DE68913422D1 - Entfernen von Verfahrenschemikalien aus labilen biologischen Gemischen durch hydrophobe Austauschchromatographie. - Google Patents

Entfernen von Verfahrenschemikalien aus labilen biologischen Gemischen durch hydrophobe Austauschchromatographie.

Info

Publication number
DE68913422D1
DE68913422D1 DE89118199T DE68913422T DE68913422D1 DE 68913422 D1 DE68913422 D1 DE 68913422D1 DE 89118199 T DE89118199 T DE 89118199T DE 68913422 T DE68913422 T DE 68913422T DE 68913422 D1 DE68913422 D1 DE 68913422D1
Authority
DE
Germany
Prior art keywords
removal
exchange chromatography
process chemicals
biological mixtures
hydrophobic exchange
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE89118199T
Other languages
English (en)
Other versions
DE68913422T2 (de
Inventor
Richard J Bonomo
Bernard Horowitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New York Blood Center Inc
Original Assignee
New York Blood Center Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22971853&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE68913422(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by New York Blood Center Inc filed Critical New York Blood Center Inc
Publication of DE68913422D1 publication Critical patent/DE68913422D1/de
Application granted granted Critical
Publication of DE68913422T2 publication Critical patent/DE68913422T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Anesthesiology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • External Artificial Organs (AREA)
  • Steroid Compounds (AREA)
  • Fats And Perfumes (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DE68913422T 1988-10-07 1989-09-30 Entfernen von Verfahrenschemikalien aus labilen biologischen Gemischen durch hydrophobe Austauschchromatographie. Expired - Lifetime DE68913422T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/256,332 US5094960A (en) 1988-10-07 1988-10-07 Removal of process chemicals from labile biological mixtures by hydrophobic interaction chromatography

Publications (2)

Publication Number Publication Date
DE68913422D1 true DE68913422D1 (de) 1994-04-07
DE68913422T2 DE68913422T2 (de) 1994-06-01

Family

ID=22971853

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68913422T Expired - Lifetime DE68913422T2 (de) 1988-10-07 1989-09-30 Entfernen von Verfahrenschemikalien aus labilen biologischen Gemischen durch hydrophobe Austauschchromatographie.

Country Status (9)

