KR920006002B1 - 무코폴리사카라이드 조성물의 제조방법 - Google Patents
무코폴리사카라이드 조성물의 제조방법 Download PDFInfo
- Publication number
- KR920006002B1 KR920006002B1 KR1019850007686A KR850007686A KR920006002B1 KR 920006002 B1 KR920006002 B1 KR 920006002B1 KR 1019850007686 A KR1019850007686 A KR 1019850007686A KR 850007686 A KR850007686 A KR 850007686A KR 920006002 B1 KR920006002 B1 KR 920006002B1
- Authority
- KR
- South Korea
- Prior art keywords
- mps
- composition
- titer
- fractionation step
- organic solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title claims description 45
- 229920002683 Glycosaminoglycan Polymers 0.000 title claims description 4
- 238000004519 manufacturing process Methods 0.000 title description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 26
- 238000000034 method Methods 0.000 claims description 25
- 239000000047 product Substances 0.000 claims description 22
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 19
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- 238000005194 fractionation Methods 0.000 claims description 11
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- LKAPTZKZHMOIRE-KVTDHHQDSA-N (2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbaldehyde Chemical compound OC[C@H]1O[C@H](C=O)[C@@H](O)[C@@H]1O LKAPTZKZHMOIRE-KVTDHHQDSA-N 0.000 claims 1
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- 108010074860 Factor Xa Proteins 0.000 description 2
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- 241000699670 Mus sp. Species 0.000 description 2
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- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 108090000190 Thrombin Proteins 0.000 description 2
- 108010000499 Thromboplastin Proteins 0.000 description 2
- 102000002262 Thromboplastin Human genes 0.000 description 2
- 239000007795 chemical reaction product Substances 0.000 description 2
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- JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
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- 235000010288 sodium nitrite Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 229960004072 thrombin Drugs 0.000 description 2
- FUFLCEKSBBHCMO-UHFFFAOYSA-N 11-dehydrocorticosterone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 FUFLCEKSBBHCMO-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical group CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 description 1
- MFYSYFVPBJMHGN-UHFFFAOYSA-N Cortisone Natural products O=C1CCC2(C)C3C(=O)CC(C)(C(CC4)(O)C(=O)CO)C4C3CCC2=C1 MFYSYFVPBJMHGN-UHFFFAOYSA-N 0.000 description 1
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- 241000287828 Gallus gallus Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
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- 102100027378 Prothrombin Human genes 0.000 description 1
- 108091006629 SLC13A2 Proteins 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 235000005811 Viola adunca Nutrition 0.000 description 1
- 240000009038 Viola odorata Species 0.000 description 1
- 235000013487 Viola odorata Nutrition 0.000 description 1
- 235000002254 Viola papilionacea Nutrition 0.000 description 1
- 230000003213 activating effect Effects 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 150000001450 anions Chemical class 0.000 description 1
- 230000000417 anti-transforming effect Effects 0.000 description 1
- 239000012736 aqueous medium Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000013330 chicken meat Nutrition 0.000 description 1
- 210000004252 chorionic villi Anatomy 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
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- 229960004544 cortisone Drugs 0.000 description 1
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- 239000002552 dosage form Substances 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
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- 238000006911 enzymatic reaction Methods 0.000 description 1
- 150000002170 ethers Chemical class 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 238000002523 gelfiltration Methods 0.000 description 1
- 229960000890 hydrocortisone Drugs 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 238000004255 ion exchange chromatography Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 230000014399 negative regulation of angiogenesis Effects 0.000 description 1
