KR910015308A - 빌로발리드 유도체, 그 용도 및 이를 함유한 제제 - Google Patents

빌로발리드 유도체, 그 용도 및 이를 함유한 제제 Download PDF

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KR910015308A
KR910015308A KR1019910002192A KR910002192A KR910015308A KR 910015308 A KR910015308 A KR 910015308A KR 1019910002192 A KR1019910002192 A KR 1019910002192A KR 910002192 A KR910002192 A KR 910002192A KR 910015308 A KR910015308 A KR 910015308A
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complex
phospholipid
frontal
rti
freeze
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KR1019910002192A
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KR0170773B1 (ko
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봄바르델리 에지오
무스띠흐 지우세뻬
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원본미기재
인데나 에스. 피. 아.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • C07F9/106—Adducts, complexes, salts of phosphatides

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cosmetics (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Steroid Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

내용 없음

Description

빌로발리드 유도체, 그 용도 및 이를 함유한 제제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 빌로발리드, 디스테아로일-포스파티딜콜린 및 복합체의 스펙트라를 나타낸 것이다.

Claims (8)

  1. 다음 일반식을 갖는 것을 특징으로 하는 빌로발리드와 천연 또는 합성, 포화 또는 불포화 인지질과의 복합체
    식중 R 및 R1은 동일하거나 상이할 수 있으며, 각각은 C16-C22포화 또는 불포화지방산의 아실잔기이고, R2는 다음과 잔기중 하나이다. -CH2-CH2-H(-CH3)3, -CH2-CH2-NH3, -CH2-CH(COOH)-NH3.
  2. 제1항에 있어서, 상기 인지질이 콜린, 에탄올아민 및 이노시톨로부터 유도되는 것을 특징으로 하는 복합체.
  3. 빌로발리드와 인지질이 비프론트 용제에서 반응되어 얻어진 복합체가 비용제로 침전되거나 동결건조하여 분리되는 것을 특징으로 하는 복합체의 제조방법.
  4. 제3항에 있어서, 사용된 비프론트용제갈 방향족 탄화수소, 수소화 유도체 또는 시클릭 에테르인 것을 특징으로 하는 복합체의 제조방법.
  5. 제3항 또는 제4항에 있어서, 약제가 화학양론비로 반응되는 것을 특징으로 하는 복합체의 제조방법.
  6. 적절한 부형제와 혼합된 제1항 및 제2항에 청구된 복합체를 활성원소로서 함유하는 것을 특징으로 하는 약학 제제.
  7. 제1항 및 제2항에 청구된 복합체를 활성원소로서 함유하는 것을 특징으로 하는 화장품 또는 피부제제.
  8. 항염중성 및 향신경성을 갖는 약의 제조에 복합체를 사용하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019910002192A 1990-02-09 1991-02-07 빌로발리드 유도체, 그 용도 및 이를 함유한 제제 KR0170773B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT19324A/90 1990-02-09
IT19324A IT1238684B (it) 1990-02-09 1990-02-09 Derivati del bilobalide,loro usi e formulazioni che li contegono

Publications (2)

Publication Number Publication Date
KR910015308A true KR910015308A (ko) 1991-09-30
KR0170773B1 KR0170773B1 (ko) 1999-03-30

Family

ID=11156741

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KR1019910002192A KR0170773B1 (ko) 1990-02-09 1991-02-07 빌로발리드 유도체, 그 용도 및 이를 함유한 제제

Country Status (11)

