FI863250A - Renin-inhibitorer med 5-amino- 2,5-disubstituerad-4-hydroxivalerianasyrarester. - Google Patents

Renin-inhibitorer med 5-amino- 2,5-disubstituerad-4-hydroxivalerianasyrarester. Download PDF

Info

Publication number
FI863250A
FI863250A FI863250A FI863250A FI863250A FI 863250 A FI863250 A FI 863250A FI 863250 A FI863250 A FI 863250A FI 863250 A FI863250 A FI 863250A FI 863250 A FI863250 A FI 863250A
Authority
FI
Finland
Prior art keywords
sup
amino
chlorobenzyl
hydroxivalerianasyrarester
disubstituerad
Prior art date
Application number
FI863250A
Other languages
English (en)
Other versions
FI86192C (fi
FI86192B (fi
FI863250A0 (fi
Inventor
Jasjit Singh Bindra
Edward Fox Kleinman
Robert Louis Rosati
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of FI863250A0 publication Critical patent/FI863250A0/fi
Publication of FI863250A publication Critical patent/FI863250A/fi
Application granted granted Critical
Publication of FI86192B publication Critical patent/FI86192B/fi
Publication of FI86192C publication Critical patent/FI86192C/fi

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/14Angiotensins: Related peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32Oxygen atoms
    • C07D307/33Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06Esters of carbamic acids
    • C07C271/08Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D207/00Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/02Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
    • C07D217/06Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with the ring nitrogen atom acylated by carboxylic or carbonic acids, or with sulfur or nitrogen analogues thereof, e.g. carbamates
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0227Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/86Renin inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polyamides (AREA)
FI863250A 1985-08-09 1986-08-08 Stereoselektiv foerfarande foer framstaellning av omaettad laktoner. FI86192C (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US76416885A 1985-08-09 1985-08-09
US76416885 1985-08-09
US06/858,324 US4729985A (en) 1985-08-09 1986-04-30 Renin inhibitors containing 5-amino-2,5-disubstituted-4-hydroxypentanoic acid residues
US85832486 1986-04-30

Publications (4)

Publication Number Publication Date
FI863250A0 FI863250A0 (fi) 1986-08-08
FI863250A true FI863250A (fi) 1987-02-10
FI86192B FI86192B (fi) 1992-04-15
FI86192C FI86192C (fi) 1992-07-27

Family

ID=27117410

Family Applications (1)

Application Number Title Priority Date Filing Date
FI863250A FI86192C (fi) 1985-08-09 1986-08-08 Stereoselektiv foerfarande foer framstaellning av omaettad laktoner.

Country Status (22)

