KR910008352B1 - 세파로스포린 유도체의 제법 - Google Patents

세파로스포린 유도체의 제법 Download PDF

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Publication number
KR910008352B1
KR910008352B1 KR1019840003102A KR840003102A KR910008352B1 KR 910008352 B1 KR910008352 B1 KR 910008352B1 KR 1019840003102 A KR1019840003102 A KR 1019840003102A KR 840003102 A KR840003102 A KR 840003102A KR 910008352 B1 KR910008352 B1 KR 910008352B1
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KR
South Korea
Prior art keywords
formula
compound
solvent
alkyl
general formula
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Expired
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KR1019840003102A
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English (en)
Korean (ko)
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KR850000458A (ko
Inventor
헨리 장 프레데릭
Original Assignee
아이.씨.아이.파마
케네스 존 하녤
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Application filed by 아이.씨.아이.파마, 케네스 존 하녤 filed Critical 아이.씨.아이.파마
Publication of KR850000458A publication Critical patent/KR850000458A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/57—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with a further substituent in position 7, e.g. cephamycines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D505/00—Heterocyclic compounds containing 5-oxa-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1019840003102A 1983-06-03 1984-06-04 세파로스포린 유도체의 제법 Expired KR910008352B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP83401135 1983-06-03
GB401135.5 1983-06-03
GB848413152A GB8413152D0 (en) 1983-06-03 1984-05-23 Cephalosporin derivatives
GB13152 1984-05-23

Publications (2)

Publication Number Publication Date
KR850000458A KR850000458A (ko) 1985-02-27
KR910008352B1 true KR910008352B1 (ko) 1991-10-12

Family

ID=8191406

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840003102A Expired KR910008352B1 (ko) 1983-06-03 1984-06-04 세파로스포린 유도체의 제법

Country Status (19)

Country Link
US (1) US4678781A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0127992B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPH0633283B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR910008352B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU585831B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1272188A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3486033T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DK (1) DK271584A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES533084A0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI80043C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (1) GB8413152D0 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR81617B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HU (1) HU196811B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL71969A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NO (1) NO164301C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ208360A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH22334A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PT (1) PT78685B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA844052B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4855420A (en) * 1983-06-03 1989-08-08 Ici Pharma Cephalosporin derivatives
FI851934L (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporinderivat.
US4868173A (en) * 1984-11-20 1989-09-19 Ici Pharma Cephalosporin derivatives
EP0187456A1 (en) * 1984-11-29 1986-07-16 Ici Pharma Cephalosporin derivatives
US4840945A (en) * 1985-04-01 1989-06-20 Mochida Pharmaceutical Co., Ltd. Cephalosporin derivatives
GB8626245D0 (en) * 1985-11-27 1986-12-03 Ici Pharma Cephalosporin compounds
US4684722A (en) * 1986-01-06 1987-08-04 E. R. Squibb & Sons, Inc. Monosulfactams
GB8611823D0 (en) * 1986-05-15 1986-06-25 Ici Plc Process
ZA877987B (en) * 1986-11-12 1988-08-31 Ici Pharma Antibiotic compounds
DE3750673T2 (de) * 1986-11-21 1995-03-16 Ici Pharma Cephalosporine, Verfahren zu ihrer Herstellung und pharmazeutische Präparate.
US5262410A (en) * 1986-12-23 1993-11-16 Ici Pharma 3-heterocyclic thiomethyl cephalosporins
EP0272827A3 (en) * 1986-12-23 1990-02-07 ZENECA Pharma S.A. 3-heterocyclicthiomethyl cephalosphorins
US5232918A (en) * 1987-07-23 1993-08-03 Imperial Chemical Industries Plc Cephalosporin derivatives
GB8816519D0 (en) * 1987-07-23 1988-08-17 Ici Plc Antibiotic compounds
EP0300665B1 (en) * 1987-07-23 1995-12-20 ZENECA Pharma S.A. Cephalosporin compounds, process for their preparation and their pharmaceutical compositions
ATE130299T1 (de) * 1987-07-23 1995-12-15 Zeneca Pharma Sa Cephalosporinverbindungen, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische präparate.
AT395854B (de) * 1991-05-24 1993-03-25 Biochemie Gmbh Neues verfahren zur herstellung von 7-amino-3azidomethyl-3-cephem-4-carbonsaeure und deren derivate
US5817520A (en) * 1991-12-20 1998-10-06 Oxis International S.A. Spectrophotometric methods for assaying total mercaptans, reduced glutathione (GSH) and mercaptans other than GSH in an aqueous medium reagents and kits for implementing same
DE19647413A1 (de) * 1996-11-15 1998-05-20 Hoechst Schering Agrevo Gmbh Substituierte Stickstoff-Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel
DE10225537A1 (de) * 2002-06-10 2003-12-18 Bayer Ag N-alkylierte Thiazoliumsalze und Verfahren zu deren Herstellung
US20150072396A1 (en) 2011-03-04 2015-03-12 Life Technologies Corporation Compounds and Methods for Conjugation of Biomolecules
JP7158717B2 (ja) * 2017-11-22 2022-10-24 国立大学法人九州工業大学 求電子的アジド化剤又はジアゾ化剤

