KR920000306B1 - 니모디핀-함유 제제의 제조방법 - Google Patents

니모디핀-함유 제제의 제조방법 Download PDF

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Publication number
KR920000306B1
KR920000306B1 KR1019840002390A KR840002390A KR920000306B1 KR 920000306 B1 KR920000306 B1 KR 920000306B1 KR 1019840002390 A KR1019840002390 A KR 1019840002390A KR 840002390 A KR840002390 A KR 840002390A KR 920000306 B1 KR920000306 B1 KR 920000306B1
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KR
South Korea
Prior art keywords
weight
nimodipine
solvent
ethanol
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019840002390A
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English (en)
Korean (ko)
Other versions
KR840009031A (ko
Inventor
호프 디터
Original Assignee
바이엘 아크티엔 게젤샤프트
귄터 슈마허, 에리히 데브리츠
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Publication date
Application filed by 바이엘 아크티엔 게젤샤프트, 귄터 슈마허, 에리히 데브리츠 filed Critical 바이엘 아크티엔 게젤샤프트
Publication of KR840009031A publication Critical patent/KR840009031A/ko
Application granted granted Critical
Publication of KR920000306B1 publication Critical patent/KR920000306B1/ko
Expired legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
KR1019840002390A 1983-05-06 1984-05-03 니모디핀-함유 제제의 제조방법 Expired KR920000306B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19833316510 DE3316510A1 (de) 1983-05-06 1983-05-06 Parenterale formulierung von nimodipin, ein verfahren zu ihrer herstellung sowie ihre verwendung bei der bekaempfung von erkrankungen
DEP3316510.6 1983-05-06

Publications (2)

Publication Number Publication Date
KR840009031A KR840009031A (ko) 1984-12-24
KR920000306B1 true KR920000306B1 (ko) 1992-01-11

Family

ID=6198265

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840002390A Expired KR920000306B1 (ko) 1983-05-06 1984-05-03 니모디핀-함유 제제의 제조방법

Country Status (19)

Country Link
US (1) US5114956A (https=)
EP (1) EP0126315B1 (https=)
JP (1) JPS59206305A (https=)
KR (1) KR920000306B1 (https=)
AT (1) ATE24835T1 (https=)
AU (1) AU562293B2 (https=)
BE (1) BE899564A (https=)
CA (1) CA1220424A (https=)
DE (2) DE3316510A1 (https=)
DK (1) DK164148C (https=)
ES (1) ES531995A0 (https=)
FR (1) FR2545354B1 (https=)
GR (1) GR81609B (https=)
HK (1) HK75889A (https=)
IL (1) IL71744A (https=)
IT (1) IT1181804B (https=)
PT (1) PT78542B (https=)
SG (1) SG44489G (https=)
ZA (1) ZA843352B (https=)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60246313A (ja) * 1984-05-22 1985-12-06 Yamanouchi Pharmaceut Co Ltd 塩酸ニカルジピンの注射剤およびその製法
FR2585574B1 (fr) * 1985-07-31 1988-09-09 Corbiere Jerome Nouvelles compositions pharmaceutiques anti-glaucomateuses a base de 1,4-dihydropyridines et leur procede d'obtention
DE3544692A1 (de) * 1985-12-18 1987-06-19 Bayer Ag Dihydropyridinspray, verfahren zu seiner herstellung und seine pharmazeutische verwendung
AT387518B (de) * 1985-12-18 1989-02-10 Bayer Ag Verfahren zur herstellung von fluessigen spruehpraeparaten von dihydropyridinen
DE3702105A1 (de) * 1987-01-24 1988-08-04 Bayer Ag Parenterale loesung
BE1003647A5 (fr) * 1989-02-28 1992-05-12 Syntex Inc Composition pharmaceutique de nicardipine pour administration parenterale.
RU1804845C (ru) * 1991-02-15 1993-03-30 Институт Органического Синтеза Латвийской Ан Ноотропное вещество
KR100517210B1 (ko) * 1994-12-12 2006-06-07 오메로스 코포레이션 통증,염증및경련억제용관주용액
JPH10510540A (ja) 1994-12-12 1998-10-13 オメロス メディカル システムズ，インコーポレーテッド 灌注用溶液並びに疼痛、炎症及びけいれんの抑制法
US6492332B1 (en) 1995-12-12 2002-12-10 Omeros Corporation Irrigation solution and methods for inhibition of tumor cell adhesion, pain and inflammation
WO1996019233A2 (en) * 1994-12-12 1996-06-27 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain, inflammation and spasm
US6413961B1 (en) 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
US6136799A (en) * 1998-04-08 2000-10-24 Abbott Laboratories Cosolvent formulations
DE10142416A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Verfahren zur Herstellung von Lösungen
DE10142417A1 (de) * 2001-08-31 2003-03-20 Molecular And Clinical Drug Re Arzneimittel
US8034762B2 (en) * 2004-09-02 2011-10-11 Cognosci, Inc. Treatment of subarachnoid hemorrhage with Apo E analogs
CA2625862A1 (en) * 2005-10-14 2007-04-26 Transform Pharmaceuticals, Inc. Liquid pharmaceutical compositions of nimodipine
EP2015730A1 (de) * 2006-04-28 2009-01-21 Basf Se Verfahren zur solubilisierung von hydrophoben wirkstoffen in wässrigem medium
WO2011095449A1 (de) 2010-02-05 2011-08-11 Basf Se Verfahren zur solubilisierung von hydrophoben wirkstoffen in wässrigem medium
US8728504B2 (en) 2010-02-05 2014-05-20 Basf Se Process for solubilizing hydrophobic active ingredients in aqueous medium
DK2701684T3 (en) 2011-04-28 2017-09-18 Platform Brightworks Two Ltd Improved parenteral formulations of lipophilic pharmaceuticals and methods for their preparation and use
PL3442586T3 (pl) * 2016-04-13 2023-01-30 Acasti Pharma U.S., Inc. Stabilny pozajelitowy preparat nimodypiny
US10092553B2 (en) 2016-04-13 2018-10-09 Nortic Holdings Inc. Stable nimodipine parenteral formulation
US20190255033A1 (en) 2018-02-22 2019-08-22 Nortic Holdings Inc. Stable Nimodipine Parenteral Formulation
JP2025517753A (ja) 2022-05-16 2025-06-10 アカスティ ファーマ ユー．エス．，インコーポレイテッド ニモジピン非経口投与
CN117502433A (zh) * 2023-11-08 2024-02-06 中国科学院海洋研究所 一种水母刺丝囊存放保护剂及其制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2117571C3 (de) * 1971-04-10 1979-10-11 Bayer Ag, 5090 Leverkusen Unsymmetrische 1,4-Dihydropyridin-33-dicarbonsäureester, Verfahren zu ihrer Herstellung sowie ihre Verwendung als Arzneimittel
US4154839A (en) * 1975-11-05 1979-05-15 Bayer Aktiengesellschaft 2,6-Dimethyl-3-carboxymethoxy-4-(2-nitrophenyl)-5-carbisobutoxy-1,4-dihydropyridine
DE2650013C3 (de) * 1976-10-30 1981-04-02 Bayer Ag, 5090 Leverkusen 1.4-Dihydro-2.6-dimethyl-4-(3-nitrophenyl)-3.5-pyridindicarbonsäureisopropyl-(2-propoxy-äthyl)-ester, Verfahren zu seiner Herstellung sowie ihn enthaltende Arzneimittel
DE2815578C2 (de) * 1978-04-11 1986-01-16 Bayer Ag, 5090 Leverkusen Neue pharmazeutische Verwendung von Nimodipin
DE2841667A1 (de) * 1978-09-25 1980-04-10 Bayer Ag Fluorhaltige 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
PT78542A (en) 1984-06-01
PT78542B (en) 1986-07-14
EP0126315A1 (de) 1984-11-28
IT1181804B (it) 1987-09-30
GR81609B (https=) 1984-12-11
AU562293B2 (en) 1987-06-04
CA1220424A (en) 1987-04-14
ATE24835T1 (de) 1987-01-15
DK224184D0 (da) 1984-05-04
DK164148B (da) 1992-05-18
JPS59206305A (ja) 1984-11-22
ZA843352B (en) 1984-12-24
IT8448139A1 (it) 1985-11-04
DK164148C (da) 1992-10-26
HK75889A (en) 1989-09-29
DE3461988D1 (en) 1987-02-19
KR840009031A (ko) 1984-12-24
SG44489G (en) 1989-11-17
FR2545354B1 (fr) 1986-09-26
BE899564A (fr) 1984-11-05
FR2545354A1 (fr) 1984-11-09
EP0126315B1 (de) 1987-01-14
DK224184A (da) 1984-11-07
IL71744A (en) 1988-04-29
DE3316510A1 (de) 1984-11-08
AU2758384A (en) 1984-11-08
ES8505542A1 (es) 1985-06-01
US5114956A (en) 1992-05-19
JPH0422888B2 (https=) 1992-04-20
ES531995A0 (es) 1985-06-01
IT8448139A0 (it) 1984-05-04
IL71744A0 (en) 1984-09-30

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