Country Link
US (1) US4729985A (fi)
EP (1) EP0212903B1 (fi)
JP (1) JPS6253952A (fi)
KR (1) KR890003603B1 (fi)
CN (1) CN86105870A (fi)
AT (1) ATE84046T1 (fi)
AU (1) AU576970B2 (fi)
CA (1) CA1294736C (fi)
DE (1) DE3687380T2 (fi)
DK (1) DK379186A (fi)
EG (1) EG17971A (fi)
ES (1) ES2000852A6 (fi)
FI (1) FI86192C (fi)
GR (1) GR862078B (fi)
HU (1) HU207101B (fi)
IE (1) IE58524B1 (fi)
IL (1) IL79626A0 (fi)
NO (1) NO170725C (fi)
NZ (1) NZ217127A (fi)
PH (1) PH24494A (fi)
PT (1) PT83172B (fi)
YU (1) YU45355B (fi)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727060A (en) * 1984-11-13 1988-02-23 Ciba-Geigy Corporation Novel 5-amino-4-hydroxyvaleryl derivatives
DE3538749A1 (de) * 1985-10-31 1987-05-07 Merck Patent Gmbh Peptide
FI870474A (fi) * 1986-02-07 1987-08-08 Ciba Geigy Ag Med svavelhaltiga grupper substituerade 5-amino-4-hydroxivalerylderivat.
DE3626130A1 (de) * 1986-08-01 1988-02-11 Merck Patent Gmbh Aminosaeurederivate
US4681972A (en) * 1986-09-16 1987-07-21 Warner-Lambert Company Separation of diastereomers
DE3789347D1 (de) * 1986-10-14 1994-04-21 Banyu Pharma Co Ltd 5-Substituierte Amino-4-hydroxy-pentansäure-Derivate und deren Verwendung.
US4927565A (en) * 1986-12-19 1990-05-22 Banyu Pharmaceutical Co., Ltd. 5-substituted amino-4-hydroxy-pentenoic acid derivatives and their use
US4758584A (en) * 1987-02-05 1988-07-19 Ciba-Geigy Corporation Antihypertensive 5-amino-4-hydroxyvaleryl derivatives substituted by sulphur-containing groups
DE3888031T2 (de) * 1987-07-01 1994-06-09 Pfizer Homocyclostatin und Cyclostatin enthaltende Polypeptide als Antihypertensiva.
US4859654A (en) * 1987-07-01 1989-08-22 Pfizer Inc. Homocyclostatine and cyclostatine containing polypeptides as antihypertensive agents
EP0312158A3 (en) * 1987-10-13 1990-07-25 Merck & Co. Inc. Tetrapeptide renin inhibitors having novel c-terminal amino acid amide
GB8728561D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
GB8728560D0 (en) * 1987-12-07 1988-01-13 Glaxo Group Ltd Chemical compounds
DE68916271T2 (de) * 1988-01-26 1995-02-23 Sankyo Co Renin inhibierende Polypeptide, ihre Herstellung und Anwendung.
EP0329295A1 (en) * 1988-02-01 1989-08-23 The Upjohn Company Renin inhibiting peptides with polar end groups
JPS6486550A (en) * 1988-08-19 1989-03-31 Seiko Epson Corp Complementary mos integrated circuit
US5436339A (en) * 1991-03-06 1995-07-25 Abbott Laboratories Process for the preparation of a substituted diaminoalcohol
US5238935A (en) * 1991-05-20 1993-08-24 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme A: cholesterol acyl transferase
US5124337A (en) * 1991-05-20 1992-06-23 Schering Corporation N-acyl-tetrahydroisoquinolines as inhibitors of acyl-coenzyme a:cholesterol acyl transferase
TW217410B (fi) * 1992-04-01 1993-12-11 Ciba Geigy
MY119161A (en) * 1994-04-18 2005-04-30 Novartis Ag Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities
EP0702004A2 (de) * 1994-09-15 1996-03-20 Ciba-Geigy Ag 2,9-Diamino- und 2-amino-8-carbamoyl-4-hydroxy-alkansäureamid-derivative
EP0716077A1 (de) * 1994-12-08 1996-06-12 Ciba-Geigy Ag Aromatisch substituierte Omega-Aminoalkansäureamide und Alkansäurediamide und ihre Verwendung als Renininhibitoren
CA2191924A1 (en) * 1995-12-05 1997-06-06 Kevin Felsenstein 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of .beta.-amyloid protein production
US5703129A (en) * 1996-09-30 1997-12-30 Bristol-Myers Squibb Company 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production
DE60124080T2 (de) 2000-03-23 2007-03-01 Elan Pharmaceuticals, Inc., San Francisco Verbindungen und verfahren zur behandlung der alzheimerschen krankheit
EP1299352B1 (en) 2000-06-30 2005-12-28 Elan Pharmaceuticals, Inc. Compounds to treat alzheimer's disease
RU2550691C2 (ru) * 2009-08-11 2015-05-10 Новартис Аг Раскрытие циклов лактонов и лактамов
CN105195868B (zh) * 2015-11-12 2018-05-15 上海电气核电设备有限公司 一种机器人焊接系统及其焊接方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4163676A (en) * 1978-04-03 1979-08-07 Blue Cross Laboratories Ethanol-modified lecithin cookware spray composition
NO812612L (no) * 1980-08-06 1982-02-08 Ferring Pharma Ltd Enzym-inhibitorer.
US4478826A (en) * 1981-10-08 1984-10-23 Merck & Co., Inc. Renin inhibitory peptides
CA1258748A (en) * 1981-10-08 1989-08-22 Daniel F. Veber Renin inhibitory peptides
US4470971A (en) 1981-10-19 1984-09-11 Merck & Co., Inc. Renin inhibitory peptides having His13
US4397786A (en) 1981-11-23 1983-08-09 Merck & Co., Inc. Method of preparing statine and derivatives
CA1245217A (en) * 1981-12-10 1988-11-22 Joshua S. Boger Renin inhibitory peptides having phe su13 xx deletion
AU573735B2 (en) * 1983-02-07 1988-06-23 Aktiebolaget Hassle Peptide analogue enzyme inhibitors
US4613676A (en) * 1983-11-23 1986-09-23 Ciba-Geigy Corporation Substituted 5-amino-4-hydroxyvaleryl derivatives
CA1254699A (en) * 1984-03-12 1989-05-23 Jasjit S. Bindra Renin inhibitors containing statine or derivatives thereof
US4661473A (en) * 1984-03-27 1987-04-28 Merck & Co., Inc. Renin inhibitors containing peptide isosteres
EP0173481A3 (en) * 1984-08-06 1988-12-21 The Upjohn Company Peptides
DE3512128A1 (de) * 1985-04-03 1986-10-09 Merck Patent Gmbh, 6100 Darmstadt Peptide

