KR900006010A - 소수성 상호작용 크로마토그래피에 의한 불안정한 생물학적 혼합물로부터의 처리화학약품의 제거 - Google Patents
소수성 상호작용 크로마토그래피에 의한 불안정한 생물학적 혼합물로부터의 처리화학약품의 제거 Download PDFInfo
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/32—Bonded phase chromatography
- B01D15/325—Reversed phase
- B01D15/327—Reversed phase with hydrophobic interaction
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- A61K35/14—Blood; Artificial blood
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
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- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
- Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
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- Treatment Of Liquids With Adsorbents In General (AREA)
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Abstract
내용 없음
Description
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
Claims (19)
- 지용성 처리 화학약품을 함유한 생물학적 물질로부터 상기한 지용성 화학약품을 제거하는 방법에 있어서, 상기한 지용성 화학약품을 함유한 상기한 생물학적 물질을 생물학적 물질이 생물학적 활성을 가지고 있고, 생물학적 활성이 실제적으로 유지되고, 컬럼을 통과하는 동안 생물학적 물질이 흡착되지 않는, C-6 내지 C-24 수지를 함유한 소수성 상호작용 크로마토그래피 컬럼에 통과시키는 것으로 이루어지는 것을 특징으로 하는 방법.
- 제1항에 있어서, 수지가 활성 작용기와 지지체로 이루어지고, 활성작용기가 옥타데실 사슬로 이루어지고, 지지체가 실리카 매트릭스로 이루어지는 것을 특징으로 하는 방법.
- 제2항에 있어서, 실리카 매트릭스에 디메틸실란으로 차단되는 미결합 위치가 있는 것을 특징으로 하는 방법.
- 제1항에 있어서, 수지가 이소프로판올, 에탄올 및 아세토니트릴로 이루어지는 군으로부터 선택된 유기용매로 활성화되는 것을 특징으로 하는 방법.
- 제1항에 있어서, 컬럼이 125 내지 175ml/㎠/hr의 유속으로 작동되는 것을 특징으로 하는 방법.
- 제1항에 있어서, 그 방법이 4° 내지 37℃의 온도에서 행해지는 것을 특징으로 하는 방법.
- 제6항에 있어서, 온도가 20 내지 25℃인 것을 특징으로 하는 방법.
- 제1항에 있어서, 지용성 처리화학약품이 유기용매, 세정제, 장쇄알코올 및 할로겐화 에테르로 이루어진 군으로부터 선택되는 것을 특징으로 하는 방법.
- 제1항에 있어서, 지용성 처리화학약품이 림포킨 합성유도체인 것을 특징으로 하는 방법.
- 제1항에 있어서, 생물학적 물질이 전혈장, 혈청, 저온 침전 혈장 및 저온침전물로 이루어진 군으로부터 선택되는 것을 특징으로 하는 방법.
- 제1항에 있어서, 생물학적 물질이 세포인 것을 특징으로 하는 방법.
- 제1항에 있어서, 생물학적 물질이 혈장, 혈청, 저온침전물, 저온침전혈청, 분설 I, 분설 II, 분설 III, 분설 IV-1, 분설 IV-4, 분설 VI, 피브로넥틴, 항혈우병인자, 프레알부민, 레티놀-결합 단백질, 알부민, 알파-그로부린, 베타-그로불린, 감마-글로불린, 항트롬빈 III, 프로트롬빈, 플라스미노겐, 피브리노겐, 인자 XIII, 면역글루빈 G, 면역글루빈 A, 면역그루빈 M, 면역글루빈 D, 면역글루빈 E, 플라스민 억제인자, 프로트롬빈, 트롬빈, 항트롬빈, 인자 V, 인자 VII, 인자 VIII, 인자 IX, 인자 X, 정상세포, 암세포, 배양액에서 성장시킨 암세포의 삼출액, 배양액에서 성장시킨 정상세포의 삼출액, 하이브리도마로부터의 세포, 유전자 스플라이싱의 생성물, 식물세포 농축액, 식물세포 현탁액, 동물조직 추출물, 식물조직의 추출물 및 미생물로 이루어지는 군으로부터 선택되는 것을 특징으로 하는 방법.
- 외생의 또는 내생의 지용성 화합물을 함유한 생물학적 물질로부터 상기한 지용성 화합물을 제거함으로써 생물학적 유체의 여과성 및/또는 안정성을 향상시키는 방법에 있어서, 상기한 지용성 화합물을 함유한 상기한 생물학적 물질을 생물학적 물질이 생물학적 활성을 가지고 있고, 생물학적 활성이 실제적으로 유지되고, 컬럼을 통과하는 동안 생물학적 물질이 거의 또는 전혀 흡착되지 않는, C-6 내지 C-24 수지를 함유한 소수성 상호작용 크로마토그래피 컬럼에 통과시키는 것으로 이루어지는 것을 특징으로 하는 방법.
- 제13항에 있어서, 수지가 활성 작용기와 지지체로 이루어지고, 활성 작용기가 옥타데실 사슬로 이루어지고 지지체가 실리칼 매트릭스로 이루어지는 것을 특징으로 하는 방법.
- 제14항에 있어서, 실리카 매트릭스는 디메틸실란으로 차단되는 미결합 위치가 있는 것을 특징으로 하는 방법.
- 제13항에 있어서, 수지가 이소프로판올, 에탄올 및 아세토니트릴로 이루어지는 군으로부터 선택한 유기용매로 활성화되는 것을 특징으로 하는 방법.
- 제13항에 있어서, 컬럼이 124 내지 175ml/㎠/hr 의 유속으로 작동되는 것을 특징으로 하는 방법.
- 제13항에 있어서, 그 방법이 4°내지 37℃ 온도에서 행해지는 것을 특징으로 하는 방법.
- 제18항에 있어서, 온도가 20℃ 내지 25℃인 것을 특징으로 하는 방법.※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US256,332 | 1988-10-07 | ||
US07/256,332 US5094960A (en) | 1988-10-07 | 1988-10-07 | Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography |
Publications (2)
Publication Number | Publication Date |
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KR900006010A true KR900006010A (ko) | 1990-05-07 |
KR970007941B1 KR970007941B1 (ko) | 1997-05-19 |
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Application Number | Title | Priority Date | Filing Date |
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KR1019890014221A KR970007941B1 (ko) | 1988-10-07 | 1989-10-04 | 소수성 상호 작용 크로마토그래피에 의한 불안정한 생물학적 혼합물로부터의 처리화학약품의 제거 |
Country Status (9)
Country | Link |
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US (1) | US5094960A (ko) |
EP (1) | EP0366946B1 (ko) |
JP (1) | JP2799747B2 (ko) |
KR (1) | KR970007941B1 (ko) |
AT (1) | ATE102071T1 (ko) |
AU (1) | AU621148B2 (ko) |
CA (1) | CA1337052C (ko) |
DE (1) | DE68913422T2 (ko) |
ES (1) | ES2051951T3 (ko) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8333446B2 (en) | 2006-05-30 | 2012-12-18 | Lg Electronics Inc. | Apparatus for preventing leakage of cooling air for refrigerator |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4008852A1 (de) * | 1990-03-20 | 1991-09-26 | Octapharma Ag | Verfahren zur herstellung von nicht-infektioesem blutplasma |
DE4125625C2 (de) * | 1991-08-02 | 1999-12-02 | Octapharma Ag Glarus | Verfahren zur Herstellung von virusinaktivierten Immunglobulinlösungen |
ATE180492T1 (de) * | 1991-09-05 | 1999-06-15 | Baxter Int | Topischer fibrinogenkomplex |
FR2690444B1 (fr) * | 1992-04-22 | 1995-07-13 | Rucheton Marcel | Procede de preparation d'une solution d'albumine plasmatique purifiee. |
AU667530B2 (en) * | 1992-05-28 | 1996-03-28 | New York Blood Center, Inc., The | Removal of antibodies from blood-derived compositions while retaining coagulation factors |
JPH06166634A (ja) * | 1992-12-01 | 1994-06-14 | Green Cross Corp:The | プラスミノーゲン含有組成物の製造方法 |
DE4302163A1 (de) * | 1993-01-27 | 1994-07-28 | Thomae Gmbh Dr K | Verfahren zur Reinigung von Proteinen und Peptiden |
AU698154B2 (en) * | 1993-06-23 | 1998-10-22 | New York Blood Center, Inc., The | System for viral inactivation of blood |
US6319662B1 (en) * | 1993-12-17 | 2001-11-20 | Baxter International Inc. | Method and apparatus for removing viral contaminants from a body fluid |
JPH08257115A (ja) * | 1995-03-20 | 1996-10-08 | Kanegafuchi Chem Ind Co Ltd | 腫瘍壊死因子の吸着剤および吸着除去方法 |
AU6267796A (en) * | 1995-06-07 | 1996-12-30 | Cerus Corporation | Methods and devices for the removal of psoralens from blood products |
US6544727B1 (en) * | 1995-06-07 | 2003-04-08 | Cerus Corporation | Methods and devices for the removal of psoralens from blood products |
DE19544297A1 (de) | 1995-11-28 | 1997-06-05 | Behringwerke Ag | Verfahren zur Entfernung von aromatischen Verbindungen aus produkthaltigen Lösungen |
US5747639A (en) * | 1996-03-06 | 1998-05-05 | Amgen Boulder Inc. | Use of hydrophobic interaction chromatography to purify polyethylene glycols |
US20020115585A1 (en) * | 1996-06-07 | 2002-08-22 | Hei Derek J. | Method and devices for the removal of psoralens from blood products |
US5811403A (en) | 1996-09-30 | 1998-09-22 | Vanderbilt University | Polysaccharide toxin from Group B β-hemolytic Streptococcus (GBS) having improved purity |
