NO863202L - Fremgangsmaate for fremstilling av terapeutisk aktive polypeptid-derivater. - Google Patents
Fremgangsmaate for fremstilling av terapeutisk aktive polypeptid-derivater.Info
- Publication number
- NO863202L NO863202L NO863202A NO863202A NO863202L NO 863202 L NO863202 L NO 863202L NO 863202 A NO863202 A NO 863202A NO 863202 A NO863202 A NO 863202A NO 863202 L NO863202 L NO 863202L
- Authority
- NO
- Norway
- Prior art keywords
- sup
- chlorobenzyl
- polypeptide derivatives
- procedure
- preparation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
- C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/86—Renin inhibitors
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polyamides (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US76416885A | 1985-08-09 | 1985-08-09 | |
US06/858,324 US4729985A (en) | 1985-08-09 | 1986-04-30 | Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues |
Publications (4)
Publication Number | Publication Date |
---|---|
NO863202D0 NO863202D0 (no) | 1986-08-08 |
NO863202L true NO863202L (no) | 1987-02-10 |
NO170725B NO170725B (no) | 1992-08-17 |
NO170725C NO170725C (no) | 1992-11-25 |
Family
ID=27117410
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO863202A NO170725C (no) | 1985-08-09 | 1986-08-08 | Stereoselektiv fremgangsmaate for fremstilling av t-butylokskarbonylamino-gamma-laktoner egnet for fremstilling av renininhibitorer inneholdende 5-amino-2,5-disubstituerte-4-hydroksypentansyre-rester |
Country Status (22)
Country | Link |
---|---|
US (1) | US4729985A (no) |
EP (1) | EP0212903B1 (no) |
JP (1) | JPS6253952A (no) |
KR (1) | KR890003603B1 (no) |
CN (1) | CN86105870A (no) |
AT (1) | ATE84046T1 (no) |
AU (1) | AU576970B2 (no) |
CA (1) | CA1294736C (no) |
DE (1) | DE3687380T2 (no) |
DK (1) | DK379186A (no) |
EG (1) | EG17971A (no) |
ES (1) | ES2000852A6 (no) |
FI (1) | FI86192C (no) |
GR (1) | GR862078B (no) |
HU (1) | HU207101B (no) |
IE (1) | IE58524B1 (no) |
IL (1) | IL79626A0 (no) |
NO (1) | NO170725C (no) |
NZ (1) | NZ217127A (no) |
PH (1) | PH24494A (no) |
PT (1) | PT83172B (no) |
YU (1) | YU45355B (no) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4727060A (en) * | 1984-11-13 | 1988-02-23 | Ciba-Geigy Corporation | Novel 5-amino-4-hydroxyvaleryl derivatives |
DE3538749A1 (de) * | 1985-10-31 | 1987-05-07 | Merck Patent Gmbh | Peptide |
FI870474A (fi) * | 1986-02-07 | 1987-08-08 | Ciba Geigy Ag | Med svavelhaltiga grupper substituerade 5-amino-4-hydroxivalerylderivat. |
DE3626130A1 (de) * | 1986-08-01 | 1988-02-11 | Merck Patent Gmbh | Aminosaeurederivate |
US4681972A (en) * | 1986-09-16 | 1987-07-21 | Warner-Lambert Company | Separation of diastereomers |
DE3789347D1 (de) * | 1986-10-14 | 1994-04-21 | Banyu Pharma Co Ltd | 5-Substituierte Amino-4-hydroxy-pentansäure-Derivate und deren Verwendung. |
US4927565A (en) * | 1986-12-19 | 1990-05-22 | Banyu Pharmaceutical Co., Ltd. | 5-substituted amino-4-hydroxy-pentenoic acid derivatives and their use |
US4758584A (en) * | 1987-02-05 | 1988-07-19 | Ciba-Geigy Corporation | Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups |
DE3888031T2 (de) * | 1987-07-01 | 1994-06-09 | Pfizer | Homocyclostatin und Cyclostatin enthaltende Polypeptide als Antihypertensiva. |
US4859654A (en) * | 1987-07-01 | 1989-08-22 | Pfizer Inc. | Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents |
EP0312158A3 (en) * | 1987-10-13 | 1990-07-25 | Merck & Co. Inc. | Tetrapeptide renin inhibitors having novel c-terminal amino acid amide |
GB8728561D0 (en) * | 1987-12-07 | 1988-01-13 | Glaxo Group Ltd | Chemical compounds |
GB8728560D0 (en) * | 1987-12-07 | 1988-01-13 | Glaxo Group Ltd | Chemical compounds |
DE68916271T2 (de) * | 1988-01-26 | 1995-02-23 | Sankyo Co | Renin inhibierende Polypeptide, ihre Herstellung und Anwendung. |
EP0329295A1 (en) * | 1988-02-01 | 1989-08-23 | The Upjohn Company | Renin inhibiting peptides with polar end groups |
JPS6486550A (en) * | 1988-08-19 | 1989-03-31 | Seiko Epson Corp | Complementary mos integrated circuit |
US5436339A (en) * | 1991-03-06 | 1995-07-25 | Abbott Laboratories | Process for the preparation of a substituted diaminoalcohol |
US5238935A (en) * | 1991-05-20 | 1993-08-24 | Schering Corporation | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme A: cholesterol acyl transferase |
US5124337A (en) * | 1991-05-20 | 1992-06-23 | Schering Corporation | N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase |
TW217410B (no) * | 1992-04-01 | 1993-12-11 | Ciba Geigy | |
MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
EP0702004A2 (de) * | 1994-09-15 | 1996-03-20 | Ciba-Geigy Ag | 2,9-Diamino- und 2-amino-8-carbamoyl-4-hydroxy-alkansäureamid-derivative |
EP0716077A1 (de) * | 1994-12-08 | 1996-06-12 | Ciba-Geigy Ag | Aromatisch substituierte Omega-Aminoalkansäureamide und Alkansäurediamide und ihre Verwendung als Renininhibitoren |
CA2191924A1 (en) * | 1995-12-05 | 1997-06-06 | Kevin Felsenstein | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production |
US5703129A (en) * | 1996-09-30 | 1997-12-30 | Bristol-Myers Squibb Company | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production |
DE60124080T2 (de) | 2000-03-23 | 2007-03-01 | Elan Pharmaceuticals, Inc., San Francisco | Verbindungen und verfahren zur behandlung der alzheimerschen krankheit |
EP1299352B1 (en) | 2000-06-30 | 2005-12-28 | Elan Pharmaceuticals, Inc. | Compounds to treat alzheimer's disease |
RU2550691C2 (ru) * | 2009-08-11 | 2015-05-10 | Новартис Аг | Раскрытие циклов лактонов и лактамов |
CN105195868B (zh) * | 2015-11-12 | 2018-05-15 | 上海电气核电设备有限公司 | 一种机器人焊接系统及其焊接方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4163676A (en) * | 1978-04-03 | 1979-08-07 | Blue Cross Laboratories | Ethanol-modified lecithin cookware spray composition |
NO812612L (no) * | 1980-08-06 | 1982-02-08 | Ferring Pharma Ltd | Enzym-inhibitorer. |
US4478826A (en) * | 1981-10-08 | 1984-10-23 | Merck & Co., Inc. | Renin inhibitory peptides |
CA1258748A (en) * | 1981-10-08 | 1989-08-22 | Daniel F. Veber | Renin inhibitory peptides |
US4470971A (en) | 1981-10-19 | 1984-09-11 | Merck & Co., Inc. | Renin inhibitory peptides having His13 |
US4397786A (en) | 1981-11-23 | 1983-08-09 | Merck & Co., Inc. | Method of preparing statine and derivatives |
CA1245217A (en) * | 1981-12-10 | 1988-11-22 | Joshua S. Boger | Renin inhibitory peptides having phe su13 xx deletion |
AU573735B2 (en) * | 1983-02-07 | 1988-06-23 | Aktiebolaget Hassle | Peptide analogue enzyme inhibitors |
US4613676A (en) * | 1983-11-23 | 1986-09-23 | Ciba-Geigy Corporation | Substituted 5-amino-4-hydroxyvaleryl derivatives |
CA1254699A (en) * | 1984-03-12 | 1989-05-23 | Jasjit S. Bindra | Renin inhibitors containing statine or derivatives thereof |
