KR880002234B1 - 4-아닐리노피리미딘 유도체의 제조방법 - Google Patents

4-아닐리노피리미딘 유도체의 제조방법 Download PDF

Info

Publication number
KR880002234B1
KR880002234B1 KR8202513A KR820002513A KR880002234B1 KR 880002234 B1 KR880002234 B1 KR 880002234B1 KR 8202513 A KR8202513 A KR 8202513A KR 820002513 A KR820002513 A KR 820002513A KR 880002234 B1 KR880002234 B1 KR 880002234B1
Authority
KR
South Korea
Prior art keywords
group
compound
atom
carbon atoms
dimethylpyrimidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR8202513A
Other languages
English (en)
Korean (ko)
Other versions
KR840000508A (ko
Inventor
도시히루 가미오까
이사오 나까야마
다께오 흔다
다까시 고바야시
도끼오 오바따
가쯔도시 후지이
마끼오 고지마
유우니 아끼요시
Original Assignee
가와무라 요시노리
산교오 가부시끼 가이샤
미쯔노 가쯔오
우베 고오산 가부시끼 가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 가와무라 요시노리, 산교오 가부시끼 가이샤, 미쯔노 가쯔오, 우베 고오산 가부시끼 가이샤 filed Critical 가와무라 요시노리
Publication of KR840000508A publication Critical patent/KR840000508A/ko
Application granted granted Critical
Publication of KR880002234B1 publication Critical patent/KR880002234B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR8202513A 1981-06-05 1982-06-04 4-아닐리노피리미딘 유도체의 제조방법 Expired KR880002234B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP86555 1981-06-05
JP86,555/1981 1981-06-05
JP56086555A JPS57203072A (en) 1981-06-05 1981-06-05 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient

Publications (2)

Publication Number Publication Date
KR840000508A KR840000508A (ko) 1984-02-22
KR880002234B1 true KR880002234B1 (ko) 1988-10-20

Family

ID=13890246

Family Applications (1)

Application Number Title Priority Date Filing Date
KR8202513A Expired KR880002234B1 (ko) 1981-06-05 1982-06-04 4-아닐리노피리미딘 유도체의 제조방법

Country Status (10)

Country Link
US (1) US4450162A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0067630B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JPS57203072A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR880002234B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA1169861A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3263653D1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES8307760A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI77454C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
PH (1) PH20130A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA823917B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK130584A (da) * 1983-04-08 1984-10-09 Ciba Geigy Ag N-(2-nitrophenyl)-4-amino-pyrimidin-derivater samt deres fremstilling og anvendelse som mikrobicider
PH21918A (en) * 1983-07-25 1988-04-08 Ciba Geigy Ag N-(2-nitrophenyl)-5-aminopyrimidine derivatives,the preparation and use thereof
EP0139613A1 (de) * 1983-08-29 1985-05-02 Ciba-Geigy Ag N-(2-Nitrophenyl)-4-aminopyrimidin-Derivate, deren Herstellung und Verwendung
US4725600A (en) * 1984-07-13 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
JPS6270A (ja) * 1985-03-07 1987-01-06 Sankyo Co Ltd シクロペンタ〔ｄ〕ピリミジン誘導体
DE3618353A1 (de) * 1986-05-31 1987-12-03 Hoechst Ag Schaedlingsbekaempfungsmittel auf der basis von aminopyrimidin-derivaten sowie neue aminopyrimidin-verbindungen
US5037980A (en) * 1988-04-18 1991-08-06 American Cyanamid Company Phenyl imidazo[1,2-a]pyrimidines
GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
US5234936A (en) * 1991-10-24 1993-08-10 American Home Products Corporation Pyrimidocycloalkanes as a ii antagonists
WO1994007890A1 (en) * 1992-10-05 1994-04-14 Ube Industries, Ltd. Pyrimidine compound
KR100643419B1 (ko) * 1998-03-27 2006-11-10 얀센 파마슈티카 엔.브이. Ｈｉｖ를 억제하는 피리미딘 유도체
CZ299380B6 (cs) * 1998-03-27 2008-07-09 Janssen Pharmaceutica N. V. Pyrimidinová sloucenina, použití této slouceniny pro prípravu léciva, farmaceutický prostredek tutoslouceninu obsahující, zpusob prípravy tohoto prostredku a uvedené slouceniny a kombinace a produktuvedenou slouceninu obsahující
EA005423B1 (ru) 1999-09-24 2005-02-24 Янссен Фармацевтика Н.В. Противовирусные композиции
CN100398524C (zh) * 2003-08-12 2008-07-02 弗·哈夫曼-拉罗切有限公司 作为crf拮抗剂的四氢喹唑啉衍生物
CN101084214A (zh) 2004-11-17 2007-12-05 迈卡纳治疗股份有限公司 激酶抑制剂
NZ567241A (en) * 2005-09-30 2010-08-27 Miikana Therapeutics Inc Substituted pyrazole compounds
EP2166849A4 (en) * 2007-06-11 2010-09-15 Miikana Therapeutics Inc SUBSTITUTED PYRAZOL COMPOUNDS
US8946239B2 (en) 2008-07-10 2015-02-03 Duquesne University Of The Holy Spirit Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
WO2015160489A2 (en) 2014-04-03 2015-10-22 Duquesne University Of The Holy Spirit Substituted cyclopenta pyrimidine bicyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
GB2578974B (en) * 2015-04-17 2020-08-19 Univ Holy Ghost Duquesne Cyclopenta[d]pyrimidines as antitubulin and antitumor agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2719846A (en) * 1954-05-06 1955-10-04 Searle & Co 4[n-(beta-diethylaminoethyl) anilino]-pyrimidine and acid addition salts thereof
US3321478A (en) * 1963-09-20 1967-05-23 American Cyanamid Co Aminoethoxyphenyl amine, ether, and sulfide derivatives of pyrimidine
FR2190818B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1972-06-28 1975-03-07 Roussel Uclaf
CH593266A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1973-09-20 1977-11-30 Delalande Sa
DE2626495A1 (de) * 1976-06-12 1977-12-29 Bayer Ag Quartaere reaktivverbindungen