JP4630405B2 (ja) * | 1997-01-06 | 2011-02-09 | セラス コーポレーション | 血液製剤から小有機化合物を減少させるための方法および装置 |
US20010018179A1 (en) | 1998-01-06 | 2001-08-30 | Derek J. Hei | Batch devices for the reduction of compounds from biological compositions containing cells and methods of use |
US20010009756A1 (en) | 1998-01-06 | 2001-07-26 | Derek Hei | Flow devices for the reduction of compounds from biological compositions and methods of use |
US5952235A (en) * | 1997-04-14 | 1999-09-14 | Case Western Reserve University | Detection of teratogen exposure |
US7611831B2 (en) * | 1998-01-06 | 2009-11-03 | Cerus Corporation | Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix |
ES2224415T3 (es) | 1998-01-06 | 2005-03-01 | Cerus Corporation | Metodos para inhibir desactivadores patogenos en materiales biologicos. |
US6495140B1 (en) | 1998-01-12 | 2002-12-17 | Her Majesty In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Canada | Process for the isolation, recovery and purification of non-polar extractives |
AT408613B (de) | 1998-06-17 | 2002-01-25 | Immuno Ag | Pharmazeutisches faktor vii-präparat |
DE19834053A1 (de) * | 1998-07-29 | 2000-03-30 | Centeon Pharma Gmbh | Verfahren und Mittel zur Sanatisierung von durch Viren verursachten Kontaminationen |
IL136552A (en) | 2000-06-05 | 2005-05-17 | Omrix Biopharmaceuticals Ltd | Method for the inactivation of viruses by a solvent - detergent combination and by nanofiltration |
ES2285427T3 (es) * | 2003-02-13 | 2007-11-16 | Octapharma Ag | Procedimiento de preparacion de una solucion de albumina. |
CN1748351B (zh) | 2003-09-10 | 2010-11-03 | 爱信艾达株式会社 | 旋转电机制造装置以及旋转电机制造方法 |
US6881573B2 (en) * | 2003-09-12 | 2005-04-19 | Allan L. Louderback | Augmented solvent/detergent method for inactivating enveloped and non-enveloped viruses |
US20060234907A1 (en) * | 2004-02-13 | 2006-10-19 | Werner Gehringer | Albumin solution and process for the production thereof |
DE102004009400A1 (de) | 2004-02-24 | 2005-09-08 | Zlb Behring Gmbh | Fibrinogen Reinigung |
AU2005265960B8 (en) * | 2004-06-29 | 2012-01-12 | Reliance Life Sciences Pvt Ltd | Process for improvement of virus-safe biological fluids |
GB0423196D0 (en) * | 2004-10-19 | 2004-11-24 | Nat Blood Authority | Method |
PL1838355T3 (pl) * | 2004-10-29 | 2014-01-31 | Cerus Corp | Ulepszone sposoby wygaszania dla procesu inaktywacji czerwonych krwinek |
AU2005229674B2 (en) * | 2004-11-18 | 2010-11-04 | Kedrion Melville Inc. | Low concentration solvent/detergent process of immuneglobulin with pre-treatment |
EP1685852A1 (en) | 2005-02-01 | 2006-08-02 | Fondation pour la Recherche Diagnostique | Set of disposable bags for viral inactivation of biological fluids |
WO2007054297A2 (de) * | 2005-11-11 | 2007-05-18 | Csl Behring Gmbh | Verwendung hydrophober interaktionschromatographie zur virusabreichung |
US8480889B2 (en) * | 2006-04-27 | 2013-07-09 | Agilent Technologies, Inc. | Chromatographic stationary phase |
US20080293623A1 (en) * | 2007-04-30 | 2008-11-27 | Nhs Blood And Transplant | Enriched haptoglobin polymers for the treatment of disease |
SG10201605663UA (en) | 2008-04-09 | 2016-09-29 | Cerus Corp | Improved quenching methods for red blood cell pathogen inactivation |
US20120039920A1 (en) * | 2009-03-31 | 2012-02-16 | Rasmussen Jerald K | Hydrophobic monomers, hydrophobically-derivatized supports, and methods of making and using the same |
EP2640834B1 (en) * | 2010-11-16 | 2017-06-28 | Cadila Healthcare Limited | A novel process for the purification of tissue plasminogen activator |
IL210162A0 (en) | 2010-12-21 | 2011-03-31 | Omrix Biopharmaceuticals | Viral inactivated platelet extract, use and preparation thereof |
US20130172536A1 (en) * | 2011-08-16 | 2013-07-04 | Shenzhen Weiguang Biological Products Co.,Ltd. | Intravenous Cytomegalovirus Human Immune Globulin and Manufacturing Method Thereof |
CH706420A1 (fr) * | 2012-04-19 | 2013-10-31 | Valerie Soulie | Procédé d'inactivation virale d'un fluide biologique, dispositif et récipient pour la mise en œuvre d'un tel procédé. |
WO2014097289A1 (en) | 2012-12-20 | 2014-06-26 | Omrix Biopharmaceuticals Ltd. | Viral inactivated biological mixture |
KR102317930B1 (ko) | 2015-02-06 | 2021-10-29 | 광저우 바이오실 바이오테크 캄파니 리미티드 | 트롬빈의 제조 방법 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2750045A1 (de) * | 1977-11-09 | 1979-05-10 | Behringwerke Ag | Verfahren zur entfernung von detergentien aus virusantigensuspensionen |
US4464474A (en) * | 1980-07-09 | 1984-08-07 | Connaught Laboratories Limited | Non-A, non-B hepatitis assay and vaccine |
US4591505A (en) * | 1982-04-14 | 1986-05-27 | New York Blood Center, Inc. | Process for inactivating hepatitis B virus |
US4481189A (en) * | 1982-04-14 | 1984-11-06 | New York Blood Center Inc. | Process for preparing sterilized plasma and plasma derivatives |
US4485017A (en) * | 1982-12-22 | 1984-11-27 | Cetus Corporation | Isolation of human interferon by immunosorbent and high performance liquid chromatography |
US4540573A (en) * | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
US4677196A (en) * | 1985-09-06 | 1987-06-30 | International Minerals & Chemical Corp. | Purification and activation of proteins from insoluble inclusion bodies |
US4789545A (en) * | 1986-03-31 | 1988-12-06 | New York Blood Center, Inc. | Removal of lipid soluble process chemicals from biological materials by extraction with naturally occurring oils or synthetic substitutes thereof |
US4773458A (en) * | 1986-10-08 | 1988-09-27 | William Touzani | Collapsible hollow articles with improved latching and dispensing configurations |
US4894330A (en) * | 1986-12-23 | 1990-01-16 | Cetus Corporation | Purification of recombinant beta-interferon incorporating RP-HPLC |
US4909940A (en) * | 1987-12-30 | 1990-03-20 | New York Blood Center, Inc. | Extraction of process chemicals from labile biological mixtures with organic alcohols or with halogenated hydrocarbons |
-
1988
- 1988-10-07 US US07/256,332 patent/US5094960A/en not_active Expired - Lifetime
-
1989
- 1989-09-05 CA CA000610272A patent/CA1337052C/en not_active Expired - Lifetime
- 1989-09-19 AU AU41559/89A patent/AU621148B2/en not_active Expired
- 1989-09-30 DE DE68913422T patent/DE68913422T2/de not_active Expired - Lifetime
- 1989-09-30 EP EP89118199A patent/EP0366946B1/en not_active Expired - Lifetime
- 1989-09-30 AT AT89118199T patent/ATE102071T1/de not_active IP Right Cessation
- 1989-09-30 ES ES89118199T patent/ES2051951T3/es not_active Expired - Lifetime
- 1989-10-03 JP JP1257179A patent/JP2799747B2/ja not_active Expired - Lifetime
- 1989-10-04 KR KR1019890014221A patent/KR970007941B1/ko not_active IP Right Cessation
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8333446B2 (en) | 2006-05-30 | 2012-12-18 | Lg Electronics Inc. | Apparatus for preventing leakage of cooling air for refrigerator |
Also Published As
Publication number | Publication date |
---|---|
JP2799747B2 (ja) | 1998-09-21 |
CA1337052C (en) | 1995-09-19 |
DE68913422D1 (de) | 1994-04-07 |
AU621148B2 (en) | 1992-03-05 |
AU4155989A (en) | 1990-09-13 |
EP0366946A1 (en) | 1990-05-09 |
DE68913422T2 (de) | 1994-06-01 |
US5094960A (en) | 1992-03-10 |
ES2051951T3 (es) | 1994-07-01 |
EP0366946B1 (en) | 1994-03-02 |
KR970007941B1 (ko) | 1997-05-19 |
JPH02198561A (ja) | 1990-08-07 |
ATE102071T1 (de) | 1994-03-15 |
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