Also Published As

Publication number Publication date
NO863202L (no) 1987-02-10
AU6102186A (en) 1987-02-12
NZ217127A (en) 1989-11-28
HU207101B (en) 1993-03-01
KR890003603B1 (ko) 1989-09-27
HUT41419A (en) 1987-04-28
FI86192C (fi) 1992-07-27
US4729985A (en) 1988-03-08
DE3687380T2 (de) 1993-04-29
PT83172A (en) 1986-09-01
ATE84046T1 (de) 1993-01-15
NO170725B (no) 1992-08-17
EP0212903A2 (en) 1987-03-04
YU142286A (en) 1988-10-31
DK379186A (da) 1987-04-01
EP0212903A3 (en) 1989-11-15
NO170725C (no) 1992-11-25
CA1294736C (en) 1992-01-21
EP0212903B1 (en) 1992-12-30
PT83172B (pt) 1989-03-30
CN86105870A (zh) 1987-03-11
YU45355B (en) 1992-05-28
JPS6253952A (ja) 1987-03-09
PH24494A (en) 1990-07-18
IL79626A0 (en) 1986-11-30
FI86192B (fi) 1992-04-15
KR870002164A (ko) 1987-03-30
AU576970B2 (en) 1988-09-08
IE58524B1 (en) 1993-10-06
EG17971A (en) 1991-11-30
GR862078B (en) 1986-12-24
ES2000852A6 (es) 1988-03-16
FI863250A0 (fi) 1986-08-08
NO863202D0 (no) 1986-08-08
IE862143L (en) 1987-02-09
DE3687380D1 (de) 1993-02-11
JPH0543697B2 (fi) 1993-07-02
DK379186D0 (da) 1986-08-08

Similar Documents

Publication Publication Date Title
FI863250A (fi) Renin-inhibitorer med 5-amino- 2,5-disubstituerad-4-hydroxivalerianasyrarester.
MA18664A1 (fr) Derives d'amino-acides utiles comme agents contre l'hypertension
TR199902923T2 (xx) Yumu�ak kas h�cresi �o�almas� inhibit�rleri olarak (imidazol-5-il)metil-2-kuinolinon t�revleri.
ATE230732T1 (de) Imidazol-derivate mit biphenylsulfonylharnstoff- oder biphenylsulfonylurethan-seitenkette, verfahren zu ihrer herstellung und ihre verwendung
ATE159945T1 (de) Beta-aminoalkyl und beta-n- peptidylaminoalkylborsäure
DK1052984T3 (da) Antibakterielle midler
AU6049696A (en) Amino acid amides of 5-amino-1,3,4-thiadiazones and their use as inhibitors for matrix metalloproteinases
FI945704A0 (fi) Eksitatorisen aminohapporeseptorin antagonisteja
DE59608154D1 (de) Verwendung von polyasparaginsäureamiden als lederhilfsmittel
EP0296581A3 (en) Amino acid 1,2-diketo derivatives as renin inhibitors
PT83535B (pt) Processo para a preparacao de composicoes farmaceuticas contendo derivados de aminoacidos
ES2002469A6 (es) Un procedimiento para la preparacion de nuevos di -.tri -. y tetrapeptidos inhibidores de renina.
EA200100661A1 (ru) Способ получения производных 2-азадигидроксибицикло [2.2.1] гептана
KR850006941A (ko) 데스-프로린 바조프레신 길항제의 제조방법
NO871575D0 (no) Fremgangsmaate for fremstilling av 1,5-benztiazepinderivater.
KR910009663A (ko) 피리딘유도체, 이들을 함유하는 약리학적 조성물 및 이들의 제조방법
ATE69806T1 (de) Zink-, blei- und/oder calciumsalze von carbonsaeuren und deren verwendung als korrosionsschutzmittel.
ATE257707T1 (de) Verwendung von prostanoiden-antagonisten zur bhandlung von primären kopfschmerzen
RU92004529A (ru) Производные 2-азабицикло /2,2,1/гепт-5-ен-2-уксусной кислоты
DE3650459D1 (de) Verwendung von Alkenylbernsteinsäurehalbamiden als Korrosionsschutzmittel
ATE69810T1 (de) Derivate von n-(2-alkyl-3-mercaptoglutaryl)-alpha-aminosaeure und deren verwendung als collagenaseinhibitoren.
ATE80400T1 (de) Tetrapeptid-hemmstoff zum eintritt in den kreislauf von hemopoietischen stammzellen, verfahren zu deren herstellung und deren anwendungen.

Legal Events

Date Code Title Description
MM Patent lapsed
MM Patent lapsed

Owner name: PFIZER INC.