SE7513671L - DESACYL-PEPSIDIN AND WAY TO PREPARE THE SAME - Google Patents

DESACYL-PEPSIDIN AND WAY TO PREPARE THE SAME

Info

Publication number
SE7513671L
SE7513671L SE7513671A SE7513671A SE7513671L SE 7513671 L SE7513671 L SE 7513671L SE 7513671 A SE7513671 A SE 7513671A SE 7513671 A SE7513671 A SE 7513671A SE 7513671 L SE7513671 L SE 7513671L
Authority
SE
Sweden
Prior art keywords
formula
amino
hydroxy
methylheptanoylalanyl
deacylpepsidin
Prior art date
Application number
SE7513671A
Other languages
Unknown language ( )
Swedish (sv)
Other versions
SE423710B (en
Inventor
N Kuwana
Y Hasegawa
Y Nozu
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Publication of SE7513671L publication Critical patent/SE7513671L/en
Publication of SE423710B publication Critical patent/SE423710B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The deacylpepsidin valylvalyl-4-amino-3-hydroxy-6-methylheptanoylalanyl-4-amino-3-hydroxy -6-methylheptanoic acid of the formula <IMAGE> is obtained by microbiological means, starting from the acylpentapeptide N-acylvalylvalyl-4-amino-3-hydroxy-6-methylheptanoylalanyl-4-amino-3-h ydroxy-6-methylheptanoic acid of the formula <IMAGE> in which R is an acyl group. The compound of the second formula is converted into the product of the first formula by contacting with bacteria of the species Bacillus pumilus or with their acellular culture preparations. The employed bacteria are specifically those of the strain Bacillus pumilus Kawaguchi EF 49-210 (ATCC No. 31132). The deacylpepsidin of the formula (I) is obtained in higher yields and greater purities than in known processes. It has high activity as a pepsin inhibitor.
SE7513671A 1974-12-05 1975-12-04 DESACYL-PEPSIDINE FOR USE AS INTERMEDIATE FOR THE PREPARATION OF N-ACYLPENTAPEPTIDES AND PROCEDURE TO PREPARE IT SE423710B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP49138862A JPS5167791A (en) 1974-12-05 1974-12-05 Desuashiruu oyobi desuashirubariruupepushijinno seizoho narabini saiashirukaho

Publications (2)

Publication Number Publication Date
SE7513671L true SE7513671L (en) 1976-06-08
SE423710B SE423710B (en) 1982-05-24

Family

ID=15231860

Family Applications (1)

Application Number Title Priority Date Filing Date
SE7513671A SE423710B (en) 1974-12-05 1975-12-04 DESACYL-PEPSIDINE FOR USE AS INTERMEDIATE FOR THE PREPARATION OF N-ACYLPENTAPEPTIDES AND PROCEDURE TO PREPARE IT

Country Status (8)

Country Link
JP (1) JPS5167791A (en)
CA (1) CA1053167A (en)
CH (1) CH620244A5 (en)
DE (2) DE2554636C2 (en)
FR (1) FR2293215A1 (en)
GB (1) GB1530921A (en)
NL (1) NL7514241A (en)
SE (1) SE423710B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2660964C2 (en) * 1975-09-12 1987-07-16 Sumitomo Chemical Co., Ltd., Osaka, Jp
JPS56164153A (en) * 1980-05-20 1981-12-17 Eisai Co Ltd Novel desacylvalypepsidin derivative and its preparation
JPS56164152A (en) * 1980-05-20 1981-12-17 Eisai Co Ltd Novel desacylpepsidin derivative and its preparation
JPS57189651U (en) * 1981-05-27 1982-12-01
JPS5956948A (en) * 1982-09-28 1984-04-02 Nippon Kokan Kk <Nkk> Mold for horizontal continuous casting machine
JPS60213347A (en) * 1984-04-06 1985-10-25 Kawasaki Heavy Ind Ltd Billet drawing device for continuous casting

Also Published As

Publication number Publication date
SE423710B (en) 1982-05-24
CH620244A5 (en) 1980-11-14
CA1053167A (en) 1979-04-24
JPS5167791A (en) 1976-06-11
GB1530921A (en) 1978-11-01
DE2554636C2 (en) 1983-02-17
FR2293215B1 (en) 1978-07-28
FR2293215A1 (en) 1976-07-02
NL7514241A (en) 1976-06-09
DE2560238C2 (en) 1984-07-19
JPS5339514B2 (en) 1978-10-21
DE2554636A1 (en) 1976-06-10

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