IL96326A - Polymyxin conjugates, their preparation and pharmaceutical preparations containing them - Google Patents

Polymyxin conjugates, their preparation and pharmaceutical preparations containing them

Info

Publication number
IL96326A
IL96326A IL9632690A IL9632690A IL96326A IL 96326 A IL96326 A IL 96326A IL 9632690 A IL9632690 A IL 9632690A IL 9632690 A IL9632690 A IL 9632690A IL 96326 A IL96326 A IL 96326A
Authority
IL
Israel
Prior art keywords
conjugate
polymyxin
carrier
conjugate according
pmb
Prior art date
Application number
IL9632690A
Other languages
English (en)
Hebrew (he)
Other versions
IL96326A0 (en
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of IL96326A0 publication Critical patent/IL96326A0/xx
Publication of IL96326A publication Critical patent/IL96326A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
IL9632690A 1989-11-15 1990-11-13 Polymyxin conjugates, their preparation and pharmaceutical preparations containing them IL96326A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US43748789A 1989-11-15 1989-11-15

Publications (2)

Publication Number Publication Date
IL96326A0 IL96326A0 (en) 1991-08-16
IL96326A true IL96326A (en) 1995-07-31

Family

ID=23736660

Family Applications (1)

Application Number Title Priority Date Filing Date
IL9632690A IL96326A (en) 1989-11-15 1990-11-13 Polymyxin conjugates, their preparation and pharmaceutical preparations containing them

Country Status (17)

Country Link
EP (1) EP0428486B1 (ko)
JP (1) JPH082917B2 (ko)
KR (1) KR0184858B1 (ko)
AT (1) ATE111746T1 (ko)
AU (1) AU639952B2 (ko)
CA (1) CA2029997A1 (ko)
CY (1) CY2052B1 (ko)
DE (1) DE69012747T2 (ko)
DK (1) DK0428486T3 (ko)
ES (1) ES2063326T3 (ko)
HK (1) HK49696A (ko)
HU (1) HU210901A9 (ko)
IE (1) IE65268B1 (ko)
IL (1) IL96326A (ko)
MY (1) MY104520A (ko)
NZ (1) NZ236050A (ko)
ZA (1) ZA909187B (ko)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5545721A (en) * 1992-12-21 1996-08-13 Ophidian Pharmaceuticals, Inc. Conjugates for the prevention and treatment of sepsis
JPH08504824A (ja) * 1992-12-21 1996-05-28 オフィディアン ファーマシューティカルズ，インコーポレーテッド 敗血症の予防および治療
US6660267B1 (en) 1992-12-21 2003-12-09 Promega Corporation Prevention and treatment of sepsis
US6579696B1 (en) * 1992-12-21 2003-06-17 Promega Corporation Polymyxin B conjugates
US6180134B1 (en) 1993-03-23 2001-01-30 Sequus Pharmaceuticals, Inc. Enhanced ciruclation effector composition and method
EP0720485B1 (en) * 1993-09-22 2003-11-19 Henry M. Jackson Foundation For The Advancement Of Military Medicine Method of activating soluble carbohydrate using novel cyanylating reagents for the production of immunogenic constructs
US5849301A (en) * 1993-09-22 1998-12-15 Henry M. Jackson Foundation For The Advancement Of Military Medicine Producing immunogenic constructs using soluable carbohydrates activated via organic cyanylating reagents
JP2581425B2 (ja) * 1993-11-12 1997-02-12 株式会社島津製作所 ペプチド合成用支持体及びそれを用いて製造されたペプチド
DE122009000056I1 (de) * 1995-03-22 2010-01-28 Jackson H M Found Military Med Herstellung von immunogenen konstrukten unter verwendung von löslichen kohlehydraten, die durch organische cyanylierungs-reagenzien aktiviert wurden
EP0814833B1 (en) * 1995-03-22 2003-05-28 Henry M. Jackson Foundation For The Advancement Of Military Medicine Producing immunogenic constructs using soluble carbohydrates activated via organic cyanylating reagents
US5691304A (en) * 1995-05-25 1997-11-25 Novartis Ag Improved process for preparing polymyxin B/dextran conjugates
US6309646B1 (en) 1996-05-09 2001-10-30 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Protein-polysaccharide conjugate vaccines and other immunological reagents prepared using homobifunctional and heterobifunctional vinylsulfones, and processes for preparing the conjugates
US5998381A (en) * 1996-12-06 1999-12-07 Ophidian Pharmaceuticals, Inc. Compounds that bind bacterial pili
IT1312110B1 (it) 1999-05-18 2002-04-04 Istituto Biochimico Pavese Pha Addotti antibiotico-polimero polisaccaridico naturale
DE10129369C1 (de) * 2001-06-21 2003-03-06 Fresenius Kabi De Gmbh Wasserlösliches, einen Aminozucker aufweisendes Antibiotikum in Form eines Pol ysaccharid-Konjugats
AT507846B1 (de) * 2009-01-22 2011-12-15 Fresenius Medical Care De Gmbh Sorptionsmittel für endotoxine
PT3200827T (pt) * 2014-10-03 2020-10-08 Xellia Pharmaceuticals Aps Composições
CN109843315A (zh) * 2016-10-21 2019-06-04 阿尔吉法玛公司 多粘菌素-藻酸盐低聚物缀合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE7702261L (sv) * 1976-03-02 1977-09-07 Pharmaco Inc Forfarande for att immobilisera antimikrobiella emnen
JPS5813519A (ja) * 1981-07-16 1983-01-26 Seikagaku Kogyo Co Ltd エンドトキシン吸着材及びそれを用いるエンドトキシンの除去方法
US4496689A (en) * 1983-12-27 1985-01-29 Miles Laboratories, Inc. Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer

Also Published As

Publication number Publication date
CA2029997A1 (en) 1991-05-16
IL96326A0 (en) 1991-08-16
AU6655590A (en) 1991-05-23
EP0428486A1 (en) 1991-05-22
JPH082917B2 (ja) 1996-01-17
AU639952B2 (en) 1993-08-12
NZ236050A (en) 1993-04-28
KR0184858B1 (ko) 1999-05-01
ATE111746T1 (de) 1994-10-15
EP0428486B1 (en) 1994-09-21
ES2063326T3 (es) 1995-01-01
IE904105A1 (en) 1991-05-22
MY104520A (en) 1994-04-30
HU210901A9 (en) 1995-09-28
DK0428486T3 (da) 1995-01-09
CY2052B1 (en) 1998-04-30
KR910009274A (ko) 1991-06-28
IE65268B1 (en) 1995-10-18
JPH03220198A (ja) 1991-09-27
DE69012747D1 (de) 1994-10-27
ZA909187B (en) 1992-07-29
HK49696A (en) 1996-03-29
DE69012747T2 (de) 1995-03-16

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Legal Events

Date Code Title Description
KB Patent renewed
HC Change of name of proprietor(s)
KB Patent renewed