コーポレイション オブ アメリカ ホールディングス 癌患者の生存可能性を決定するためおよび癌患者における転移可能性を予測するための方法
KR101851425B1 (ko) 2011-09-02 2018-04-23 네스텍 소시에테아노님 치료 효능 결정을 위한 신호 경로 단백질의 프로파일링
US8771964B2 (en) 2012-02-02 2014-07-08 Siemens Healthcare Diagnostics Inc. Compositions and methods for detection of methadone metabolite
CN102798725B (zh) * 2012-08-13 2015-03-18 沃克(天津)生物科技有限公司 血清总IgE测定诊断试剂盒及制备和使用方法
US9244083B2 (en) 2012-11-30 2016-01-26 Siemens Healthcare Diagnostics Inc. Compositions and methods for detecting vitamin D
JP6402173B2 (ja) 2013-04-05 2018-10-10 ラボラトリー コーポレイション オブ アメリカ ホールディングス Ｈｅｒ３の検出に基づく癌の診断、予後予測、および処置を容易にするためのシステムおよび方法
US20140308751A1 (en) 2013-04-12 2014-10-16 Siemens Healthcare Diagnostics Inc. Assays for Analyte Homologs
KR101783438B1 (ko) * 2013-05-06 2017-09-29 한국과학기술연구원 형광 바코드를 이용한 미생물의 구별 방법, 미생물 검출용 조성물 및 키트
US9933421B2 (en) * 2013-08-19 2018-04-03 Catassays Catalytic marking nanoparticles for ultrasensitive bioassay applications
US10124072B2 (en) * 2013-09-18 2018-11-13 Caliper Life Sciences, Inc. In-vivo reactive species imaging
CN103837675B (zh) * 2014-03-07 2016-01-13 天津市南开医院 多组分同时定量分析的均相发光免疫分析方法及其所使用的试剂盒
MX2016011809A (es) * 2014-03-26 2017-05-10 Siemens Healthcare Diagnostics Inc Inmunoensayo de canalización de oxígeno luminiscente utilizando tres anticuerpos y metodos de produccion y uso de los mismos.
CN103954776B (zh) * 2014-05-12 2016-05-18 武汉生之源生物科技有限公司 Ngal光激发化学发光检测试剂盒、其制备及使用方法
EP3172239A4 (en) 2014-06-27 2017-06-21 Siemens Healthcare Diagnostics Inc. Binding partners specific for vitamin d epimers
CN106661114B (zh) 2014-06-27 2019-01-29 西门子医疗保健诊断公司 维生素d测定法中对维生素d差向异构体特异性的结合配偶体
US10677734B2 (en) * 2014-09-05 2020-06-09 Thermo Fisher Scientific Oy Method and apparatus for optical measurement of liquid sample
WO2017040962A1 (en) * 2015-09-04 2017-03-09 Pioneer Hi-Bred International, Inc. Compositions and methods of detecting a substance of interest
JP2019515252A (ja) 2016-03-15 2019-06-06 ラボラトリー コーポレイション オブ アメリカ ホールディングス 細胞間のタンパク質相互作用を評価する方法
DK3482210T3 (da) 2016-07-06 2021-07-12 Prothena Biosciences Ltd Assay til detektering af totalt og s129-phosphoryleret alpha-synuklein
EP4252629A3 (en) 2016-12-07 2023-12-27 Biora Therapeutics, Inc. Gastrointestinal tract detection methods, devices and systems
AU2017378398B2 (en) 2016-12-14 2023-02-02 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a JAK inhibitor and devices
EP3554346B1 (en) 2016-12-14 2024-01-31 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with an immunosuppressant
US20200315540A1 (en) 2016-12-14 2020-10-08 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an il-1 inhibitor
US11426566B2 (en) 2016-12-14 2022-08-30 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with a TLR modulator
CN116712540A (zh) 2016-12-14 2023-09-08 比奥拉治疗股份有限公司 使用整联蛋白抑制剂治疗胃肠道疾病
BR112019011689A2 (pt) 2016-12-14 2019-10-22 Progenity Inc tratamento de uma doença do trato gastrointestinal com um inibidor de tnf
CA3045475A1 (en) 2016-12-14 2018-06-21 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with an il-12/il-23 inhibitor released using an ingestible device
CA3045472A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a smad7 inhibitor
WO2018112237A1 (en) 2016-12-14 2018-06-21 Progenity Inc. Treatment of a disease of the gastrointestinal tract with an il-6r inhibitor
CA3045310A1 (en) 2016-12-14 2018-06-21 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
US10682602B2 (en) * 2017-01-19 2020-06-16 National University Of Singapore Nanofibrous filter
US11596670B2 (en) 2017-03-30 2023-03-07 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with IL-10 or an IL-10 agonist
WO2018183932A1 (en) 2017-03-30 2018-10-04 Progenity Inc. Treatment of a disease of the gastrointestinal tract with a il-13 inhibitor
EP4108183A1 (en) 2017-03-30 2022-12-28 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with an immune modulatory agent released using an ingestible device
EP3601531B1 (en) 2017-03-30 2023-06-07 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with live biotherapeutics
CA3054159A1 (en) 2017-03-30 2018-10-04 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a chst15 inhibitor
