KR890011890A - 약제학적 화합물 - Google Patents

약제학적 화합물 Download PDF

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Publication number
KR890011890A
KR890011890A KR1019890000214A KR890000214A KR890011890A KR 890011890 A KR890011890 A KR 890011890A KR 1019890000214 A KR1019890000214 A KR 1019890000214A KR 890000214 A KR890000214 A KR 890000214A KR 890011890 A KR890011890 A KR 890011890A
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KR
South Korea
Prior art keywords
alkyl
hydrogen
halo
hydroxy
alkoxy
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KR1019890000214A
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English (en)
Inventor
피터 클라크 배리
에드워드 터퍼 데이비드
Original Assignee
티.알.크로우더
릴리 인더스트리즈 리미티드
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Publication date
Application filed by 티.알.크로우더, 릴리 인더스트리즈 리미티드 filed Critical 티.알.크로우더
Publication of KR890011890A publication Critical patent/KR890011890A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)

Abstract

내용 없음

Description

약제학적 화합물
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (7)

  1. 일반식(Ⅱ)의 화합물을 폐환시킨 후, 임의로, R1, R2및 R4중 하나 이상이 수소일 경우에 적절한 치환체를 도입시킴을 특징으로 하여, 일반식(Ⅰ)의 화합물 또는 이의 염을 제조하는 방법.
    상기식에서, R1은 수소, 하이드록시, 니트로, 시아노, 할로, 아미노, 아세트아미도, 하이드록시- C1-4알킬, 카복스알데하이도, C1-4알킬카보닐, 카복시, C1-4알콕시-카보닐, C1-4알킬, C1-4알콕시, C1-4알킬티오, C1-4알킬설포닐 또는 C1-4알콕시-C1-4알킬이고 ; R2는 수소, 하이드록시, 니트로, 시아노, 할로, 아미노, 카복스아미도, 아세트아미도, 하이드록시-C1-4알킬, 카복스알데하이도, C1-4알킬카보닐, 카복시, C1-4알콕시 카보닐, C1-4알킬, C1-4알콕시, C1-4알킬티오, C1-4알킬설포닐, C1-4알콕시-C1-4알킬, 옥스이미노 또는 아미노 메틸이며 ; R3는 임의치환된 페닐, 또는 벤젠, 사이클로헥산, 사이클로헥센, 사이클로펜탄 또는 사이클로 펜텐중에서 선택된 임의치환된 환(이 환에서, 탄소원자중 하나는 산소, 황 또는 질소에 의해 대체될 수 있다)에 의해 오르토 축합된, 임의치환된 페닐이고 ; R4는 수소, C1-4알킬, C2-4알케닐 또는 임의치환된 벤질이다.
  2. 제1항에 있어서, R3이 페닐 또는 벤조푸라닐인 방법.
  3. 제1항 또는 2항에 있어서, R1이 수소, 할로 또는 C1-4알킬티오이고, R2가 수소, 하이드록시-C1-4알킬, 할로 또는 C1-4알킬인 방법.
  4. 제1항 내지 3항중 어느 한 항에 있어서, R4가 C1-4알킬인 방법.
  5. 제1항에 있어서, R1이 할로겐 또는 C1-4알킬티오이고, R2가 수소, 하이드록시 -C1-4알킬, C1-4알킬 또는 할로이며, R3이 페닐 또는 벤조푸라닐이고, R4가 수소 또는 C1-4알킬인 방법.
  6. 제1항에 있어서, R1이 수소, 할로 또는 C1-4알킬티오이고, R2가 수소, 하이드록시메틸, 할로 또는 C1-4알킬이며, R3이 페닐 또는 벤조푸라닐이고, R4가 수소 또는 C1-4알킬인 방법.
  7. 제1항에 따른 약제학적 활성 성분을 약제학적으로 허용되는 희석제 또는 담체와 함께 함유함을 특징으로 하는 약제학적 조성물.
    ※ 참고사항: 최초출원 내용에 의하여 공개하는 것임.
KR1019890000214A 1988-01-15 1989-01-11 약제학적 화합물 KR890011890A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB888800891A GB8800891D0 (en) 1988-01-15 1988-01-15 Pharmaceutical compounds
GB8800891 1988-01-15

Publications (1)

Publication Number Publication Date
KR890011890A true KR890011890A (ko) 1989-08-23

Family

ID=10630022

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890000214A KR890011890A (ko) 1988-01-15 1989-01-11 약제학적 화합물

Country Status (21)

Country Link
US (1) US4904653A (ko)
EP (1) EP0324610B1 (ko)
JP (1) JPH01216994A (ko)
KR (1) KR890011890A (ko)
CN (1) CN1024009C (ko)
AR (1) AR246270A1 (ko)
AT (1) ATE104300T1 (ko)
AU (1) AU616460B2 (ko)
CA (1) CA1335593C (ko)
DE (1) DE68914471T2 (ko)
DK (1) DK13089A (ko)
ES (1) ES2063117T3 (ko)
GB (1) GB8800891D0 (ko)
HU (1) HU201328B (ko)
IE (1) IE63217B1 (ko)
IL (1) IL88927A (ko)
MX (1) MX173766B (ko)
NZ (1) NZ227610A (ko)
PH (1) PH25102A (ko)
PT (1) PT89431B (ko)
ZA (1) ZA89260B (ko)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3818660A1 (de) * 1987-06-05 1988-12-15 Colgate Palmolive Co Freifliessendes, pulvriges geschirrwaschmittel und verfahren zur herstellung desselben
GB8909132D0 (en) * 1989-04-21 1989-06-07 Lilly Industries Ltd Pharmaceutical compounds
DE69123090D1 (de) * 1990-07-06 1996-12-19 Yoshitomi Pharmaceutical Kondensierte Thiophenverbindungen und deren Verwendung
GB9025890D0 (en) * 1990-11-28 1991-01-09 Lilly Industries Ltd Pharmaceutical compounds
WO1995018092A1 (fr) * 1993-12-28 1995-07-06 Maruho Co., Ltd. Derive de l'aminocetone
TW414795B (en) * 1996-07-01 2000-12-11 Yamanouchi Pharma Co Ltd A thiophene derivative and the pharmaceutical composition
US6114572A (en) * 1996-11-20 2000-09-05 Hoechst Marion Roussel, Inc. Substituted phenols and thiophenols useful as antioxidant agents
GB0017951D0 (en) * 2000-07-22 2000-09-13 Univ Manchester Treatment of movement disorders
NZ550891A (en) * 2004-06-30 2009-10-30 Athersys Inc Substituted azepine derivatives as serotonin receptor modulators
ATE507832T1 (de) * 2004-09-03 2011-05-15 Athersys Inc Trizyklische heteroaryl-piperazine, pyrrolidine und azetidine als serotonin-rezeptor-modulatoren
BRPI0707183A2 (pt) * 2006-01-19 2011-04-26 Athersys Inc composto, composição farmacêutica, e, método de tratar uma doença, distúrbio e/ou condição em um paciente
AU2013364022A1 (en) 2012-12-21 2015-07-02 Abt Holding Company Benzazepines as serotonin 5-HT2C receptor ligands and uses thereof
US9309262B2 (en) 2013-03-13 2016-04-12 Abt Holding Company Thienylindole azepines as serotonin 5-HT2C receptor ligands and uses thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA792043B (en) * 1978-05-08 1980-05-28 Scherico Ltd Esters of substituted 8-hydroxy-1-phenyl-2,3,4,5-tetrahydro-1h-3-benzazepines,process for the preparation thereof and pharmaceutical compositions containing them
ZA821020B (en) * 1981-02-18 1983-10-26 Thomae Gmbh Dr K Azepine derivatives, process for their preparation and pharmaceutical compositions thereof
DE3230696A1 (de) * 1982-08-18 1984-02-23 Dr. Karl Thomae Gmbh, 7950 Biberach Neue thieno-thiazol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DK180485D0 (da) * 1985-04-22 1985-04-23 Novo Industri As Nitrogenholdige forbindelser

Also Published As

Publication number Publication date
PT89431A (pt) 1990-02-08
ES2063117T3 (es) 1995-01-01
HUT50829A (en) 1990-03-28
MX14533A (es) 1993-10-01
PH25102A (en) 1991-02-19
DK13089D0 (da) 1989-01-12
IL88927A (en) 1992-09-06
CN1034725A (zh) 1989-08-16
US4904653A (en) 1990-02-27
AR246270A1 (es) 1994-07-29
AU2837289A (en) 1989-07-20
EP0324610B1 (en) 1994-04-13
DE68914471T2 (de) 1994-07-28
ATE104300T1 (de) 1994-04-15
CA1335593C (en) 1995-05-16
MX173766B (es) 1994-03-28
JPH01216994A (ja) 1989-08-30
EP0324610A2 (en) 1989-07-19
EP0324610A3 (en) 1991-03-13
AU616460B2 (en) 1991-10-31
DE68914471D1 (de) 1994-05-19
IE63217B1 (en) 1995-04-05
NZ227610A (en) 1991-03-26
DK13089A (da) 1989-07-16
ZA89260B (en) 1990-09-26
HU201328B (en) 1990-10-28
CN1024009C (zh) 1994-03-16
IE890094L (en) 1989-07-15
GB8800891D0 (en) 1988-02-17
IL88927A0 (en) 1989-08-15
PT89431B (pt) 1993-09-30

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