KR910009628A - 5-플루오로벤조산류 및 그의 중간물질의 제조방법 - Google Patents

5-플루오로벤조산류 및 그의 중간물질의 제조방법 Download PDF

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Publication number
KR910009628A
KR910009628A KR1019900018495A KR900018495A KR910009628A KR 910009628 A KR910009628 A KR 910009628A KR 1019900018495 A KR1019900018495 A KR 1019900018495A KR 900018495 A KR900018495 A KR 900018495A KR 910009628 A KR910009628 A KR 910009628A
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South Korea
Prior art keywords
general formula
halogen atom
following general
fluorobenzotrichloride
give
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KR1019900018495A
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English (en)
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KR0177802B1 (ko
Inventor
세이사꾸 구마이
마사오 오하시
유따까 야기누마
가쓰히꼬 다께다
Original Assignee
후루모또 지로
아사히가라스 가부시끼가이샤
아오모리 다이조
세이미케미칼 가부시끼가이샤
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Priority claimed from JP1297609A external-priority patent/JP2595109B2/ja
Priority claimed from JP29761089A external-priority patent/JP2788512B2/ja
Application filed by 후루모또 지로, 아사히가라스 가부시끼가이샤, 아오모리 다이조, 세이미케미칼 가부시끼가이샤 filed Critical 후루모또 지로
Publication of KR910009628A publication Critical patent/KR910009628A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
    • C07C63/70—Monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/50—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton to carbon atoms of non-condensed six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00—Preparation of halogenated hydrocarbons
    • C07C17/26—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton
    • C07C17/32—Preparation of halogenated hydrocarbons by reactions involving an increase in the number of carbon atoms in the skeleton by introduction of halogenated alkyl groups into ring compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/08—Preparation of carboxylic acids or their salts, halides or anhydrides from nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/093—Preparation of carboxylic acids or their salts, halides or anhydrides by hydrolysis of —CX3 groups, X being halogen

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음

Description

5-플루오로벤조산류 및 그의 중간물질의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 하기 일반식(I)의 플로오로벤젠을 트리클로로메틸화시켜 하기 일반식(Ⅱ)의 5-플루오로벤조트리클로라이드를 수득한 다음, 이것을 암모니아 수용액과 반응시켜 하기 일반식(Ⅲ)의 5-플루오로벤조니트릴을 수득하고, 이것을 플루로르화제와 반응시켜 하기 일반식(Ⅳ)의 5-플루오로벤조니트릴을 수득하고 이것을 가수분해시키는 것으로 구성된,하기 일반식(Ⅴ)의 5-플루오로벤조산의 제조방법 :
    [식중, X1,X3,Y1및 Y3의 각각은 할로겐 원자이고, X2및 Y2의 각각은 수소 또는 할로겐원자이다.]
  2. 하기 일반식(I)의 플루오로벤젠을 트리클로로메틸화시켜 하기 일반식(Ⅱ)의 5-플루오로젠조트리클로라이드를 수득한 다음, 이것을 암모니아 수용액과 반응시켜 하기 일반식(Ⅲ)의 5-플루오로벤조니트릴을 수득하는 것으로 구성된, 5-플루오로벤조니트릴의 제조방법 :
    [식중, X1및 X3의 각각은 할로겐 원자이고, X2는 수소 또는 할로겐 원자이다.]
  3. 하기 일반식의 2,4-디클로로-5-플루오로벤조니트릴 :
  4. 하기 일반식 2-클로로-4,5-디플루오로벤조니트릴 :
  5. 하기 일반식(I)의 플루오로벤젠을 로이스산 촉매의 존재하에서 사염화 탄소와 반응시켜 하기 일반식(Ⅱ)의 5-플루오로벤조트리클로라이드를 수득하고 이것을 가수분해시키는 것으로 구성된, 하기 일반식(Ⅵ)의 5-플루오로벤조산의 제조 방법 :
    [식중, X1및 X3의 각각은 할로겐 원자이고, X2는 수소 또는 할로겐 원자이다.]
  6. 하기 일반식(I)의 플루오로벤젠을 루이스산 촉매의 존재하에서 사염화 탄소와 반응시켜 하기 일반식(Ⅱ)의 5-플루오로벤조트리클로라이드를 수득하는 것으로 구성되, 5-플루오로벤조트리클로라이드의 제조방법 :
    [식중, 식중, X1및 X3의 각각은 할로겐 원자이고, X2는 수소 또는 할로겐 원자이다.]
  7. 하기 일반식의 2-클로로-4,5-디플루오로벤조트리클로라이드:
  8. 하기 일반식의 2,4,5-트리플루오로벤조트리클로라이드:
  9. 하기 일반식의 2-브로모-4,5-디플루오로벤조트리클로라이드:
  10. 하기 일반식의 2,3,4-트리클로로-5-플루오로벤조트리클로라이드:
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900018495A 1989-11-17 1990-11-15 5-플루오로벤조산류 및 그의 중간물질의 제조방법 KR0177802B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP1297609A JP2595109B2 (ja) 1989-11-17 1989-11-17 新規フルオロベンゾトリクロリド化合物およびフルオロ安息香酸類の製造方法
JP29761089A JP2788512B2 (ja) 1989-11-17 1989-11-17 ５‐フルオロベンゾニトリル類および４，５‐ジフルオロ安息香酸類の製造方法
JP297609/1989 1989-11-17
JP297610/1989 1989-11-17

Publications (2)

Publication Number Publication Date
KR910009628A true KR910009628A (ko) 1991-06-28
KR0177802B1 KR0177802B1 (ko) 1999-05-15

