KR910014377A - 6-원 환을 함유하는 마크로사이클릭 테트라아자 화합물, 이의 제조방법 및 이를 함유하는 약제 - Google Patents

6-원 환을 함유하는 마크로사이클릭 테트라아자 화합물, 이의 제조방법 및 이를 함유하는 약제 Download PDF

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Publication number
KR910014377A
KR910014377A KR1019910000816A KR910000816A KR910014377A KR 910014377 A KR910014377 A KR 910014377A KR 1019910000816 A KR1019910000816 A KR 1019910000816A KR 910000816 A KR910000816 A KR 910000816A KR 910014377 A KR910014377 A KR 910014377A
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KR
South Korea
Prior art keywords
group
compound
optionally
functional group
macromolecule
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KR1019910000816A
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English (en)
Korean (ko)
Inventor
그리스 하인쯔
라뒤첼 베른트
플랏젝 요하네스
바인만 한스-요아힘
프레스 볼프-뤼디거
Original Assignee
원본미기재
쉐링 아크티엔게젤샤프트
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Application filed by 원본미기재, 쉐링 아크티엔게젤샤프트 filed Critical 원본미기재
Publication of KR910014377A publication Critical patent/KR910014377A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic System without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
KR1019910000816A 1990-01-18 1991-01-18 6-원 환을 함유하는 마크로사이클릭 테트라아자 화합물, 이의 제조방법 및 이를 함유하는 약제 KR910014377A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4001655.2 1990-01-18
DE4001655A DE4001655A1 (de) 1990-01-18 1990-01-18 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (1)

Publication Number Publication Date
KR910014377A true KR910014377A (ko) 1991-08-31

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910000816A KR910014377A (ko) 1990-01-18 1991-01-18 6-원 환을 함유하는 마크로사이클릭 테트라아자 화합물, 이의 제조방법 및 이를 함유하는 약제

Country Status (19)

Country Link
EP (1) EP0438206B1 (pt-PT)
JP (1) JPH05112567A (pt-PT)
KR (1) KR910014377A (pt-PT)
AT (1) ATE141602T1 (pt-PT)
AU (1) AU6981291A (pt-PT)
CA (1) CA2034242A1 (pt-PT)
DE (2) DE4001655A1 (pt-PT)
DK (1) DK0438206T3 (pt-PT)
ES (1) ES2091865T3 (pt-PT)
FI (1) FI94758C (pt-PT)
GR (1) GR3020973T3 (pt-PT)
HU (1) HUT56569A (pt-PT)
IE (1) IE75898B1 (pt-PT)
IL (1) IL96840A0 (pt-PT)
NO (1) NO910191L (pt-PT)
NZ (1) NZ236803A (pt-PT)
PT (1) PT96505B (pt-PT)
TW (1) TW233298B (pt-PT)
ZA (1) ZA91389B (pt-PT)

