KR910009663A - 피리딘유도체, 이들을 함유하는 약리학적 조성물 및 이들의 제조방법 - Google Patents
피리딘유도체, 이들을 함유하는 약리학적 조성물 및 이들의 제조방법 Download PDFInfo
- Publication number
- KR910009663A KR910009663A KR1019900017881A KR900017881A KR910009663A KR 910009663 A KR910009663 A KR 910009663A KR 1019900017881 A KR1019900017881 A KR 1019900017881A KR 900017881 A KR900017881 A KR 900017881A KR 910009663 A KR910009663 A KR 910009663A
- Authority
- KR
- South Korea
- Prior art keywords
- pyridine
- general formula
- cyinoimino
- compound
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 238000000034 method Methods 0.000 title claims 9
- 150000003222 pyridines Chemical class 0.000 title claims 8
- 239000008196 pharmacological composition Substances 0.000 title claims 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 19
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 8
- -1 1- (2-chlorobenzyl) -2- (nitroamino) pyridine Chemical compound 0.000 claims 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- 150000007529 inorganic bases Chemical class 0.000 claims 3
- 150000007530 organic bases Chemical class 0.000 claims 3
- ICSNLGPSRYBMBD-UHFFFAOYSA-N 2-aminopyridine Chemical class NC1=CC=CC=N1 ICSNLGPSRYBMBD-UHFFFAOYSA-N 0.000 claims 2
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 239000000010 aprotic solvent Substances 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 125000006282 2-chlorobenzyl group Chemical group [H]C1=C([H])C(Cl)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000004847 2-fluorobenzyl group Chemical group [H]C1=C([H])C(F)=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 125000003852 3-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C(Cl)=C1[H])C([H])([H])* 0.000 claims 1
- 125000006281 4-bromobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Br)C([H])([H])* 0.000 claims 1
- 125000006283 4-chlorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1Cl)C([H])([H])* 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001024304 Mino Species 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 229910000288 alkali metal carbonate Inorganic materials 0.000 claims 1
- 150000008041 alkali metal carbonates Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 claims 1
- 239000006227 byproduct Substances 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 230000027119 gastric acid secretion Effects 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- NNFOHTKXYYCOCC-UHFFFAOYSA-N n-(1-benzylpyridin-2-ylidene)nitramide Chemical compound [O-][N+](=O)N=C1C=CC=CN1CC1=CC=CC=C1 NNFOHTKXYYCOCC-UHFFFAOYSA-N 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C07D213/77—Hydrazine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU895807A HU207047B (en) | 1989-11-07 | 1989-11-07 | Process for producing new pyridine derivatives and pharmaceutical copositions comprising same |
| HU5907/89 | 1989-11-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR910009663A true KR910009663A (ko) | 1991-06-28 |
Family
ID=10970765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1019900017881A Withdrawn KR910009663A (ko) | 1989-11-07 | 1990-11-06 | 피리딘유도체, 이들을 함유하는 약리학적 조성물 및 이들의 제조방법 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5155123A (cg-RX-API-DMAC10.html) |
| EP (1) | EP0427526B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JPH03169862A (cg-RX-API-DMAC10.html) |
| KR (1) | KR910009663A (cg-RX-API-DMAC10.html) |
| CN (1) | CN1052305A (cg-RX-API-DMAC10.html) |
| AR (1) | AR248394A1 (cg-RX-API-DMAC10.html) |
| AT (1) | ATE109137T1 (cg-RX-API-DMAC10.html) |
| AU (1) | AU631261B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2029222A1 (cg-RX-API-DMAC10.html) |
| DE (1) | DE69011046T2 (cg-RX-API-DMAC10.html) |
| DK (1) | DK0427526T3 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2057441T3 (cg-RX-API-DMAC10.html) |
| FI (1) | FI905493A7 (cg-RX-API-DMAC10.html) |
| HU (1) | HU207047B (cg-RX-API-DMAC10.html) |
| IL (1) | IL96252A (cg-RX-API-DMAC10.html) |
| IN (1) | IN171700B (cg-RX-API-DMAC10.html) |
| NO (1) | NO177263C (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ235984A (cg-RX-API-DMAC10.html) |