- 150000002826 nitrites Chemical class 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000003791 organic solvent mixture Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
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- 159000000000 sodium salts Chemical class 0.000 description 1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Polymers & Plastics (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8415978A FR2572080B1 (fr) | 1984-10-18 | 1984-10-18 | Procede de preparation de compositions de mucopolysaccharides dotees d'une activite antithrombotique elevee, les compositions obtenues et leur application en tant que medicaments |
FR8415978 | 1984-10-18 |
Publications (2)
Publication Number | Publication Date |
---|---|
KR860003275A KR860003275A (ko) | 1986-05-21 |
KR920006002B1 true KR920006002B1 (ko) | 1992-07-25 |
Family
ID=9308784
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1019850007686A Expired KR920006002B1 (ko) | 1984-10-18 | 1985-02-27 | 무코폴리사카라이드 조성물의 제조방법 |
Country Status (18)
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20180037622A (ko) * | 2010-09-14 | 2018-04-12 | 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 | 고순도 헤파린 및 그 제조방법 |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69005251T2 (de) * | 1989-10-04 | 1994-05-05 | Akzo Nv | Sulfatierte Glykosaminoglykuronane mit antithrombotischer Wirkung. |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2478646A2 (fr) * | 1980-03-20 | 1981-09-25 | Choay Sa | Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir |
FR2440376A1 (fr) * | 1978-11-06 | 1980-05-30 | Choay Sa | Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir |
FR2495935A1 (fr) * | 1980-12-15 | 1982-06-18 | Choay Sa | Fractions mucopolysaccharidiques possedant des proprietes biologiques, leur procede de preparation et leur application en tant que medicaments |
FR2503714B1 (fr) * | 1981-04-10 | 1986-11-21 | Choay Sa | Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine |
-
1984
- 1984-10-18 FR FR8415978A patent/FR2572080B1/fr not_active Expired
-
1985
- 1985-02-27 KR KR1019850007686A patent/KR920006002B1/ko not_active Expired
- 1985-10-13 EG EG650/85A patent/EG17478A/xx active
- 1985-10-14 IL IL76701A patent/IL76701A/xx not_active IP Right Cessation
- 1985-10-14 DZ DZ850225A patent/DZ844A1/fr active
- 1985-10-15 ZA ZA857902A patent/ZA857902B/xx unknown
- 1985-10-15 AR AR85301959A patent/AR243539A1/es active
- 1985-10-17 YU YU1660/85A patent/YU45285B/xx unknown
- 1985-10-17 UA UA3965564A patent/UA5929A1/uk unknown
- 1985-10-17 DD DD85281840A patent/DD239798A5/de not_active IP Right Cessation
- 1985-10-17 SU SU853965564A patent/SU1570651A3/ru active
- 1985-10-18 HU HU854046A patent/HU197931B/hu unknown
- 1985-10-18 FI FI854073A patent/FI81810C/fi not_active IP Right Cessation
- 1985-10-18 PL PL1985255832A patent/PL146770B1/pl unknown
- 1985-10-18 JP JP60233118A patent/JPS61101502A/ja active Granted
- 1985-10-18 NO NO854154A patent/NO166369C/no not_active IP Right Cessation
- 1985-10-18 MA MA20778A patent/MA20554A1/fr unknown
- 1985-10-18 CS CS857467A patent/CS270420B2/cs not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20180037622A (ko) * | 2010-09-14 | 2018-04-12 | 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 | 고순도 헤파린 및 그 제조방법 |
Also Published As
Publication number | Publication date |
---|---|
HU197931B (en) | 1989-06-28 |
FI81810B (fi) | 1990-08-31 |
FI81810C (fi) | 1990-12-10 |
CS746785A2 (en) | 1989-11-14 |
NO166369C (no) | 1991-07-17 |
FI854073L (fi) | 1986-04-19 |
DD239798A5 (de) | 1986-10-08 |
FR2572080B1 (fr) | 1987-06-26 |
MA20554A1 (fr) | 1986-07-01 |
HUT38657A (en) | 1986-06-30 |
NO854154L (no) | 1986-04-21 |
YU45285B (en) | 1992-05-28 |
FI854073A0 (fi) | 1985-10-18 |
YU166085A (en) | 1988-06-30 |
CS270420B2 (en) | 1990-06-13 |
IL76701A (en) | 1990-09-17 |
ZA857902B (en) | 1987-03-25 |
IL76701A0 (en) | 1986-02-28 |
FR2572080A1 (fr) | 1986-04-25 |
NO166369B (no) | 1991-04-02 |
AR243539A1 (es) | 1993-08-31 |
SU1570651A3 (ru) | 1990-06-07 |
JPH0552841B2 (enrdf_load_stackoverflow) | 1993-08-06 |
JPS61101502A (ja) | 1986-05-20 |
DZ844A1 (fr) | 2004-09-13 |
UA5929A1 (uk) | 1994-12-29 |
PL146770B1 (en) | 1989-03-31 |
PL255832A1 (en) | 1987-02-09 |
KR860003275A (ko) | 1986-05-21 |
EG17478A (en) | 1991-03-30 |
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