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JPH07502043A (ja) * 1991-12-10 1995-03-02 ザ　ダウ　ケミカル　カンパニー ビシクロポリアザ大環状ホスホン酸、結合体、造影剤及び製造
IL104062A0 (en) * 1991-12-10 1993-05-13 Dow Chemical Co Bicyclopolyazamacrocyclophosphonic acid complexes,their conjugates,processes for their preparation,and use as radiopharmaceuticals
US5739294A (en) * 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
AU3415493A (en) * 1991-12-10 1993-07-19 Dow Chemical Company, The Bicycle-polyazamacrocyclocarboxylic acid complexes, conjugates, preparation and use as contrast agents
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
US5480990A (en) * 1991-12-10 1996-01-02 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents
WO1994026313A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents
WO1994026315A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
US5417959A (en) * 1993-10-04 1995-05-23 Mallinckrodt Medical, Inc. Functionalized aza-crytand ligands for diagnostic imaging applications
SK22795A3 (en) * 1994-02-21 1995-09-13 Pliva Pharm & Chem Works Sulfonamidodioxepanes, method of their preparation, intermediates, salts and their using
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
EP0817787A4 (en) * 1995-03-27 2000-09-13 Isis Pharmaceuticals Inc NITROGEN MACROCYCLIC COMPOUNDS
IL126659A (en) * 1996-04-19 2003-05-29 Dow Global Technologies Inc Fluorescent chelates as visual tissue specific imaging agents
IT1291624B1 (it) * 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
AU7066698A (en) * 1997-04-22 1998-11-13 Nycomed Imaging As Nmr image compounds
FR2794744B1 (fr) * 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
EP1940841B9 (fr) 2005-10-07 2017-04-19 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
EP2004642B1 (en) * 2006-03-10 2017-07-26 Nordion (Canada) Inc. Bifunctional polyazamacrocyclic chelating agents
EP2988756B2 (fr) 2013-04-26 2022-05-18 Guerbet Formulation de produit de contraste et son procede de preparation associe
EP3544964B1 (en) 2016-11-28 2020-06-17 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
AU2019382881A1 (en) 2018-11-23 2021-05-20 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
FR3091873B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
FR3091872B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
WO2022013454A1 (fr) 2020-07-17 2022-01-20 Guerbet Procede de preparation d'un ligand chelateur derive de pcta
CN114105983B (zh) * 2021-11-09 2023-08-11 国科温州研究院(温州生物材料与工程研究所) 手性1,4,7,10-四氮杂-2,6-吡啶环蕃衍生物及其金属螯合物的制备和应用

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DE3150917A1 (de) 1981-12-18 1983-06-30 Schering Ag, 1000 Berlin Und 4619 Bergkamen "2-amino-1-(1,3-dioxolan-4-yl)-ethanol-verbindungen, deren herstellung und verwendung zur weiterverarbeitung"
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DE3324235A1 (de) * 1983-07-01 1985-01-10 Schering AG, 1000 Berlin und 4709 Bergkamen Neue komplexbildner, komplexe und komplexsalze
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SE8502573D0 (sv) * 1985-05-23 1985-05-23 Jouko Kanakre Fluorescent lanthanide chelates useful as labels of physiologically active materials
EP0232751B1 (en) 1986-01-23 1991-09-11 E.R. Squibb & Sons, Inc. 1-substituted-4,7,10-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs
DE3625417C2 (de) * 1986-07-28 1998-10-08 Schering Ag Tetraazacyclododecan-Derivate
IT1224416B (it) 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
DE3713842A1 (de) 1987-04-22 1988-11-17 Schering Ag Substituierte cyclische komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel
US5198208A (en) 1987-07-16 1993-03-30 Nycomed Imaging As Aminopolycarboxylic acids and derivatives thereof
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Also Published As

Publication number Publication date
FI94758B (fi) 1995-07-14
DK0438206T3 (pt-PT) 1997-01-20
DE4001655A1 (de) 1991-07-25
ATE141602T1 (de) 1996-09-15
PT96505A (pt) 1991-10-15
ES2091865T3 (es) 1996-11-16
IE75898B1 (en) 1997-09-24
DE59108091D1 (de) 1996-09-26
FI910276A0 (fi) 1991-01-18
TW233298B (pt-PT) 1994-11-01
FI910276A (fi) 1991-07-19
NZ236803A (en) 1993-08-26
NO910191D0 (no) 1991-01-17
AU6981291A (en) 1991-08-22
CA2034242A1 (en) 1991-07-19
FI94758C (fi) 1995-10-25
EP0438206A1 (de) 1991-07-24
GR3020973T3 (en) 1996-12-31
HUT56569A (en) 1991-09-30
IL96840A0 (en) 1991-09-16
IE910162A1 (en) 1991-07-31
NO910191L (no) 1991-07-19
PT96505B (pt) 1998-07-31
JPH05112567A (ja) 1993-05-07
HU910156D0 (en) 1991-08-28
EP0438206B1 (de) 1996-08-21
ZA91389B (en) 1991-10-30

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