Country Link
US (1) US5202313A (ko)
EP (1) EP0441279B1 (ko)
JP (1) JP3036881B2 (ko)
KR (1) KR0170773B1 (ko)
AT (1) ATE115585T1 (ko)
CA (1) CA2035951C (ko)
DE (1) DE69105767T2 (ko)
DK (1) DK0441279T3 (ko)
ES (1) ES2066239T3 (ko)
HK (1) HK160795A (ko)
IT (1) IT1238684B (ko)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5895785A (en) * 1987-10-20 1999-04-20 Ruth Korth Treatment and prevention of disorders mediated by LA-paf or endothelial cells
DE540766T1 (de) * 1991-11-04 2002-11-28 Ruth-Maria Korth Behandlung von Eosinophil-mediierten Erkrankungen mit PAF-Antagonisten, und Verfahren zur Bestimmung deren Effektivität.
ATE221779T1 (de) * 1991-11-04 2002-08-15 Ruth-Maria Korth Behandlung und vorbeugung von erhöhten lyso-paf- spiegel mediierten mentalen erkrankungen mit paf- antagonisten
GB9202993D0 (en) * 1992-02-13 1992-03-25 Indena Spa Novel pharmaceutical uses of bilobalide and derivatives thereof and pharmaceutical compositions adapted for such use
GB9205670D0 (en) * 1992-03-16 1992-04-29 Indena Spa New derivatives of physostigmine,their use and pharmaceutical formulations containing them
US5456912A (en) * 1993-12-28 1995-10-10 The Regents Of The University Of California Non-methylene interrupted fatty acids as immunomodulators
US6379714B1 (en) 1995-04-14 2002-04-30 Pharmaprint, Inc. Pharmaceutical grade botanical drugs
JP2002517456A (ja) * 1998-06-11 2002-06-18 ソシエテ・ドゥ・コンセイユ・ドゥ・ルシェルシュ・エ・ダプリカーション・シャンティフィック・エス・ア・エス 虚血からのニューロンの保護
US7494643B2 (en) * 2003-07-22 2009-02-24 Rendon Marta I Method and topical composition for the treatment of hyperpigmented skin
SI1559430T1 (sl) * 2004-01-29 2009-08-31 Indena Spa Uporaba kompleksov ginkga za izboljĺ anje kognitivnih funkcij in ublaĺ˝itev duĺ evne izäśrpanosti
ITMI20060136A1 (it) * 2006-01-27 2007-07-28 Pharmextracta S R L Composizioni a base di derivati della ginkgo biloba per il trattamento di condizioni asmatiche e allergiche
ITMI20071492A1 (it) 2007-07-24 2009-01-25 S I I T Srl Servizio Internazi "composizioni per il trattamento e la prevenzione di condizioni di vertigine e acufeni comprendenti citicolina, estratto di ginkgo biloba e flavoni dimerici di ginkgo biloba"
IT1397386B1 (it) 2010-01-12 2013-01-10 Indena Spa Composizioni a base di estratti di andrographis paniculata combinati con estratti di ginkgo biloba complessati con fosfolipidi e loro uso.
IT1402672B1 (it) 2010-11-08 2013-09-13 Medestea Biotech S P A Composizioni comprendenti principi attivi di origine vegetale associati o meno a promotori e/o protettori di ossido nitrico per il trattamento e la prevenzione dei deficit erettili e dell' impotenza e per il potenziamento della performance sportiva
ITTO20110901A1 (it) 2011-10-10 2013-04-11 Medestea Biotech S P A Composizione sinergica per la prevenzione ed il trattamento di disturbi connessi all'invecchiamento
CN109851634B (zh) * 2018-12-25 2020-12-22 华东师范大学 手性单膦配体Yu-Phos及其全构型的制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3338995A1 (de) * 1983-10-27 1985-05-09 Dr. Willmar Schwabe GmbH & Co, 7500 Karlsruhe Bilobalid enthaltende arzneimittel
DD213672A1 (de) * 1983-03-04 1984-09-19 Akad Wissenschaften Ddr Verfahren zur herstellung von gibberellin-derivaten mit 13,16-anneliertem oxathiaphospholan-ring
IT1215291B (it) * 1985-07-17 1990-01-31 Inverni Della Beffa Spa Complessi di flavanolignani con fosfolipidi, loro preparazione e relative composizioni farmaceutiche.
IT1201149B (it) * 1987-01-14 1989-01-27 Indena Spa Complessi di bioflavonoidi con fosfolipidi,loro preparazione,uso e composizioni farmaceutici e cosmetiche
IT1203515B (it) * 1987-02-26 1989-02-15 Indena Spa Complessi di saponine con fosfolipidi e composizioni farmaceutiche e cosmetiche che li contengono
JPH0231646A (ja) * 1988-07-21 1990-02-01 Daicel Chem Ind Ltd イチョウ抽出物入りチョコレート
JPH0231648A (ja) * 1988-07-21 1990-02-01 Daicel Chem Ind Ltd イチョウ抽出物入りチューインガム

Also Published As

Publication number Publication date
DK0441279T3 (da) 1995-05-08
CA2035951C (en) 2001-07-31
ES2066239T3 (es) 1995-03-01
JPH06145174A (ja) 1994-05-24
EP0441279A1 (en) 1991-08-14
HK160795A (en) 1995-10-20
DE69105767T2 (de) 1995-04-27
IT1238684B (it) 1993-09-01
CA2035951A1 (en) 1991-08-10
DE69105767D1 (de) 1995-01-26
JP3036881B2 (ja) 2000-04-24
EP0441279B1 (en) 1994-12-14
IT9019324A0 (it) 1990-02-09
US5202313A (en) 1993-04-13
KR0170773B1 (ko) 1999-03-30
IT9019324A1 (it) 1991-08-09
ATE115585T1 (de) 1994-12-15

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