DE4001655A1 - 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel - Google Patents

6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Info

Publication number
DE4001655A1
DE4001655A1 DE4001655A DE4001655A DE4001655A1 DE 4001655 A1 DE4001655 A1 DE 4001655A1 DE 4001655 A DE4001655 A DE 4001655A DE 4001655 A DE4001655 A DE 4001655A DE 4001655 A1 DE4001655 A1 DE 4001655A1
Authority
DE
Germany
Prior art keywords
meaning
group
groups
hydrogen atom
general formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE4001655A
Other languages
German (de)
English (en)
Inventor
Heinz Dr Gries
Bernd Dr Raduechel
Johannes Dr Platzek
Hanns-Joachim Dr Weinmann
Wolf-Ruediger Press
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Priority to DE4001655A priority Critical patent/DE4001655A1/de
Priority to IL96840A priority patent/IL96840A0/xx
Priority to JP3002602A priority patent/JPH05112567A/ja
Priority to DK91250008.9T priority patent/DK0438206T3/da
Priority to DE59108091T priority patent/DE59108091D1/de
Priority to CA002034242A priority patent/CA2034242A1/en
Priority to EP91250008A priority patent/EP0438206B1/de
Priority to AT91250008T priority patent/ATE141602T1/de
Priority to ES91250008T priority patent/ES2091865T3/es
Priority to NO91910191A priority patent/NO910191L/no
Priority to NZ236803A priority patent/NZ236803A/xx
Priority to HU91156A priority patent/HUT56569A/hu
Priority to PT96505A priority patent/PT96505B/pt
Priority to ZA91389A priority patent/ZA91389B/xx
Priority to AU69812/91A priority patent/AU6981291A/en
Priority to FI910276A priority patent/FI94758C/fi
Priority to KR1019910000816A priority patent/KR910014377A/ko
Priority to IE16291A priority patent/IE75898B1/en
Publication of DE4001655A1 publication Critical patent/DE4001655A1/de
Priority to TW080108935A priority patent/TW233298B/zh
Priority to US07/907,929 priority patent/US5334371A/en
Priority to US08/213,431 priority patent/US5403572A/en
Priority to GR960402335T priority patent/GR3020973T3/el
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/003—Compounds containing elements of Groups 3 or 13 of the Periodic System without C-Metal linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
DE4001655A 1988-07-20 1990-01-18 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel Withdrawn DE4001655A1 (de)

Priority Applications (22)

Application Number Priority Date Filing Date Title
DE4001655A DE4001655A1 (de) 1990-01-18 1990-01-18 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
IL96840A IL96840A0 (en) 1990-01-18 1990-12-31 Macrocyclic tetraaza compounds containing a six-membered ring,process for their production,and pharmaceutical agents containing the same
JP3002602A JPH05112567A (ja) 1990-01-18 1991-01-14 ６員環を有する巨大環式テトラアザ化合物、その製法及びこれを含有する薬剤
DK91250008.9T DK0438206T3 (pt-PT) 1990-01-18 1991-01-16
DE59108091T DE59108091D1 (de) 1990-01-18 1991-01-16 6-Ring enthaltende makrocyclische Tetraaza-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
CA002034242A CA2034242A1 (en) 1990-01-18 1991-01-16 Macrocyclic tetraaza compounds containing a six-membered ring, processes for their production, and pharmaceutical agents containing same
EP91250008A EP0438206B1 (de) 1990-01-18 1991-01-16 6-Ring enthaltende makrocyclische Tetraaza-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel
AT91250008T ATE141602T1 (de) 1990-01-18 1991-01-16 6-ring enthaltende makrocyclische tetraaza- verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
ES91250008T ES2091865T3 (es) 1990-01-18 1991-01-16 Tetraaza-compuestos macrociclicos que contienen 6 anillos, procedimiento para su preparacion y agentes farmaceuticos que los contienen.
HU91156A HUT56569A (en) 1990-01-18 1991-01-17 Process for producing macrocyclic tetraaza compounds, their metal complexes and pharmaceutical compositions comprising such compounds
NZ236803A NZ236803A (en) 1990-01-18 1991-01-17 Tetra-aza macrocyclic complexing agents for metal ions, optionally attached to another macromolecule; therapeutic and diagnostic uses
NO91910191A NO910191L (no) 1990-01-18 1991-01-17 Makrocykliske tetraazaforbindelser som inneholder en seksring, fremgangsmaate for fremstilling derav, samt farmasoeytiske midler som inneholder slike.
PT96505A PT96505B (pt) 1990-01-18 1991-01-17 Processo para preparacao de compostos tetra-aza macrociclicos contendo um anel de 6 elementos e de composicoes farmaceuticas que os contem
KR1019910000816A KR910014377A (ko) 1990-01-18 1991-01-18 6-원 환을 함유하는 마크로사이클릭 테트라아자 화합물, 이의 제조방법 및 이를 함유하는 약제
AU69812/91A AU6981291A (en) 1990-01-18 1991-01-18 Macrocyclic tetraaza compounds containing a six-membered ring, processes for their production, and pharmaceutical agents containing them
FI910276A FI94758C (fi) 1990-01-18 1991-01-18 Makrosyklisiä yhdisteitä, joissa on 3,6,9,15-tetra-atsabisyklo/9.3.1/pentadekaanirakenne, niiden käyttö NMR-, röntgen- tai radiodiagnostiikkaan käytettävissä koostumuksissa ja tällaiset koostumukset
ZA91389A ZA91389B (en) 1990-01-18 1991-01-18 Macrocyclic tetraaza compounds containing a six-membered ring,processes for their production,and pharmaceutical agents containing same
IE16291A IE75898B1 (en) 1990-01-18 1991-01-18 Macrocyclic tetraaza compounds containing a six-membered ring processes for their production and pharmaceutical agents containing the same
TW080108935A TW233298B (pt-PT) 1990-01-18 1991-08-06
US07/907,929 US5334371A (en) 1988-07-20 1992-07-06 Marcocyclic polyaza bicyclo compounds containing 5 or 6 membered rings, and method for MRI
US08/213,431 US5403572A (en) 1988-07-20 1994-03-15 Macrocyclic polyaza compounds containing 5 or 6 membered rings, process for producing them and pharmaceutical media containing them
GR960402335T GR3020973T3 (en) 1990-01-18 1996-09-06 6-Ring-containing macrocyclic tetraaza compounds, processes for their preparation, and pharmaceutical agents containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4001655A DE4001655A1 (de) 1990-01-18 1990-01-18 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

Publications (1)

Publication Number Publication Date
DE4001655A1 true DE4001655A1 (de) 1991-07-25

Family

ID=6398485

Family Applications (2)

Application Number Title Priority Date Filing Date
DE4001655A Withdrawn DE4001655A1 (de) 1988-07-20 1990-01-18 6-ring enthaltende makrocyclische tetraaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE59108091T Expired - Lifetime DE59108091D1 (de) 1990-01-18 1991-01-16 6-Ring enthaltende makrocyclische Tetraaza-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE59108091T Expired - Lifetime DE59108091D1 (de) 1990-01-18 1991-01-16 6-Ring enthaltende makrocyclische Tetraaza-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel

Country Status (19)

Country Link
EP (1) EP0438206B1 (pt-PT)
JP (1) JPH05112567A (pt-PT)
KR (1) KR910014377A (pt-PT)
AT (1) ATE141602T1 (pt-PT)
AU (1) AU6981291A (pt-PT)
CA (1) CA2034242A1 (pt-PT)
DE (2) DE4001655A1 (pt-PT)
DK (1) DK0438206T3 (pt-PT)
ES (1) ES2091865T3 (pt-PT)
FI (1) FI94758C (pt-PT)
GR (1) GR3020973T3 (pt-PT)
HU (1) HUT56569A (pt-PT)
IE (1) IE75898B1 (pt-PT)
IL (1) IL96840A0 (pt-PT)
NO (1) NO910191L (pt-PT)
NZ (1) NZ236803A (pt-PT)
PT (1) PT96505B (pt-PT)
TW (1) TW233298B (pt-PT)
ZA (1) ZA91389B (pt-PT)

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FR2644785B1 (fr) * 1989-03-24 1991-07-05 Guerbet Sa Nouveaux ligands macrocycliques azotes, procede de preparation, complexes metalliques formes par ces ligands et composition de diagnostic les contenant
IL104060A (en) * 1991-12-10 1998-12-06 Dow Chemical Co Bicyclopolyazamacyclophosphonic acids, their complexes and conjugates, for use as contrast agents, and processes for their preparation
WO1994026313A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as contrast agents
ZA929578B (en) * 1991-12-10 1994-06-10 Dow Chemical Co Bicyclopolyazamacrocyclocarboxylic acid complexes their conjugates processes for their preparation and use as radiopharmaceuticals
US5428139A (en) * 1991-12-10 1995-06-27 The Dow Chemical Company Bicyclopolyazamacrocyclophosphonic acid complexes for use as radiopharmaceuticals
US5480990A (en) * 1991-12-10 1996-01-02 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes for use as contrast agents
SG48889A1 (en) * 1991-12-10 1998-05-18 Dow Chemical Co Bicycle-polyamacrocyclocarboxylic acid complexes conjugates preparation and use as contrast agents
US5739294A (en) * 1991-12-10 1998-04-14 The Dow Chemical Company Bicyclopol yazamacrocyclophosphonic acid complexes for use as contrast agents
WO1994026315A1 (en) * 1993-05-06 1994-11-24 The Dow Chemical Company Bicyclopolyazamacrocyclocarboxylic acid complexes, their conjugates, processes for their preparation, and use as radiopharmaceuticals
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
US5417959A (en) * 1993-10-04 1995-05-23 Mallinckrodt Medical, Inc. Functionalized aza-crytand ligands for diagnostic imaging applications
ES2123167T3 (es) * 1994-02-21 1999-01-01 Pliva Pharm & Chem Works Sulfonamidodioxepanos con una actividad hipoglicemica, metodos para su preparacion, sus intermediarios y sus sales.
US6207826B1 (en) 1995-03-27 2001-03-27 Isis Pharmaceuticals, Inc. Macrocyclic compounds having nitrogen-containing linkages
EP0817787A4 (en) 1995-03-27 2000-09-13 Isis Pharmaceuticals Inc NITROGEN MACROCYCLIC COMPOUNDS
EP0898574B1 (en) * 1996-04-19 2003-11-12 Dow Global Technologies Inc. Fluorescent chelates as visual tissue specific imaging agents
IT1291624B1 (it) * 1997-04-18 1999-01-11 Bracco Spa Chelati complessi di metalli paramagnetici a bassa tossicita'
EP0977598A1 (en) * 1997-04-22 2000-02-09 Nycomed Imaging As Nmr image compounds
FR2794744B1 (fr) * 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale
US8986650B2 (en) 2005-10-07 2015-03-24 Guerbet Complex folate-NOTA-Ga68
WO2007042504A2 (fr) 2005-10-07 2007-04-19 Guerbet Composes comprenant une partie de reconnaissance d'une cible biologique, couplee a une partie de signal capable de complexer le gallium
FR2891830B1 (fr) * 2005-10-07 2011-06-24 Guerbet Sa Composes a chaines aminoalcools courtes et complexes metalliques pour l'imagerie medicale
JP5503149B2 (ja) * 2006-03-10 2014-05-28 ノルディオン・（カナダ）・インコーポレイテッド 二官能性ポリアザ大環状キレート剤
BR112015026473B1 (pt) 2013-04-26 2020-12-01 Guerbet composições farmacêuticas líquidas e processo de preparação das mesmas e meio de contraste para imagiologia médica
JP7034160B2 (ja) 2016-11-28 2022-03-11 バイエル・ファルマ・アクティエンゲゼルシャフト 磁気共鳴画像法に使用するための高緩和度ガドリニウムキレート化合物
US11944690B2 (en) 2018-11-23 2024-04-02 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof
FR3091872B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de synthese
FR3091873B1 (fr) 2019-01-17 2020-12-25 Guerbet Sa Complexe de gadolinium et d’un ligand chelateur derive de pcta diastereoisomeriquement enrichi et procede de preparation et de purification
KR20230041007A (ko) 2020-07-17 2023-03-23 게르브 Pcta로부터 유도된 킬레이팅 리간드의 제조 방법
CN114105983B (zh) * 2021-11-09 2023-08-11 国科温州研究院(温州生物材料与工程研究所) 手性1,4,7,10-四氮杂-2,6-吡啶环蕃衍生物及其金属螯合物的制备和应用

