KR890014456A - 플루페남산의 2-(2-히드록시에톡시)에탄올아민을 제조하는 방법 - Google Patents

플루페남산의 2-(2-히드록시에톡시)에탄올아민을 제조하는 방법 Download PDF

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Publication number
KR890014456A
KR890014456A KR1019890003843A KR890003843A KR890014456A KR 890014456 A KR890014456 A KR 890014456A KR 1019890003843 A KR1019890003843 A KR 1019890003843A KR 890003843 A KR890003843 A KR 890003843A KR 890014456 A KR890014456 A KR 890014456A
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South Korea
Prior art keywords
acid
excess
reaction mixture
diol
hydroxyethoxy
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KR1019890003843A
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KR950013472B1 (ko
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메츠 군터
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아돌프 메르클레
메르클레 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

내용 없음.

Description

플루페남산의 2-(2-히드록시에톡시)에탄올아민을 제조하는 방법
내용없음

Claims (7)

  1. (a) 산촉매의 존재하에서 100 내지 140℃, 바람직하게는 100 내지 120℃의 반응온도에서 플루페남산을 과잉의 2-(2-히드록시에톡시)에탄올과 직접 반응시키고, (b) 반응혼합물로부터 과잉의 디올을 제거하고, (c) 조에스테르를 처리함으로써 플로페남산(N-(α, α, α-트리플루오로-m-톨릴)안트라닐산)의 2-(2-히드록시에톡시)에탄올에스테르를 제조하는 방법에 있어서, 반응혼합물로부터 반응수를 동시 제거함이 없이 플루페남산 몰당 8 내지 15몰의 과잉의 디올로 반응을 행하는 것을 특징으로 하는 플루페남산의 2-(2-히드록시에톡시)에탄올에스테르를 제조하는 방법.
  2. 제1항에 있어서, 산몰당 0.25 내지 1몰의 촉매를 사용하는 것을 특징으로 하는 방법.
  3. 제1항에 있어서, 플루페남산 몰당 10.5 내지 12몰의 디올과잉량으로 반응을 행하는 것을 특징으로 하는 방법.
  4. 제1항 내지 제3항중의 어느 하나에 있어서, 에스테르화 반응의 종결후 과잉의 디올을 분리하기 위해 알칼리금속 수산화물 또는 알칼리토금속수산화물 또는그들의 탄산염의 수용액을 반응혼합물에 가하고, 그리하여 에스테르 조제품을 분리하고 과잉의 2-(2-히드록시에톡시)에탄올을 물층(수상)내로 이행하게 하는 것을 특징으로 하는 방법.
  5. 제1항 내지 제3항중의 어느 하나에 있어서, 과잉의 디올을 제거하기 위해 중화될 때까지 반응혼합물을 고형의 알칼리금속 수산화물 또는 알칼리토금속수산화물 또는 그들의 탄산염과 혼합시키고 이어서 조에스테르를 탄화수소용제, 바람직하게는 톨루엔으로 추출하는 것을 특징으로 하는 방법.
  6. 제1항 내지 제5항중의 어느 하나에 있어서, 통상의 흡착제 바람직하게는 실리카겔을 사용하여 10 내지 20바아의 압력에서 중간압력 액체크로마토그래피에 의해 조 에스테르제품을 정제하는 것을 특징으로 하는 방법.
  7. 제1항 내지 제6항중의 어느 하나에 있어서, 촉매가 p-톨루엔술폰산-1수염인 것을 특징으로 하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890003843A 1988-03-31 1989-03-27 플루페남산의 2-(2-히드록시에톡시)에탄올아민을 제조하는 방법 KR950013472B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP3811119.5 1988-03-31
DEP3811119,5 1988-03-31
DE3811119A DE3811119C1 (ko) 1988-03-31 1988-03-31

Publications (2)

Publication Number Publication Date
KR890014456A true KR890014456A (ko) 1989-10-23
KR950013472B1 KR950013472B1 (ko) 1995-11-08

Family

ID=6351240

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890003843A KR950013472B1 (ko) 1988-03-31 1989-03-27 플루페남산의 2-(2-히드록시에톡시)에탄올아민을 제조하는 방법

Country Status (9)

Country Link
US (1) US4980498A (ko)
EP (1) EP0336146B1 (ko)
JP (1) JPH029850A (ko)
KR (1) KR950013472B1 (ko)
AT (1) ATE92911T1 (ko)
CA (1) CA1307538C (ko)
DE (2) DE3811119C1 (ko)
ES (1) ES2042834T3 (ko)
FI (1) FI90659C (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2578749Y2 (ja) * 1991-10-28 1998-08-13 株式会社日本フォトサイエンス 液体の光化学反応処理装置
US5595813A (en) * 1992-09-22 1997-01-21 Takenaka Corporation Architectural material using metal oxide exhibiting photocatalytic activity
JP2568157Y2 (ja) * 1993-05-31 1998-04-08 水青工業株式会社 吐水口および浄水器
US6106955A (en) * 1997-01-14 2000-08-22 Takenaka Corporation Metal material having photocatalytic activity and method of manufacturing the same
MX2021003730A (es) 2018-09-28 2021-06-18 Univ Griffith Agentes y métodos para modular la actividad patógena.

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA726767A (en) * 1966-01-25 Parke, Davis And Company Anthranilic acid esters and methods for producing same
CA904340A (en) * 1972-07-04 Boltze Karl-Heinz Esters of substituted anthranilic acid
DE1939111C3 (de) * 1969-08-01 1974-04-18 Troponwerke Dinklage & Co, 5000 Koeln Derivate der N- eckige Klammer auf 3-Trifluormethylphenyl eckige Klammer zu -anthranilsäure, Verfahren zu ihrer Herstellung und pharmakologisch wirksame Zubereitungen derselben
DE1939112C3 (de) * 1969-08-01 1975-03-06 Troponwerke Dinklage & Co, 5000 Koeln Ester der N-(3-Trifluormethylphenyl) -anthranilsäure, Verfahren zu ihrer Herstellung und pharmakologisch wirksame Zubereitungen derselben
JPS53105445A (en) * 1977-02-26 1978-09-13 Hokuriku Pharmaceutical Nn*33trifluoromethylphenyl* anthranylate alklyester derivative and process for preparing same
JPS543032A (en) * 1977-06-06 1979-01-11 Hokuriku Pharmaceutical Furphenamicester derivative and process for preparing same
DE2834167C2 (de) * 1978-08-04 1984-01-26 Troponwerke GmbH & Co KG, 5000 Köln Verfahren zur Herstellung von 2-(2-Hydroxyäthoxy)äthyl-N-(α,α,α-trifluor-m-tolyl)anthranilat
DE2834170C2 (de) * 1978-08-04 1984-02-23 Troponwerke GmbH & Co KG, 5000 Köln Verfahren zur Herstellung von 2-(2-Hydroxyäthoxy)äthyl-N-(α,α,α-trifluor-m-tolyl)anthranilat
JPS58148840A (ja) * 1982-03-01 1983-09-05 Dainippon Pharmaceut Co Ltd Ｎ−（α，α，α−トリフルオロ−ｍ−トリル）アントラニル酸２−（２−ヒドロキシエトキシ）エチルエステルの製法
KR840009066A (ko) * 1983-03-24 1984-12-24 베르너 쇤, 게르트 바디케 에토 페나메이트의 정제방법

Also Published As

Publication number Publication date
DE3811119C1 (ko) 1989-10-12
ES2042834T3 (es) 1993-12-16
CA1307538C (en) 1992-09-15
FI891410A0 (fi) 1989-03-23
KR950013472B1 (ko) 1995-11-08
ATE92911T1 (de) 1993-08-15
DE58905205D1 (de) 1993-09-16
US4980498A (en) 1990-12-25
FI891410A (fi) 1989-10-01
FI90659B (fi) 1993-11-30
FI90659C (fi) 1994-03-10
EP0336146B1 (de) 1993-08-11
EP0336146A2 (de) 1989-10-11
JPH029850A (ja) 1990-01-12
EP0336146A3 (de) 1991-03-27

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