KR880003622A - 카테콜유도체 및 그것을 함유하는 중추신경계 퇴행성 질환의 진행방지 및 치료제 - Google Patents

카테콜유도체 및 그것을 함유하는 중추신경계 퇴행성 질환의 진행방지 및 치료제 Download PDF

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Publication number
KR880003622A
KR880003622A KR870010738A KR870010738A KR880003622A KR 880003622 A KR880003622 A KR 880003622A KR 870010738 A KR870010738 A KR 870010738A KR 870010738 A KR870010738 A KR 870010738A KR 880003622 A KR880003622 A KR 880003622A
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South Korea
Prior art keywords
group
general formula
lower alkyl
represented
preventing
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KR870010738A
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English (en)
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KR900001511B1 (ko
Inventor
후미아끼 이께다
시게노부 나까야마
Original Assignee
사와무라 하루오
미쓰이 토오아쓰 카가꾸 가부시끼가이샤
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Priority claimed from JP61226135A external-priority patent/JPS6383020A/ja
Priority claimed from JP61303761A external-priority patent/JPS63156751A/ja
Priority claimed from JP62035697A external-priority patent/JPS63203678A/ja
Priority claimed from JP62128444A external-priority patent/JPS63295571A/ja
Application filed by 사와무라 하루오, 미쓰이 토오아쓰 카가꾸 가부시끼가이샤 filed Critical 사와무라 하루오
Publication of KR880003622A publication Critical patent/KR880003622A/ko
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Publication of KR900001511B1 publication Critical patent/KR900001511B1/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
    • A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

Abstract

내용 없음

Description

카테콜 유도체 및 그것을 함유하는 중추신경계 퇴행성질환의 진행방지 및 치료제
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 일반식(A)로 표시되는 카테콜유도체를 유효성분으로 함유하는 중추신경계 퇴행성질환의 진행방지 및 치료제
    (식중, R은 2개의 수소원소자, 2개의 아실기, -CO-기, -CO·CO-가 또는 -C(CH3)2-기이고, R1, R2는 각각 따로 수소원자 또는 저급알킬기를 표시한다).
  2. 일반식(B)로 표시되는 카테콜유도체
    (식중, R3는 2개의 아실기, -CO-기, -CO·CO-기 또는 -C(CH3)2-기이고, R4는 저급알킬기를 나타낸다. 그러나 R3이 아세틸기이고, 또는 R4가 메틸기인 경우 및 R3이 -CO·CO-기이고, 또 R4가 메틸기인 경우를 제외한다).
  3. 제2항에 있어서, 일반식(C)로 표시되는 카테콜유도체
    (식중, R5는 아실기, R6은 저급알킬기를 표시한다. 그러나 R5가 아세틸기이고, 또 R6이 메틸기인 경우를 제외한다).
  4. 제2항에 있어서, 일반식(D)로 표시되는 카테콜유도체
    (식중, R7은 저급알킬기를 표시한다).
  5. 제2항에 있어서, 일반식(E)로 표시되는 카테콜유도체
    (식중, R8은 저급알킬기를 표시한다. 그러나 R8이 메틸기의 경우를 제외한다).
  6. 제2항에 있어서, 일반식(F)로 표시되는 카테콜유도체
    (식중, R9는 저급알킬기를 표시한다).
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870010738A 1986-09-26 1987-09-25 카테콜 유도체 및 그것을 함유하는 중추신경계 퇴행성질환의 진행방지 및 치료제 KR900001511B1 (ko)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
JP226135 1986-09-26
JP61226135A JPS6383020A (ja) 1986-09-26 1986-09-26 中枢性神経退行性疾患の進行防止および治療剤
JP61303761A JPS63156751A (ja) 1986-12-22 1986-12-22 カテコール誘導体の製造方法
JP303761 1986-12-22
JP62035697A JPS63203678A (ja) 1987-02-20 1987-02-20 新規なカテコール誘導体
JP35697 1987-02-20
JP128444 1987-05-27
JP62128444A JPS63295571A (ja) 1987-05-27 1987-05-27 カテコ−ル誘導体

Publications (2)

Publication Number Publication Date
KR880003622A true KR880003622A (ko) 1988-05-28
KR900001511B1 KR900001511B1 (ko) 1990-03-12

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870010738A KR900001511B1 (ko) 1986-09-26 1987-09-25 카테콜 유도체 및 그것을 함유하는 중추신경계 퇴행성질환의 진행방지 및 치료제

Country Status (9)

Country Link
US (2) US4985458A (ko)
EP (1) EP0261977B1 (ko)
KR (1) KR900001511B1 (ko)
AU (1) AU603137B2 (ko)
DE (1) DE3777050D1 (ko)
DK (1) DK505787A (ko)
FI (1) FI874163A (ko)
NO (1) NO874032L (ko)
NZ (1) NZ221933A (ko)

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Also Published As

Publication number Publication date
AU603137B2 (en) 1990-11-08
EP0261977B1 (en) 1992-03-04
EP0261977A3 (en) 1989-04-05
US5102906A (en) 1992-04-07
DE3777050D1 (de) 1992-04-09
FI874163A (fi) 1988-03-27
FI874163A0 (fi) 1987-09-23
NO874032D0 (no) 1987-09-25
AU7895687A (en) 1988-03-31
NO874032L (no) 1988-03-28
US4985458A (en) 1991-01-15
KR900001511B1 (ko) 1990-03-12
DK505787D0 (da) 1987-09-25
EP0261977A2 (en) 1988-03-30
NZ221933A (en) 1989-09-27
DK505787A (da) 1988-03-27

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