ES8202588A1 - Un procedimiento para la preparacion de una proteina quimera - Google Patents
Un procedimiento para la preparacion de una proteina quimeraInfo
- Publication number
- ES8202588A1 ES8202588A1 ES499045A ES499045A ES8202588A1 ES 8202588 A1 ES8202588 A1 ES 8202588A1 ES 499045 A ES499045 A ES 499045A ES 499045 A ES499045 A ES 499045A ES 8202588 A1 ES8202588 A1 ES 8202588A1
- Authority
- ES
- Spain
- Prior art keywords
- growth hormone
- cloning
- therefor
- human pre
- transfer vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 244000005700 microbiome Species 0.000 title abstract 3
- 108010057578 pregrowth hormone Proteins 0.000 title abstract 3
- 239000013598 vector Substances 0.000 title abstract 3
- 238000010367 cloning Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 108020004414 DNA Proteins 0.000 abstract 3
- 108020004511 Recombinant DNA Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000002194 synthesizing effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/185—Escherichia
- C12R2001/19—Escherichia coli
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plant Pathology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Saccharide Compounds (AREA)
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE UNA PROTEINA QUIMERA CONSTITUIDA POR LA SECUENCIA DE AMINOACIDOS DE LA HORMONA HUMANA DE PRECRECIMIENTO COMO SU SECUENCIA C-TERMINAL, Y UNA PARTE DE UNA PROTEINA PROCARIONTE COMO SU SECUENCIA N-TERMINAL. CONSISTE EN LA INCUBACION DE UN MICROORGANISMO TRANASFORMADO POR UN VECTOR DE TRANSFERENCIA DE EXPRESION, QUE SE PREPARA POR REACCION DE UNA SECUENCIA DE DESOXINUCLEOTIDOS, LOS CUALES CODIFICAN PARA LA HORMONA HUMANA DE PRECRECIMIENTO CON UN VECTOR DE TRANSFERENCIA DNA. ESTE SE PREPARARA MEDIANTE SEGMENTACION DE UN VECTOR DE TRANSFERENCIA CON UNA ENZIMA DE RESTRICCION. LA PROTEINA PROCARIONTE ES CONTROLADA POR UNA REGION DE CONTROL EN EL VECTOR DE TRANSFERENCIA. ESTE GEN TIENE APLICACIONES EN LA PRODUCCION DE LA HORMONA HUMANA DE CRECIMIENTO CON FINES TERAPEUTICOS.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4464779A | 1979-06-01 | 1979-06-01 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8202588A1 true ES8202588A1 (es) | 1982-02-01 |
| ES499045A0 ES499045A0 (es) | 1982-02-01 |
Family
ID=21933526
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES492044A Expired ES8105391A1 (es) | 1979-06-01 | 1980-05-30 | Un procedimiento para la preparacion de un vector de trans- ferencia. |
| ES499045A Granted ES499045A0 (es) | 1979-06-01 | 1981-02-02 | Un procedimiento para la preparacion de una proteina quimera |
| ES499046A Expired ES8202586A1 (es) | 1979-06-01 | 1981-02-02 | Un procedimiento para clonar una secuencia de desoxinucleo- tidos |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES492044A Expired ES8105391A1 (es) | 1979-06-01 | 1980-05-30 | Un procedimiento para la preparacion de un vector de trans- ferencia. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES499046A Expired ES8202586A1 (es) | 1979-06-01 | 1981-02-02 | Un procedimiento para clonar una secuencia de desoxinucleo- tidos |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP0020147B2 (es) |
| JP (1) | JPH0630582B2 (es) |
| KR (1) | KR860001515B1 (es) |
| AR (1) | AR248049A1 (es) |
| AT (1) | ATE5978T1 (es) |
| AU (1) | AU543917B2 (es) |
| BG (1) | BG41134A3 (es) |
