DK379186A - Polypeptidderivater indeholdende 2,5-disubstituerede 5-amino-4-hydroxypentansyrerester, 2,5-disubstituerede 5-amino-4-hydroxypentansyrederivater til anvendelse som mellemprodukter og stereoselektive fremgangsmaader til fremstilling af disse - Google Patents

Polypeptidderivater indeholdende 2,5-disubstituerede 5-amino-4-hydroxypentansyrerester, 2,5-disubstituerede 5-amino-4-hydroxypentansyrederivater til anvendelse som mellemprodukter og stereoselektive fremgangsmaader til fremstilling af disse Download PDF

Info

Publication number
DK379186A
DK379186A DK379186A DK379186A DK379186A DK 379186 A DK379186 A DK 379186A DK 379186 A DK379186 A DK 379186A DK 379186 A DK379186 A DK 379186A DK 379186 A DK379186 A DK 379186A
Authority
DK
Denmark
Prior art keywords
sup
disubstituted
amino
hydroxypentanic
acid residues
Prior art date
Application number
DK379186A
Other languages
English (en)
Other versions
DK379186D0 (da
Inventor
Jasjit Singh Bindra
Edward Fox Kleinman
Robert Louis Rosati
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK379186D0 publication Critical patent/DK379186D0/da
Publication of DK379186A publication Critical patent/DK379186A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/14—Angiotensins: Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86—Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polyamides (AREA)
DK379186A 1985-08-09 1986-08-08 Polypeptidderivater indeholdende 2,5-disubstituerede 5-amino-4-hydroxypentansyrerester, 2,5-disubstituerede 5-amino-4-hydroxypentansyrederivater til anvendelse som mellemprodukter og stereoselektive fremgangsmaader til fremstilling af disse DK379186A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76416885A 1985-08-09 1985-08-09
US06/858,324 US4729985A (en) 1985-08-09 1986-04-30 Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues

Publications (2)

Publication Number Publication Date
DK379186D0 DK379186D0 (da) 1986-08-08
DK379186A true DK379186A (da) 1987-04-01

Family

ID=27117410

Family Applications (1)

Application Number Title Priority Date Filing Date
DK379186A DK379186A (da) 1985-08-09 1986-08-08 Polypeptidderivater indeholdende 2,5-disubstituerede 5-amino-4-hydroxypentansyrerester, 2,5-disubstituerede 5-amino-4-hydroxypentansyrederivater til anvendelse som mellemprodukter og stereoselektive fremgangsmaader til fremstilling af disse

Country Status (22)

