KR910004575B1 - 안정화 항균성 동결 건조 제제의 제조방법 - Google Patents

안정화 항균성 동결 건조 제제의 제조방법 Download PDF

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Publication number
KR910004575B1
KR910004575B1 KR1019840004996A KR840004996A KR910004575B1 KR 910004575 B1 KR910004575 B1 KR 910004575B1 KR 1019840004996 A KR1019840004996 A KR 1019840004996A KR 840004996 A KR840004996 A KR 840004996A KR 910004575 B1 KR910004575 B1 KR 910004575B1
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KR
South Korea
Prior art keywords
stabilizer
acid
alkali metal
sodium
hours
Prior art date
Application number
KR1019840004996A
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English (en)
Korean (ko)
Other versions
KR850001687A (ko
Inventor
가즈히로 시마
마사요시 이노우에
다까유끼 스까다
Original Assignee
시오노기 세이야꾸 가부시끼가이샤
요시또시 가즈오
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 시오노기 세이야꾸 가부시끼가이샤, 요시또시 가즈오 filed Critical 시오노기 세이야꾸 가부시끼가이샤
Publication of KR850001687A publication Critical patent/KR850001687A/ko
Application granted granted Critical
Publication of KR910004575B1 publication Critical patent/KR910004575B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Cephalosporin Compounds (AREA)
KR1019840004996A 1983-08-22 1984-08-18 안정화 항균성 동결 건조 제제의 제조방법 KR910004575B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP153938 1983-08-22
JP153938/83 1983-08-22
JP58153938A JPS6045514A (ja) 1983-08-22 1983-08-22 安定な抗菌性凍結乾燥製剤

Publications (2)

Publication Number Publication Date
KR850001687A KR850001687A (ko) 1985-04-01
KR910004575B1 true KR910004575B1 (ko) 1991-07-06

Family

ID=15573358

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019840004996A KR910004575B1 (ko) 1983-08-22 1984-08-18 안정화 항균성 동결 건조 제제의 제조방법

Country Status (20)

Country Link
US (1) US4616083A (fr)
EP (1) EP0134568B1 (fr)
JP (1) JPS6045514A (fr)
KR (1) KR910004575B1 (fr)
AR (1) AR242390A1 (fr)
AT (1) ATE38774T1 (fr)
CA (1) CA1231896A (fr)
DE (2) DE3475268D1 (fr)
DK (1) DK163032C (fr)
ES (1) ES535654A0 (fr)
FI (1) FI83476C (fr)
GB (1) GB2145333B (fr)
GR (1) GR80147B (fr)
IE (1) IE57587B1 (fr)
IL (1) IL72731A (fr)
NO (1) NO165223C (fr)
NZ (1) NZ209111A (fr)
PT (1) PT79093B (fr)
SU (1) SU1433390A3 (fr)
ZA (1) ZA846104B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61130223A (ja) * 1984-11-28 1986-06-18 Shionogi & Co Ltd 抗菌性凍結乾燥製剤
US4808617A (en) * 1985-12-18 1989-02-28 Bristol-Myers Company Lyophilized or precipitated cephalosporin zwitterion and salt combination
DE3801179A1 (de) * 1988-01-18 1989-07-27 Hoechst Ag Stabilisierung von cephalosporinderivaten durch trocknung mit einem stabilisator sowie stabile zubereitungsformen mit cephalosporinderivaten
KR0154343B1 (ko) * 1990-11-06 1998-11-16 아만 히데아키 동결 건조 제제 및 이의 제조방법
US7378408B2 (en) * 2001-11-30 2008-05-27 Pfizer Inc. Methods of treatment and formulations of cephalosporin
AU2003241675A1 (en) * 2002-06-21 2004-01-06 Shionogi And Co., Ltd. Medicinal cephem compound composition for injection
KR101314500B1 (ko) 2012-12-28 2013-10-07 제일약품주식회사 안정성이 개선된 옥사세펨 제제 및 그 제조방법
KR102226197B1 (ko) 2013-03-15 2021-03-11 머크 샤프 앤드 돔 코포레이션 세프톨로잔 항균성 조성물
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US9320740B2 (en) 2013-03-15 2016-04-26 Merck Sharp & Dohme Corp. Ceftolozane-tazobactam pharmaceutical compositions
WO2015035376A2 (fr) 2013-09-09 2015-03-12 Calixa Therapeutics, Inc. Traitement d'infections au moyen de ceftolozane/tazobactam chez des sujets ayant une fonction rénale altérée
US20150094293A1 (en) 2013-09-27 2015-04-02 Calixa Therapeutics, Inc. Solid forms of ceftolozane
WO2016035846A1 (fr) * 2014-09-04 2016-03-10 塩野義製薬株式会社 Préparation pharmaceutique comprenant une céphalosporine ayant des groupes catéchol

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA919593A (en) * 1969-03-31 1973-01-23 Nippon Kayaku Kabushiki Kaisha Process for manufacturing a preparation containing finely divided chloramphenicol palmitate
US3993753A (en) * 1974-08-26 1976-11-23 American Home Products Corporation Anhydrous ampicillin stabilization and resultant compositions
US4180571A (en) * 1976-03-25 1979-12-25 Shionogi & Co., Ltd. Arylmalonamido-1-oxadethiacephalosporins
JPS5711909A (en) * 1980-06-23 1982-01-21 Shionogi & Co Ltd Stable freeze-dried preparation of beta-lactam
JPS5762284A (en) * 1980-10-01 1982-04-15 Sumitomo Chem Co Ltd Stabilizing method
JPS59139385A (ja) * 1982-12-23 1984-08-10 Shionogi & Co Ltd フルオロメチルチオオキサセフアロスポリン

Also Published As

Publication number Publication date
GB8420296D0 (en) 1984-09-12
KR850001687A (ko) 1985-04-01
IE842072L (en) 1985-02-22
NZ209111A (en) 1987-02-20
FI843261A0 (fi) 1984-08-17
JPS6045514A (ja) 1985-03-12
DK163032C (da) 1992-06-15
US4616083A (en) 1986-10-07
NO843313L (no) 1985-02-25
ES8505815A1 (es) 1985-06-16
EP0134568B1 (fr) 1988-11-23
GB2145333B (en) 1987-01-07
FI843261A (fi) 1985-02-23
ATE38774T1 (de) 1988-12-15
AR242390A1 (es) 1993-03-31
DK399684D0 (da) 1984-08-21
ZA846104B (en) 1985-03-27
NO165223C (no) 1991-01-30
FI83476C (fi) 1991-07-25
NO165223B (no) 1990-10-08
ES535654A0 (es) 1985-06-16
DE3475268D1 (en) 1988-12-29
DK163032B (da) 1992-01-13
IL72731A (en) 1988-04-29
FI83476B (fi) 1991-04-15
IE57587B1 (en) 1993-01-13
SU1433390A3 (ru) 1988-10-23
PT79093B (en) 1986-08-14
EP0134568A1 (fr) 1985-03-20
IL72731A0 (en) 1984-11-30
JPH0370688B2 (fr) 1991-11-08
DE134568T1 (de) 1985-08-29
PT79093A (en) 1984-09-01
DK399684A (da) 1985-02-23
GB2145333A (en) 1985-03-27
GR80147B (en) 1984-12-18
CA1231896A (fr) 1988-01-26

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