| CA (1) | CA1194432A (es) |
| DD (3) | DD154022A5 (es) |
| DE (1) | DE3066256D1 (es) |
| DK (1) | DK232980A (es) |
| EG (1) | EG15156A (es) |
| ES (3) | ES8105391A1 (es) |
| FI (1) | FI801743A (es) |
| GR (1) | GR68404B (es) |
| HU (1) | HU196237B (es) |
| IE (1) | IE50378B1 (es) |
| IL (1) | IL60186A (es) |
| NZ (1) | NZ193867A (es) |
| PH (3) | PH21531A (es) |
| PL (1) | PL224664A1 (es) |
| PT (1) | PT71323A (es) |
| RO (1) | RO79982A (es) |
| YU (1) | YU145380A (es) |
| ZA (1) | ZA802992B (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU542264B2 (en) * | 1979-06-01 | 1985-02-14 | G.D. Searle & Co. | Plasmid vectors |
| US4342832A (en) * | 1979-07-05 | 1982-08-03 | Genentech, Inc. | Method of constructing a replicable cloning vehicle having quasi-synthetic genes |
| US6835557B1 (en) | 1980-01-08 | 2004-12-28 | Biogen, Inc. | DNA sequences, recombinant DNA molecules and processes for producing human interferon-like polypeptides |
| US4530901A (en) * | 1980-01-08 | 1985-07-23 | Biogen N.V. | Recombinant DNA molecules and their use in producing human interferon-like polypeptides |
| US4338397A (en) * | 1980-04-11 | 1982-07-06 | President And Fellows Of Harvard College | Mature protein synthesis |
| GB2121048B (en) * | 1980-07-03 | 1984-06-06 | Genentech Inc | Microbial expression of quasi-synthetic genes |
| IE52755B1 (en) * | 1980-08-26 | 1988-02-17 | Univ California | Bovine pre-growth and growth hormone |
| US4775622A (en) * | 1982-03-08 | 1988-10-04 | Genentech, Inc. | Expression, processing and secretion of heterologous protein by yeast |
| US4665160A (en) * | 1982-03-22 | 1987-05-12 | Genentech, Inc. | Novel human growth hormone like protein HGH-V encoded in the human genome |
| US4446235A (en) * | 1982-03-22 | 1984-05-01 | Genentech, Inc. | Method for cloning human growth hormone varient genes |
| US4508826A (en) * | 1982-04-15 | 1985-04-02 | Merck & Co., Inc. | Bacteriophage DNA cloning vector TG1 and microorganisms containing TG1 |
| US4460689A (en) * | 1982-04-15 | 1984-07-17 | Merck & Co., Inc. | DNA Cloning vector TG1, derivatives, and processes of making |
| DE3380262D1 (en) * | 1982-05-25 | 1989-08-31 | Lilly Co Eli | Cloning vectors for expression of exogenous protein |
| CA1341012C (en) | 1982-09-27 | 2000-06-06 | Biogen, Inc. | Dna sequences, recombinant dna molecules and processes for producing swine growth hormone-like polypeptides |
| FR2534273B1 (fr) * | 1982-10-07 | 1985-09-13 | Pasteur Institut | Lignees cellulaires originaires de mammiferes superieurs, productrices d'hormone de croissance, de preference humaine, et vecteurs pour leur obtention |
| AU2092983A (en) * | 1982-11-08 | 1984-05-17 | Genentech Inc. | Porcine growth hormone produced by recombinant dna technology |
| JPS6011557A (ja) * | 1983-04-19 | 1985-01-21 | ジエネツクス・コ−ポレイシヨン | クロ−ンヒツジ成長ホルモン遺伝子 |
| US4755465A (en) * | 1983-04-25 | 1988-07-05 | Genentech, Inc. | Secretion of correctly processed human growth hormone in E. coli and Pseudomonas |
| US4859600A (en) * | 1983-04-25 | 1989-08-22 | Genentech, Inc. | Recombinant procaryotic cell containing correctly processed human growth hormone |
| ZA844380B (en) * | 1983-07-05 | 1985-01-30 | Salk Inst For Biological Studi | Dna encoding a grf precursor |
| BG49718A3 (en) * | 1983-07-15 | 1992-01-15 | Bio- Technology General Corp | Method for preparing of polypeptid with superoxiddismutasne activitty |
| IL78775A (en) * | 1985-05-15 | 1992-06-21 | Biotech Australia Pty Ltd | Oral vaccines |
| DE3526995A1 (de) * | 1985-07-27 | 1987-02-05 | Hoechst Ag | Fusionsproteine, verfahren zu ihrer herstellung und ihre verwendung |
| JP2500312B2 (ja) * | 1986-01-13 | 1996-05-29 | 工業技術院長 | ヒト成長ホルモンの生産法 |
| FR2599753B1 (fr) * | 1986-06-05 | 1989-12-08 | Sanofi Sa | Sequence d'adn composite et son application pour la production de l'hormone de croissance |
| JP4383530B2 (ja) | 1996-04-05 | 2009-12-16 | ノバルティス バクシンズ アンド ダイアグノスティックス， インコーポレーテッド | 細胞巨大分子合成の阻害が減少したアルファウイルスベクター |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ187300A (en) * | 1977-05-27 | 1982-08-17 | Univ California | Dna transfer vector and micro-organism modified to contain a nucleotide sequence equivalent to the gene of a higher organism |
| ZA782933B (en) * | 1977-09-23 | 1979-05-30 | Univ California | Purification of nucleotide sequences suitable for expression in bacteria |
| AT373279B (de) * | 1977-11-08 | 1984-01-10 | Genentech Inc | Verfahren zur herstellung eines rekombinationsclonbildungstraegers |
| FI792481A (fi) * | 1978-08-11 | 1980-02-12 | Univ California | Syntes av enkaroytiskt protein genom anvaendning av mikro-organismer |
-
1980
- 1980-05-20 ZA ZA00802992A patent/ZA802992B/xx unknown
- 1980-05-20 GR GR62003A patent/GR68404B/el unknown
- 1980-05-28 NZ NZ193867A patent/NZ193867A/xx unknown
- 1980-05-28 PH PH24077A patent/PH21531A/en unknown
- 1980-05-29 AT AT80301785T patent/ATE5978T1/de active
- 1980-05-29 FI FI801743A patent/FI801743A/fi not_active Application Discontinuation
- 1980-05-29 DE DE8080301785T patent/DE3066256D1/de not_active Expired
- 1980-05-29 AR AR80281231A patent/AR248049A1/es active
- 1980-05-29 IL IL60186A patent/IL60186A/xx unknown
- 1980-05-29 EP EP80301785A patent/EP0020147B2/en not_active Expired
- 1980-05-29 PT PT71323A patent/PT71323A/pt not_active IP Right Cessation
- 1980-05-30 DK DK232980A patent/DK232980A/da not_active Application Discontinuation
- 1980-05-30 ES ES492044A patent/ES8105391A1/es not_active Expired
- 1980-05-30 CA CA000353090A patent/CA1194432A/en not_active Expired
- 1980-05-30 YU YU01453/80A patent/YU145380A/xx unknown
- 1980-05-30 HU HU801371A patent/HU196237B/hu not_active IP Right Cessation
- 1980-05-30 BG BG047972A patent/BG41134A3/xx unknown
- 1980-05-30 IE IE1137/80A patent/IE50378B1/en not_active IP Right Cessation
- 1980-05-30 AU AU58926/80A patent/AU543917B2/en not_active Expired
- 1980-05-31 PL PL22466480A patent/PL224664A1/xx unknown
- 1980-05-31 RO RO80101293A patent/RO79982A/ro unknown
- 1980-05-31 KR KR1019800002178A patent/KR860001515B1/ko active
- 1980-05-31 EG EG337/80A patent/EG15156A/xx active
- 1980-06-02 DD DD80221521A patent/DD154022A5/de not_active IP Right Cessation
- 1980-06-02 DD DD80234741A patent/DD202045A5/de unknown
- 1980-06-02 DD DD80234739A patent/DD202046A5/de unknown
- 1980-06-02 JP JP55074122A patent/JPH0630582B2/ja not_active Expired - Lifetime
-
1981
- 1981-02-02 ES ES499045A patent/ES499045A0/es active Granted
- 1981-02-02 ES ES499046A patent/ES8202586A1/es not_active Expired
-
1982
- 1982-11-05 PH PH28092A patent/PH21939A/en unknown
-
1985
- 1985-01-24 PH PH31764A patent/PH22089A/en unknown
Also Published As
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