KR890700679A - 에이.심플렉스(A. simplex)에 의한 스테로이드성 21-에스테르의 I,2-탈수소화 - Google Patents

에이.심플렉스(A. simplex)에 의한 스테로이드성 21-에스테르의 I,2-탈수소화

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Publication number
KR890700679A
KR890700679A KR1019880701452A KR880701452A KR890700679A KR 890700679 A KR890700679 A KR 890700679A KR 1019880701452 A KR1019880701452 A KR 1019880701452A KR 880701452 A KR880701452 A KR 880701452A KR 890700679 A KR890700679 A KR 890700679A
Authority
KR
South Korea
Prior art keywords
dehydrogenation
simplex
steroidal
esters
hemiester
Prior art date
Application number
KR1019880701452A
Other languages
English (en)
Other versions
KR960013094B1 (ko
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of KR890700679A publication Critical patent/KR890700679A/ko
Application granted granted Critical
Publication of KR960013094B1 publication Critical patent/KR960013094B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/02—Dehydrogenating; Dehydroxylating
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/83—Arthrobacter

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019880701452A 1987-03-12 1988-02-19 에이. 심플렉스(A. simplex)에 의한 스테로이드성 21-에스테르의 1,2-탈수소화 KR960013094B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2512787A 1987-03-12 1987-03-12
US025,127 1987-03-12
PCT/US1988/000405 WO1988007092A1 (en) 1987-03-12 1988-02-19 1,2-dehydrogenation of steroidal 21-esters with a. simplex

Publications (2)

Publication Number Publication Date
KR890700679A true KR890700679A (ko) 1989-04-26
KR960013094B1 KR960013094B1 (ko) 1996-09-30

Family

ID=21824196

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880701452A KR960013094B1 (ko) 1987-03-12 1988-02-19 에이. 심플렉스(A. simplex)에 의한 스테로이드성 21-에스테르의 1,2-탈수소화

Country Status (12)

Country Link
US (1) US5225335A (ko)
EP (1) EP0350488B1 (ko)
JP (1) JP2680870B2 (ko)
KR (1) KR960013094B1 (ko)
AT (1) ATE94212T1 (ko)
AU (1) AU1340888A (ko)
BG (1) BG50389A3 (ko)
DE (1) DE3883973T2 (ko)
DK (1) DK175173B1 (ko)
HK (1) HK153896A (ko)
HU (1) HU204305B (ko)
WO (1) WO1988007092A1 (ko)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270660B (it) * 1994-10-13 1997-05-07 Poli Ind Chimica Spa Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi
AU5873300A (en) * 1999-07-07 2001-01-30 Pharmacia & Upjohn Company Process to prepare exemestane
WO2002102826A1 (en) * 2001-06-18 2002-12-27 Pharmacia & Upjohn Company PROCESS TO PREPARE 11β,17α,21-TRIHYDROXY-6α-METHYLPREGNA-1,4-DIENE-3,20-DIONE 21-ACETATE
HU227117B1 (en) 2002-05-10 2010-07-28 Richter Gedeon Nyrt Process for dehydrogenation of aza-androstane compounds
US20090142342A1 (en) * 2006-12-27 2009-06-04 Johns Hopkins University B7-h4 receptor agonist compositions and methods for treating inflammation and auto-immune diseases
KR101591482B1 (ko) 2008-05-28 2016-02-03 레베라겐 바이오파마 인코포레이티드 질환의 치료를 위한 ＮＦ-κＢ 의 비호르몬성 스테로이드 조절제
EP2556083A4 (en) 2010-04-05 2013-12-04 Validus Biopharma Inc NONHORMONAL STEROID MODULATORS OF NF-KAPPA-B FOR DISEASE TREATMENT
RU2480475C1 (ru) * 2011-11-16 2013-04-27 Российская Федерация, От Имени Которой Выступает Министерство Промышленности И Торговли Российской Федерации Микробиологический способ получения 21-ацетоксипрегна-1,4,9( 11 ),16-тетраен-3,20-диона из 21-ацетоксипрегна-4,9( 11 ),16-триен-3,20-диона
CN103159817A (zh) * 2011-12-13 2013-06-19 辽宁海思科制药有限公司 一种琥珀酸甲泼尼龙的制备方法
CN104650172A (zh) * 2015-03-25 2015-05-27 浙江仙琚制药股份有限公司 琥珀酸甲泼尼龙的制备方法
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2837464A (en) * 1955-01-11 1958-06-03 Schering Corp Process for production of dienes by corynebacteria
US2822318A (en) * 1956-12-07 1958-02-04 Olin Mathieson Production of 3-keto-delta pregnadienes by bacterium cyclo-oxydans
US2902411A (en) * 1957-06-28 1959-09-01 Upjohn Co Use of second steroid to accelerate 1-dehydrogenation of substrate steroid
US2902410A (en) * 1957-09-26 1959-09-01 Upjohn Co Process for the 1,2-dehydrogenation of a steroid with septomyxa
US3360439A (en) * 1964-08-19 1967-12-26 Squibb & Sons Inc Process for preparing 1-dehydro steroids
US3770586A (en) * 1971-03-24 1973-11-06 Upjohn Co Process for the microbiological 1-dehydrogenation of certain 4,9-(11)-pregnadienes
US4524134A (en) * 1982-07-30 1985-06-18 The Upjohn Company Process for preparing 1,2-dehydro steroids
DE3322120A1 (de) * 1982-07-30 1984-02-02 The Upjohn Co., 49001 Kalamazoo, Mich. Verfahren zur umwandlung von 1,2-gesaettigten 3-ketosteroiden in 1,2-dehydrosteroide
US4704358A (en) * 1982-10-25 1987-11-03 The Upjohn Company Δ1 -dehydrogenation with heat or air-dried B. cyclooxidans
US4749649A (en) * 1983-05-16 1988-06-07 The Upjohn Company Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen

Also Published As

Publication number Publication date
HK153896A (en) 1996-08-16
DK175173B1 (da) 2004-06-21
EP0350488A1 (en) 1990-01-17
BG50389A3 (en) 1992-07-15
EP0350488B1 (en) 1993-09-08
DE3883973D1 (de) 1993-10-14
AU1340888A (en) 1988-10-10
HU204305B (en) 1991-12-30
DK630988A (da) 1988-11-11
DK630988D0 (da) 1988-11-11
DE3883973T2 (de) 1994-02-17
KR960013094B1 (ko) 1996-09-30
ATE94212T1 (de) 1993-09-15
HUT50881A (en) 1990-03-28
JPH02502514A (ja) 1990-08-16
WO1988007092A1 (en) 1988-09-22
JP2680870B2 (ja) 1997-11-19
US5225335A (en) 1993-07-06

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