KR910018016A - 피복 조성물 및 그의 제조방법 - Google Patents

피복 조성물 및 그의 제조방법 Download PDF

Info

Publication number
KR910018016A
KR910018016A KR1019910005907A KR910005907A KR910018016A KR 910018016 A KR910018016 A KR 910018016A KR 1019910005907 A KR1019910005907 A KR 1019910005907A KR 910005907 A KR910005907 A KR 910005907A KR 910018016 A KR910018016 A KR 910018016A
Authority
KR
South Korea
Prior art keywords
hot melt
melt material
coating composition
coating
active substance
Prior art date
Application number
KR1019910005907A
Other languages
English (en)
Other versions
KR0168849B1 (ko
Inventor
노보루 나가후지
다까유끼 쓰까다
가즈히로 시마
야스시 다까기시
유스께 스즈끼
요시따까 도모다
다까시 하야시
Original Assignee
요시또시 가즈오
시오노기세이야꾸 가부시끼가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 요시또시 가즈오, 시오노기세이야꾸 가부시끼가이샤 filed Critical 요시또시 가즈오
Publication of KR910018016A publication Critical patent/KR910018016A/ko
Application granted granted Critical
Publication of KR0168849B1 publication Critical patent/KR0168849B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Glanulating (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

내용 없음

Description

피복 조성물 및 그의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 후술되는 실시예 3에서 수득된 피복 과립, 및 용해 매질로 제1시험액 및 정제수를 사용하여 측정한 용해곡선을 나타낸다. 제2도는 후술되는 실시예 4에서 수득된 피복 과립, 및 용해 매질로 제1시험액 및 정제수를 사용하여 측정한 용해 곡선을 나타낸다.

Claims (16)

  1. 결합체인 제1열용융 물질의 도움으로 서로 응집하는 열-안정성 약 학상 활성 물질 미립자를 함유하는 과립을 함유하며, 이들 과립의 각각이 제1열용융 물질의 융점보다 저융점을 갖는 제2열용융 물질로 피복되고, 이들 과립이 용매 부재하에 원심력 과립화 방법에 의해 제조됨을 특징으로 하는, 열-안정성 약학상 활성 물질을 함유하는 피복 조성물.
  2. 제1항에 있어서, 경구 투여성인 피복 조성물,
  3. 제1항에 있어서, 과립제인 피복 조성물.
  4. 제1항에 있어서, 활성 물질이 4-구아니디노메틸 시클로헥산카르복실산2′-벤질옥시카르보닐페닐 에스테르 히드로클로덱스트린의 시클로덱스트린 내포 화합물인 피복 조성물.
  5. 열-안정성 약학상 활성 물질 및 결합제로 제1열용융 물질을 함유하는 혼합물을 가열하에 용매 부재하에 원심 과립화하고, 생성 과립을 제1열용융 물질의 융점보다 저융점을 갖는 제2열용융 물질을 피복 물질로 사용하여 가열하에 피복 시킴을 특징으로 하는, 열-안정성 약학상 활성 물질을 함유하는 피복 조성물의 제조방법.
  6. 제5항에 있어서, 과립화가 제1열용융 물질이용융 상태로 유지되는 조건하에 혼합물을 회전시킴으로써 수행되는 방법.
  7. 제5항에 있어서, 피복이 제2열용융 물질이 용융 상태로 유지되는 조건하에 제2열용융 물질을 가하면서 과립을 회전시킴으로써 수행되는 방법.
  8. 제5항에 있어서, 제2열용융 물질이 혼합물을 기준으로 약 5∼30중량%의 친수성 물질 및 약 10∼60중량%의 소수성 물질을 함유하는 혼합물인 방법.
  9. 제5항에 있어서, 제1열용융 물질이 폴리에틸렌 글리콜을 함유하는 방법.
  10. 제9항에 있어서, 폴리에틸렌 글리콜이 평균 분자량 약1,000 이상을 갖는 방법.
  11. 제5항에 있어서, 제1열용융 물질이 소량의-d-토코페롤을 부가적으로 함유하는 방법.
  12. 제5항에 있어서, 제1열용융 물질이 친수성이며 물에 용이하게 용해될 수 있는 방법.
  13. 제5항에 있어서, 피복물이 2층으로 형성되는 방법.
  14. 제13항에 있어서, 2층이 친수성 물질을 갖는 내부층 및 소수성 물질을 갖는 외부층을 함유하는 방법.
  15. 제5항에 있어서, 피복 조성물이 경구 투여성인 방법.
  16. 제5항에 있어서, 피복 조성물이 과립제인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910005907A 1990-04-12 1991-04-12 피목 조성물 및 그의 제조방법 KR0168849B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP9666390 1990-04-12
JP96663/1990 1990-04-12
JP096663/1990 1990-04-12

