KR900003361A - 모에노마이신을 분해하는 미생물, 분해방법 및 분해 생성물의 용도 - Google Patents

모에노마이신을 분해하는 미생물, 분해방법 및 분해 생성물의 용도 Download PDF

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KR900003361A
KR900003361A KR1019890011754A KR890011754A KR900003361A KR 900003361 A KR900003361 A KR 900003361A KR 1019890011754 A KR1019890011754 A KR 1019890011754A KR 890011754 A KR890011754 A KR 890011754A KR 900003361 A KR900003361 A KR 900003361A
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compound
moenomycin
formula
degradation
dms
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KR1019890011754A
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아레쯔 베르너
뵈트거 디르크
사이베르트 게르하르트
투물카 알로이스
벨젤 페터
호버트 쿠르트
Original Assignee
하인리히벡커, 베른하르트 베크
훽스트 아크티엔게젤샤프트
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Publication of KR900003361A publication Critical patent/KR900003361A/ko

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    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
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Abstract

내용 없음

Description

모에노마이신을 분해하는 미생물, 분해방법 및 분해 생성물의 용도
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (10)

  1. 바실러스 종(Bacillus spec.) DSM 4675 및 이의 변형체 및 변이체.
  2. 구조식(I)의 화합물.
  3. 일반식(II)의 화합물
    상기식에서, R¹은 수소 또는 포스포노 그룹이고, R²는 측쇄 또는 비측쇄, 포화 또는 불포화된 (C5내지 C55)-알킬 그룹이다.
  4. 제 3항에 있어서, 알킬 그룹이 탄소원자수 10 내지 30의 쇄길이를 갖는 화합물.
  5. 제 3 또는 4항에 있어서, 알킬 그룹이 탄소원자수 20 내지 25의 쇄길이를 갖는 화합물.
  6. 포스포글리코사이드 결합에서 포스포글리코리피드 항생물질을 분해하고, 적정 ph가 8.0 내지 8.5이며, 최적온도가 45 내지 55℃이고 기질로서 모에노마이신 A를 기준으로 하여 Km값이 4 내지 10㎛ol임을 특징으로 하는 모에노마이신아제.
  7. 제 3항에서 청구한 화합물을 탈이산화하고, 37℃ 이상 및 pH가 5이하로 감소되는 경우 불활성화 되는 바실러스 종 (Bacillus spec.) DMS 4675로부터의 효소.
  8. 바실러스 종(Bacillus spec.) DMS 4675 또는 이로부터 수득된 효소 분리물과 모에노마이신 A를 배양함을 특징으로 하여, 제 2항에서 청구한 구조식 (I)의 화합물을 제조하는 방법.
  9. 바실러스 종(Bacillus spec.) DMS 4675 또는 이로부터 수득된 효소 분리물과 포스포글리코리피드 항생물질을 배양함을 특징으로 하여, 제 3항에서 청구한 일반식(II)의 화합물을 제조하는 방법.
  10. 제 8 또는 9항에 있어서, 배양을 pH 5.5 내지 8.5에서 수행하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890011754A 1988-08-20 1989-08-18 모에노마이신을 분해하는 미생물, 분해방법 및 분해 생성물의 용도 KR900003361A (ko)

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DE3828337 1988-08-20
DEP3828337.9 1988-08-20

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KR900003361A true KR900003361A (ko) 1990-03-26

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KR1019890011754A KR900003361A (ko) 1988-08-20 1989-08-18 모에노마이신을 분해하는 미생물, 분해방법 및 분해 생성물의 용도

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EP (1) EP0355679B1 (ko)
JP (2) JP2863557B2 (ko)
KR (1) KR900003361A (ko)
AT (1) ATE134641T1 (ko)
AU (2) AU619034B2 (ko)
DE (1) DE58909610D1 (ko)
DK (1) DK407789A (ko)
ES (1) ES2085855T3 (ko)
FI (1) FI893878A (ko)
GR (1) GR3019332T3 (ko)
IL (1) IL91354A0 (ko)
NO (1) NO893327L (ko)
NZ (1) NZ230352A (ko)
PH (1) PH26511A (ko)
PT (1) PT91469B (ko)
ZA (1) ZA896310B (ko)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0355679B1 (de) * 1988-08-20 1996-02-28 Hoechst Aktiengesellschaft Neuer Mikroorganismus zum Abbau von Moenomycinen, Verfahren zum Abbau sowie die Verwendung der Abbauprodukte
EP0503419B1 (de) * 1991-03-08 1997-07-09 Hoechst Aktiengesellschaft Verfahren zur Herstellung von MA
US5316929A (en) * 1991-03-08 1994-05-31 Hoechst Aktiengesellschaft Process for the preparation of MA
EP0652205A3 (de) * 1993-11-04 1995-08-30 Hoechst Ag Moenomycin-Abbauprodukte mit hydroxylierter oder oxidierter Lipidseitenkette und Moenomycin-Analoga, ein Verfahren zur Herstellung und die Verwendung dieser Verbindungen.
DE19709897A1 (de) * 1997-03-11 1998-09-17 Hoechst Ag Wismutsalze von Antibiotika der Moenomycin-Gruppe, Verfahren zu ihrer Herstellung, ihre Verwendung und solche Salze enthaltende Arzneimittel
EP0872556A3 (de) * 1997-04-17 2000-06-14 Hoechst Aktiengesellschaft Verfahren zur Herstellung von Moenomycin A
EP1069130B1 (en) * 1999-07-15 2004-08-11 Hoechst Marion Roussel Moenomycin A Derivatives, their preparation, and use as antibacterial products

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6601300A (ko) * 1966-02-01 1967-08-02 Stamicarbon
DE3467171D1 (en) * 1983-05-21 1987-12-10 Hoechst Ag Moenomycin-a derivatives, their preparation and their use as antibiotics
EP0355679B1 (de) * 1988-08-20 1996-02-28 Hoechst Aktiengesellschaft Neuer Mikroorganismus zum Abbau von Moenomycinen, Verfahren zum Abbau sowie die Verwendung der Abbauprodukte

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ZA896310B (en) 1990-04-25
NO893327L (no) 1990-02-21
FI893878A (fi) 1990-02-21
GR3019332T3 (en) 1996-06-30
DK407789D0 (da) 1989-08-18
PT91469A (pt) 1990-03-08
JP2863557B2 (ja) 1999-03-03
ES2085855T3 (es) 1996-06-16
FI893878A0 (fi) 1989-08-17
AU619034B2 (en) 1992-01-16
NZ230352A (en) 1991-07-26
JPH1171323A (ja) 1999-03-16
DE58909610D1 (de) 1996-04-04
EP0355679A2 (de) 1990-02-28
NO893327D0 (no) 1989-08-18
DK407789A (da) 1990-02-21
AU3998589A (en) 1990-02-22
PT91469B (pt) 1995-05-04
EP0355679A3 (de) 1991-07-24
IL91354A0 (en) 1990-03-19
JPH02150273A (ja) 1990-06-08
ATE134641T1 (de) 1996-03-15
EP0355679B1 (de) 1996-02-28
AU8835391A (en) 1992-02-06
PH26511A (en) 1992-08-07
AU635452B2 (en) 1993-03-18

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