DE69012747D1 - Polymyxinkonjugate. - Google Patents

Polymyxinkonjugate.

Info

Publication number
DE69012747D1
DE69012747D1 DE69012747T DE69012747T DE69012747D1 DE 69012747 D1 DE69012747 D1 DE 69012747D1 DE 69012747 T DE69012747 T DE 69012747T DE 69012747 T DE69012747 T DE 69012747T DE 69012747 D1 DE69012747 D1 DE 69012747D1
Authority
DE
Germany
Prior art keywords
polymyxin
conjugates
polymyxin conjugates
bloodstream
potent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69012747T
Other languages
English (en)
Other versions
DE69012747T2 (de
Inventor
Dean Allen Handley
Philip Lake
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Sandoz AG
Sandoz Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG, Sandoz Patent GmbH filed Critical Sandoz AG
Publication of DE69012747D1 publication Critical patent/DE69012747D1/de
Application granted granted Critical
Publication of DE69012747T2 publication Critical patent/DE69012747T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
DE69012747T 1989-11-15 1990-11-13 Polymyxinkonjugate. Expired - Fee Related DE69012747T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43748789A 1989-11-15 1989-11-15

Publications (2)

Publication Number Publication Date
DE69012747D1 true DE69012747D1 (de) 1994-10-27
DE69012747T2 DE69012747T2 (de) 1995-03-16

Family

ID=23736660

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69012747T Expired - Fee Related DE69012747T2 (de) 1989-11-15 1990-11-13 Polymyxinkonjugate.

Country Status (17)

Country Link
EP (1) EP0428486B1 (de)
JP (1) JPH082917B2 (de)
KR (1) KR0184858B1 (de)
AT (1) ATE111746T1 (de)
AU (1) AU639952B2 (de)
CA (1) CA2029997A1 (de)
CY (1) CY2052B1 (de)
DE (1) DE69012747T2 (de)
DK (1) DK0428486T3 (de)
ES (1) ES2063326T3 (de)
HK (1) HK49696A (de)
HU (1) HU210901A9 (de)
IE (1) IE65268B1 (de)
IL (1) IL96326A (de)
MY (1) MY104520A (de)
NZ (1) NZ236050A (de)
ZA (1) ZA909187B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545721A (en) * 1992-12-21 1996-08-13 Ophidian Pharmaceuticals, Inc. Conjugates for the prevention and treatment of sepsis
JPH08504824A (ja) * 1992-12-21 1996-05-28 オフィディアン ファーマシューティカルズ，インコーポレーテッド 敗血症の予防および治療
US6660267B1 (en) 1992-12-21 2003-12-09 Promega Corporation Prevention and treatment of sepsis
US6579696B1 (en) * 1992-12-21 2003-06-17 Promega Corporation Polymyxin B conjugates
US6180134B1 (en) 1993-03-23 2001-01-30 Sequus Pharmaceuticals, Inc. Enhanced ciruclation effector composition and method
EP0720485B1 (de) * 1993-09-22 2003-11-19 Henry M. Jackson Foundation For The Advancement Of Military Medicine Verfahren zur aktivierung von löslichem kohlenhydraten durch verwendung von neuen cyanylierungsreagenzien, zur herstellung von immunogenischen konstrukten
US5849301A (en) * 1993-09-22 1998-12-15 Henry M. Jackson Foundation For The Advancement Of Military Medicine Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents
JP2581425B2 (ja) * 1993-11-12 1997-02-12 株式会社島津製作所 ペプチド合成用支持体及びそれを用いて製造されたペプチド
DE122009000056I1 (de) * 1995-03-22 2010-01-28 Jackson H M Found Military Med Herstellung von immunogenen konstrukten unter verwendung von löslichen kohlehydraten, die durch organische cyanylierungs-reagenzien aktiviert wurden
EP0814833B1 (de) * 1995-03-22 2003-05-28 Henry M. Jackson Foundation For The Advancement Of Military Medicine Herstellung von immunogenen konstrukten unter verwendung von löslichen kohlehydraten, die durch organische cyanylierungs-reagenzien aktiviert wurden
US5691304A (en) * 1995-05-25 1997-11-25 Novartis Ag Improved process for preparing polymyxin B/dextran conjugates
US6309646B1 (en) 1996-05-09 2001-10-30 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Protein-polysaccharide conjugate vaccines and other immunological reagents prepared using homobifunctional and heterobifunctional vinylsulfones, and processes for preparing the conjugates
US5998381A (en) * 1996-12-06 1999-12-07 Ophidian Pharmaceuticals, Inc. Compounds that bind bacterial pili
IT1312110B1 (it) 1999-05-18 2002-04-04 Istituto Biochimico Pavese Pha Addotti antibiotico-polimero polisaccaridico naturale
DE10129369C1 (de) * 2001-06-21 2003-03-06 Fresenius Kabi De Gmbh Wasserlösliches, einen Aminozucker aufweisendes Antibiotikum in Form eines Pol ysaccharid-Konjugats
AT507846B1 (de) * 2009-01-22 2011-12-15 Fresenius Medical Care De Gmbh Sorptionsmittel für endotoxine
PT3200827T (pt) * 2014-10-03 2020-10-08 Xellia Pharmaceuticals Aps Composições
CN109843315A (zh) * 2016-10-21 2019-06-04 阿尔吉法玛公司 多粘菌素-藻酸盐低聚物缀合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7702261L (sv) * 1976-03-02 1977-09-07 Pharmaco Inc Forfarande for att immobilisera antimikrobiella emnen
JPS5813519A (ja) * 1981-07-16 1983-01-26 Seikagaku Kogyo Co Ltd エンドトキシン吸着材及びそれを用いるエンドトキシンの除去方法
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer

Also Published As

Publication number Publication date
CA2029997A1 (en) 1991-05-16
IL96326A0 (en) 1991-08-16
AU6655590A (en) 1991-05-23
EP0428486A1 (de) 1991-05-22
JPH082917B2 (ja) 1996-01-17
AU639952B2 (en) 1993-08-12
NZ236050A (en) 1993-04-28
KR0184858B1 (ko) 1999-05-01
ATE111746T1 (de) 1994-10-15
EP0428486B1 (de) 1994-09-21
ES2063326T3 (es) 1995-01-01
IE904105A1 (en) 1991-05-22
MY104520A (en) 1994-04-30
HU210901A9 (en) 1995-09-28
DK0428486T3 (da) 1995-01-09
CY2052B1 (en) 1998-04-30
KR910009274A (ko) 1991-06-28
IL96326A (en) 1995-07-31
IE65268B1 (en) 1995-10-18
JPH03220198A (ja) 1991-09-27
ZA909187B (en) 1992-07-29
HK49696A (en) 1996-03-29
DE69012747T2 (de) 1995-03-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: NOVARTIS AG, BASEL, CH

8328 Change in the person/name/address of the agent

Free format text: SPOTT WEINMILLER & PARTNER, 80336 MUENCHEN

8339 Ceased/non-payment of the annual fee