GB1530921A - Desacylpepsidine and the preparation thereof - Google Patents

Desacylpepsidine and the preparation thereof

Info

Publication number
GB1530921A
GB1530921A GB49988/75A GB4998875A GB1530921A GB 1530921 A GB1530921 A GB 1530921A GB 49988/75 A GB49988/75 A GB 49988/75A GB 4998875 A GB4998875 A GB 4998875A GB 1530921 A GB1530921 A GB 1530921A
Authority
GB
United Kingdom
Prior art keywords
formula
amino
hydroxy
methylheptanoylalanyl
deacylpepsidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB49988/75A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of GB1530921A publication Critical patent/GB1530921A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

The deacylpepsidin valylvalyl-4-amino-3-hydroxy-6-methylheptanoylalanyl-4-amino-3-hydroxy -6-methylheptanoic acid of the formula <IMAGE> is obtained by microbiological means, starting from the acylpentapeptide N-acylvalylvalyl-4-amino-3-hydroxy-6-methylheptanoylalanyl-4-amino-3-h ydroxy-6-methylheptanoic acid of the formula <IMAGE> in which R is an acyl group. The compound of the second formula is converted into the product of the first formula by contacting with bacteria of the species Bacillus pumilus or with their acellular culture preparations. The employed bacteria are specifically those of the strain Bacillus pumilus Kawaguchi EF 49-210 (ATCC No. 31132). The deacylpepsidin of the formula (I) is obtained in higher yields and greater purities than in known processes. It has high activity as a pepsin inhibitor.
GB49988/75A 1974-12-05 1975-12-05 Desacylpepsidine and the preparation thereof Expired GB1530921A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP49138862A JPS5167791A (en) 1974-12-05 1974-12-05 Desuashiruu oyobi desuashirubariruupepushijinno seizoho narabini saiashirukaho

Publications (1)

Publication Number Publication Date
GB1530921A true GB1530921A (en) 1978-11-01

Family

ID=15231860

Family Applications (1)

Application Number Title Priority Date Filing Date
GB49988/75A Expired GB1530921A (en) 1974-12-05 1975-12-05 Desacylpepsidine and the preparation thereof

Country Status (8)

Country Link
JP (1) JPS5167791A (en)
CA (1) CA1053167A (en)
CH (1) CH620244A5 (en)
DE (2) DE2554636C2 (en)
FR (1) FR2293215A1 (en)
GB (1) GB1530921A (en)
NL (1) NL7514241A (en)
SE (1) SE423710B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2640420C2 (en) * 1975-09-12 1985-01-10 Sumitomo Chemical Co., Ltd., Osaka Peptides designated as procidins, processes for their production and agents containing these compounds
JPS56164153A (en) * 1980-05-20 1981-12-17 Eisai Co Ltd Novel desacylvalypepsidin derivative and its preparation
JPS56164152A (en) * 1980-05-20 1981-12-17 Eisai Co Ltd Novel desacylpepsidin derivative and its preparation
JPS57189651U (en) * 1981-05-27 1982-12-01
JPS5956948A (en) * 1982-09-28 1984-04-02 Nippon Kokan Kk <Nkk> Mold for horizontal continuous casting machine
JPS60213347A (en) * 1984-04-06 1985-10-25 Kawasaki Heavy Ind Ltd Billet drawing device for continuous casting

Also Published As

Publication number Publication date
FR2293215B1 (en) 1978-07-28
CH620244A5 (en) 1980-11-14
SE7513671L (en) 1976-06-08
JPS5339514B2 (en) 1978-10-21
DE2554636C2 (en) 1983-02-17
FR2293215A1 (en) 1976-07-02
CA1053167A (en) 1979-04-24
JPS5167791A (en) 1976-06-11
DE2560238C2 (en) 1984-07-19
SE423710B (en) 1982-05-24
DE2554636A1 (en) 1976-06-10
NL7514241A (en) 1976-06-09

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee