AU3998589A - A new microorganism for breaking down moenomycins, a process for the breakdown, and the use of the breakdown products - Google Patents

A new microorganism for breaking down moenomycins, a process for the breakdown, and the use of the breakdown products

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Publication number
AU3998589A
AU3998589A AU39985/89A AU3998589A AU3998589A AU 3998589 A AU3998589 A AU 3998589A AU 39985/89 A AU39985/89 A AU 39985/89A AU 3998589 A AU3998589 A AU 3998589A AU 3998589 A AU3998589 A AU 3998589A
Authority
AU
Australia
Prior art keywords
breakdown
moenomycins
breaking down
new microorganism
products
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
AU39985/89A
Other versions
AU619034B2 (en
Inventor
Werner Aretz
Dirk Bottger
Kurt Hobert
Gerhard Seibert
Alois Tumulka
Peter Welzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of AU3998589A publication Critical patent/AU3998589A/en
Application granted granted Critical
Publication of AU619034B2 publication Critical patent/AU619034B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/125—Saturated compounds having only one carboxyl group and containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/60—Unsaturated compounds containing ether groups, groups, groups, or groups the non-carboxylic part of the ether being unsaturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6552—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

It is possible with the aid of a Bacillus species or the appropriate enzymes obtained therefrom to degrade phosphoglycolipid antibiotics. The degradation products of the moenomycins have antibiotic activity or can be used as building block in the synthetic preparation of transglycosylase inhibitors.
AU39985/89A 1988-08-20 1989-08-18 A new microorganism for breaking down moenomycins, a process for the breakdown, and the use of the breakdown products Ceased AU619034B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3828337 1988-08-20
DE3828337 1988-08-20

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU88353/91A Division AU635452B2 (en) 1988-08-20 1991-12-02 Moenomycin breakdown products

Publications (2)

Publication Number Publication Date
AU3998589A true AU3998589A (en) 1990-02-22
AU619034B2 AU619034B2 (en) 1992-01-16

Family

ID=6361268

Family Applications (2)

Application Number Title Priority Date Filing Date
AU39985/89A Ceased AU619034B2 (en) 1988-08-20 1989-08-18 A new microorganism for breaking down moenomycins, a process for the breakdown, and the use of the breakdown products
AU88353/91A Ceased AU635452B2 (en) 1988-08-20 1991-12-02 Moenomycin breakdown products

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU88353/91A Ceased AU635452B2 (en) 1988-08-20 1991-12-02 Moenomycin breakdown products

Country Status (16)

Country Link
EP (1) EP0355679B1 (en)
JP (2) JP2863557B2 (en)
KR (1) KR900003361A (en)
AT (1) ATE134641T1 (en)
AU (2) AU619034B2 (en)
DE (1) DE58909610D1 (en)
DK (1) DK407789A (en)
ES (1) ES2085855T3 (en)
FI (1) FI893878A (en)
GR (1) GR3019332T3 (en)
IL (1) IL91354A0 (en)
NO (1) NO893327L (en)
NZ (1) NZ230352A (en)
PH (1) PH26511A (en)
PT (1) PT91469B (en)
ZA (1) ZA896310B (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE134641T1 (en) * 1988-08-20 1996-03-15 Hoechst Ag NEW MICROORGANISM FOR THE DEGRADATION OF MOENOMYCINS, METHOD FOR DEGRADATION AND THE USE OF THE DEGRADATION PRODUCTS
DK0503419T3 (en) * 1991-03-08 1998-02-02 Hoechst Ag Method of Preparation of MA
US5316929A (en) * 1991-03-08 1994-05-31 Hoechst Aktiengesellschaft Process for the preparation of MA
EP0652205A3 (en) * 1993-11-04 1995-08-30 Hoechst Ag Moenomycin degradation products containing hydroxylated or oxidized lateral lipid chain and moenomycin analogs, process for preparing and their use.
DE19709897A1 (en) * 1997-03-11 1998-09-17 Hoechst Ag Bismuth salts of antibiotics of the moenomycin group, process for their preparation, their use and medicaments containing such salts
EP0872556A3 (en) * 1997-04-17 2000-06-14 Hoechst Aktiengesellschaft Process for the preparation of moenomycin A
EP1069130B1 (en) * 1999-07-15 2004-08-11 Hoechst Marion Roussel Moenomycin A Derivatives, their preparation, and use as antibacterial products

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6601300A (en) * 1966-02-01 1967-08-02 Stamicarbon
EP0130327B1 (en) * 1983-05-21 1987-11-04 Hoechst Aktiengesellschaft Moenomycin-a derivatives, their preparation and their use as antibiotics
ATE134641T1 (en) * 1988-08-20 1996-03-15 Hoechst Ag NEW MICROORGANISM FOR THE DEGRADATION OF MOENOMYCINS, METHOD FOR DEGRADATION AND THE USE OF THE DEGRADATION PRODUCTS

Also Published As

Publication number Publication date
FI893878A (en) 1990-02-21
EP0355679A2 (en) 1990-02-28
JPH1171323A (en) 1999-03-16
KR900003361A (en) 1990-03-26
DK407789D0 (en) 1989-08-18
NZ230352A (en) 1991-07-26
IL91354A0 (en) 1990-03-19
PT91469B (en) 1995-05-04
EP0355679A3 (en) 1991-07-24
PH26511A (en) 1992-08-07
JP2863557B2 (en) 1999-03-03
NO893327D0 (en) 1989-08-18
DE58909610D1 (en) 1996-04-04
FI893878A0 (en) 1989-08-17
JPH02150273A (en) 1990-06-08
AU635452B2 (en) 1993-03-18
DK407789A (en) 1990-02-21
AU619034B2 (en) 1992-01-16
ATE134641T1 (en) 1996-03-15
NO893327L (en) 1990-02-21
ZA896310B (en) 1990-04-25
AU8835391A (en) 1992-02-06
GR3019332T3 (en) 1996-06-30
ES2085855T3 (en) 1996-06-16
EP0355679B1 (en) 1996-02-28
PT91469A (en) 1990-03-08

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