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1584713A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1967-01-18 1970-01-02
GB1478055A (en) * 1973-07-27 1977-06-29 Erba Carlo Spa Cephalosporin compounds
DE2715385A1 (de) * 1976-04-14 1977-11-10 Takeda Chemical Industries Ltd Cephalosporinderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
FR2432521A1 (fr) 1978-03-31 1980-02-29 Roussel Uclaf Nouvelles oximes o-substituees derivees de l'acide 7-amino thiazolyl acetamido cephalosporanique, leur procede de preparation et leur application comme medicaments
DE2818263A1 (de) * 1978-04-26 1979-11-08 Bayer Ag Beta-lactamantibiotika
GB1604724A (en) * 1978-05-26 1981-12-16 Glaxo Operations Ltd 7-(2-aminothiazol-4-yl)-2-oxymino-acedamido)-cephem derivatives
ZA807323B (en) * 1978-05-26 1981-02-25 Glaxo Group Ltd Cephalosporin antibiotics
GB2036738B (en) * 1978-11-17 1983-01-19 Glaxo Group Ltd Cephalosporin antibiotics
GB2046261B (en) * 1979-03-22 1983-07-20 Glaxo Group Ltd Cephalosporin antibiotics
DE3071707D1 (en) * 1979-04-27 1986-09-25 Merck & Co Inc 7-n-heterocyclyl cephalosporins, a process for preparing and a pharmaceutical composition comprising the same
JPS57167993A (en) * 1981-04-09 1982-10-16 Yamanouchi Pharmaceut Co Ltd Novel 3-((4-carboxy-3-hydroxyisothiazole-5-yl) thiomethyl)-delta3-cephem derivative
GB2103205A (en) * 1981-06-15 1983-02-16 Fujisawa Pharmaceutical Co New cephem compounds
AU8474382A (en) * 1981-06-19 1982-12-23 Imperial Chemical Industries Plc Process of preparing cephalosporin antibiotics
JPS5876088A (ja) * 1981-10-27 1983-05-09 Nippon Paint Co Ltd 固定化植物組織
US4401668A (en) * 1981-10-02 1983-08-30 Eli Lilly And Company Pyrazinium substituted cephalosporins
FR2516515A1 (fr) * 1981-11-16 1983-05-20 Sanofi Sa Nouveaux derives de pyridinium thiomethyl cephalosporines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2530248A1 (fr) * 1982-07-13 1984-01-20 Sanofi Sa Nouveaux derives des cephalosporines, leur procede de preparation et medicaments antibiotiques contenant lesdits derives
HU188874B (en) * 1983-04-19 1986-05-28 Biogal Gyogyszergyar,Hu Process for producing new 7-acylamido-3-acylaminomethyl-ceph-3-eme-4-carboxylic acid derivatives and pharmaceutically acceptable salts thereof
US4560749A (en) * 1983-11-18 1985-12-24 Eli Lilly And Company Cephem-3-imidates and 3-amidines
FI851934L (fi) * 1984-05-30 1985-12-01 Ici Plc Kefalosporinderivat.

Also Published As

Publication number Publication date
IL71969A (en) 1988-03-31
KR850000458A (ko) 1985-02-27
ZA844052B (en) 1985-01-30
CA1272188A (en) 1990-07-31
PT78685A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-06-01
NO164301C (no) 1990-09-19
AU2894384A (en) 1984-12-06
PH22334A (en) 1988-08-12
EP0127992A3 (en) 1985-11-21
US4678781A (en) 1987-07-07
HUT34499A (en) 1985-03-28
JPS6045584A (ja) 1985-03-12
HU196811B (en) 1989-01-30
DE3486033T2 (de) 1993-05-06
DK271584D0 (da) 1984-06-01
NO164301B (no) 1990-06-11
NZ208360A (en) 1988-01-08
EP0127992B1 (en) 1993-01-13
GB8413152D0 (en) 1984-06-27
PT78685B (en) 1986-10-21
FI80043C (fi) 1990-04-10
FI842211A7 (fi) 1984-12-04
IL71969A0 (en) 1984-09-30
AU585831B2 (en) 1989-06-29
FI80043B (fi) 1989-12-29
ES8601213A1 (es) 1985-10-16
ES533084A0 (es) 1985-10-16
DE3486033D1 (de) 1993-02-25
JPH0633283B2 (ja) 1994-05-02
GR81617B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1984-12-11
FI842211A0 (fi) 1984-06-01
EP0127992A2 (en) 1984-12-12
NO842214L (no) 1984-12-04
DK271584A (da) 1984-12-04

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