Country Link
US (1) US4729985A (da)
EP (1) EP0212903B1 (da)
JP (1) JPS6253952A (da)
KR (1) KR890003603B1 (da)
CN (1) CN86105870A (da)
AT (1) ATE84046T1 (da)
AU (1) AU576970B2 (da)
CA (1) CA1294736C (da)
DE (1) DE3687380T2 (da)
DK (1) DK379186A (da)
EG (1) EG17971A (da)
ES (1) ES2000852A6 (da)
FI (1) FI86192C (da)
GR (1) GR862078B (da)
HU (1) HU207101B (da)
IE (1) IE58524B1 (da)
IL (1) IL79626A0 (da)
NO (1) NO170725C (da)
NZ (1) NZ217127A (da)
PH (1) PH24494A (da)
PT (1) PT83172B (da)
YU (1) YU45355B (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
DE3538749A1 (de) * 1985-10-31 1987-05-07 Merck Patent Gmbh Peptide
FI870474A (fi) * 1986-02-07 1987-08-08 Ciba Geigy Ag Med svavelhaltiga grupper substituerade 5-amino-4-hydroxivalerylderivat.
DE3626130A1 (de) * 1986-08-01 1988-02-11 Merck Patent Gmbh Aminosaeurederivate
US4681972A (en) * 1986-09-16 1987-07-21 Warner-Lambert Company Separation of diastereomers
EP0264106B1 (en) * 1986-10-14 1994-03-16 Banyu Pharmaceutical Co., Ltd. 5-Substituted amino-4-hydroxy-pentanoic acid derivatives and their use
US4927565A (en) * 1986-12-19 1990-05-22 Banyu Pharmaceutical Co., Ltd. 5-substituted amino-4-hydroxy-pentenoic acid derivatives and their use
US4758584A (en) * 1987-02-05 1988-07-19 Ciba-Geigy Corporation Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups
US4859654A (en) * 1987-07-01 1989-08-22 Pfizer Inc. Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents
EP0297816B1 (en) * 1987-07-01 1994-03-02 Pfizer Inc. Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents
EP0312158A3 (en) * 1987-10-13 1990-07-25 Merck & Co. Inc. Tetrapeptide renin inhibitors having novel c-terminal amino acid amide
GB8728560D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
GB8728561D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
ATE107658T1 (de) * 1988-01-26 1994-07-15 Sankyo Co Renin inhibierende polypeptide, ihre herstellung und anwendung.
WO1989007109A1 (en) * 1988-02-01 1989-08-10 The Upjohn Company Renin inhibiting peptides with polar end groups
JPS6486550A (en) * 1988-08-19 1989-03-31 Seiko Epson Corp Complementary mos integrated circuit
US5436339A (en) * 1991-03-06 1995-07-25 Abbott Laboratories Process for the preparation of a substituted diaminoalcohol
US5238935A (en) * 1991-05-20 1993-08-24 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme A: cholesterol acyl transferase
US5124337A (en) * 1991-05-20 1992-06-23 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase
TW217410B (da) * 1992-04-01 1993-12-11 Ciba Geigy
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
EP0702004A2 (de) * 1994-09-15 1996-03-20 Ciba-Geigy Ag 2,9-Diamino- und 2-amino-8-carbamoyl-4-hydroxy-alkansäureamid-derivative
EP0716077A1 (de) * 1994-12-08 1996-06-12 Ciba-Geigy Ag Aromatisch substituierte Omega-Aminoalkansäureamide und Alkansäurediamide und ihre Verwendung als Renininhibitoren
CA2191924A1 (en) * 1995-12-05 1997-06-06 Kevin Felsenstein 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production
US5703129A (en) * 1996-09-30 1997-12-30 Bristol-Myers Squibb Company 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production
ATE343562T1 (de) 2000-03-23 2006-11-15 Elan Pharm Inc Verbindungen und verfahren zur behandlung der alzheimerschen krankheit
DE60112942T2 (de) 2000-06-30 2006-06-22 Elan Pharmaceuticals, Inc., South San Francisco Verbindungen zur behandlung der alzheimerischen krankheit
EP2464623B1 (en) * 2009-08-11 2020-11-04 Novartis AG The ring opening of lactones and lactams
CN105195868B (zh) * 2015-11-12 2018-05-15 上海电气核电设备有限公司 一种机器人焊接系统及其焊接方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163676A (en) * 1978-04-03 1979-08-07 Blue Cross Laboratories Ethanol-modified lecithin cookware spray composition
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
CA1258748A (en) * 1981-10-08 1989-08-22 Daniel F. Veber Renin inhibitory peptides
US4478826A (en) * 1981-10-08 1984-10-23 Merck & Co., Inc. Renin inhibitory peptides
US4470971A (en) 1981-10-19 1984-09-11 Merck & Co., Inc. Renin inhibitory peptides having His13
US4397786A (en) 1981-11-23 1983-08-09 Merck & Co., Inc. Method of preparing statine and derivatives
CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
WO1984003044A1 (en) * 1983-02-07 1984-08-16 Ferring Ab Enzyme inhibitors
US4613676A (en) * 1983-11-23 1986-09-23 Ciba-Geigy Corporation Substituted 5-amino-4-hydroxyvaleryl derivatives
DK110285A (da) * 1984-03-12 1985-09-13 Pfizer Polypeptider og polypeptidderivater indeholdende statin eller derivater deraf og farmaceutiske praeparater
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
EP0173481A3 (en) * 1984-08-06 1988-12-21 The Upjohn Company Peptides
DE3512128A1 (de) * 1985-04-03 1986-10-09 Merck Patent Gmbh, 6100 Darmstadt Peptide