CA3066756A1 (en) 2017-06-15 2018-12-20 Cancer Advances Inc. Compositions and methods for inducing humoral and cellular immunities against tumors and cancer
JP7365241B2 (ja) 2017-06-27 2023-10-19 ライフ テクノロジーズ ホールディングス プライベート リミテッド サンプルの分析方法、分析装置、およびコンピュータプログラム
WO2019036363A1 (en) 2017-08-14 2019-02-21 Progenity Inc. TREATMENT OF GASTROINTESTINAL TRACT DISEASE WITH GLATIRAMER OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF
JP7488812B2 (ja) 2018-05-21 2024-05-22 ケムクリン ダイアグノスティックス （シャンハイ） カンパニー リミテッド 化学発光免疫分析測定法及び該方法を使用するシステム、試薬キット
CN110514651A (zh) 2018-05-21 2019-11-29 博阳生物科技（上海）有限公司 一种化学发光免疫分析测定方法及使用该方法的系统、试剂盒
CN112400024B (zh) 2018-06-01 2024-04-09 比奥拉治疗股份有限公司 用于胃肠道微生物组检测和处理的装置和系统
US11320424B2 (en) 2018-07-13 2022-05-03 3M Innovative Properties Company Specific binding chemiluminescent assay
CN110736739A (zh) * 2018-07-18 2020-01-31 博阳生物科技（上海）有限公司 一种均相化学发光检测试剂盒及其应用
WO2020028110A1 (en) 2018-07-30 2020-02-06 Siemens Healthcare Diagnostics Inc. Kits, microfluidics devices, and methods for performing biotin assays
US20200284807A1 (en) 2019-03-05 2020-09-10 Victor Manneh Saturation binding ratiometric assay
CN111735942A (zh) * 2020-03-03 2020-10-02 浙江卓运生物科技有限公司 一种均相法化学发光检测方法
EP4326437A4 (en) * 2021-04-21 2024-09-11 Siemens Healthcare Diagnostics Inc COMPOSITIONS, KITS AND METHODS FOR ANTIMICROBIAL SEROLOGY TESTS USING ANTI-HUMAN IMMUNOGLOBULIN ANTIBODIES
WO2024163318A1 (en) * 2023-01-30 2024-08-08 Amgen Inc. System and method for analyzing antibody co-formulations

Family Cites Families (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3720622A (en) 1970-01-02 1973-03-13 American Cyanamid Co Generation of light from the decomposition of dioxetaneones in the presence of a fluorescer
US3850578A (en) 1973-03-12 1974-11-26 H Mcconnell Process for assaying for biologically active molecules
US4043792A (en) * 1974-04-09 1977-08-23 Uniroyal, Inc. Plant growth regulation using certain substituted 2,3-dihydro-1,4-oxathiins
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4199559A (en) 1974-08-12 1980-04-22 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4383031A (en) 1975-04-28 1983-05-10 Miles Laboratories, Inc. Homogeneous chemiluminescent specific binding assay
US4174384A (en) 1975-06-30 1979-11-13 Syva Company Fluorescence quenching with immunological pairs in immunoassays
GB1575343A (en) 1977-05-10 1980-09-17 Ici Ltd Method for preparing liposome compositions containing biologically active compounds
US4529561A (en) 1978-03-24 1985-07-16 The Regents Of The University Of California Method for producing liposomes in selected size range
US4277437A (en) 1978-04-05 1981-07-07 Syva Company Kit for carrying out chemically induced fluorescence immunoassay
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4233402A (en) 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4220450A (en) 1978-04-05 1980-09-02 Syva Company Chemically induced fluorescence immunoassay
US4380580A (en) 1978-04-10 1983-04-19 Miles Laboratories, Inc. Heterogenous chemiluminescent specific binding assay
US4193983A (en) 1978-05-16 1980-03-18 Syva Company Labeled liposome particle compositions and immunoassays therewith
AU517292B2 (en) 1978-06-20 1981-07-23 Syva Co. Fluorescence quenching system
US4226993A (en) 1978-07-24 1980-10-07 Miles Laboratories, Inc. Amino-functionalized phthalhydrazides
US4318707A (en) 1978-11-24 1982-03-09 Syva Company Macromolecular fluorescent quencher particle in specific receptor assays
US4576912A (en) 1978-11-30 1986-03-18 Technicon Instruments Corporation Fluoroimmunoassaying
US4261968A (en) 1979-05-10 1981-04-14 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4299916A (en) 1979-12-26 1981-11-10 Syva Company Preferential signal production on a surface in immunoassays
US4483921A (en) 1981-01-12 1984-11-20 Collaborative Research, Inc. Immunoassay with antigen or antibody labeled liposomes sequestering enzyme
US4650770A (en) 1981-04-27 1987-03-17 Syntex (U.S.A.) Inc. Energy absorbing particle quenching in light emitting competitive protein binding assays
CA1190838A (en) 1981-07-17 1985-07-23 Cavit Akin Homogeneous nucleic acid hybridization diagnostics by non-radiative energy transfer
CA1180647A (en) 1981-07-17 1985-01-08 Cavit Akin Light-emitting polynucleotide hybridization diagnostic method
US4522803A (en) 1983-02-04 1985-06-11 The Liposome Company, Inc. Stable plurilamellar vesicles, their preparation and use
US4654300A (en) 1982-04-02 1987-03-31 Syntex (U.S.A.) Inc. Fluorescent microbead quenching assay
US4483929A (en) 1982-05-03 1984-11-20 Liposome Technology Incorporated Liposomes with glycolipid-linked antibodies
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4568649A (en) 1983-02-22 1986-02-04 Immunex Corporation Immediate ligand detection assay
US4588578A (en) 1983-08-08 1986-05-13 The Liposome Company, Inc. Lipid vesicles prepared in a monophase
US4652533A (en) 1983-04-28 1987-03-24 Pandex Laboratories, Inc. Method of solid phase immunoassay incorporating a luminescent label
JPS6036962A (ja) 1983-08-09 1985-02-26 Toray Ind Inc 生物学的検査用微粒子
EP0144914A3 (en) 1983-12-12 1986-08-13 Miles Inc. Hybridization assay employing labeled pairs of hybrid binding reagents
CA1273552A (en) 1985-12-23 1990-09-04 Michael J. Heller Fluorescent stokes shift probes for polynucleotide hybridization assays
EP0232967B1 (en) 1986-01-10 1993-04-28 Amoco Corporation Competitive homogeneous assay
JPS63502875A (ja) 1986-03-04 1988-10-27 ケンブリッジ　バイオサイエンス　コーポレーション 粒子凝集を用いる核酸検出
US5143853A (en) 1986-06-25 1992-09-01 Trustees Of Tufts College Absorbance modulated fluorescence detection methods and sensors
US5254477A (en) 1986-06-25 1993-10-19 Trustees Of Tufts College Flourescence intramolecular energy transfer conjugate compositions and detection methods
US4959182A (en) 1986-07-17 1990-09-25 Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US5004565A (en) 1986-07-17 1991-04-02 The Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US4978614A (en) 1988-10-26 1990-12-18 Tropix, Inc. Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
BR8707399A (pt) 1986-07-24 1988-09-13 Quest Systems Inc Metodo de detectar uma substancia usando decomposicao enzimaticamente induzida de dioxetanos
US4891324A (en) 1987-01-07 1990-01-02 Syntex (U.S.A.) Inc. Particle with luminescer for assays
US5017473A (en) 1987-05-26 1991-05-21 Becton, Dickinson And Company Homogeneous chemiluminescence immunoassay using a light absorbing material
US4943525A (en) 1987-11-02 1990-07-24 Bioventures, Inc. Simultaneous immunoassay for the determination of antigens and antibodies
US5006309A (en) * 1988-04-22 1991-04-09 Abbott Laboratories Immunoassay device with liquid transfer between wells by washing
JP2681061B2 (ja) 1988-06-08 1997-11-19 ロンドン・ダイアグノスティック・インコーポレーテッド 検出可能なシグナルのセンシタイザー誘導発生を利用したアッセイ
WO1990002205A1 (en) 1988-08-25 1990-03-08 Angenics, Inc. Detection of nucleic acid sequences using particle agglutination
US5061445A (en) * 1988-11-03 1991-10-29 Igen, Inc. Apparatus for conducting measurements of electrochemiluminescent phenomena
US5019496A (en) * 1989-02-17 1991-05-28 Gerald Oster Photopolymerization diagnostic test composition and method for immunoassay and nucleic acid assay
CA2035029C (en) 1989-09-06 2001-12-18 Brooks Edwards Synthesis of stable water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
AU6602890A (en) 1989-10-05 1991-04-28 Exoxemis, Inc. Haloperoxidase acid optimum chemiluminescence assay system
DE69125992T2 (de) 1990-09-14 1997-08-21 Tosoh Corp Verfahren und Kit für Immunoassay
EP0515194B1 (en) 1991-05-22 2001-10-31 Dade Behring Marburg GmbH Assay methods utilizing induced luminescence
US5578498A (en) * 1991-05-22 1996-11-26 Behringwerke Ag Metal chelate containing compositions for use in chemiluminescent assays
US5340716A (en) 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
EP0653066B1 (en) 1992-07-31 1998-01-28 BEHRINGWERKE Aktiengesellschaft Photoactivatable chemiluminescent matrices
FR2707658B1 (fr) 1993-07-12 1995-11-24 Prolabo Sa Latex fluorescent comportant au moins deux fluorochromes, procédé d'obtention et application dudit latex comme marqueur, notamment en biologie.
ATE177842T1 (de) 1993-09-03 1999-04-15 Behringwerke Ag Fluoreszenz-sauerstoffkanalisation-immunteste

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FI922309A0 (fi) 1992-05-21
FI922309A (fi) 1992-11-23
US6406913B1 (en) 2002-06-18
NO922009D0 (no) 1992-05-21

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