KR890015988A - 레티노이드 유사활성을 갖는 페놀 또는 벤조산의 테트랄린 에스테르 - Google Patents

레티노이드 유사활성을 갖는 페놀 또는 벤조산의 테트랄린 에스테르 Download PDF

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KR890015988A
KR890015988A KR1019890004567A KR890004567A KR890015988A KR 890015988 A KR890015988 A KR 890015988A KR 1019890004567 A KR1019890004567 A KR 1019890004567A KR 890004567 A KR890004567 A KR 890004567A KR 890015988 A KR890015988 A KR 890015988A
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tetrahydro
naphthoyloxy
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에이.에스.챤드라라트나 토쉬안타
제이.웨인캄 로버트
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제임스 엠.캐내지
알러간, 인코포레이티드
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Abstract

내용 없음

Description

레티노이드 유사활성을 갖는 페놀 또는 벤조산의 테트랄린 에스테르
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (18)

  1. 다음 일반식 (Ⅰ)의 화합물
    상기식에서 R그릅은 독립적으로 수소 또는 저급 알킬이고 ; A는 -C(O)O-, -OC(O)-, -C(O)S- 또는 -SC(O)- 이며 ; n은 0 내지 5이고, Z는 수소, -COB[여기에서 B는 -OH 또는 약제학적으로 허용되는 염이거나, -OR1(여기에서 R1은 에스테르-형성 그룹이다)이거나, -N(R)2(여기에서 R은 수소 또는 저급알킬이다)], -OE(여기에서 E는 수소 또는 에테르-형성 그룹이다) 또는 -COR2(여기에서 R2는 수소, 저급알킬, 페닐 또는 저급 알킬페닐이다)이거나, -CHO 또는 이의 아세탈 유도체이거나, -COR3[여기에서 R3는 - (CH2)mCH3이며, m은 0내지 4이다]이며 ; n 및 m의 합은 4이하이다.
  2. 제 1 항 있어서, A가 -C(O)O-이고 ; n이 0 내지 1이며 Z가 -COOH 또는 이의 저급알킬 에스테르 또는 아미드 또는 약제학적으로 허용되는 염, 또는 -OH 또는 이의 에스테르 또는 에테르, 또는-CHO 또는 이의 아세탈인 화합물.
  3. 제 2 항에 있어서, 에틸 4-(5,5,8,8,-테트라메틸-5,6,7,8-테트라하이드로-2-나프토일옥시) 벤조에이트.
  4. 제 2 항에 있어서, 4-(5,5,8,8-테트라메틸-5,6,7,8-테트라하이드로-2-나프토일옥시) 벤조산 또는 이의 약제학적으로 허용되는 염.
  5. 제 2 항에 있어서, 4-메톡시메틸페닐-5,5,8,8-테트라메틸-5,6,7,8-테트라하이드로-2-나프토에이트 또는 4-디메톡시메틸페닐-5,5,8,8-테트라메틸-5,6,7,8-테트라하이드로-2-나프토에이트.
  6. 제 2 항에 있어서, 4-(5,5,8,8-테트라메틸-5,6,7,8-테트라하이드로-2-나프토일옥시) 벤즈아미드.
  7. 제 2 항에 있어서, 4-(8,8-디메틸-5,6,7,8-테트라하이드로-2-나프토일옥시) 벤조산 또는 이의 약제학적으로 허용되는 염, 에틸 4-(8,8-디메틸-5,6,7,8-테트라하이드로-2-나프토일옥시) 벤조에이트, 또는 벤질 4-(8,8-디메틸-5,6,7,8-테트라하이드로-2-나프토일옥시) 벤조에이트.
  8. 제 2 항에 있어서, 4-(5,5-디메틸-5,6,7,8-테트라하이드로-2-나프토일옥시) 벤조산 또는 이의 약제학적으로 허용되는 염, 에틸 4- (5,5-디메틸-5,6,7,8-테트라하이드로-2-나프토일옥시) 벤조에이트, 또는 벤질 4-(5,5-디메틸-5,6,7,8-테트라하이드로-2-나프토일옥시) 벤조에이트.
  9. 제 1 항에 있어서,A가 -C(O)O-이고 , n이 0 내지 1이며 ; 위치 3의 R그룹이 저급 알킬이고 ; Z가 -COOH 또는 이의 저급 알킬 에스테르 또는 아미드 또는 약제학적으로 허용되는 염, -OH 또는 이의 에스테르 또는 에테르 유도체, 또는 -CHO 또는 이의 아세탈유도체인 화합물.
  10. 제 9 항에 있어서, 4-(3,5,5,8,8-펜타메틸-5,6,7,8-테트라하이드로-2-나프토일옥시) 벤조산 또는 이의 약제학적으로 허용되는 염.
  11. 제 9 항에 있어서, 에틸 4-(3,5,5,8,6-펜타메틸-5,6,7,8-테트라하이드로-2-나프토일옥시) 벤조에이트
  12. 제 9 항에 있어서, 벤질 4-(3,5,5,8,8-펜타메틸-5,6,7,8-테트라하이드로-2-나프토일옥시) 벤조에이트.
  13. 제 9 항에 있어서, 4-메톡시메틸페닐 3,5,5,8,8-펜타메틸-5,6,7,8-테트라하이드로-2-나프토에이트 또는 4-포르밀페닐 3,5,5,8,8-펜타메틸 -5,6,7,8∼테트라하이드로-2-나프토에이트.
  14. 제 1 항에 있어서, A가 -C(O)O-이고 ; n이 0 내지 1이며 , 2가 -COOH 또는 이의 저급 알킬 에스테르 또는 아미드 또는 약제학적으로 허용되는 염, -OH 또는 이의 에스테르 또는 에테르, 또는 -CHO 또는 이의 아세탈인 화합물.
  15. 제14항에 있어서, 에틸 4-(5,5,8,8-테트라메틸-5,6,7,8-테트라하이드로-2-나프틸) 테레프탈레이트.
  16. 제14항에 있어서, (5,5,8,8-테트라메틸-5,6,7,8-테트라하이드로-2-나프틸) 하이드로겐 테레프탈 레이트 .
  17. 치료학적으로 유효한 양의 제 1 항에 따르는 화합물을, 단독으로 또는 약제학적으로 허용되는 부형제와 함에 투여함을 특징으로 하여, 포유동물의 건선을 치료하는 방법.
  18. 치료학적으로 유효한 양의 제 1 항에 따르는 화합물 및 약제학적으로 허용되는 부형제를 함유하는 약제학적 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890004567A 1988-04-11 1989-04-07 레티노이드 유사활성을 갖는 페놀 또는 벤조산의 테트랄린 에스테르 KR0139216B1 (ko)

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NO891466D0 (no) 1989-04-10
ATE86601T1 (de) 1993-03-15
US5130335A (en) 1992-07-14
ES2053982T3 (es) 1994-08-01
ZA892583B (en) 1989-12-27
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NO891466L (no) 1989-10-12
SG32564G (en) 1995-09-01
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PT90251B (pt) 1994-06-30
AU618590B2 (en) 1992-01-02
AU3258589A (en) 1989-10-12
KR0139216B1 (ko) 1998-05-01
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HU201727B (en) 1990-12-28
NO170008B (no) 1992-05-25
CN1038092A (zh) 1989-12-20
IE63712B1 (en) 1995-05-31
NO170008C (no) 1992-09-02
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