Country Link
US (1) US5094960A (de)
EP (1) EP0366946B1 (de)
JP (1) JP2799747B2 (de)
KR (1) KR970007941B1 (de)
AT (1) ATE102071T1 (de)
AU (1) AU621148B2 (de)
CA (1) CA1337052C (de)
DE (1) DE68913422T2 (de)
ES (1) ES2051951T3 (de)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4008852A1 (de) * 1990-03-20 1991-09-26 Octapharma Ag Verfahren zur herstellung von nicht-infektioesem blutplasma
DE4125625C2 (de) * 1991-08-02 1999-12-02 Octapharma Ag Glarus Verfahren zur Herstellung von virusinaktivierten Immunglobulinlösungen
CA2117058A1 (en) * 1991-09-05 1993-03-18 Daphne C. Tse Topical fibrinogen complex
FR2690444B1 (fr) * 1992-04-22 1995-07-13 Rucheton Marcel Procede de preparation d'une solution d'albumine plasmatique purifiee.
AU667530B2 (en) * 1992-05-28 1996-03-28 New York Blood Center, Inc., The Removal of antibodies from blood-derived compositions while retaining coagulation factors
JPH06166634A (ja) * 1992-12-01 1994-06-14 Green Cross Corp:The プラスミノーゲン含有組成物の製造方法
DE4302163A1 (de) * 1993-01-27 1994-07-28 Thomae Gmbh Dr K Verfahren zur Reinigung von Proteinen und Peptiden
WO1995000631A1 (en) * 1993-06-23 1995-01-05 New York Blood Center, Inc. System for viral inactivation of blood
US6319662B1 (en) 1993-12-17 2001-11-20 Baxter International Inc. Method and apparatus for removing viral contaminants from a body fluid
JPH08257115A (ja) * 1995-03-20 1996-10-08 Kanegafuchi Chem Ind Co Ltd 腫瘍壊死因子の吸着剤および吸着除去方法
US6544727B1 (en) * 1995-06-07 2003-04-08 Cerus Corporation Methods and devices for the removal of psoralens from blood products
ES2337852T3 (es) * 1995-06-07 2010-04-29 Cerus Corporation Metodos y dispositivos para la eliminacion de psoralenos de productos sanguineos.
DE19544297A1 (de) 1995-11-28 1997-06-05 Behringwerke Ag Verfahren zur Entfernung von aromatischen Verbindungen aus produkthaltigen Lösungen
US5747639A (en) * 1996-03-06 1998-05-05 Amgen Boulder Inc. Use of hydrophobic interaction chromatography to purify polyethylene glycols
US20020115585A1 (en) * 1996-06-07 2002-08-22 Hei Derek J. Method and devices for the removal of psoralens from blood products
US5811403A (en) * 1996-09-30 1998-09-22 Vanderbilt University Polysaccharide toxin from Group B β-hemolytic Streptococcus (GBS) having improved purity
EP0954374B1 (de) * 1997-01-06 2004-11-24 Cerus Corporation Adsorbentien und geräte zur verminderung von kleinen organischen verbindungen aus blutprodukten
US20010009756A1 (en) 1998-01-06 2001-07-26 Derek Hei Flow devices for the reduction of compounds from biological compositions and methods of use
US20010018179A1 (en) 1998-01-06 2001-08-30 Derek J. Hei Batch devices for the reduction of compounds from biological compositions containing cells and methods of use
US5952235A (en) * 1997-04-14 1999-09-14 Case Western Reserve University Detection of teratogen exposure
US7611831B2 (en) * 1998-01-06 2009-11-03 Cerus Corporation Adsorbing pathogen-inactivating compounds with porous particles immobilized in a matrix
AU745209B2 (en) 1998-01-06 2002-03-14 Cerus Corporation Methods for quenching pathogen inactivators in biological materials
US6495140B1 (en) 1998-01-12 2002-12-17 Her Majesty In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Canada Process for the isolation, recovery and purification of non-polar extractives
AT408613B (de) 1998-06-17 2002-01-25 Immuno Ag Pharmazeutisches faktor vii-präparat
DE19834053A1 (de) * 1998-07-29 2000-03-30 Centeon Pharma Gmbh Verfahren und Mittel zur Sanatisierung von durch Viren verursachten Kontaminationen
IL136552A (en) 2000-06-05 2005-05-17 Omrix Biopharmaceuticals Ltd Method for the inactivation of viruses by a solvent - detergent combination and by nanofiltration
PT1592439E (pt) * 2003-02-13 2007-06-22 Octapharma Ag Processo para a preparação de uma solução de albumina
KR100961029B1 (ko) 2003-09-10 2010-06-01 아이신에이더블류 가부시키가이샤 회전 전기 기기 제조 장치 및 회전 전기 기기 제조 방법
US6881573B2 (en) * 2003-09-12 2005-04-19 Allan L. Louderback Augmented solvent/detergent method for inactivating enveloped and non-enveloped viruses
US20060234907A1 (en) * 2004-02-13 2006-10-19 Werner Gehringer Albumin solution and process for the production thereof
DE102004009400A1 (de) 2004-02-24 2005-09-08 Zlb Behring Gmbh Fibrinogen Reinigung
AU2005265960B8 (en) * 2004-06-29 2012-01-12 Reliance Life Sciences Pvt Ltd Process for improvement of virus-safe biological fluids
GB0423196D0 (en) * 2004-10-19 2004-11-24 Nat Blood Authority Method
US7655392B2 (en) * 2004-10-29 2010-02-02 Cerus Corporation Quenching methods for red blood cell inactivation process
AU2005229674B2 (en) * 2004-11-18 2010-11-04 Kedrion Melville Inc. Low concentration solvent/detergent process of immuneglobulin with pre-treatment
EP1685852A1 (de) 2005-02-01 2006-08-02 Fondation pour la Recherche Diagnostique Set von Einwegbeuteln zur Virusinaktivierung von biologischen Fluids
WO2007054297A2 (de) * 2005-11-11 2007-05-18 Csl Behring Gmbh Verwendung hydrophober interaktionschromatographie zur virusabreichung
US8480889B2 (en) * 2006-04-27 2013-07-09 Agilent Technologies, Inc. Chromatographic stationary phase
KR100885410B1 (ko) 2006-05-30 2009-02-25 엘지전자 주식회사 냉기 유출 방지장치를 갖는 냉장고
US20080293623A1 (en) * 2007-04-30 2008-11-27 Nhs Blood And Transplant Enriched haptoglobin polymers for the treatment of disease
ES2636563T3 (es) 2008-04-09 2017-10-06 Cerus Corporation Método de reducción de la deshidratación en una composición de glóbulos rojos
JP5681166B2 (ja) * 2009-03-31 2015-03-04 スリーエム イノベイティブ プロパティズ カンパニー 疎水性モノマー、疎水的に誘導体化された支持体、並びにその製造及び使用方法
WO2012066569A1 (en) * 2010-11-16 2012-05-24 Cadila Healthcare Limited A novel process for the purification of tissue plasminogen activator
IL210162A0 (en) 2010-12-21 2011-03-31 Omrix Biopharmaceuticals Viral inactivated platelet extract, use and preparation thereof
US20130172536A1 (en) * 2011-08-16 2013-07-04 Shenzhen Weiguang Biological Products Co.,Ltd. Intravenous Cytomegalovirus Human Immune Globulin and Manufacturing Method Thereof
CH706420A1 (fr) * 2012-04-19 2013-10-31 Valerie Soulie Procédé d'inactivation virale d'un fluide biologique, dispositif et récipient pour la mise en œuvre d'un tel procédé.
CA2895652C (en) 2012-12-20 2020-10-27 Omrix Biopharmaceuticals Ltd. Viral inactivated biological mixture
KR102317930B1 (ko) 2015-02-06 2021-10-29 광저우 바이오실 바이오테크 캄파니 리미티드 트롬빈의 제조 방법

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2750045A1 (de) * 1977-11-09 1979-05-10 Behringwerke Ag Verfahren zur entfernung von detergentien aus virusantigensuspensionen
US4464474A (en) * 1980-07-09 1984-08-07 Connaught Laboratories Limited Non-A, non-B hepatitis assay and vaccine
US4591505A (en) * 1982-04-14 1986-05-27 New York Blood Center, Inc. Process for inactivating hepatitis B virus
US4481189A (en) * 1982-04-14 1984-11-06 New York Blood Center Inc. Process for preparing sterilized plasma and plasma derivatives
US4485017A (en) * 1982-12-22 1984-11-27 Cetus Corporation Isolation of human interferon by immunosorbent and high performance liquid chromatography
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
US4677196A (en) * 1985-09-06 1987-06-30 International Minerals & Chemical Corp. Purification and activation of proteins from insoluble inclusion bodies
US4789545A (en) * 1986-03-31 1988-12-06 New York Blood Center, Inc. Removal of lipid soluble process chemicals from biological materials by extraction with naturally occurring oils or synthetic substitutes thereof
US4773458A (en) * 1986-10-08 1988-09-27 William Touzani Collapsible hollow articles with improved latching and dispensing configurations
US4894330A (en) * 1986-12-23 1990-01-16 Cetus Corporation Purification of recombinant beta-interferon incorporating RP-HPLC
US4909940A (en) 1987-12-30 1990-03-20 New York Blood Center, Inc. Extraction of process chemicals from labile biological mixtures with organic alcohols or with halogenated hydrocarbons

Also Published As

Publication number Publication date
AU4155989A (en) 1990-09-13
CA1337052C (en) 1995-09-19
EP0366946A1 (de) 1990-05-09
US5094960A (en) 1992-03-10
ES2051951T3 (es) 1994-07-01
ATE102071T1 (de) 1994-03-15
JPH02198561A (ja) 1990-08-07
AU621148B2 (en) 1992-03-05
EP0366946B1 (de) 1994-03-02
JP2799747B2 (ja) 1998-09-21
DE68913422T2 (de) 1994-06-01
KR900006010A (ko) 1990-05-07
KR970007941B1 (ko) 1997-05-19

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8310 Action for declaration of annulment
8313 Request for invalidation rejected/withdrawn