DK422786A - Rekombinant-dna-sekvens til styring af den intracellulaere produktionaf metalloproteinase-inhibitorer og fremgangsmaade til fremstillingaf en saadan sekvens - Google Patents
Rekombinant-dna-sekvens til styring af den intracellulaere produktionaf metalloproteinase-inhibitorer og fremgangsmaade til fremstillingaf en saadan sekvens Download PDFInfo
- Publication number
- DK422786A DK422786A DK422786A DK422786A DK422786A DK 422786 A DK422786 A DK 422786A DK 422786 A DK422786 A DK 422786A DK 422786 A DK422786 A DK 422786A DK 422786 A DK422786 A DK 422786A
- Authority
- DK
- Denmark
- Prior art keywords
- sequence
- dna sequence
- preparing
- procedure
- control
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/81—Protease inhibitors
- C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- C07K14/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P15/00—Preparation of compounds containing at least three condensed carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69918185A | 1985-02-05 | 1985-02-05 | |
US69918185 | 1985-02-05 | ||
US78431985A | 1985-10-04 | 1985-10-04 | |
US78431985 | 1985-10-04 | ||
PCT/US1986/000302 WO1986004608A1 (en) | 1985-02-05 | 1986-02-05 | Metalloproteinase inhibitor sequence recombinant vector system for using same and recombinant-dna method for the manufacture of same |
US8600302 | 1986-02-05 |
Publications (3)
Publication Number | Publication Date |
---|---|
DK422786D0 DK422786D0 (da) | 1986-09-04 |
DK422786A true DK422786A (da) | 1986-12-05 |
DK175964B1 DK175964B1 (da) | 2005-09-26 |
Family
ID=27106361
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK198604227A DK175964B1 (da) | 1985-02-05 | 1986-09-04 | Rekombinant metalloproteinaseinhibitorsekvensvektorsystem, anvendelse af denne samt rekombinant DNA-fremgangsmåde til fremstilling af denne |
Country Status (9)
Country | Link |
---|---|
US (3) | US6090585A (da) |
EP (1) | EP0211077B1 (da) |
JP (1) | JPH088870B2 (da) |
KR (1) | KR940010862B1 (da) |
AT (1) | ATE89005T1 (da) |
AU (2) | AU5549386A (da) |
DE (1) | DE3688383T2 (da) |
DK (1) | DK175964B1 (da) |
WO (1) | WO1986004608A1 (da) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0198014A4 (en) * | 1984-10-01 | 1987-11-23 | Sandoz Ltd | VECTORS CONTAINING A GENE FOR A PROTEIN HAVING ERYTHROID ACTIVATION ACTIVITY AND A RECOMBINANT DNA PROCESS FOR PRODUCING THE PROTEIN. |
DK4286A (da) * | 1985-01-07 | 1986-07-08 | Celltech Ltd | Fremgangsmaade til fremstilling af en metalloproteinaseinhibitor |
JPH01213232A (ja) * | 1988-02-22 | 1989-08-28 | Fuji Yakuhin Kogyo Kk | 新規な皮膚潰瘍治療剤 |
US5714465A (en) | 1989-05-19 | 1998-02-03 | Amgen Inc. | Method of inhibiting tumor cell dissemination with a metalloproteinase inhibitor |
JP2877509B2 (ja) * | 1989-05-19 | 1999-03-31 | アムジエン・インコーポレーテツド | メタロプロテイナーゼ阻害剤 |
ATE403714T1 (de) | 1996-11-06 | 2008-08-15 | Univ California | Tumor necrosis factor rezeptor abspaltendes enzym,dessen zubereitungen und verwendungen |
DE60229867D1 (de) * | 2001-07-02 | 2008-12-24 | Merrion Res Iii Ltd | Zielgerichtete ligande gegen peyer's flecke- und/oder m-zellen |
EP2069054A1 (en) * | 2006-08-30 | 2009-06-17 | GE Healthcare Bio-Sciences Corp. | System and method for characterizing membranes and membrane filtration devices |
US8189753B1 (en) | 2007-04-12 | 2012-05-29 | Russound/Fmp Incorporated | Distributed intercom system with audio bus |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4276284A (en) * | 1971-07-26 | 1981-06-30 | Brown Stuart I | Prevention of collagenase induced disease by treatment with collagenase inhibitors |
US4530901A (en) * | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