| PH (1) | PH27440A (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA908889B (cg-RX-API-DMAC10.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1035115B1 (en) | 1999-02-24 | 2004-09-29 | F. Hoffmann-La Roche Ag | 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists |
| US7288658B2 (en) | 2003-07-15 | 2007-10-30 | Hoffmann-La Roche Inc. | Process for preparation of pyridine derivatives |
| ATE453384T1 (de) | 2005-09-23 | 2010-01-15 | Hoffmann La Roche | Neue dosierformulierung |
| AU2011297160B2 (en) * | 2010-08-31 | 2014-11-20 | Mitsui Chemicals Crop & Life Solutions, Inc. | Noxious organism control agent |
| HUE056549T2 (hu) * | 2011-08-26 | 2022-02-28 | Meiji Seika Pharma Co Ltd | Eljárás kártevõirtószer elõállítására |
| PY1960131A (es) | 2018-08-07 | 2020-11-20 | Syngenta Crop Protection Ag | Compuestos heteroatomáticos bicíclicos activos como pesticidas |
| AR117291A1 (es) | 2018-12-14 | 2021-07-28 | Syngenta Crop Protection Ag | Compuestos heterocíclicos de cianamida con actividad pesticida |
| WO2020169526A1 (en) | 2019-02-18 | 2020-08-27 | Syngenta Crop Protection Ag | Pesticidally-active cyanamide heterocyclic compounds |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1201119A (en) * | 1978-09-18 | 1986-02-25 | Mcneilab, Inc. | Diaza-cyclic derivatives of guanidine |
| HU188852B (en) * | 1983-03-16 | 1986-05-28 | Richter Gedeon Vegyeszeti Gyar Rt,Hu | Process for producing thiazolidine derivatives active against gastric ulcer and intestinal ulcer |
| JPH07121909B2 (ja) * | 1986-09-10 | 1995-12-25 | 日本バイエルアグロケム株式会社 | 新規複素環式化合物及び殺虫剤 |
-
1989
- 1989-11-07 HU HU895807A patent/HU207047B/hu unknown
-
1990
- 1990-10-31 US US07/607,153 patent/US5155123A/en not_active Expired - Fee Related
- 1990-11-02 CA CA002029222A patent/CA2029222A1/en not_active Abandoned
- 1990-11-06 ZA ZA908889A patent/ZA908889B/xx unknown
- 1990-11-06 PH PH41502A patent/PH27440A/en unknown
- 1990-11-06 FI FI905493A patent/FI905493A7/fi not_active Application Discontinuation
- 1990-11-06 IN IN930/CAL/90A patent/IN171700B/en unknown
- 1990-11-06 KR KR1019900017881A patent/KR910009663A/ko not_active Withdrawn
- 1990-11-06 IL IL9625290A patent/IL96252A/en not_active IP Right Cessation
- 1990-11-06 JP JP2299084A patent/JPH03169862A/ja active Pending
- 1990-11-06 NO NO904822A patent/NO177263C/no unknown
- 1990-11-06 NZ NZ235984A patent/NZ235984A/en unknown
- 1990-11-06 AR AR90318303A patent/AR248394A1/es active
- 1990-11-06 AU AU65823/90A patent/AU631261B2/en not_active Ceased
- 1990-11-07 EP EP90312167A patent/EP0427526B1/en not_active Expired - Lifetime
- 1990-11-07 CN CN90109755A patent/CN1052305A/zh active Pending
- 1990-11-07 AT AT90312167T patent/ATE109137T1/de not_active IP Right Cessation
- 1990-11-07 ES ES90312167T patent/ES2057441T3/es not_active Expired - Lifetime
- 1990-11-07 DK DK90312167.1T patent/DK0427526T3/da active
- 1990-11-07 DE DE69011046T patent/DE69011046T2/de not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| AU631261B2 (en) | 1992-11-19 |
| HU895807D0 (en) | 1990-01-28 |
| EP0427526A1 (en) | 1991-05-15 |
| NO904822L (no) | 1991-05-08 |
| IL96252A0 (en) | 1991-08-16 |
| AR248394A1 (es) | 1995-08-18 |
| NO177263C (no) | 1995-08-16 |
| EP0427526B1 (en) | 1994-07-27 |
| NO177263B (no) | 1995-05-08 |
| DK0427526T3 (da) | 1994-08-29 |
| FI905493A7 (fi) | 1991-05-08 |
| NO904822D0 (no) | 1990-11-06 |
| DE69011046T2 (de) | 1994-11-24 |
| FI905493A0 (fi) | 1990-11-06 |
| ZA908889B (en) | 1991-10-30 |
| ES2057441T3 (es) | 1994-10-16 |
| JPH03169862A (ja) | 1991-07-23 |
| HUT55758A (en) | 1991-06-28 |
| DE69011046D1 (de) | 1994-09-01 |
| CA2029222A1 (en) | 1991-05-08 |
| HU207047B (en) | 1993-03-01 |
| AU6582390A (en) | 1991-05-23 |
| US5155123A (en) | 1992-10-13 |
| IN171700B (cg-RX-API-DMAC10.html) | 1992-12-12 |
| ATE109137T1 (de) | 1994-08-15 |
| PH27440A (en) | 1993-07-02 |
| IL96252A (en) | 1994-12-29 |
| NZ235984A (en) | 1992-08-26 |
| CN1052305A (zh) | 1991-06-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0109 | Patent application |
Patent event code: PA01091R01D Comment text: Patent Application Patent event date: 19901106 |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |