KR910000135A - 심장혈관활성을 가진 2-아미노-1,2,3,4-테트라히드로나프탈렌 유도체, 그 제조방법 및 이를 함유한 약제 조성물 - Google Patents

심장혈관활성을 가진 2-아미노-1,2,3,4-테트라히드로나프탈렌 유도체, 그 제조방법 및 이를 함유한 약제 조성물 Download PDF

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KR910000135A
KR910000135A KR1019900009498A KR900009498A KR910000135A KR 910000135 A KR910000135 A KR 910000135A KR 1019900009498 A KR1019900009498 A KR 1019900009498A KR 900009498 A KR900009498 A KR 900009498A KR 910000135 A KR910000135 A KR 910000135A
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South Korea
Prior art keywords
amino
compound
methylethyl
dimethoxy
hydroxy
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KR1019900009498A
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English (en)
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키에시 파올로
봉라니 스테파노
텔차날레 마우리지오
세르바디오 비토리노
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키에시 파르마체우티치 에스.피.에이.
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Publication of KR910000135A publication Critical patent/KR910000135A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C217/74—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with rings other than six-membered aromatic rings being part of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
  • Farming Of Fish And Shellfish (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

내용 없음

Description

심장혈관활성을 가진 2-아미노-1,2,3,4-테트라히드로나프탈렌 유도체, 그 제조방법 및 이를 함유한 약제 조성물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (9)

  1. 다음 구조식의 화합물, 그의 입체 이성체 및 한가지 또는 그 이상의 입체이성체와 약리적으로 허용되는 그의 염의 혼합물.
  2. 제1항에 있어서, 에리트로-5,6-디메톡시-2〔[2-(4-히드록시페닐)-2-히드록시-1-메틸에틸〕아미노〕-1,2,3,4-테트라히드로나프탈렌 ; 트리오-5,6-디메톡시-2〔(2-(4-히드록시페닐)-2-히드록시-1-메틸에틸〕아미노〕-1,2,3,4-테트라히드로나프탈렌 ; (αR, βS)-5,6-디메톡시-2〔(2-(4-히드록시페닐)-2-히드록시-1-메틸에틸〕아미노〕-1,2,3,4-테트라히드로나프탈렌 ; (αS, βR)-5,6-디메톡시-2〔[2-(4-히드록시페닐)-2-히드록시-1-메틸에틸〕아미노〕-1,2,3,4-테트라히드로나프탈렌 ; (-)(αR, βS, γS)-5,6디메톡시-2(+)〔[2-(40히드록시 페닐)-2-히드록시-1-메틸에틸〕아미노〕-1,2,3,4-테트라히드로나프탈렌 ; (αS, βR, γR)-5,6-디메톡시-2〔(2-(4-히드록시페닐)-2-히드록시-1-메틸에틸〕아미노〕-1,2,3,4-테트라히드로나프탈렌 ; (+)(αR, βS, γS)-5,6-디메톡시-2〔(2-(4-히드록시페닐)-2-히드록시-1-메틸에틸〕아미노〕-1,2,3,4-테트라히드로나프탈렌 ; (-)(αS, βR, γS)-5,6-디메톡시-2〔[2-(4-히드록시페닐)-2-히드록시-1-메틸에틸〕아미노〕-1,2,3,4-테트라히드로나프탈렌 중에서 선택된 것을 특징으로 하는 수조식(Ⅰ)의 화합물.
  3. 다음의 5,6-디메톡시-2-테트랄론(Ⅱ)을 다음 구조식(Ⅲ)의 아민과 환원아민화반응 시키는 것을 특징으로 하는 제1항의 화합물의 제조방법.
  4. 제3항에 있어서, 수소화금속을 사용하여 환원 아민화반응을 수행하는 것을 특징으로 하는 제1항의 화합물의 제조방법.
  5. 제4항에 있어서, 수소화 금속으로서 시아노보론 수소나트륨 또는 중량비 4:1-1:1로 시아노보론 수소화나트륨의 시아노보론 수소화 테트라부틸암모늄과 혼합물을 사용하는 것을 특징으로 하는 제1항의 화합물의 제조방법.
  6. 다음 일반식(Ⅵ)의 화합물을 환원반응시키는 것으로 이루어진 것을 특징으로 하는 제1항의 화합물의 제조방법.
    상기식에서 R1및 R2는 수소 또는 벤질기 또는 유사한 입체장애를 가지며 이어서 자체공지방법으로 제거될 수 있는 기이다.
  7. 다음 일반식(Ⅵ)의 화합물,
    상기식에서 R1및 R2는 수소 또는 벤질기 또는 제1항의 화합물 제조용 중간체로서 유사한 입체장애를 가지는 기이다.
  8. 활성성분으로서 제1-2항의 화합물을 단위 투여량 당 10-100㎎의 양을 함유한 것을 특징으로 하는 심장마비와 같은 심장혈관질병의 치료용 약제조성물.
  9. 심장혈관 활성을 가진 약물의 제조를 위한 제1-2항의 화합물의 용도.
    ※참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019900009498A 1989-06-27 1990-06-26 심장혈관활성을 가진 2-아미노-1,2,3,4-테트라히드로나프탈렌 유도체, 그 제조방법 및 이를 함유한 약제 조성물 KR910000135A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8920996A IT1230931B (it) 1989-06-27 1989-06-27 Derivati di 2 ammino 1,2,3,4 tetraidronaftalene ad attivita' cardiovascolare, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono
IT20996A/89 1989-06-27