US4661473A (en) * | 1984-03-27 | 1987-04-28 | Merck & Co., Inc. | Renin inhibitors containing peptide isosteres |
EP0173481A3 (en) * | 1984-08-06 | 1988-12-21 | The Upjohn Company | Peptides |
DE3512128A1 (de) * | 1985-04-03 | 1986-10-09 | Merck Patent Gmbh, 6100 Darmstadt | Peptide |
-
1986
- 1986-04-30 US US06/858,324 patent/US4729985A/en not_active Expired - Fee Related
- 1986-08-04 EP EP86305995A patent/EP0212903B1/en not_active Expired - Lifetime
- 1986-08-04 AT AT86305995T patent/ATE84046T1/de not_active IP Right Cessation
- 1986-08-04 DE DE8686305995T patent/DE3687380T2/de not_active Expired - Fee Related
- 1986-08-05 IL IL79626A patent/IL79626A0/xx not_active IP Right Cessation
- 1986-08-06 GR GR862078A patent/GR862078B/el unknown
- 1986-08-07 PH PH34110A patent/PH24494A/en unknown
- 1986-08-07 CA CA000515464A patent/CA1294736C/en not_active Expired - Fee Related
- 1986-08-07 NZ NZ217127A patent/NZ217127A/xx unknown
- 1986-08-08 KR KR1019860006535A patent/KR890003603B1/ko not_active IP Right Cessation
- 1986-08-08 YU YU1422/86A patent/YU45355B/xx unknown
- 1986-08-08 IE IE214386A patent/IE58524B1/en not_active IP Right Cessation
- 1986-08-08 AU AU61021/86A patent/AU576970B2/en not_active Ceased
- 1986-08-08 FI FI863250A patent/FI86192C/fi not_active IP Right Cessation
- 1986-08-08 ES ES8600952A patent/ES2000852A6/es not_active Expired
- 1986-08-08 HU HU863517A patent/HU207101B/hu not_active IP Right Cessation
- 1986-08-08 DK DK379186A patent/DK379186A/da not_active Application Discontinuation
- 1986-08-08 PT PT83172A patent/PT83172B/pt not_active IP Right Cessation
- 1986-08-08 NO NO863202A patent/NO170725C/no unknown
- 1986-08-09 CN CN198686105870A patent/CN86105870A/zh active Pending
- 1986-08-09 JP JP61187653A patent/JPS6253952A/ja active Granted
- 1986-08-10 EG EG503/86A patent/EG17971A/xx active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO863202D0 (no) | Fremgangsmaate for fremstilling av terapeutisk aktive polypeptid-derivater. | |
ATE14882T1 (de) | Amino- und substituierte amino-phosphinylalkanoyl-zubereitungen. | |
MA18664A1 (fr) | Derives d'amino-acides utiles comme agents contre l'hypertension | |
UA40578C2 (uk) | Сульфоніламінопіримідини і фармацевтичний препарат на їх основі | |
DK0560177T3 (da) | Imidazol-derivater med biphenylsulfonylurinstof- eller biphenylsulfonylurethan-sidekæde, fremgangsmåder til deres fremstilling og deres anvendelse. | |
ATE248150T1 (de) | Lactam-enthaltende hydroxamsäure-derivate, deren herstellung und deren verwendung als inhibitoren von matrix-metalloproteasen | |
FI94354C (fi) | Menetelmä farmaseuttisesti aktiivisten peptidien valmistamiseksi | |
IT1277113B1 (it) | Composti oligopeptidici contenenti d-2-alchiltriptofano in grado di promuovere la liberazione dell'ormone della crescita | |
KR850006941A (ko) | 데스-프로린 바조프레신 길항제의 제조방법 | |
FI871637A0 (fi) | Foerfarande foer framstaellning av 1,5-benzotiazepinderivat. | |
CA2278057A1 (en) | Tachykinin antagonists | |
DE3584250D1 (de) | Mittel zum stimulieren des haarwuchses. | |
KR910009663A (ko) | 피리딘유도체, 이들을 함유하는 약리학적 조성물 및 이들의 제조방법 | |
ITMI921151A1 (it) | Composti terapeuticamente attivi, particolarmente ad attivita' nootropica e procedimento per la loro preparazione | |
DE3571031D1 (en) | Antihypertensive 1,2-benzisothiazole piperidines, a method for synthesizing the same and their use as medicaments | |
RU93050566A (ru) | Три и тетрациклические соединения |