JPS56164153A - Novel desacylvalypepsidin derivative and its preparation - Google Patents

Novel desacylvalypepsidin derivative and its preparation

Info

Publication number
JPS56164153A
JPS56164153A JP6597480A JP6597480A JPS56164153A JP S56164153 A JPS56164153 A JP S56164153A JP 6597480 A JP6597480 A JP 6597480A JP 6597480 A JP6597480 A JP 6597480A JP S56164153 A JPS56164153 A JP S56164153A
Authority
JP
Japan
Prior art keywords
derivative
formula
acid
action
desacylvalypepsidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP6597480A
Other languages
Japanese (ja)
Inventor
Noriaki Kuwana
Yoshikazu Hasegawa
Yukio Nozu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eisai Co Ltd
Original Assignee
Eisai Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Co Ltd filed Critical Eisai Co Ltd
Priority to JP6597480A priority Critical patent/JPS56164153A/en
Priority to DE8181103882T priority patent/DE3160647D1/en
Priority to EP19810103882 priority patent/EP0040435B1/en
Publication of JPS56164153A publication Critical patent/JPS56164153A/en
Pending legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:A desacylvalylpepsdin derivative of formula I (R is carboxypropanoyl, 2-carboxybenzoyl, nicotinoyl, etc.).
EXAMPLE: N-3-Carboxypropanoyl-desacylvalylpepsidin.
USE: Useful for the prevention and remedy of various diseases due to hypersecretion, e.g. peptic ulcer or hypertension, having a powerful antipepsin action, inhibitory action on acidic protease and antirenin action.
PROCESS: Desacylvalylpepsidin of formula II is reacted with an organic carboxylic acid, e.g. succinic acid, phthalic acid or nicotinic acid, or a reactive derivative thereof, e.g. acid anhydride, to give the compound of formula I.
COPYRIGHT: (C)1981,JPO&Japio
JP6597480A 1980-05-20 1980-05-20 Novel desacylvalypepsidin derivative and its preparation Pending JPS56164153A (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP6597480A JPS56164153A (en) 1980-05-20 1980-05-20 Novel desacylvalypepsidin derivative and its preparation
DE8181103882T DE3160647D1 (en) 1980-05-20 1981-05-20 Peptide derivatives and process for the preparation thereof
EP19810103882 EP0040435B1 (en) 1980-05-20 1981-05-20 Peptide derivatives and process for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP6597480A JPS56164153A (en) 1980-05-20 1980-05-20 Novel desacylvalypepsidin derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS56164153A true JPS56164153A (en) 1981-12-17

Family

ID=13302473

Family Applications (1)

Application Number Title Priority Date Filing Date
JP6597480A Pending JPS56164153A (en) 1980-05-20 1980-05-20 Novel desacylvalypepsidin derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS56164153A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5989649A (en) * 1982-08-17 1984-05-23 サノフイ Acid-protease inhibitive peptide derivative

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50131925A (en) * 1974-04-10 1975-10-18
JPS5154982A (en) * 1974-11-02 1976-05-14 Takeda Chemical Industries Ltd
JPS5167791A (en) * 1974-12-05 1976-06-11 Eisai Co Ltd Desuashiruu oyobi desuashirubariruupepushijinno seizoho narabini saiashirukaho
JPS5257121A (en) * 1975-11-01 1977-05-11 Microbial Chem Res Found Process for novel physiologycal active n-acylpeptide
JPS5283708A (en) * 1976-01-01 1977-07-12 Eisai Co Ltd Desacyl-pepsidin
JPS5285117A (en) * 1976-01-05 1977-07-15 Microbial Chem Res Found Novel n-acylpeptides, their salts and esters
JPS5287116A (en) * 1976-01-16 1977-07-20 Sanraku Inc Novel physiologically active peptide

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS50131925A (en) * 1974-04-10 1975-10-18
JPS5154982A (en) * 1974-11-02 1976-05-14 Takeda Chemical Industries Ltd
JPS5167791A (en) * 1974-12-05 1976-06-11 Eisai Co Ltd Desuashiruu oyobi desuashirubariruupepushijinno seizoho narabini saiashirukaho
JPS5257121A (en) * 1975-11-01 1977-05-11 Microbial Chem Res Found Process for novel physiologycal active n-acylpeptide
JPS5283708A (en) * 1976-01-01 1977-07-12 Eisai Co Ltd Desacyl-pepsidin
JPS5285117A (en) * 1976-01-05 1977-07-15 Microbial Chem Res Found Novel n-acylpeptides, their salts and esters
JPS5287116A (en) * 1976-01-16 1977-07-20 Sanraku Inc Novel physiologically active peptide

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5989649A (en) * 1982-08-17 1984-05-23 サノフイ Acid-protease inhibitive peptide derivative

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