KR910002704B1 - 폴리삭카라이드-단백질 결합체, 이의 제조방법 및 이를 함유하는 조성물 - Google Patents

폴리삭카라이드-단백질 결합체, 이의 제조방법 및 이를 함유하는 조성물 Download PDF

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Publication number
KR910002704B1
KR910002704B1 KR1019850009584A KR850009584A KR910002704B1 KR 910002704 B1 KR910002704 B1 KR 910002704B1 KR 1019850009584 A KR1019850009584 A KR 1019850009584A KR 850009584 A KR850009584 A KR 850009584A KR 910002704 B1 KR910002704 B1 KR 910002704B1
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South Korea
Prior art keywords
polysaccharide
protein
polysaccharides
reagent
conjugate
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Expired
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KR1019850009584A
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English (en)
Korean (ko)
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KR860004923A (ko
Inventor
마버그 스테판
엘. 톨맨 리챠드
에이. 죤 데보라
Original Assignee
머크 앤드 컴패니 인코포레이티드
제임스 에프. 노톤
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Publication of KR860004923A publication Critical patent/KR860004923A/ko
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Publication of KR910002704B1 publication Critical patent/KR910002704B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6068—Other bacterial proteins, e.g. OMP
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/831—Drug, bio-affecting and body treating compositions involving capsular polysaccharide of bacterium, e.g. polyribosyl ribitol phosphate

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicinal Preparation (AREA)
KR1019850009584A 1984-12-20 1985-12-19 폴리삭카라이드-단백질 결합체, 이의 제조방법 및 이를 함유하는 조성물 Expired KR910002704B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US68440184A 1984-12-20 1984-12-20
US684,401 1984-12-20

Publications (2)

Publication Number Publication Date
KR860004923A KR860004923A (ko) 1986-07-16
KR910002704B1 true KR910002704B1 (ko) 1991-05-03

Family

ID=24747887

Family Applications (1)

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KR1019850009584A Expired KR910002704B1 (ko) 1984-12-20 1985-12-19 폴리삭카라이드-단백질 결합체, 이의 제조방법 및 이를 함유하는 조성물

Country Status (20)

Country Link
US (1) US4830852A (cg-RX-API-DMAC7.html)
EP (1) EP0186576B1 (cg-RX-API-DMAC7.html)
JP (1) JPH0825900B2 (cg-RX-API-DMAC7.html)
KR (1) KR910002704B1 (cg-RX-API-DMAC7.html)
CN (1) CN1017867B (cg-RX-API-DMAC7.html)
AT (1) ATE78492T1 (cg-RX-API-DMAC7.html)
AU (1) AU584149B2 (cg-RX-API-DMAC7.html)
CA (1) CA1256250A (cg-RX-API-DMAC7.html)
CY (1) CY1766A (cg-RX-API-DMAC7.html)
DE (1) DE3586398T2 (cg-RX-API-DMAC7.html)
DK (2) DK171421B1 (cg-RX-API-DMAC7.html)
ES (1) ES8701498A1 (cg-RX-API-DMAC7.html)
GR (1) GR853071B (cg-RX-API-DMAC7.html)
HK (1) HK18794A (cg-RX-API-DMAC7.html)
IE (1) IE58977B1 (cg-RX-API-DMAC7.html)
IL (1) IL77293A (cg-RX-API-DMAC7.html)
NZ (1) NZ214503A (cg-RX-API-DMAC7.html)
PT (1) PT81656B (cg-RX-API-DMAC7.html)
SG (1) SG14294G (cg-RX-API-DMAC7.html)
ZA (1) ZA859676B (cg-RX-API-DMAC7.html)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
KR20180120482A (ko) * 2017-04-27 2018-11-06 주식회사 유바이오로직스 스트렙토코커스 뉴모니아 협막 다당체의 생산방법

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FR2581877B1 (fr) * 1985-05-14 1987-12-18 Louvain Universite Catholique Conjugue constitue d'une adhesine de paroi de s. mutans, de nature proteique et d'un polysaccharide de s. mutans, sa preparation et son utilisation notamment dans des vaccins anti-caries
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KR20180120482A (ko) * 2017-04-27 2018-11-06 주식회사 유바이오로직스 스트렙토코커스 뉴모니아 협막 다당체의 생산방법

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Publication number Publication date
US4830852A (en) 1989-05-16
KR860004923A (ko) 1986-07-16
DK171421B1 (da) 1996-10-21
EP0186576A3 (en) 1989-01-25
CA1256250A (en) 1989-06-20
SG14294G (en) 1994-06-10
DE3586398D1 (de) 1992-08-27
ES550152A0 (es) 1986-12-01
AU584149B2 (en) 1989-05-18
PT81656B (pt) 1988-04-21
IE853227L (en) 1986-06-20
DK171951B1 (da) 1997-08-25
DK593285D0 (da) 1985-12-19
GR853071B (cg-RX-API-DMAC7.html) 1986-04-21
NZ214503A (en) 1990-02-26
JPH0825900B2 (ja) 1996-03-13
ATE78492T1 (de) 1992-08-15
DK98695A (da) 1995-09-07
DE3586398T2 (de) 1993-01-07
AU5146885A (en) 1986-06-26
JPS61186400A (ja) 1986-08-20
EP0186576A2 (en) 1986-07-02
HK18794A (en) 1994-03-11
CN85108890A (zh) 1986-11-19
IE58977B1 (en) 1993-12-15
IL77293A (en) 1990-11-05
CY1766A (en) 1994-07-15
EP0186576B1 (en) 1992-07-22
DK593285A (da) 1986-06-21
PT81656A (en) 1986-01-01
ZA859676B (en) 1986-08-27
ES8701498A1 (es) 1986-12-01
CN1017867B (zh) 1992-08-19

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