KR910011783A - 아릴피페리딘 유도체 - Google Patents

아릴피페리딘 유도체 Download PDF

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KR910011783A
KR910011783A KR1019890017770A KR890017770A KR910011783A KR 910011783 A KR910011783 A KR 910011783A KR 1019890017770 A KR1019890017770 A KR 1019890017770A KR 890017770 A KR890017770 A KR 890017770A KR 910011783 A KR910011783 A KR 910011783A
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methoxyphenyl
compound
naphthyl
dioxo
phenyl
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KR1019890017770A
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KR910006980B1 (ko
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아담 나겔 아더
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알렌 제이.스피겔
화이자 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/20—Spiro-condensed ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/24—Camphidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

내용 없음

Description

아릴피레리딘 유도체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일반식(I)의 N-치환된 아릴피페리딘 화합물, 또는 그의 약학적으로 허용되는 산 부가염.
    상기식에서, Ar은 페닐, 플루오로페닐, 클로로페닐, 트리플루오로메틸페닐, 메톡시페닐, 임의로 불소, 염소, 트리플루오로메틸 또는 메톡시로 치환된 톨릴 또는 나프틸이고, n은 2 내지 4의 정수이며, X는 산소, 황 또는 직접 결합이고; R은 페닐, 하이드록시페닐, 메톡시페닐, 톨릴, 2-아미노-4-티아졸릴페닐, 5-옥시인돌릴, 2-메틸-4-옥소-4H-피리도[1,2a]피리미딘-3-일, 7,9-디옥소-8-아자스피로[4,5]데칸-8-일 또는 1,8,8-트리메틸-2,4-디옥소-3-아자비사이클로[3,2,1]헵탄-3-일이다.
  2. 제1항에 있어서, Ar이 피페리딘 고리의 3번 위치에 부착되고 메톡시페닐 또는 나프틸이며; X는 직접 결합인 화합물.
  3. 제2항에 있어서, Ar이 2-메톡시페닐이며; n은 2 또는 4이고; R이 4-(2-4-티아졸릴)페닐인 화합물.
  4. 제1항에 있어서, Ar이 피페리딘 고리의 4번 위치에 부착되고, 페닐, 트리플루오로메틸페닐, 메톡시페닐 또는 나프틸이며, X가 산소 또는 직접 결합인 화합물.
  5. 제4항에 있어서, X가 직접 결합인 화합물.
  6. 제5항에 있어서, Ar이 2-메톡시페닐이고; n이 2 또는 4이며; R이 4-(2-아미노-타아졸릴)페닐인 화합물.
  7. 제5항에 있어서, Ar이 2-메톡시페닐 또는 1-나프틸이고 n이 2이며, R이 5-옥스인돌린인 화합물.
  8. 제5항에 있어서, Ar이 2-메톡시페닐이고, n이 4이며, R이 1,8,8-트리메틸-2,4-디옥소-3-아자비사이클로[3,2,1]헵탄-3-일인 화합물.
  9. 제5항에 있어서, Ar이 1-나프틸이고; n이 2이며, R이 2-메틸-4-옥소-4H-피리도[1,2a]피리미딘-3-일인 화합물.
  10. 약학적으로 허용되는 담체 또는 희석제 및 정신병 치료 효과량의 제1항의 화합물을 포함하는 경구 또는 비경구 투여에 적합한 정신병 치료용 약학 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890017770A 1988-12-02 1989-12-01 아릴피페리딘 유도체 KR910006980B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
USPCT/US88/04300 1988-12-02
PCT/US1988/004300 WO1990006303A1 (en) 1988-12-02 1988-12-02 Arylpiperidine derivatives

Publications (2)

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KR910011783A true KR910011783A (ko) 1991-08-07
KR910006980B1 KR910006980B1 (ko) 1991-09-14

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US (2) US5153206A (ko)
EP (1) EP0372776B1 (ko)
JP (1) JPH0710850B2 (ko)
KR (1) KR910006980B1 (ko)
AT (1) ATE143366T1 (ko)
AU (1) AU633858B2 (ko)
CA (1) CA2004249C (ko)
DE (1) DE68927254T2 (ko)
DK (1) DK606889A (ko)
ES (1) ES2092475T3 (ko)
FI (1) FI95465C (ko)
GR (1) GR3021496T3 (ko)
HU (1) HU207310B (ko)
IE (1) IE75359B1 (ko)
IL (1) IL92466A (ko)
NO (1) NO175257C (ko)
NZ (1) NZ231612A (ko)
PT (1) PT92468B (ko)
WO (1) WO1990006303A1 (ko)
ZA (1) ZA899192B (ko)

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FI95465B (fi) 1995-10-31
EP0372776A2 (en) 1990-06-13
NO175257B (no) 1994-06-13
US5153206A (en) 1992-10-06
KR910006980B1 (ko) 1991-09-14
US5294619A (en) 1994-03-15
NZ231612A (en) 1991-02-26
NO903383L (no) 1990-10-01
HUT59127A (en) 1992-04-28
ES2092475T3 (es) 1996-12-01
IL92466A0 (en) 1990-08-31
DE68927254D1 (de) 1996-10-31
DE68927254T2 (de) 1997-02-06
PT92468B (pt) 1995-07-18
WO1990006303A1 (en) 1990-06-14
FI95465C (fi) 1996-02-12
EP0372776B1 (en) 1996-09-25
AU4586989A (en) 1990-06-28
JPH0710850B2 (ja) 1995-02-08
HU207310B (en) 1993-03-29
GR3021496T3 (en) 1997-01-31
ZA899192B (en) 1991-07-31
FI903829A0 (fi) 1990-08-01
HU892324D0 (en) 1990-12-28
IL92466A (en) 1994-02-27
EP0372776A3 (en) 1991-10-23
DK606889D0 (da) 1989-12-01
IE75359B1 (en) 1997-08-27
NO175257C (no) 1994-09-21
ATE143366T1 (de) 1996-10-15
JPH02275853A (ja) 1990-11-09
CA2004249C (en) 1996-09-17
CA2004249A1 (en) 1990-06-02
IE893813L (en) 1990-06-02
AU633858B2 (en) 1993-02-11
NO903383D0 (no) 1990-08-01
DK606889A (da) 1990-07-18
PT92468A (pt) 1990-06-29

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