ATE507832T1 - Trizyklische heteroaryl-piperazine, pyrrolidine und azetidine als serotonin-rezeptor-modulatoren - Google Patents

Trizyklische heteroaryl-piperazine, pyrrolidine und azetidine als serotonin-rezeptor-modulatoren

Info

Publication number
ATE507832T1
ATE507832T1 AT05794345T AT05794345T ATE507832T1 AT E507832 T1 ATE507832 T1 AT E507832T1 AT 05794345 T AT05794345 T AT 05794345T AT 05794345 T AT05794345 T AT 05794345T AT E507832 T1 ATE507832 T1 AT E507832T1
Authority
AT
Austria
Prior art keywords
azetidines
pyrrolidines
piperazines
receptor modulators
serotonin receptor
Prior art date
Application number
AT05794345T
Other languages
English (en)
Inventor
Youssef Bennani
David C Bom
Michael Robarge
Original Assignee
Athersys Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Athersys Inc filed Critical Athersys Inc
Application granted granted Critical
Publication of ATE507832T1 publication Critical patent/ATE507832T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Addiction (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Anesthesiology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AT05794345T 2004-09-03 2005-09-01 Trizyklische heteroaryl-piperazine, pyrrolidine und azetidine als serotonin-rezeptor-modulatoren ATE507832T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60714204P 2004-09-03 2004-09-03
PCT/US2005/031306 WO2006028961A2 (en) 2004-09-03 2005-09-01 Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators

Publications (1)

Publication Number Publication Date
ATE507832T1 true ATE507832T1 (de) 2011-05-15

Family

ID=36036866

Family Applications (1)

Application Number Title Priority Date Filing Date
AT05794345T ATE507832T1 (de) 2004-09-03 2005-09-01 Trizyklische heteroaryl-piperazine, pyrrolidine und azetidine als serotonin-rezeptor-modulatoren

Country Status (9)

Country Link
US (2) US7423056B2 (de)
EP (1) EP1796663B1 (de)
JP (1) JP4960235B2 (de)
AR (1) AR050624A1 (de)
AT (1) ATE507832T1 (de)
DE (1) DE602005027861D1 (de)
DK (1) DK1796663T3 (de)
TW (1) TWI406866B (de)
WO (1) WO2006028961A2 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006028961A2 (en) * 2004-09-03 2006-03-16 Athersys, Inc. Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators
JP5007988B2 (ja) * 2005-10-27 2012-08-22 国立大学法人名古屋大学 多環縮環化合物およびそれらの製造法ならびに多環縮環化合物を用いる有機電界発光素子
WO2007132841A1 (ja) 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited 縮合複素環化合物およびその用途
CN101230058A (zh) * 2007-01-23 2008-07-30 上海恒瑞医药有限公司 双环氮杂烷类衍生物、其制备方法及其在医药上的用途
JP5520051B2 (ja) 2007-11-15 2014-06-11 武田薬品工業株式会社 縮合ピリジン誘導体およびその用途
CA2712352C (en) * 2008-01-23 2016-05-10 Jiangsu Hansoh Pharmaceutical Co., Ltd. Dicycloazaalkane derivates, preparation processes and medical uses thereof
US8518933B2 (en) 2009-04-23 2013-08-27 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
US8546377B2 (en) 2009-04-23 2013-10-01 Abbvie Inc. Modulators of 5-HT receptors and methods of use thereof
JPWO2011071136A1 (ja) 2009-12-11 2013-04-22 アステラス製薬株式会社 線維筋痛症治療剤
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2012120054A1 (de) 2011-03-08 2012-09-13 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
US9937002B2 (en) 2011-03-08 2018-04-10 Nexus Control Systems, Llc Ablation catheter system with safety features
KR101273566B1 (ko) * 2011-09-05 2013-06-11 한국과학기술연구원 신규한 아제티딘 유도체 및 이를 함유하는 항우울제 조성물
CN102827064B (zh) * 2012-08-14 2014-01-29 华东师范大学 一种氮杂双环[3.3.0]辛烷衍生物的合成方法
US20210052600A1 (en) 2017-12-27 2021-02-25 Takeda Pharmaceutical Company Limited Therapeutic agents for stress urinary incontinence and incotinence of feces
CN116283899A (zh) * 2022-12-28 2023-06-23 南京林业大学 一种3-全氟烷基苯并噻吩[b]环戊烯酮化合物及其合成方法
CN116813532A (zh) * 2023-06-29 2023-09-29 上海柯君医药科技有限公司 一种哌啶化合物的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA821020B (en) 1981-02-18 1983-10-26 Thomae Gmbh Dr K Azepine derivatives, process for their preparation and pharmaceutical compositions thereof
GB8800891D0 (en) 1988-01-15 1988-02-17 Lilly Industries Ltd Pharmaceutical compounds
WO1993013105A1 (en) 1991-12-26 1993-07-08 Yoshitomi Pharmaceutical Industries, Ltd. Condensed thiophene compound and pharmaceutical use thereof
FR2725792A1 (fr) 1994-10-13 1996-04-19 Centre Nat Etd Spatiales Procede pour evaluer des effets non-euclidiens affectant une image obtenue avec un radar spatial, et satellite pour sa mise en oeuvre
AU742735B2 (en) * 1997-01-08 2002-01-10 F. Hoffmann-La Roche Ag Tricyclic benzo{e}isoindoles and benzo{h}isoquinolines
AU727654B2 (en) * 1997-06-13 2000-12-21 Yamanouchi Pharmaceutical Co., Ltd. Tricyclic pyrazole derivative
US6063803A (en) 1998-06-16 2000-05-16 Ortho-Mcneil Pharmaceutical, Inc. Octahydropyrrolo-[3,4-c]carbazoles useful as analgesic agents
JPWO2002074746A1 (ja) * 2001-03-16 2004-07-08 山之内製薬株式会社 ベンゾアゼピン誘導体
GB0118892D0 (en) * 2001-08-02 2001-09-26 Vernalis Res Ltd Method of treatment
EP1464645A1 (de) 2001-12-18 2004-10-06 Kyowa Hakko Kogyo Co., Ltd. Indolderivat
US6953787B2 (en) * 2002-04-12 2005-10-11 Arena Pharmaceuticals, Inc. 5HT2C receptor modulators
WO2006028961A2 (en) * 2004-09-03 2006-03-16 Athersys, Inc. Tricyclic heteroaryl piperazines, pyrrolidines and azetidines as serotonin receptor modulators

Also Published As

Publication number Publication date
JP4960235B2 (ja) 2012-06-27
DE602005027861D1 (de) 2011-06-16
US7981919B2 (en) 2011-07-19
WO2006028961A2 (en) 2006-03-16
AR050624A1 (es) 2006-11-08
TW200621787A (en) 2006-07-01
DK1796663T3 (da) 2011-08-15
US20090069365A1 (en) 2009-03-12
WO2006028961A3 (en) 2006-12-28
JP2008512377A (ja) 2008-04-24
EP1796663A4 (de) 2009-08-05
EP1796663B1 (de) 2011-05-04
EP1796663A2 (de) 2007-06-20
TWI406866B (zh) 2013-09-01
US7423056B2 (en) 2008-09-09
US20060079567A1 (en) 2006-04-13

Similar Documents

Publication Publication Date Title
ATE507832T1 (de) Trizyklische heteroaryl-piperazine, pyrrolidine und azetidine als serotonin-rezeptor-modulatoren
MY144753A (en) Muscarinic acetylcholine receptor antagonists
ATE439357T1 (de) Indolylderivate als liver-x-rezeptormodulatoren
LTPA2017005I1 (lt) Nauji junginiai, kaip opioido receptoriaus moduliatoriai
ATE440085T1 (de) 3-substituierte 1,5-diphenylpyrazolderivate, die sich als cb1-modulatoren eignen
MY143366A (en) Muscarinic acetylcholine receptor antagonists
ATE328882T1 (de) Tropanderivative als ccr5-modulatoren
ZA200604778B (en) Azabicyclic heterocycles as cannabinoid receptor modulators
TW200600093A (en) M3 muscarinic acetylcholine receptor antagonists
ATE399777T1 (de) Pyrrol-2,5-dionderivate als modulatoren des liver-x-rezeptors
DE602004014772D1 (de) Pyrrol-2,5-dithionderivate als modulatoren des liver-x-rezeptors
TW200633715A (en) Medical combinations
MXPA06000662A (es) Antagonistas del receptor muscarinico de acetilcolina.
DE602007011495D1 (de) 1,5-DIPHENYL-3-BENZYLAMINO-1,5-DIHYDROPYRROLIDIN-2-ONE AlS CB1-REZEPTOR-MODULATOREN
TW200519109A (en) Muscarinic acetylcholine receptor antagonists
MXPA06000663A (es) Antagonistas del receptor muscarinico de acetilcolina.
TW200633706A (en) Medical combinations
ZA200609234B (en) Substituted azeplne derivatives as serotonin receptor modulators
TW200600500A (en) M3 muscarinic acetylcholine receptor antagonists
TW200606161A (en) Muscarinic acetylcholine receptor antagonists
WO2007016650A3 (en) M3 muscarinic acetylcholine receptor antagonists
WO2007016639A3 (en) M3 muscarinic acetylcholine receptor antagonists
DE602005007265D1 (de) Tetrazyklische imidazobenzodiazepine als gaba-rezeptormodulatoren
ATE531706T1 (de) Neue piperidin-substituierte indole und ihre verwendung als ccr-3-modulatoren
DE602006015186D1 (de) Oxindole als kinaseinhibitoren

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties