KR880002704B1 - 1,4-디하이드로피리딘 화합물의 제조방법 - Google Patents

1,4-디하이드로피리딘 화합물의 제조방법 Download PDF

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Publication number
KR880002704B1
KR880002704B1 KR8204705A KR820004705A KR880002704B1 KR 880002704 B1 KR880002704 B1 KR 880002704B1 KR 8204705 A KR8204705 A KR 8204705A KR 820004705 A KR820004705 A KR 820004705A KR 880002704 B1 KR880002704 B1 KR 880002704B1
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KR
South Korea
Prior art keywords
group
nitrophenyl
dihydropyridine
dimethyl
dicarboxylate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR8204705A
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English (en)
Korean (ko)
Other versions
KR840001954A (ko
Inventor
사찌오 오오노
기요시 미스고시
오사무 고마쓰
겐지 이찌하라
다까시 모리시마
Original Assignee
고지마 시계오
마루고 세이야꾸 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP16696381A external-priority patent/JPS5867668A/ja
Priority claimed from JP259782A external-priority patent/JPS58121288A/ja
Priority claimed from JP2839182A external-priority patent/JPS58146565A/ja
Application filed by 고지마 시계오, 마루고 세이야꾸 가부시기가이샤 filed Critical 고지마 시계오
Publication of KR840001954A publication Critical patent/KR840001954A/ko
Application granted granted Critical
Publication of KR880002704B1 publication Critical patent/KR880002704B1/ko
Expired legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR8204705A 1981-10-19 1982-10-19 1,4-디하이드로피리딘 화합물의 제조방법 Expired KR880002704B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
JP56-166963 1981-10-19
JP16696381A JPS5867668A (ja) 1981-10-19 1981-10-19 １，４−ジヒドロピリジン誘導体
JP166963 1981-10-19
JP57-2597 1982-01-11
JP259782A JPS58121288A (ja) 1982-01-11 1982-01-11 １，４−ジヒドロピリジン誘導体
JP2839182A JPS58146565A (ja) 1982-02-24 1982-02-24 １，４−ジヒドロピリジン誘導体
JP57-28391 1982-02-25

Publications (2)

Publication Number Publication Date
KR840001954A KR840001954A (ko) 1984-06-07
KR880002704B1 true KR880002704B1 (ko) 1988-12-26

Family

ID=27275435

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8204705A Expired KR880002704B1 (ko) 1981-10-19 1982-10-19 1,4-디하이드로피리딘 화합물의 제조방법

Country Status (12)

Country Link
US (1) US4446325A (https=)
KR (1) KR880002704B1 (https=)
AU (1) AU555036B2 (https=)
CA (1) CA1177079A (https=)
CH (1) CH650498A5 (https=)
DE (1) DE3238705A1 (https=)
ES (2) ES8406439A1 (https=)
FR (1) FR2514761B1 (https=)
GB (1) GB2111978B (https=)
IT (1) IT1189393B (https=)
NL (1) NL194203C (https=)
SE (1) SE442864B (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE57810B1 (en) * 1984-03-27 1993-04-21 Delagrange Lab 1,4-dihydropyridine derivatives,their preparation and their use
FR2577552B1 (fr) * 1985-02-20 1987-09-04 Sori Soc Rech Ind Esters heterocycliques dissymetriques d'acides 1,4-dihydropyridine-3,5-dicarboxyliques, procede de preparation et utilisation en therapeutique
US4833150A (en) * 1985-03-14 1989-05-23 Nelson Research & Development Co. 1,4-dihydropyridines
DE3514865A1 (de) * 1985-04-25 1986-11-06 Bayer Ag, 5090 Leverkusen 1,4-dihydropyridin-derivate, verfahren zu ihrer herstellung und ihre verwendung in arzneimitteln
US4849436A (en) * 1986-03-11 1989-07-18 Nelson Research & Development Co. 1,4-dihydropyridines
EP0272336B1 (de) * 1986-12-18 1991-10-23 Kurt H. Prof. Dr. Bauer Gegenüber Lichteinfluss stabilisiertes Nifedipin-Konzentrat und Verfahren zu seiner Herstellung
ES2287110T3 (es) * 2000-04-11 2007-12-16 Sankyo Company, Limited Composicion farmaceutica estabilizada que contiene un bloqueador de calcio consistente en azelnidipina.
CA2495962A1 (en) 2002-08-19 2004-03-04 Pfizer Products Inc. Combination therapy for hyperproliferative diseases
MX2007000979A (es) * 2004-07-26 2007-07-11 Cotherix Inc Tratamiento de la hipertension pulmonar por iloprost inhalado con una formulacion microparticulada.
EP1951253A2 (en) 2005-10-26 2008-08-06 Cotherix, Inc. Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
EP2351569B1 (en) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
TW200736245A (en) * 2005-11-29 2007-10-01 Sankyo Co Acid addition salts of optically active dihydropyridine derivatives
TW200806648A (en) * 2005-11-29 2008-02-01 Sankyo Co Acid addition salts of dihydropyridine derivatives
US8883844B2 (en) 2010-09-24 2014-11-11 Nitrogenix Inc. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
RU2570752C2 (ru) 2011-08-26 2015-12-10 Вокхардт Лимитед Способы лечения сердечно-сосудистых нарушений

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1670827C3 (de) * 1967-03-20 1974-10-24 Bayer Ag, 5090 Leverkusen 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin
DE1670824C3 (de) * 1967-03-20 1978-08-03 Bayer Ag, 5090 Leverkusen 1,4-Dihydropyridin-33-dicarbonsäurealkylester
DE2228363A1 (de) * 1972-06-10 1974-01-03 Bayer Ag 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2747513A1 (de) * 1977-10-22 1979-05-03 Bayer Ag Dihydropyridine mit schwefelhaltigen estergruppierungen
DE2847236A1 (de) * 1978-10-31 1980-05-14 Bayer Ag Neue dihydropyridine mit substituierten estergruppierungen, mehrer verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
DE2935451A1 (de) * 1979-09-01 1981-03-19 Bayer Ag, 5090 Leverkusen Optisch aktive 1,4-dihydropyridine, verfahren zu ihrer herstellung und ihre verwendung als arneimittel
NZ201395A (en) * 1981-07-30 1987-02-20 Bayer Ag Pharmaceutical compositions containing 1,4-dihydropyridines and certain of these dihydropyridines

Also Published As

Publication number Publication date
CA1177079A (en) 1984-10-30
IT8249295A1 (it) 1984-04-18
ES517022A0 (es) 1984-08-16
SE442864B (sv) 1986-02-03
DE3238705C2 (https=) 1989-11-09
SE8205905D0 (sv) 1982-10-18
CH650498A5 (de) 1985-07-31
ES8504127A1 (es) 1985-04-16
FR2514761B1 (fr) 1985-09-06
US4446325A (en) 1984-05-01
ES527980A0 (es) 1985-04-16
FR2514761A1 (fr) 1983-04-22
GB2111978A (en) 1983-07-13
AU555036B2 (en) 1986-09-11
GB2111978B (en) 1985-05-01
IT1189393B (it) 1988-02-04
ES8406439A1 (es) 1984-08-16
DE3238705A1 (de) 1983-07-14
NL8204014A (nl) 1983-05-16
NL194203B (nl) 2001-05-01
SE8205905L (sv) 1983-04-20
AU8931782A (en) 1983-04-28
IT8249295A0 (it) 1982-10-18
KR840001954A (ko) 1984-06-07
NL194203C (nl) 2001-09-04

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Patent event code: PA01091R01D

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Patent event date: 19821019

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