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US (2) US5241111A (ko)
EP (1) EP0431373B1 (ko)
KR (1) KR0177802B1 (ko)
DE (1) DE69026476T2 (ko)
ES (1) ES2088402T3 (ko)
IE (1) IE72169B1 (ko)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4238125A1 (de) * 1992-11-12 1994-05-19 Bayer Ag Substituierte Triazolinone
US6906006B1 (en) 1988-11-23 2005-06-14 Bayer Aktiengesellschaft N-arly-substituted nitrogen-containing heterocycles, processes and novel intermediates for their preparation, and their use as herbicides and plant growth regulators
EP0497239A1 (de) * 1991-01-30 1992-08-05 Hoechst Aktiengesellschaft 2-Chlor-4,5-difluorbenzonitril und Verfahren zu seiner Herstellung
DE4200512C2 (de) * 1992-01-11 1994-09-15 Riedel De Haen Ag Verfahren zur Herstellung von Halogenanthranilsäuren und aromatische Bromverbindungen als Vorstufen
EP0557949B1 (de) * 1992-02-26 1998-12-16 Clariant GmbH Verfahren zur Herstellung von 2,4,5-Trifluorbenzonitril
DE4414841A1 (de) * 1994-04-28 1995-11-02 Bayer Ag Brom enthaltende aromatische Verbindungen, Verfahren zu ihrer Herstellung und ihre Verwendung als Zwischenprodukte bei der Synthese von Wirkstoffen
DE4416329A1 (de) * 1994-05-09 1995-11-16 Hoechst Ag Substituierte 2-Chlor-3,4,5-trifluorbenzole und ein Verfahren zu ihrer Herstellung
DE19507912A1 (de) * 1995-03-07 1996-09-12 Bayer Ag Verfahren zur Herstellung von 2,4-Dichlor-5-fluorbenzonitril und 2,6-Dichlor-3-fluorbenzonitril
WO1997031891A1 (en) * 1996-03-01 1997-09-04 Merck & Co., Inc. Process for regioselective substitution of trifluorobenzoate or trifluorobenzonitrile
US5777123A (en) * 1996-03-01 1998-07-07 Merck & Co., Inc. Process for regioselective substitution of trifluorobenzoate or trifluorobenzonitrile
US6008407A (en) * 1998-11-03 1999-12-28 Zelinsky Institute Of Organic Chemistry Method of preparing fluoroaromatic compounds
CN100360550C (zh) 2001-05-03 2008-01-09 芝加哥大学 肝脏x受体激动剂
CN104649890B (zh) * 2015-02-15 2016-04-13 浙江永太科技股份有限公司 一种2,4-二氯-5-氟苯甲酰氯的制备方法
CN105669435B (zh) * 2015-02-15 2017-12-08 浙江永太科技股份有限公司 一种2,4‑二氯‑5‑氟苯甲酰氯的制备方法
CN104725221B (zh) * 2015-03-19 2016-04-27 浙江本立科技股份有限公司 一种2,4-二氯-5-氟苯甲酰氯的合成方法
CN105175245B (zh) * 2015-10-22 2017-07-18 山东国邦药业股份有限公司 一种2,4‑二氯‑5‑氟苯甲酰氯的合成方法
CN105859620B (zh) * 2016-05-05 2018-07-13 大连理工大学 一类6-三氯甲基菲啶类化合物及其制备方法和应用
CN106278860A (zh) * 2016-08-11 2017-01-04 常州工程职业技术学院 一种3‑氯‑2,4‑二氟苯甲酸的合成方法
JP7353011B2 (ja) * 2019-02-15 2023-09-29 フジアン ヨンジン テクノロジー カンパニー リミテッド フッ素化ベンゼン、フッ素化ベンゾフェノン、およびその誘導体の新しい製造方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3187057A (en) * 1958-05-19 1965-06-01 Standard Oil Co Trichloromethyl polymethyl benzenes
DE1668068A1 (de) * 1967-12-30 1971-07-15 Hoechst Ag Verfahren zur Herstellung von Benzonitrilen
DE3142856A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen Verfahren zur herstellung von 2,4-dichlor-5-fluor-benzoylchlorid
DE3420796A1 (de) * 1984-06-04 1985-12-05 Bayer Ag, 5090 Leverkusen 2,4,5-trihalogen- bzw. 2,3,4,5-tetrahalogenbenzolderivate und verfahren zu ihrer herstellung
US4791225A (en) * 1986-01-20 1988-12-13 Kyorin Pharmaceutical Co., Ltd. Halogenobenzoic acid derivatives and their preparation
JPS63188643A (ja) * 1987-01-30 1988-08-04 Central Glass Co Ltd 新規な含フツ素ベンゾフエノンおよびその製造法
JP2566976B2 (ja) * 1987-04-08 1996-12-25 日本カーバイド工業株式会社 ハロゲン置換ベンゼンカルボン酸の脱炭酸方法
CN1007150B (zh) * 1987-06-22 1990-03-14 国家医药管理局天津医药工业研究所 2，4-二氯-5-氟苯甲酸的合成
JP2577567B2 (ja) * 1987-07-07 1997-02-05 イハラケミカル工業株式会社 芳香族フッ素化合物の製造方法
EP0303291B1 (en) * 1987-08-14 1995-04-26 Asahi Glass Company Ltd. Fluorinated benzoyl compounds

Also Published As

Publication number Publication date
EP0431373A3 (en) 1992-09-02
EP0431373A2 (en) 1991-06-12
EP0431373B1 (en) 1996-04-10
KR0177802B1 (ko) 1999-05-15
IE72169B1 (en) 1997-03-26
DE69026476T2 (de) 1996-10-31
US5241111A (en) 1993-08-31
ES2088402T3 (es) 1996-08-16
US5332851A (en) 1994-07-26
DE69026476D1 (de) 1996-05-15
IE904085A1 (en) 1991-05-22

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