KR880013944A - 신규 방법 - Google Patents

신규 방법 Download PDF

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Publication number
KR880013944A
KR880013944A KR1019880005594A KR880005594A KR880013944A KR 880013944 A KR880013944 A KR 880013944A KR 1019880005594 A KR1019880005594 A KR 1019880005594A KR 880005594 A KR880005594 A KR 880005594A KR 880013944 A KR880013944 A KR 880013944A
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KR
South Korea
Prior art keywords
substituted
unsubstituted
compound
group
methyl
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KR1019880005594A
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English (en)
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존 페리맨 브룸 나이젤
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데이빗 로버츠
비이참 그루우프 피이엘시이
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Publication of KR880013944A publication Critical patent/KR880013944A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Reverberation, Karaoke And Other Acoustics (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
  • Glass Compositions (AREA)

Abstract

내용 없음

Description

신규 방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (11)

  1. 하기 일반식(Ⅱ)의 화합물을 염기 존재하에 하기 일반식(Ⅲ)의 화합물로 처리하는 것을 포함하는 하기 일반식(Ⅰ)의 화합물의 제조방법.
    상기 식들에서, R3는 수소원자 또는 유기기이고 ; R4는 수소원자, 카르복시-염-형성 이온 또는 카르복시-에스테르-형성기이고; R12는 비치환 또는 치환 탄화수소기 또는 비치환 또는 치환 헤테로시클릴기이고; R5는 비치환 또는 치환 방향족 헤테로시클릴기이다.
  2. 제1항에 있어서, R12가 비치환 도는 치환(C1-6)알킬기 또는 비치환 또는 치환 페닐기인 방법.
  3. 제1항에 있어서, R12가 다른 고리 원자들은 탄소원자이고, 산소 질소 또는 황으로부터 선택된 하나 또는 그 이상의 헤테로원자를 포함하는 비치환 또는 치환5-각 또는 6-각 방향족 헤테로시클릴기인 방법.
  4. 제3항에 있어서, R12가 비치환 또는 치환 푸란, 티오펜, 피롤, 피라졸, 이미다졸, 트리아졸, 테트라졸, 티아졸, 이소티아졸, 옥사졸, 이속사졸, 티아디아졸, 옥사디아졸, 피리딘, 피라진, 피리미딘, 피리다진 또는 트리아진 고리인 방법.
  5. 제4항에 있어서, R12가 비치환 또는 치환 푸틸, 이소티아졸릴, 이속사졸릴, 메틸티오졸릴, 메틸옥사졸릴, 디메틸옥사졸릴, 메틸-1,2,3-티아디아졸릴, 메틸-1,2,4-옥사디아졸릴, N-메틸피라졸릴, N-메틸이미다졸릴, N-메틸-1,2,3-트리아졸릴, N-메틸-1,2,4-트리아졸릴, N-메틸테트라졸릴, 3-피리딜, 4-피리딜, 메톡시피리딜, 피라지닐, 4-피리미디닐, 3-피리다지닐 또는 디메틸트리아지닐기인 방법.
  6. 제1항 내지 제5항중 어느 한 항에 있어서, R3는 수소, (C1-10)알킬 또는 (C1-10)알킬티오, 또는 치환체가 히드록시, (C1-6)알콕시, (C1-6)알카노일옥시, 할로겐, 메르캅토, (C1-6)알킬티오, 헤테로시클릴티오, 아미노, (모노 또는 디)-(C1-6)알킬아미노, (C1-6)알카노일아미노, 카르복시, 또는 (C1-6)알콕시카르보닐인 치환(C1-10)알킬 또는 치환(C1-10)알킬티오인 방법.
  7. 제1항 내지 제6항중 어느 한 항에 있어서, R4는 카르복실 보호기인 방법.
  8. 제1항 내지 제7항중 어느 한 항에 있어서, R5가 비치환 또는 치환 피리딜, 피라지닐, 피리미디닐, 피리다지닐 또는 벤즈티아졸릴기인 방법.
  9. 제8항에 있어서, 일반식(Ⅲ)의 화합물이 2-메르캅토-피리딘, 2-메르캅토-피리미딘, 2-메르캅토-4-6-디메틸-피리미딘 또는 2-메르캅토-벤즈티아졸인 방법.
  10. 제1항 내지 제9항중 어느 한 항에 있어서, 염기가 탄산 알카리금속 또는 치환 아민인 방법.
  11. 제1항에 있어서, (5R)-P-니트로벤질(Z)-6-(1-메틸-1,2,3-트리아졸-4-일메틸렌)페냄-3-카르복실레이트 및 (5R)-P-메톡시벤질(Z)-6-(1-메틸-1,2,3-트리아졸-4-일메틸렌)페냄-3-카르복실레이트 중 하나의 제조방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019880005594A 1987-05-14 1988-05-13 신규 방법 KR880013944A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8711391 1987-05-14
GB878711391A GB8711391D0 (en) 1987-05-14 1987-05-14 Process

Publications (1)

Publication Number Publication Date
KR880013944A true KR880013944A (ko) 1988-12-22

Family

ID=10617325

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880005594A KR880013944A (ko) 1987-05-14 1988-05-13 신규 방법

Country Status (15)

Country Link
US (1) US4897476A (ko)
EP (1) EP0291304B1 (ko)
JP (1) JPH0816112B2 (ko)
KR (1) KR880013944A (ko)
AT (1) ATE72815T1 (ko)
AU (1) AU614517B2 (ko)
CA (1) CA1300603C (ko)
DE (1) DE3868534D1 (ko)
DK (1) DK260288A (ko)
ES (1) ES2030167T3 (ko)
GB (1) GB8711391D0 (ko)
GR (1) GR3003907T3 (ko)
NZ (1) NZ224592A (ko)
PT (1) PT87465B (ko)
ZA (1) ZA883346B (ko)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8729613D0 (en) * 1987-12-18 1988-02-03 Beecham Group Plc Novel compounds
US5693515A (en) * 1995-04-28 1997-12-02 Arris Pharmaceutical Corporation Metal complexed serine protease inhibitors
US6255091B1 (en) 1995-04-28 2001-07-03 Axys Pharmaceuticals, Inc. Potentiating metal mediated serine protease inhibitors with cobalt or zinc ions
CN114681435A (zh) 2020-12-31 2022-07-01 上海汇伦生物科技有限公司 吸入用药物组合物

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0050927B1 (en) * 1980-10-25 1985-03-27 Beecham Group Plc The preparation of beta-lactam antibiotics
EP0120613A1 (en) * 1983-03-02 1984-10-03 Beecham Group Plc Penem derivatives and precursors
FI82471C (fi) * 1984-01-26 1991-03-11 Beecham Group Plc Foerfarande foer framstaellning av farmakologiskt aktiva 6-metylenpenemderivater.
GB8402086D0 (en) * 1984-01-26 1984-02-29 Beecham Group Plc Compounds
GB8518422D0 (en) * 1985-07-22 1985-08-29 Beecham Group Plc Compounds
EP0232966B1 (en) * 1986-01-17 1997-10-08 Beecham Group Plc Process for the preparation of penem compounds and intermediates for this preparation
AT396788B (de) * 1990-02-07 1993-11-25 Hofer Kerzen Gmbh Kerzenleuchte

Also Published As

Publication number Publication date
DK260288A (da) 1988-11-15
AU1609288A (en) 1988-11-17
US4897476A (en) 1990-01-30
EP0291304B1 (en) 1992-02-26
CA1300603C (en) 1992-05-12
JPS63303985A (ja) 1988-12-12
PT87465B (pt) 1992-09-30
PT87465A (pt) 1989-05-31
ATE72815T1 (de) 1992-03-15
ZA883346B (en) 1989-11-29
AU614517B2 (en) 1991-09-05
DK260288D0 (da) 1988-05-11
EP0291304A1 (en) 1988-11-17
GR3003907T3 (ko) 1993-03-16
DE3868534D1 (de) 1992-04-02
JPH0816112B2 (ja) 1996-02-21
NZ224592A (en) 1990-07-26
ES2030167T3 (es) 1992-10-16
GB8711391D0 (en) 1987-06-17

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