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EP0071564A1 (de) * 1981-07-24 1983-02-09 Schering Aktiengesellschaft Paramagnetische Komplexsalze, deren Herstellung und Verwendung bei der NMR-Diagnostik
DE3401052A1 (de) * 1983-01-21 1984-07-26 Schering AG, 1000 Berlin und 4709 Bergkamen Diagnostische mittel
EP0130934A1 (de) * 1983-07-01 1985-01-09 Schering Aktiengesellschaft Neue Komplexbildner, Komplexe und Komplexsalze
EP0203047A1 (en) * 1985-05-23 1986-11-26 Jouko Kankare Fluorescent lanthanide chelates
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

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Publication number Priority date Publication date Assignee Title
EP0071564A1 (de) * 1981-07-24 1983-02-09 Schering Aktiengesellschaft Paramagnetische Komplexsalze, deren Herstellung und Verwendung bei der NMR-Diagnostik
DE3401052A1 (de) * 1983-01-21 1984-07-26 Schering AG, 1000 Berlin und 4709 Bergkamen Diagnostische mittel
EP0130934A1 (de) * 1983-07-01 1985-01-09 Schering Aktiengesellschaft Neue Komplexbildner, Komplexe und Komplexsalze
EP0203047A1 (en) * 1985-05-23 1986-11-26 Jouko Kankare Fluorescent lanthanide chelates
DE3825040A1 (de) * 1988-07-20 1990-01-25 Schering Ag 5- oder 6-ring- enthaltende makrocyclische polyaza-verbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel
DE3938992A1 (de) * 1989-11-21 1991-05-23 Schering Ag Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel

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GB-Z.: Tetrahedron 37 (1981), 767-72 *

Also Published As

Publication number Publication date
CA2034242A1 (en) 1991-07-19
TW233298B (pt-PT) 1994-11-01
DK0438206T3 (pt-PT) 1997-01-20
JPH05112567A (ja) 1993-05-07
IE75898B1 (en) 1997-09-24
FI94758B (fi) 1995-07-14
NZ236803A (en) 1993-08-26
NO910191L (no) 1991-07-19
ZA91389B (en) 1991-10-30
EP0438206B1 (de) 1996-08-21
IL96840A0 (en) 1991-09-16
EP0438206A1 (de) 1991-07-24
FI94758C (fi) 1995-10-25
ATE141602T1 (de) 1996-09-15
ES2091865T3 (es) 1996-11-16
AU6981291A (en) 1991-08-22
PT96505B (pt) 1998-07-31
DE59108091D1 (de) 1996-09-26
IE910162A1 (en) 1991-07-31
HUT56569A (en) 1991-09-30
KR910014377A (ko) 1991-08-31
NO910191D0 (no) 1991-01-17
PT96505A (pt) 1991-10-15
FI910276A0 (fi) 1991-01-18
FI910276A (fi) 1991-07-19
HU910156D0 (en) 1991-08-28
GR3020973T3 (en) 1996-12-31

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