KR910009250A - 약제의 국부 투여에 있어서 이온삼투요법과 함께 사용되는 경피 유출 증진제 - Google Patents

약제의 국부 투여에 있어서 이온삼투요법과 함께 사용되는 경피 유출 증진제 Download PDF

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KR910009250A
KR910009250A KR1019900019334A KR900019334A KR910009250A KR 910009250 A KR910009250 A KR 910009250A KR 1019900019334 A KR1019900019334 A KR 1019900019334A KR 900019334 A KR900019334 A KR 900019334A KR 910009250 A KR910009250 A KR 910009250A
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cis
acid
pharmaceutically acceptable
formula
medicament
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KR1019900019334A
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KR930007248B1 (ko
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리 프랑코이어 마이클
오웬 파츠 러셀
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제이. 트레버 럼
화이자 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0009—Galenical forms characterised by the drug release technique; Application systems commanded by energy involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M2037/0007—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin having means for enhancing the permeation of substances through the epidermis, e.g. using suction or depression, electric or magnetic fields, sound waves or chemical agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

내용 없음

Description

약제의 국부 투여에 있어서 이온삼투요법과 함께 사용되는 경피 유출 증진제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. (a) 안전효과량의 약제; (b)수성 용매; 및 (c)경피 유출을 증가시키는 양의 1-알킬아자사이클로헵탄-2-온(여기에서, 상기 알킬은 8개 내지 16개의 탄소원자를 갖는다), 또는 일반식 CH₃(CH₂)×CH=CH(CH₂)yR³(여기에서, R³는 CH₂OH, CH₂NH₂또는 COR⁴이고, R⁴는 OH또는 (C₁-C₄)알콕시이며, x 및 y는 각각 3내지 13의 정수이고 x와 y의 합은 10 내지 16이다)의 시스-올레핀인 피부침투 증진제를 포함하는 약학적 조성물을 이온삼투 요법으로 투여함을 포함하는 인간 또는 하등동물의 질병치료 방법.
  2. 제 1항에 있어서, 상기 피부 침투 증진제가 시스-9-테트라데세노산, 시스-6-펜타데세노산, 시스-6-헥사데세노산, 시스-9-헥사데세노산, 시스-9-옥타데세노산(올레산), 시스-6-옥타데세노산, 시스-11-옥타데세노산, 시스-12-옥타데세노산, 시스-5-에이코세노산, 시스-9-에이코세노산, 시스-11-에이코세노산, 시스-14-에이코세노산, 1-데실아자사이클로헵탄-2-온 또는 1-테트라데실아자사이클로헵탄-2-온인 방법.
  3. 제 2항에 있어서, 상기 피부 침투 증진제가 시스-9-옥타데세노산인 방법.
  4. 제 1항에 있어서, 상기 약제가 이온화되거나, 또는 이온화될 수 있는 방법.
  5. 제 4항에 있어서, 상기 진통제 또는 소염제가 아스피린, 아세트 아미노펜, 인도메타신, 이부프로펜, 나프록센, 하기 구조식(Ⅰ)화합물, 피록시캄, 또는 하기 일반식(Ⅱa) 또는 하기 구조식(Ⅱb)의 피록시캄 전구약제 또는 그의 약학적으로 허용가능한 염인 방법:
    상기식에서, R은 CH(R¹)OCOR²또는 초(R¹)OCOOR²이고, R¹은 수소 또는 메틸이며, R²는 (C₁-C)알킬이다.
  6. 제 4항에 있어서, 상기 항세균제가 에러트로마이신, 아지트로마이신, 옥시테트라사이클린, 테트라사이클린, 독시사이클린, 페니실린 G, 페니실린 V, 암피실린 또는 아목시실린; 또는 그의 약학적으로 허용가능한 염인 방법.
  7. 제 4항에 있어서, 상기 항진균제가 플루콘아졸 또는 티오콘아졸, 또는 그의 약학적으로 허용가능한 염인 방법.
  8. 제 4항에 있어서, 상기 약제가 니페디핀, 암로디핀, 프라조신, 독사조신, 하기 구조식(Ⅲ) 화합물;또는 하기 일반식(Ⅳ)화합물; 또는 그의 약학적으로 허용 가능한 염인 방법:
    상기식에서, x는 O 또는 C=O이다.
  9. 제4항에 있어서, 상기 약재가 세트랄린, 인슐린, 글리피지드, 하기 구조식(Ⅴ)화합물, 또는 하기 구조식(Ⅵ)화합물;또는 그의 약학적으로 허용가능한 염인 방법:
  10. 제4항 내지 제9항중 어느 한 항에 있어서, 상기 피부 침투 증진제가 시스-9-옥타데세노산인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900019334A 1989-11-29 1990-11-28 약제의 국부 투여에 있어서 이온삼투요법과 함께 사용되는 경피 유출 증진제를 포함하는 약학조성물 KR930007248B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US443.699 1989-11-29
US07/443,699 US5023085A (en) 1989-11-29 1989-11-29 Transdermal flux enhancers in combination with iontophoresis in topical administration of pharmaceuticals

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KR910009250A true KR910009250A (ko) 1991-06-28
KR930007248B1 KR930007248B1 (ko) 1993-08-04

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US (1) US5023085A (ko)
EP (1) EP0435436B1 (ko)
JP (1) JPH0688912B2 (ko)
KR (1) KR930007248B1 (ko)
AT (1) ATE99961T1 (ko)
AU (1) AU613281B1 (ko)
CA (1) CA2030943A1 (ko)
DE (1) DE69006000T2 (ko)
DK (1) DK0435436T3 (ko)
HU (1) HUT55629A (ko)
IE (1) IE63597B1 (ko)
IL (1) IL96449A (ko)
MY (1) MY109727A (ko)
NZ (1) NZ236253A (ko)
PH (1) PH27105A (ko)
PT (1) PT96021B (ko)
ZA (1) ZA909512B (ko)

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EP0435436B1 (en) 1994-01-12
DE69006000D1 (de) 1994-02-24
PH27105A (en) 1993-03-16
PT96021A (pt) 1991-09-13
JPH0688912B2 (ja) 1994-11-09
JPH03176426A (ja) 1991-07-31
HUT55629A (en) 1991-06-28
IE904281A1 (en) 1991-06-05
ATE99961T1 (de) 1994-01-15
IE63597B1 (en) 1995-05-17
DK0435436T3 (da) 1994-02-28
US5023085A (en) 1991-06-11
MY109727A (en) 1997-05-31
PT96021B (pt) 1998-02-27
DE69006000T2 (de) 1994-05-05
CA2030943A1 (en) 1991-05-30
NZ236253A (en) 1993-05-26
ZA909512B (en) 1992-06-24
AU613281B1 (en) 1991-07-25
EP0435436A3 (en) 1992-01-08
IL96449A (en) 1996-07-23
KR930007248B1 (ko) 1993-08-04
EP0435436A2 (en) 1991-07-03

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