Also Published As

Publication number Publication date
NO170725B (no) 1992-08-17
EP0212903A2 (en) 1987-03-04
PT83172A (en) 1986-09-01
EP0212903A3 (en) 1989-11-15
JPS6253952A (ja) 1987-03-09
HU207101B (en) 1993-03-01
NZ217127A (en) 1989-11-28
JPH0543697B2 (da) 1993-07-02
GR862078B (en) 1986-12-24
IE58524B1 (en) 1993-10-06
AU6102186A (en) 1987-02-12
DK379186D0 (da) 1986-08-08
IL79626A0 (en) 1986-11-30
ATE84046T1 (de) 1993-01-15
FI863250A (fi) 1987-02-10
FI863250A0 (fi) 1986-08-08
KR890003603B1 (ko) 1989-09-27
PH24494A (en) 1990-07-18
CA1294736C (en) 1992-01-21
NO170725C (no) 1992-11-25
DE3687380T2 (de) 1993-04-29
YU45355B (en) 1992-05-28
NO863202L (no) 1987-02-10
PT83172B (pt) 1989-03-30
NO863202D0 (no) 1986-08-08
AU576970B2 (en) 1988-09-08
US4729985A (en) 1988-03-08
DE3687380D1 (de) 1993-02-11
FI86192C (fi) 1992-07-27
HUT41419A (en) 1987-04-28
ES2000852A6 (es) 1988-03-16
KR870002164A (ko) 1987-03-30
FI86192B (fi) 1992-04-15
CN86105870A (zh) 1987-03-11
EG17971A (en) 1991-11-30
YU142286A (en) 1988-10-31
IE862143L (en) 1987-02-09
EP0212903B1 (en) 1992-12-30

Similar Documents

Publication Publication Date Title
DK379186D0 (da) Polypeptidderivater indeholdende 2,5-disubstituerede 5-amino-4-hydroxypentansyrerester, 2,5-disubstituerede 5-amino-4-hydroxypentansyrederivater til anvendelse som mellemprodukter og stereoselektive fremgangsmaader til fremstilling af disse
DK0741694T3 (da) Phenyleddikesyrederivater, fremgangsmåder og mellemprodukter til deres fremstilling og midler indeholdende disse
MA18664A1 (fr) Derives d'amino-acides utiles comme agents contre l'hypertension
NO975729L (no) Forbindelser og peptider som binder til etytropoietinreseptoren
DK0560177T3 (da) Imidazol-derivater med biphenylsulfonylurinstof- eller biphenylsulfonylurethan-sidekæde, fremgangsmåder til deres fremstilling og deres anvendelse.
TR199901667T2 (xx) 3-Heterosiklil-ikame edilmi� benzoil t�revleri
ATE248150T1 (de) Lactam-enthaltende hydroxamsäure-derivate, deren herstellung und deren verwendung als inhibitoren von matrix-metalloproteasen
CA2211668A1 (en) Substituted heterocyclic compounds, preparation method therefor and pharmaceutical compositions containing the same
FI945704A0 (fi) Eksitatorisen aminohapporeseptorin antagonisteja
PT83535B (pt) Processo para a preparacao de composicoes farmaceuticas contendo derivados de aminoacidos
FR2575164B1 (fr) Esters de tri- et tetrapeptides inhibiteurs de la secretion gastrique, procede d'obtention et compositions pharmaceutiques les contenant
EA200100661A1 (ru) Способ получения производных 2-азадигидроксибицикло [2.2.1] гептана
IT1148008B (it) Composti di n-(cicloalchil)ammino acido utili come inibitori dell'enzima di conversione dell'angiotensina i
DE3688383D1 (de) Rekombinantes vektorsystem fuer metalloproteinase-inhibitorsequenz und dessen verwendung und herstellung nach dem rekombinant-dns-verfahren.
PT1115404E (pt) Utilizacao de antagonistas prostanoides para o tratamento de cefaleias primarias
RU92004529A (ru) Производные 2-азабицикло /2,2,1/гепт-5-ен-2-уксусной кислоты
DE3650459D1 (de) Verwendung von Alkenylbernsteinsäurehalbamiden als Korrosionsschutzmittel
ATE325104T1 (de) Verfahren zu fabrikation von alpha 1l- adrenorezeptor antagonisten
ATE69810T1 (de) Derivate von n-(2-alkyl-3-mercaptoglutaryl)-alpha-aminosaeure und deren verwendung als collagenaseinhibitoren.
MX9708753A (es) Procedimiento de preparacion de formas enantiomeras del acido amino alquilaminofenilo proparanoico.

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment