KR920019751A - 2-클로로피리딘의 제조방법 - Google Patents

2-클로로피리딘의 제조방법 Download PDF

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Publication number
KR920019751A
KR920019751A KR1019920005512A KR920005512A KR920019751A KR 920019751 A KR920019751 A KR 920019751A KR 1019920005512 A KR1019920005512 A KR 1019920005512A KR 920005512 A KR920005512 A KR 920005512A KR 920019751 A KR920019751 A KR 920019751A
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South Korea
Prior art keywords
reaction
process according
pyridine
methanol
chloro
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KR1019920005512A
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English (en)
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KR100211504B1 (ko
Inventor
크람 귄터
린델 한스
Original Assignee
만프레트 조벨, 요아힘 그렘
바이엘 악티엔게젤샤프트
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Publication of KR920019751A publication Critical patent/KR920019751A/ko
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Publication of KR100211504B1 publication Critical patent/KR100211504B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/26—Radicals substituted by halogen atoms or nitro radicals

Abstract

내용 없음

Description

2-클로로피리딘의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 일반식(II)의 2-아미노피리딘 유도체를 메탄올, 물, 및 메탄올과 물의 혼합물로 이루어진 계열중에서 선택된 용매중, -10℃ 내지 +50℃의 온도에서 염화 수소를 동시에 도입시키면서 염화 수소-포화 용액중에서 메틸니트라이트와 반응시킴을 특징으로 하여 일반식(I)의 2-클로로피리딘을 제조하는 방법.
    상기식에서, R은 수소, C1-C4-알킬 또는 할로겐을 나타내며, n은 1 내지 4를 나타낸다.
  2. 제1항에 있어서, 반응을 0℃ 내지 20℃에서 수행함을 특징으로 하는 방법.
  3. 제1 또는 2항에 있어서, 일반식(II)의 2-아미노피리딘 화합물 1몰당 1매지 5몰 당량의 메틸 니트라이트를 사용함을 특징으로 하는 방법.
  4. 제1 내지 3항중 어느 한 항에 있어서, 반응을 대기압 하에서 수행함을 특징으로 하는 방법.
  5. 제1 내지 4항중 어느 한 항에 있어서, 반응이 완결된 후, 용매를 증류 제거하여 반응 혼합물을 농축시킨 후, 수성 염기를 첨가하여 알칼리성이 되게 하고, 형성된 유기상을 분리하여 증류시켜 유기상으로부터 2-클로로 피리딘(I)을 순수한 형태로 수득함을 특징으로 하는 방법.
  6. 제1 내지 5항중 어느 한 항에 있어서, 반응이 완결된 후, 용매를 증류 제거하여 반응 혼합물을 농축시킨 후, 수성 염기를 첨가하여 알칼리성이 되게 하고, 반응 생성물인 일반식(I)의 2-클로로피리딘 유도체를 공비 증류에 의해 단리시킴을 특징으로 하는 방법.
  7. 제1 내지 6항중 어느 한 항에 있어서, R이 수소, 염소 또는 C1-C2-알킬을 나타내고 n이 1 또는 2를 나타내는 일반식(I)의 화합물을 제조함을 특징으로 하는 방법.
  8. 제1 내지 7항중 어느 한 항에 있어서, 화합물 2-클로로-5-메틸-피리딘을 2-아미노-5-메틸-피리딘으로부터 제조함을 특징으로 하는 방법.
  9. 제1 내지 8항중 어느 한 항에 있어서, 반응에서 생성되는 2-피리돈을 그 자체가 공지된 방법으로 후처리하여 일반식(I)의 2-클로로-피리딘 유도체를 수득함을 특징으로 하는 방법.
  10. 제1 내지 9항중 어느 한 항에 있어서, 반응을 메탄올 또는 메탄올/물 혼합물 중에서 수행한 경우 부산물로서 생성되는 2-메톡시-피피딘 화합물을 증류에 의해 분리시켜 그로부터 그 자체가 공지된 방법에 의해 일반식(I)의 2-클로로-피리딘 유도체를 제조함을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019920005512A 1991-04-06 1992-04-02 2-클로로피리딘의 제조방법 KR100211504B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4111214A DE4111214A1 (de) 1991-04-06 1991-04-06 Verfahren zur herstellung von 2-chlorpyridinen
DEP4111214.8 1991-04-06

Publications (2)

Publication Number Publication Date
KR920019751A true KR920019751A (ko) 1992-11-19
KR100211504B1 KR100211504B1 (ko) 1999-08-02

Family

ID=6428995

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920005512A KR100211504B1 (ko) 1991-04-06 1992-04-02 2-클로로피리딘의 제조방법

Country Status (6)

Country Link
EP (1) EP0508217B1 (ko)
JP (1) JP3046137B2 (ko)
KR (1) KR100211504B1 (ko)
DE (2) DE4111214A1 (ko)
ES (1) ES2086018T3 (ko)
TW (1) TW212172B (ko)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5508410A (en) * 1993-11-30 1996-04-16 Reilly Industries, Inc. Process for preparing 2-halo-5-substituted pyridines
ES2546960T3 (es) 2005-02-09 2015-09-30 Syngenta Participations Ag Procedimiento para la preparación de unos compuestos intermedios

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1178052B (de) * 1959-08-12 1964-09-17 Badische Anilin- &. Soda-Fabrik Aktiengesellschaft, Ludwigshafen/Rhein Verfahren zur Herstellung von heterocyclischen Verbindungne, die mindestens ein einem Ringstickstoffatom benachbartes Chloratom enthalten.
DE1695659B1 (de) * 1967-12-18 1971-12-16 Ruetgerswerke Ag Verfahren zur Herstellung von 2-Chlorpyridinen
GB2026865A (en) * 1978-03-01 1980-02-13 Ici Ltd Herbicides
DE4005115A1 (de) * 1990-02-17 1991-08-22 Bayer Ag Verfahren zur herstellung von in 2-stellung halogensubstituierten pyridinen

Also Published As

Publication number Publication date
JP3046137B2 (ja) 2000-05-29
TW212172B (ko) 1993-09-01
JPH05125047A (ja) 1993-05-21
KR100211504B1 (ko) 1999-08-02
EP0508217B1 (de) 1996-05-01
DE4111214A1 (de) 1992-10-08
DE59206151D1 (de) 1996-06-05
ES2086018T3 (es) 1996-06-16
EP0508217A1 (de) 1992-10-14

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