Publications (1)

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KR910000135A true KR910000135A (ko) 1991-01-29

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KR1019900009498A KR910000135A (ko) 1989-06-27 1990-06-26 심장혈관활성을 가진 2-아미노-1,2,3,4-테트라히드로나프탈렌 유도체, 그 제조방법 및 이를 함유한 약제 조성물

Country Status (18)

Country Link
US (1) US5096929A (ko)
EP (1) EP0405344B1 (ko)
JP (1) JPH0363253A (ko)
KR (1) KR910000135A (ko)
AT (1) ATE93837T1 (ko)
AU (1) AU633931B2 (ko)
CA (1) CA2019828A1 (ko)
DE (1) DE69003031T2 (ko)
DK (1) DK0405344T3 (ko)
FI (1) FI903202A0 (ko)
HU (1) HUT58276A (ko)
IE (1) IE902313A1 (ko)
IT (1) IT1230931B (ko)
MA (1) MA21884A1 (ko)
NO (1) NO173542C (ko)
NZ (1) NZ234253A (ko)
PT (1) PT94498A (ko)
ZA (1) ZA904962B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2041211B1 (es) * 1992-02-17 1994-05-16 Uriach & Cia Sa J Procedimiento para la obtencion de nuevos dihidro y tetrahidronaftalenos.
JP3708624B2 (ja) * 1996-03-27 2005-10-19 キッセイ薬品工業株式会社 ３，４−ジ置換フェニルエタノールアミノテトラリンカルボン酸誘導体
AU758370B2 (en) * 1997-08-08 2003-03-20 Duke University Compositions, apparatus and methods for facilitating surgical procedures
US6711436B1 (en) 1997-08-08 2004-03-23 Duke University Compositions, apparatus and methods for facilitating surgical procedures

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2776993A (en) * 1954-06-09 1957-01-08 Gordon A Alles 1-paramethoxyphenyl-2-cyclopentylamino-1-propanol compounds
DE1618005A1 (de) * 1966-09-22 1971-09-09 Thomae Gmbh Dr K Verfahren zur Herstellung von neuen Amino-dihalogen-phenyl-aethylaminen
US4011258A (en) * 1973-06-21 1977-03-08 Aktiebolaget Draco Orally active bronchospasmolytic compounds
IT1218322B (it) * 1982-06-10 1990-04-12 Chiesi Farma Spa Derivati di 1,2,3,4-tetraidronaftalene,procedimento di preparazione e relative composizioni farmaceutiche
ATE38029T1 (de) * 1985-06-26 1988-11-15 Smithkline Beckman Corp Benz-trisubstituierte 2-aminotetraline.
IL79323A (en) * 1985-07-10 1990-03-19 Sanofi Sa Phenylethanolaminotetralines,their preparation and pharmaceutical compositions containing them
IT1199339B (it) * 1986-12-23 1988-12-30 Sigma Tau Ind Farmaceuti N-alchil derivati della 2-ammino-6,7-dimetossi tetralina,procedimenti per la loro preparazione e composizioni farmaceutiche ad attivita'an tiipertensiva che li contengono

Also Published As

Publication number Publication date
MA21884A1 (fr) 1990-12-31
DE69003031D1 (de) 1993-10-07
NO173542B (no) 1993-09-20
AU5783290A (en) 1991-01-10
JPH0363253A (ja) 1991-03-19
EP0405344A2 (en) 1991-01-02
ATE93837T1 (de) 1993-09-15
EP0405344B1 (en) 1993-09-01
NO902838L (no) 1990-12-28
PT94498A (pt) 1991-02-08
IE902313L (en) 1990-12-27
AU633931B2 (en) 1993-02-11
FI903202A0 (fi) 1990-06-26
IE902313A1 (en) 1991-01-16
HUT58276A (en) 1992-02-28
DK0405344T3 (da) 1993-10-25
HU903990D0 (en) 1990-11-28
DE69003031T2 (de) 1993-12-16
US5096929A (en) 1992-03-17
ZA904962B (en) 1991-04-24
EP0405344A3 (en) 1991-02-06
CA2019828A1 (en) 1990-12-27
NZ234253A (en) 1992-04-28
IT8920996A0 (it) 1989-06-27
IT1230931B (it) 1991-11-08
NO902838D0 (no) 1990-06-26
NO173542C (no) 1993-12-29

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