Publications (2)

Publication Number Publication Date
KR910018016A true KR910018016A (ko) 1991-11-30
KR0168849B1 KR0168849B1 (ko) 1999-01-15

Family

ID=14171060

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910005907A KR0168849B1 (ko) 1990-04-12 1991-04-12 피목 조성물 및 그의 제조방법

Country Status (8)

Country Link
EP (1) EP0452145B1 (ko)
JP (1) JP3191948B2 (ko)
KR (1) KR0168849B1 (ko)
AT (1) ATE145131T1 (ko)
DE (1) DE69123075T2 (ko)
DK (1) DK0452145T3 (ko)
ES (1) ES2096624T3 (ko)
GR (1) GR3021606T3 (ko)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4217920C2 (de) * 1992-05-30 1996-05-09 Goldwell Gmbh Verfahren zur Herstellung von pulverförmigen Mitteln zum Blondieren von menschlichen Haaren
US5429825A (en) * 1992-06-26 1995-07-04 Mcneil-Ppc, Inc. Rotomelt granulation
IL109460A (en) 1993-05-10 1998-03-10 Euro Celtique Sa Controlled release formulation comprising tramadol
GB9310030D0 (en) * 1993-05-15 1993-06-30 Scras Dry processed particles and process for the preparation of the same
FR2705677B1 (fr) * 1993-05-28 1995-08-11 Roquette Freres Micro-granules obtenus par extrusion-sphéronisation contenant une cyclodextrine.
IL110014A (en) 1993-07-01 1999-11-30 Euro Celtique Sa Solid controlled-release oral dosage forms of opioid analgesics
US7740881B1 (en) 1993-07-01 2010-06-22 Purdue Pharma Lp Method of treating humans with opioid formulations having extended controlled release
US5879705A (en) * 1993-07-27 1999-03-09 Euro-Celtique S.A. Sustained release compositions of morphine and a method of preparing pharmaceutical compositions
US5891471A (en) 1993-11-23 1999-04-06 Euro-Celtique, S.A. Pharmaceutical multiparticulates
KR100354702B1 (ko) 1993-11-23 2002-12-28 유로-셀티크 소시에떼 아노뉨 약학조성물의제조방법및서방형조성물
US5843480A (en) 1994-03-14 1998-12-01 Euro-Celtique, S.A. Controlled release diamorphine formulation
GB9422154D0 (en) 1994-11-03 1994-12-21 Euro Celtique Sa Pharmaceutical compositions and method of producing the same
US5965161A (en) 1994-11-04 1999-10-12 Euro-Celtique, S.A. Extruded multi-particulates
JP3466921B2 (ja) * 1998-06-03 2003-11-17 大塚製薬株式会社 味マスキング医薬製剤
US6806294B2 (en) 1998-10-15 2004-10-19 Euro-Celtique S.A. Opioid analgesic
AU1323400A (en) * 1998-10-27 2000-05-15 Fuisz Technologies Ltd. Microparticles containing peg and/or peg glyceryl esters
AT407111B (de) 1998-12-22 2000-12-27 Gergely Dr & Co Zucker- und/oder zuckeralkoholhältiges matrixmaterial und verfahren zu seiner herstellung
DE19918325A1 (de) 1999-04-22 2000-10-26 Euro Celtique Sa Verfahren zur Herstellung von Arzneiformen mit regulierter Wirkstofffreisetzung mittels Extrusion
MXPA02004293A (es) 1999-10-29 2002-10-31 Euro Celtique Sa Formulaciones de hidrocodona de liberacion controlada..
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
JP4658306B2 (ja) * 2000-10-18 2011-03-23 ナガセ医薬品株式会社 錠剤用医薬組成物
CN100518827C (zh) 2000-10-30 2009-07-29 欧罗赛铁克股份有限公司 控释氢可酮制剂
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
UA81224C2 (uk) 2001-05-02 2007-12-25 Euro Celtic S A Дозована форма оксикодону та її застосування
JP2005506323A (ja) * 2001-09-05 2005-03-03 ベクトゥラ・リミテッド 経口送達用機能性散剤
JP2005298412A (ja) * 2004-04-13 2005-10-27 Minato Pharmaceutical Co Ltd 被覆粒子
KR20100015845A (ko) * 2007-04-26 2010-02-12 에자이 알앤드디 매니지먼트 가부시키가이샤 정제의 제조 방법
CN115209877A (zh) * 2020-03-11 2022-10-18 泽井制药株式会社 颗粒和使用该颗粒的制剂
WO2023145865A1 (ja) * 2022-01-31 2023-08-03 住友精化株式会社 製剤用ポリアルキレンオキシド粒子、医薬用組成物、製剤用組成物及び製剤

