DK630988A - Fremgangsmaade til fremstilling af delta1,4-3-keto-21-hemiester-steroider - Google Patents

Fremgangsmaade til fremstilling af delta1,4-3-keto-21-hemiester-steroider

Info

Publication number
DK630988A
DK630988A DK630988A DK630988A DK630988A DK 630988 A DK630988 A DK 630988A DK 630988 A DK630988 A DK 630988A DK 630988 A DK630988 A DK 630988A DK 630988 A DK630988 A DK 630988A
Authority
DK
Denmark
Prior art keywords
hemiester
keto
steroids
delta1
preparing
Prior art date
Application number
DK630988A
Other languages
English (en)
Other versions
DK175173B1 (da
DK630988D0 (da
Inventor
Leo A Kominek
Holly Jo Wolf
Paula S Steiert
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of DK630988A publication Critical patent/DK630988A/da
Publication of DK630988D0 publication Critical patent/DK630988D0/da
Application granted granted Critical
Publication of DK175173B1 publication Critical patent/DK175173B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/02—Dehydrogenating; Dehydroxylating
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/007—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 17 (20)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/83—Arthrobacter

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK198806309A 1987-03-12 1988-11-11 Fremgangsmåde til fremstilling af delta1,4-3-keto-21-hemiester-steroider DK175173B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US2512787A 1987-03-12 1987-03-12
US2512787 1987-03-12
US8800405 1988-02-19
PCT/US1988/000405 WO1988007092A1 (en) 1987-03-12 1988-02-19 1,2-dehydrogenation of steroidal 21-esters with a. simplex

Publications (3)

Publication Number Publication Date
DK630988A true DK630988A (da) 1988-11-11
DK630988D0 DK630988D0 (da) 1988-11-11
DK175173B1 DK175173B1 (da) 2004-06-21

Family

ID=21824196

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198806309A DK175173B1 (da) 1987-03-12 1988-11-11 Fremgangsmåde til fremstilling af delta1,4-3-keto-21-hemiester-steroider

Country Status (12)

Country Link
US (1) US5225335A (da)
EP (1) EP0350488B1 (da)
JP (1) JP2680870B2 (da)
KR (1) KR960013094B1 (da)
AT (1) ATE94212T1 (da)
AU (1) AU1340888A (da)
BG (1) BG50389A3 (da)
DE (1) DE3883973T2 (da)
DK (1) DK175173B1 (da)
HK (1) HK153896A (da)
HU (1) HU204305B (da)
WO (1) WO1988007092A1 (da)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270660B (it) * 1994-10-13 1997-05-07 Poli Ind Chimica Spa Procedimento microbiologico per la preparazione di 3-oxo-4-azasteroidi-17beta-carbossi sostituiti e uso dei prodotti come inibitori dell'enzima 5alfa-riduttasi
AU5873300A (en) * 1999-07-07 2001-01-30 Pharmacia & Upjohn Company Process to prepare exemestane
CA2448037A1 (en) * 2001-06-18 2002-12-27 Pharmacia & Upjohn Company Process to prepare 11.beta.,17.alpha.,21-trihydroxy-6.alpha.-methylpregna-1,4-diene-3,20-dione 21-acetate
HU227117B1 (en) 2002-05-10 2010-07-28 Richter Gedeon Nyrt Process for dehydrogenation of aza-androstane compounds
US20090142342A1 (en) * 2006-12-27 2009-06-04 Johns Hopkins University B7-h4 receptor agonist compositions and methods for treating inflammation and auto-immune diseases
LT2805720T (lt) 2008-05-28 2019-09-25 Reveragen Biopharma, Inc. Nehormoniniai steroidiniai nf-kb moduliatoriai, skirti ligoms gydyti
WO2011127048A2 (en) 2010-04-05 2011-10-13 Validus Biopharma NON-HORMONAL STEROID MODULATORS OF NF-ĸB FOR TREATMENT OF DISEASE
RU2480475C1 (ru) * 2011-11-16 2013-04-27 Российская Федерация, От Имени Которой Выступает Министерство Промышленности И Торговли Российской Федерации Микробиологический способ получения 21-ацетоксипрегна-1,4,9( 11 ),16-тетраен-3,20-диона из 21-ацетоксипрегна-4,9( 11 ),16-триен-3,20-диона
CN103159817A (zh) * 2011-12-13 2013-06-19 辽宁海思科制药有限公司 一种琥珀酸甲泼尼龙的制备方法
CN104650172A (zh) * 2015-03-25 2015-05-27 浙江仙琚制药股份有限公司 琥珀酸甲泼尼龙的制备方法
US10799514B2 (en) 2015-06-29 2020-10-13 Reveragen Biopharma, Inc. Non-hormonal steroid modulators of NF-kappa beta for treatment of disease
US11382922B2 (en) 2019-03-07 2022-07-12 Reveragen Biopharma, Inc. Aqueous oral pharmaceutical suspension compositions

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2837464A (en) * 1955-01-11 1958-06-03 Schering Corp Process for production of dienes by corynebacteria
US2822318A (en) * 1956-12-07 1958-02-04 Olin Mathieson Production of 3-keto-delta pregnadienes by bacterium cyclo-oxydans
US2902411A (en) * 1957-06-28 1959-09-01 Upjohn Co Use of second steroid to accelerate 1-dehydrogenation of substrate steroid
US2902410A (en) * 1957-09-26 1959-09-01 Upjohn Co Process for the 1,2-dehydrogenation of a steroid with septomyxa
US3360439A (en) * 1964-08-19 1967-12-26 Squibb & Sons Inc Process for preparing 1-dehydro steroids
US3770586A (en) * 1971-03-24 1973-11-06 Upjohn Co Process for the microbiological 1-dehydrogenation of certain 4,9-(11)-pregnadienes
US4524134A (en) * 1982-07-30 1985-06-18 The Upjohn Company Process for preparing 1,2-dehydro steroids
DE3322120A1 (de) * 1982-07-30 1984-02-02 The Upjohn Co., 49001 Kalamazoo, Mich. Verfahren zur umwandlung von 1,2-gesaettigten 3-ketosteroiden in 1,2-dehydrosteroide
US4704358A (en) * 1982-10-25 1987-11-03 The Upjohn Company Δ1 -dehydrogenation with heat or air-dried B. cyclooxidans
US4749649A (en) * 1983-05-16 1988-06-07 The Upjohn Company Microbial Δ1-dehydrogenation process using a scavenger of toxic oxygen

Also Published As

Publication number Publication date
JPH02502514A (ja) 1990-08-16
JP2680870B2 (ja) 1997-11-19
AU1340888A (en) 1988-10-10
DK175173B1 (da) 2004-06-21
EP0350488A1 (en) 1990-01-17
HUT50881A (en) 1990-03-28
HK153896A (en) 1996-08-16
DE3883973D1 (de) 1993-10-14
US5225335A (en) 1993-07-06
KR960013094B1 (ko) 1996-09-30
HU204305B (en) 1991-12-30
KR890700679A (ko) 1989-04-26
DE3883973T2 (de) 1994-02-17
DK630988D0 (da) 1988-11-11
EP0350488B1 (en) 1993-09-08
BG50389A3 (en) 1992-07-15
WO1988007092A1 (en) 1988-09-22
ATE94212T1 (de) 1993-09-15

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Legal Events

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PUP Patent expired