ZA814375B (en) * | 1980-07-01 | 1982-07-28 | Hoffmann La Roche | Interferons and process for their preparation |
US4394443A (en) * | 1980-12-18 | 1983-07-19 | Yale University | Method for cloning genes |
US4438032A (en) * | 1981-01-30 | 1984-03-20 | The Regents Of The University Of California | Unique T-lymphocyte line and products derived therefrom |
US4382081A (en) * | 1981-06-12 | 1983-05-03 | E. R. Squibb & Sons, Inc. | Inhibitors of mammalian collagenase |
US4361574A (en) * | 1981-10-02 | 1982-11-30 | American Home Products Corporation | Inhibitors of mammalian collagenase |
AU577259B2 (en) * | 1982-08-13 | 1988-09-22 | Zymogenetics Inc. | Glycolytic promters for regulated protein expression protease inhibitor |
US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
GR79124B (da) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
WO1984003711A1 (en) * | 1983-03-25 | 1984-09-27 | Celltech Ltd | A process for the production of a protein |
US4609667A (en) * | 1983-12-19 | 1986-09-02 | American Home Products Corporation | Inhibitor of mammalian collagenase and elastase |
US4602006A (en) * | 1984-05-09 | 1986-07-22 | Syntex (U.S.A.) Inc. | Ynenolactone protease inhibitors |
EP0198014A4 (en) * | 1984-10-01 | 1987-11-23 | Sandoz Ltd | VECTORS CONTAINING A GENE FOR A PROTEIN HAVING ERYTHROID ACTIVATION ACTIVITY AND A RECOMBINANT DNA PROCESS FOR PRODUCING THE PROTEIN. |
GB8500341D0 (en) * | 1985-01-07 | 1985-02-13 | Celltech Ltd | Production of protein |
DK4286A (da) * | 1985-01-07 | 1986-07-08 | Celltech Ltd | Fremgangsmaade til fremstilling af en metalloproteinaseinhibitor |
DE3666826D1 (en) * | 1985-01-18 | 1989-12-14 | Searle & Co | Human natural inhibitor of collagenases |
US4897444A (en) * | 1985-05-31 | 1990-01-30 | The Research Foundation Of The State University Of New York | Immobilized fluorogenic substrates for enzymes; and processes for their preparation |
-
1986
- 1986-02-05 AU AU55493/86A patent/AU5549386A/en not_active Abandoned
- 1986-02-05 AT AT86902087T patent/ATE89005T1/de not_active IP Right Cessation
- 1986-02-05 KR KR1019860700678A patent/KR940010862B1/ko not_active IP Right Cessation
- 1986-02-05 WO PCT/US1986/000302 patent/WO1986004608A1/en active IP Right Grant
- 1986-02-05 EP EP86902087A patent/EP0211077B1/en not_active Expired - Lifetime
- 1986-02-05 JP JP61501640A patent/JPH088870B2/ja not_active Expired - Lifetime
- 1986-02-05 DE DE8686902087T patent/DE3688383T2/de not_active Expired - Lifetime
- 1986-09-04 DK DK198604227A patent/DK175964B1/da not_active IP Right Cessation
-
1990
- 1990-07-20 AU AU59710/90A patent/AU636370B2/en not_active Expired
-
1995
- 1995-06-07 US US08/474,553 patent/US6090585A/en not_active Expired - Fee Related
-
1999
- 1999-12-01 US US09/452,817 patent/US6342374B1/en not_active Expired - Fee Related
-
2001
- 2001-11-14 US US09/987,357 patent/US6800732B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US6090585A (en) | 2000-07-18 |
JPH088870B2 (ja) | 1996-01-31 |
DK422786D0 (da) | 1986-09-04 |
KR940010862B1 (ko) | 1994-11-18 |
AU5971090A (en) | 1990-11-01 |
US6800732B2 (en) | 2004-10-05 |
US20030003556A1 (en) | 2003-01-02 |
DK175964B1 (da) | 2005-09-26 |
JPS62502101A (ja) | 1987-08-20 |
WO1986004608A1 (en) | 1986-08-14 |
ATE89005T1 (de) | 1993-05-15 |
DE3688383T2 (de) | 1993-08-26 |
AU5549386A (en) | 1986-08-26 |
KR870700096A (ko) | 1987-02-28 |
DE3688383D1 (de) | 1993-06-09 |
US6342374B1 (en) | 2002-01-29 |
EP0211077A1 (en) | 1987-02-25 |
AU636370B2 (en) | 1993-04-29 |
EP0211077A4 (en) | 1987-11-23 |
EP0211077B1 (en) | 1993-05-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUP | Patent expired |