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5838250A (ja) * 1981-09-01 1983-03-05 Teikoku Chem Ind Corp Ltd 複合体
US4797288A (en) * 1984-10-05 1989-01-10 Warner-Lambert Company Novel drug delivery system
US4940665A (en) * 1985-12-27 1990-07-10 Showa Denko K. K. Method for granulation of enzyme
US5019302A (en) * 1986-03-12 1991-05-28 Washington University Technology Associates, Inc. Method for granulation
DE3721721C1 (de) * 1987-07-01 1988-06-09 Hoechst Ag Verfahren zur Umhuellung von Granulaten
NZ231281A (en) * 1988-11-08 1991-01-29 Takeda Chemical Industries Ltd Sustained release pharmaceutical preparations comprising the active agent dispersed in a solid matrix of a fatty acid ester of a polyglycerol

Also Published As

Publication number Publication date
EP0452145B1 (en) 1996-11-13
GR3021606T3 (en) 1997-02-28
ATE145131T1 (de) 1996-11-15
DK0452145T3 (da) 1996-12-02
DE69123075D1 (de) 1996-12-19
KR0168849B1 (ko) 1999-01-15
ES2096624T3 (es) 1997-03-16
JPH04217913A (ja) 1992-08-07
DE69123075T2 (de) 1997-03-20
EP0452145A2 (en) 1991-10-16
EP0452145A3 (en) 1993-03-10
JP3191948B2 (ja) 2001-07-23

Similar Documents

Publication Publication Date Title
KR910018016A (ko) 피복 조성물 및 그의 제조방법
JP4015229B2 (ja) セメント材料
DE3580154D1 (de) Nifedipin enthaltende darreichungsform und verfahren zu ihrer herstellung.
KR890006369A (ko) 호흡가능한 방수성 시이트물질및 그의 제조방법
GB1016839A (en) Process for the encapsulation of acetylsalicylic acid particles
PT85244B (pt) Processo para a preparacao de concentrados de resinas solidos biocidas
JPH02215838A (ja) ポリエステル、ポリカーボネート又はポリアミド粒子の非摩砕的製造方法、該方法によって得られる粒子及びその使用方法
IE58245B1 (en) Micro-encapsulation of medicaments
EP0112396A4 (en) COMPOSITION FOR PRODUCING REMOVABLE FILMS.
KR910002425A (ko) 활성 물질의 당과성 송달계
Quaglia et al. Microspheres Made of Poly (ε‐caprolactone)‐Based Amphiphilic Copolymers: Potential in Sustained Delivery of Proteins
JPS6013816A (ja) 熱可塑性樹脂微粒子の製造法
EP0117825B1 (fr) Utilisation comme catalyseurs et accélérateurs latents de systèmes époxy-phénoliques, d'halogénobisphénates d'amines tertiaires, leur procédé de préparation et systèmes époxy-phénoliques les contenant
JPH0439441B2 (ko)
KR880005228A (ko) 열가소성 중합체 및 그 제조방법
JP4859185B2 (ja) ゲル化剤、その製造方法およびそれを用いた固化・分離方法
JPS6213049B2 (ko)
DE69129036T2 (de) Überdeckte zusammensetzung mit schneller freisetzung
US2793398A (en) Preparation of urea in granular form
JPS5857406B2 (ja) 貼り付け材
RU93037187A (ru) Способ приготовления битумно-полимерной композиции
JPS54108828A (en) Coating composition of fluorescent substance
KR100197756B1 (ko) 세파클로 마이크로캅셀 및 매트릭스형 과립의 제조방법
FR2703064B1 (fr) Compositions bitume/polymère non gélifiables et stables au stockage à température élevée, leur procédé de préparation et leur application à la production de liants bitume/polymère pour revêtements .
JPS61171788A (ja) 潜熱型蓄熱剤

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20030828

Year of fee payment: 6

LAPS Lapse due to unpaid annual fee