DE3688383D1 - Rekombinantes vektorsystem fuer metalloproteinase-inhibitorsequenz und dessen verwendung und herstellung nach dem rekombinant-dns-verfahren. - Google Patents

Rekombinantes vektorsystem fuer metalloproteinase-inhibitorsequenz und dessen verwendung und herstellung nach dem rekombinant-dns-verfahren.

Info

Publication number
DE3688383D1
DE3688383D1 DE8686902087T DE3688383T DE3688383D1 DE 3688383 D1 DE3688383 D1 DE 3688383D1 DE 8686902087 T DE8686902087 T DE 8686902087T DE 3688383 T DE3688383 T DE 3688383T DE 3688383 D1 DE3688383 D1 DE 3688383D1
Authority
DE
Germany
Prior art keywords
production
recombinant
metalloproteinase inhibitor
vector system
dna method
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686902087T
Other languages
English (en)
Other versions
DE3688383T2 (de
Inventor
David Carmichael
David C Anderson
George Stricklin
Howard Welgus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Synergen Biologicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synergen Biologicals Inc filed Critical Synergen Biologicals Inc
Application granted granted Critical
Publication of DE3688383D1 publication Critical patent/DE3688383D1/de
Publication of DE3688383T2 publication Critical patent/DE3688383T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
DE8686902087T 1985-02-05 1986-02-05 Rekombinantes vektorsystem fuer metalloproteinase-inhibitorsequenz und dessen verwendung und herstellung nach dem rekombinant-dns-verfahren. Expired - Lifetime DE3688383T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US69918185A 1985-02-05 1985-02-05
US78431985A 1985-10-04 1985-10-04
PCT/US1986/000302 WO1986004608A1 (en) 1985-02-05 1986-02-05 Metalloproteinase inhibitor sequence recombinant vector system for using same and recombinant-dna method for the manufacture of same

Publications (2)

Publication Number Publication Date
DE3688383D1 true DE3688383D1 (de) 1993-06-09
DE3688383T2 DE3688383T2 (de) 1993-08-26

Family

ID=27106361

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686902087T Expired - Lifetime DE3688383T2 (de) 1985-02-05 1986-02-05 Rekombinantes vektorsystem fuer metalloproteinase-inhibitorsequenz und dessen verwendung und herstellung nach dem rekombinant-dns-verfahren.

Country Status (9)

Country Link
US (3) US6090585A (de)
EP (1) EP0211077B1 (de)
JP (1) JPH088870B2 (de)
KR (1) KR940010862B1 (de)
AT (1) ATE89005T1 (de)
AU (2) AU5549386A (de)
DE (1) DE3688383T2 (de)
DK (1) DK175964B1 (de)
WO (1) WO1986004608A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62500424A (ja) * 1984-10-01 1987-02-26 サンド・リミテッド 赤血球の増強活性を有する蛋白質のための遺伝子を含有するベクタ−および前記蛋白質を生産するための組み換えｄｎａ法
AU589935B2 (en) * 1985-01-07 1989-10-26 Celltech Limited Recombinant DNA processes for the production of tissue inhibitor of metalloproteinase
JPH01213232A (ja) * 1988-02-22 1989-08-28 Fuji Yakuhin Kogyo Kk 新規な皮膚潰瘍治療剤
JP2877509B2 (ja) * 1989-05-19 1999-03-31 アムジエン・インコーポレーテツド メタロプロテイナーゼ阻害剤
US5714465A (en) 1989-05-19 1998-02-03 Amgen Inc. Method of inhibiting tumor cell dissemination with a metalloproteinase inhibitor
ATE403714T1 (de) 1996-11-06 2008-08-15 Univ California Tumor necrosis factor rezeptor abspaltendes enzym,dessen zubereitungen und verwendungen
EP1432729B1 (de) * 2001-07-02 2008-11-12 Merrion Research III Limited Zielgerichtete ligande gegen peyer's flecke- und/oder m-zellen
JP2010502425A (ja) * 2006-08-30 2010-01-28 ジーイー・ヘルスケア・バイオサイエンス・コーポレイション 膜を評価するシステム及び方法並びに膜濾過装置
US8189753B1 (en) 2007-04-12 2012-05-29 Russound/Fmp Incorporated Distributed intercom system with audio bus

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276284A (en) * 1971-07-26 1981-06-30 Brown Stuart I Prevention of collagenase induced disease by treatment with collagenase inhibitors
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
ZA814375B (en) * 1980-07-01 1982-07-28 Hoffmann La Roche Interferons and process for their preparation
US4394443A (en) * 1980-12-18 1983-07-19 Yale University Method for cloning genes
US4438032A (en) * 1981-01-30 1984-03-20 The Regents Of The University Of California Unique T-lymphocyte line and products derived therefrom
US4382081A (en) * 1981-06-12 1983-05-03 E. R. Squibb & Sons, Inc. Inhibitors of mammalian collagenase
US4361574A (en) * 1981-10-02 1982-11-30 American Home Products Corporation Inhibitors of mammalian collagenase
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
GR79124B (de) * 1982-12-22 1984-10-02 Genentech Inc
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
JPH06102034B2 (ja) * 1983-03-25 1994-12-14 セルテク リミテツド タンパク質の生産方法
US4609667A (en) * 1983-12-19 1986-09-02 American Home Products Corporation Inhibitor of mammalian collagenase and elastase
US4602006A (en) * 1984-05-09 1986-07-22 Syntex (U.S.A.) Inc. Ynenolactone protease inhibitors
JPS62500424A (ja) * 1984-10-01 1987-02-26 サンド・リミテッド 赤血球の増強活性を有する蛋白質のための遺伝子を含有するベクタ−および前記蛋白質を生産するための組み換えｄｎａ法
GB8500341D0 (en) * 1985-01-07 1985-02-13 Celltech Ltd Production of protein
AU589935B2 (en) * 1985-01-07 1989-10-26 Celltech Limited Recombinant DNA processes for the production of tissue inhibitor of metalloproteinase
EP0189784B1 (de) * 1985-01-18 1989-11-08 G.D. Searle & Co. Menschlicher, natürlicher Collagenaseninhibitor
US4897444A (en) * 1985-05-31 1990-01-30 The Research Foundation Of The State University Of New York Immobilized fluorogenic substrates for enzymes; and processes for their preparation

Also Published As

Publication number Publication date
DE3688383T2 (de) 1993-08-26
DK422786A (da) 1986-12-05
AU5971090A (en) 1990-11-01
ATE89005T1 (de) 1993-05-15
EP0211077A4 (de) 1987-11-23
US20030003556A1 (en) 2003-01-02
KR940010862B1 (ko) 1994-11-18
DK175964B1 (da) 2005-09-26
JPS62502101A (ja) 1987-08-20
DK422786D0 (da) 1986-09-04
WO1986004608A1 (en) 1986-08-14
EP0211077A1 (de) 1987-02-25
EP0211077B1 (de) 1993-05-05
KR870700096A (ko) 1987-02-28
US6342374B1 (en) 2002-01-29
JPH088870B2 (ja) 1996-01-31
US6800732B2 (en) 2004-10-05
AU5549386A (en) 1986-08-26
US6090585A (en) 2000-07-18
AU636370B2 (en) 1993-04-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: AMGEN INC.(N.D.GES D. STAATES DELAWARE), THOUSAND