IL96326A - Polymyxin conjugates, their preparation and pharmaceutical preparations containing them - Google Patents

Polymyxin conjugates, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL96326A
IL96326A IL9632690A IL9632690A IL96326A IL 96326 A IL96326 A IL 96326A IL 9632690 A IL9632690 A IL 9632690A IL 9632690 A IL9632690 A IL 9632690A IL 96326 A IL96326 A IL 96326A
Authority
IL
Israel
Prior art keywords
conjugate
polymyxin
carrier
conjugate according
pmb
Prior art date
Application number
IL9632690A
Other languages
English (en)
Hebrew (he)
Other versions
IL96326A0 (en
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IL96326A0 publication Critical patent/IL96326A0/xx
Publication of IL96326A publication Critical patent/IL96326A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
IL9632690A 1989-11-15 1990-11-13 Polymyxin conjugates, their preparation and pharmaceutical preparations containing them IL96326A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43748789A 1989-11-15 1989-11-15

Publications (2)

Publication Number Publication Date
IL96326A0 IL96326A0 (en) 1991-08-16
IL96326A true IL96326A (en) 1995-07-31

Family

ID=23736660

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9632690A IL96326A (en) 1989-11-15 1990-11-13 Polymyxin conjugates, their preparation and pharmaceutical preparations containing them

Country Status (17)

Country Link
EP (1) EP0428486B1 (de)
JP (1) JPH082917B2 (de)
KR (1) KR0184858B1 (de)
AT (1) ATE111746T1 (de)
AU (1) AU639952B2 (de)
CA (1) CA2029997A1 (de)
CY (1) CY2052B1 (de)
DE (1) DE69012747T2 (de)
DK (1) DK0428486T3 (de)
ES (1) ES2063326T3 (de)
HK (1) HK49696A (de)
HU (1) HU210901A9 (de)
IE (1) IE65268B1 (de)
IL (1) IL96326A (de)
MY (1) MY104520A (de)
NZ (1) NZ236050A (de)
ZA (1) ZA909187B (de)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6660267B1 (en) 1992-12-21 2003-12-09 Promega Corporation Prevention and treatment of sepsis
WO1994014437A1 (en) * 1992-12-21 1994-07-07 Ophidian Pharmaceuticals, Inc. Prevention and treatment of sepsis
US6579696B1 (en) * 1992-12-21 2003-06-17 Promega Corporation Polymyxin B conjugates
US5545721A (en) * 1992-12-21 1996-08-13 Ophidian Pharmaceuticals, Inc. Conjugates for the prevention and treatment of sepsis
US6180134B1 (en) 1993-03-23 2001-01-30 Sequus Pharmaceuticals, Inc. Enhanced ciruclation effector composition and method
US5849301A (en) * 1993-09-22 1998-12-15 Henry M. Jackson Foundation For The Advancement Of Military Medicine Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents
JP3828145B2 (ja) * 1993-09-22 2006-10-04 ヘンリー エム．ジャクソン ファウンデイション フォー ザ アドバンスメント オブ ミリタリー メディスン 免疫原性構成物の製造のための新規シアン化試薬を使った可溶性炭水化物の活性化方法
JP2581425B2 (ja) * 1993-11-12 1997-02-12 株式会社島津製作所 ペプチド合成用支持体及びそれを用いて製造されたペプチド
ES2200059T3 (es) * 1995-03-22 2004-03-01 Henry M. Jackson Foundation For The Advancement Of Military Medicine Produccion de construcciones inmunogenicas usando carbohidratos solubles activados mediante reactivos cianilados organicos.
DE122009000056I1 (de) * 1995-03-22 2010-01-28 Jackson H M Found Military Med Herstellung von immunogenen konstrukten unter verwendung von löslichen kohlehydraten, die durch organische cyanylierungs-reagenzien aktiviert wurden
US5691304A (en) * 1995-05-25 1997-11-25 Novartis Ag Improved process for preparing polymyxin B/dextran conjugates
US6309646B1 (en) 1996-05-09 2001-10-30 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Protein-polysaccharide conjugate vaccines and other immunological reagents prepared using homobifunctional and heterobifunctional vinylsulfones, and processes for preparing the conjugates
US5998381A (en) * 1996-12-06 1999-12-07 Ophidian Pharmaceuticals, Inc. Compounds that bind bacterial pili
IT1312110B1 (it) 1999-05-18 2002-04-04 Istituto Biochimico Pavese Pha Addotti antibiotico-polimero polisaccaridico naturale
DE10129369C1 (de) * 2001-06-21 2003-03-06 Fresenius Kabi De Gmbh Wasserlösliches, einen Aminozucker aufweisendes Antibiotikum in Form eines Pol ysaccharid-Konjugats
AT507846B1 (de) * 2009-01-22 2011-12-15 Fresenius Medical Care De Gmbh Sorptionsmittel für endotoxine
MX2017004176A (es) * 2014-10-03 2017-08-28 Xellia Pharmaceuticals Aps Composicion.
KR20190072579A (ko) * 2016-10-21 2019-06-25 알지파마 에이에스 폴리믹신-알기네이트 올리고머 콘주게이트

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7702261L (sv) * 1976-03-02 1977-09-07 Pharmaco Inc Forfarande for att immobilisera antimikrobiella emnen
JPS5813519A (ja) * 1981-07-16 1983-01-26 Seikagaku Kogyo Co Ltd エンドトキシン吸着材及びそれを用いるエンドトキシンの除去方法
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer

Also Published As

Publication number Publication date
AU639952B2 (en) 1993-08-12
DE69012747T2 (de) 1995-03-16
AU6655590A (en) 1991-05-23
JPH082917B2 (ja) 1996-01-17
JPH03220198A (ja) 1991-09-27
CA2029997A1 (en) 1991-05-16
IE65268B1 (en) 1995-10-18
ATE111746T1 (de) 1994-10-15
ZA909187B (en) 1992-07-29
HK49696A (en) 1996-03-29
HU210901A9 (en) 1995-09-28
DE69012747D1 (de) 1994-10-27
DK0428486T3 (da) 1995-01-09
EP0428486A1 (de) 1991-05-22
MY104520A (en) 1994-04-30
EP0428486B1 (de) 1994-09-21
NZ236050A (en) 1993-04-28
ES2063326T3 (es) 1995-01-01
CY2052B1 (en) 1998-04-30
KR0184858B1 (ko) 1999-05-01
KR910009274A (ko) 1991-06-28
IL96326A0 (en) 1991-08-16
IE904105A1 (en) 1991-05-22

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Legal Events

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