KR910009274A - 폴리믹신 복합체 - Google Patents

폴리믹신 복합체 Download PDF

Info

Publication number
KR910009274A
KR910009274A KR1019900018434A KR900018434A KR910009274A KR 910009274 A KR910009274 A KR 910009274A KR 1019900018434 A KR1019900018434 A KR 1019900018434A KR 900018434 A KR900018434 A KR 900018434A KR 910009274 A KR910009274 A KR 910009274A
Authority
KR
South Korea
Prior art keywords
complex
polymyxin
dextran
carrier
pmb
Prior art date
Application number
KR1019900018434A
Other languages
English (en)
Other versions
KR0184858B1 (ko
Inventor
알렌 핸들리 딘
레이크 필립
Original Assignee
쟝 크리머, 한스 루돌프 하우스
산도즈 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쟝 크리머, 한스 루돌프 하우스, 산도즈 리미티드 filed Critical 쟝 크리머, 한스 루돌프 하우스
Publication of KR910009274A publication Critical patent/KR910009274A/ko
Application granted granted Critical
Publication of KR0184858B1 publication Critical patent/KR0184858B1/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)

Abstract

내용 없음

Description

폴리믹신 복합체
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 폴리믹신과 담체의 수용성 복합체.
  2. 제1항에 있어서, 상기 담체가 덱스트란 또는 하이드록시에틸 전분과 같은 다당류, 알부민과 같은 단백질, 또는 폴리비닐 피롤리돈, 폴리에틸렌 글리콜 또는 폴리비닐 알콜과 같은 중합체인 복합체.
  3. 제1항에 있어서, 상기 폴리믹신이 PMB인 복합체.
  4. 제2항에 있어서, 상기 담체가 덱스트란인 복합체.
  5. 제3항에 있어서, 상기 담체가 덱스트란인 복합체.
  6. 제5항에 있어서, PMB가 카르바민산염 결합을 통해 결합된 복합체.
  7. 제5항에 있어서, PMB가 아민 결합을 통해 결합된 복합체.
  8. a)폴리믹신을 덱스트란에 적절히 결합시켜 수용성 폴리믹신-덱스트란 복합체를 형성하고; b)생성된 복합체를 저급 알콜중에 침전시키고; c)복합체를 재현탁시키고; d)복합체에 결합되지 않은 폴리믹신이 실질적으로 없어질 때까지 b) 및 c)단계를 반복함을 포함하는 제4항에 따른 폴리믹신-덱스트란 복합체의 제조방법.
  9. 추가의 약학적으로 허용가능한 담체 또는 희석제와 함께 제1항에 따른 복합체를 포함하는 약학적 조성물.
  10. 제1항에 있어서, 상기 복합체가 실질적으로 무독성인 주사가능한 복합체.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900018434A 1989-11-15 1990-11-14 폴리믹신 복합체 KR0184858B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US43748789A 1989-11-15 1989-11-15
US437487 1989-11-15

Publications (2)

Publication Number Publication Date
KR910009274A true KR910009274A (ko) 1991-06-28
KR0184858B1 KR0184858B1 (ko) 1999-05-01

Family

ID=23736660

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019900018434A KR0184858B1 (ko) 1989-11-15 1990-11-14 폴리믹신 복합체

Country Status (17)

Country Link
EP (1) EP0428486B1 (ko)
JP (1) JPH082917B2 (ko)
KR (1) KR0184858B1 (ko)
AT (1) ATE111746T1 (ko)
AU (1) AU639952B2 (ko)
CA (1) CA2029997A1 (ko)
CY (1) CY2052B1 (ko)
DE (1) DE69012747T2 (ko)
DK (1) DK0428486T3 (ko)
ES (1) ES2063326T3 (ko)
HK (1) HK49696A (ko)
HU (1) HU210901A9 (ko)
IE (1) IE65268B1 (ko)
IL (1) IL96326A (ko)
MY (1) MY104520A (ko)
NZ (1) NZ236050A (ko)
ZA (1) ZA909187B (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660267B1 (en) 1992-12-21 2003-12-09 Promega Corporation Prevention and treatment of sepsis
JPH08504824A (ja) * 1992-12-21 1996-05-28 オフィディアン ファーマシューティカルズ，インコーポレーテッド 敗血症の予防および治療
US5545721A (en) * 1992-12-21 1996-08-13 Ophidian Pharmaceuticals, Inc. Conjugates for the prevention and treatment of sepsis
US6579696B1 (en) * 1992-12-21 2003-06-17 Promega Corporation Polymyxin B conjugates
US6180134B1 (en) 1993-03-23 2001-01-30 Sequus Pharmaceuticals, Inc. Enhanced ciruclation effector composition and method
US5849301A (en) * 1993-09-22 1998-12-15 Henry M. Jackson Foundation For The Advancement Of Military Medicine Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents
DE122009000058I1 (de) * 1993-09-22 2009-12-31 Jackson H M Found Military Med Verfahren zur aktivierung von löslichem kohlenhydraten durch verwendung von neuen cyanylierungsreagenzien, zur herstellung von immunogenischen konstrukten
JP2581425B2 (ja) * 1993-11-12 1997-02-12 株式会社島津製作所 ペプチド合成用支持体及びそれを用いて製造されたペプチド
DE122009000055I1 (de) * 1995-03-22 2009-12-31 Jackson H M Found Military Med Herstellung von immunogenen konstrukten unter verwendung von löslichen kohlehydraten, die durch organische cyanylierungs-reagenzien aktiviert wurden
NZ304715A (en) * 1995-03-22 1999-07-29 Jackson H M Found Military Med Production of immunogenic constructs using organic cyanylating reagents to activate carbohydrates and then coupling the carbohydrate to a protein, peptide or hapten
US5691304A (en) * 1995-05-25 1997-11-25 Novartis Ag Improved process for preparing polymyxin B/dextran conjugates
US6309646B1 (en) 1996-05-09 2001-10-30 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Protein-polysaccharide conjugate vaccines and other immunological reagents prepared using homobifunctional and heterobifunctional vinylsulfones, and processes for preparing the conjugates
US5998381A (en) * 1996-12-06 1999-12-07 Ophidian Pharmaceuticals, Inc. Compounds that bind bacterial pili
IT1312110B1 (it) 1999-05-18 2002-04-04 Istituto Biochimico Pavese Pha Addotti antibiotico-polimero polisaccaridico naturale
DE10129369C1 (de) * 2001-06-21 2003-03-06 Fresenius Kabi De Gmbh Wasserlösliches, einen Aminozucker aufweisendes Antibiotikum in Form eines Pol ysaccharid-Konjugats
AT507846B1 (de) * 2009-01-22 2011-12-15 Fresenius Medical Care De Gmbh Sorptionsmittel für endotoxine
US10532080B2 (en) * 2014-10-03 2020-01-14 Xellia Pharmaceuticals Aps Sulfomethylated polymixin compositions
EP3528830B1 (en) * 2016-10-21 2022-10-05 Algipharma AS Polymyxin-alginate oligomer conjugates

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7702261L (sv) * 1976-03-02 1977-09-07 Pharmaco Inc Forfarande for att immobilisera antimikrobiella emnen
JPS5813519A (ja) * 1981-07-16 1983-01-26 Seikagaku Kogyo Co Ltd エンドトキシン吸着材及びそれを用いるエンドトキシンの除去方法
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer

Also Published As

Publication number Publication date
AU6655590A (en) 1991-05-23
ZA909187B (en) 1992-07-29
ATE111746T1 (de) 1994-10-15
CY2052B1 (en) 1998-04-30
JPH082917B2 (ja) 1996-01-17
HU210901A9 (en) 1995-09-28
DE69012747D1 (de) 1994-10-27
IE65268B1 (en) 1995-10-18
EP0428486A1 (en) 1991-05-22
KR0184858B1 (ko) 1999-05-01
AU639952B2 (en) 1993-08-12
IE904105A1 (en) 1991-05-22
HK49696A (en) 1996-03-29
DK0428486T3 (da) 1995-01-09
NZ236050A (en) 1993-04-28
EP0428486B1 (en) 1994-09-21
ES2063326T3 (es) 1995-01-01
CA2029997A1 (en) 1991-05-16
IL96326A (en) 1995-07-31
JPH03220198A (ja) 1991-09-27
DE69012747T2 (de) 1995-03-16
IL96326A0 (en) 1991-08-16
MY104520A (en) 1994-04-30

Similar Documents

Publication Publication Date Title
KR910009274A (ko) 폴리믹신 복합체
KR910016770A (ko) 글리코사미노글리칸-변형된 단백질
IE861706L (en) Solubilization of proteins for pharmaceutical compositions¹using polymer conjugation
HU227643B1 (en) Interferon solution
KR19980701305A (ko) 1,3,7-옥타트리엔등의 공액 폴리엔으로부터 제조되는 가교결합된 중합체(crosslinked polymers made from 1,3,7-octatriene and like conjugated polyenes)
DE69830326D1 (de) Iminbildende polysaccharide, deren herstellung und verwendung als zusatzmittel und immunstimulierende mittel
TNSN93045A1 (fr) Nouveaux composes actifs
KR880010769A (ko) 안정한 안과용 수성 조성물 및 그 제조방법
KR900017977A (ko) 폴리에틸렌 글리콜 유도체, 변성된 펩티드 및 그 제조방법
DE69116144T2 (de) Bindung substratspezifischer affinitätssubstanzen an liposomen
ES2033429T3 (es) Un metodo de preparacion de una composicion farmaceutica.
GB1247896A (en) A method of binding, by covalent bonds, organic compounds to polymers
CA2268433A1 (en) Improved interferon polymer conjugates
ES2007536A6 (es) Procedimiento para la fabricacion de un conjugado de superoxido dismutasa soluble en agua y sustancialmente no inmunogenico.
DE3468689D1 (en) Immunostiumulating derivatives, their preparation and their use as medicines
KR900003163A (ko) 시클로헥산 유도체
GB1509707A (en) Immunological compounds
DE1189595T1 (de) Ophthalmische zusammensetzungen in form wässriger gele
DE59010462D1 (de) Neue Cobalamin-Säurehydrazide und davon abgeleitete Cobalamin-Konjugate
NZ316970A (en) Viral recombinant pseudo-particles and vaccinal and anti-tumoral applications
CA2056381A1 (en) Cysteine thiol-protected peptides for use in immunoassays
CA2079443A1 (en) Binding of growth hormone to liposomes
KR890009386A (ko) 백금화합물 동결건조제제
WO2004043884A3 (en) Novel acylating reagents
KR960031594A (ko) 재조합 인간 초-산화물 불균화효소(rhSOD)의 고분자 결합체 및 이를 제조하는 방법

Legal Events

Date Code Title Description
A201 Request for examination
N231 Notification of change of applicant
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
LAPS Lapse due to unpaid annual fee