Also Published As

Publication number Publication date
ZA823917B (en) 1983-04-27
FI77454B (fi) 1988-11-30
US4450162A (en) 1984-05-22
ES512880A0 (es) 1983-08-01
DE3263653D1 (en) 1985-06-13
EP0067630B1 (en) 1985-05-08
ES8307760A1 (es) 1983-08-01
CA1169861A (en) 1984-06-26
KR840000508A (ko) 1984-02-22
FI821990A0 (fi) 1982-06-04
JPS57203072A (en) 1982-12-13
JPH0440347B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1992-07-02
FI77454C (fi) 1989-03-10
PH20130A (en) 1986-10-02
EP0067630A1 (en) 1982-12-22

Similar Documents

Publication Publication Date Title
KR880002234B1 (ko) 4-아닐리노피리미딘 유도체의 제조방법
US3780040A (en) 2-substituted-3,4-dihydroquinazolines
FI73682B (fi) Foerfarande foer framstaellning av antiviralt 9-(1,3-dihydroxi-2-propoximetyl)guanin samt mellanprodukt.
DE69202243T2 (de) 2,4-Diaminochinazolin-Derivate, um die Antitumorwirkung zu erhöhen.
DE3689848T2 (de) Zyklopenta[D]pyrimidinderivate, ihre Herstellung und Verwendung.
JPH0517457A (ja) ベンズイソチアゾールおよびベンズイソキサゾールピペラジン誘導体
IE46652B1 (en) 4-amino-6,7-dimethoxy-2(4-(1,2,3-thiadiazole carbonyl)-pioerazin-1-yl)quinazolines
UA45985C2 (uk) Похідні карбонових кислот
SK45096A3 (en) Alkoxy alkyl carbamates from imidazo (1,2-a)pyridines, preparation method thereof, pharmaceutical composition containing them and their use
IE913459A1 (en) 2-Aminopyrimidine-4-carboxamide derivatives, their¹preparation and their use in therapy
JP2002541144A (ja) 医薬的に活性のある化合物及びその使用方法
KR860001252B1 (ko) 9-[3-(3, 5-시스-디메틸피페라지노)프로필] 카르바졸의 제조방법
KR20080044273A (ko) 아실구아니딘 유도체 또는 그의 염
DE9290039U1 (de) Pyrimidinderivate zur Verbesserung der Anti-Tumor-Aktivität
JPH0747574B2 (ja) ピリジン誘導体及びそれを有効成分とする向精神剤
JPH01250316A (ja) 抗脂血剤
KR900003301B1 (ko) 2-피페라지닐-4-페닐 퀴나졸린 유도체 및 그의 산염의 제조 방법
CS244145B2 (en) Method of 4,5,6,7-tetrahydrothiazolo-(5,4-c)pyridine derivatives production
JPH0223548B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
US3578666A (en) Substituted imidazolines,pyrimidines and diazepines
JP2879918B2 (ja) カルシウム拮抗剤
EP0364091B1 (en) Antipsychotic 4-(4-(3-benzisothiazolyl)-1-piperazinyl)butyl bridged bicyclic imides
SE463154B (sv) 6-fenetylaminoalkyl-furo(3,4-c)pyridinderivat,framstaellning daerav och terapeutiska kompositioner innehaallande dem
JPS59148780A (ja) 精神病治療性５−フルオロ−ピリミジン−２−イルピペラジン化合物
IE44614B1 (en) 4-amino-6,7-dimethoxy-2-(4-(heterocyclylcarbonyl) piperazin-1-yl) quinazolines

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19921021

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19921021

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-5-5-R10-R18-oth-X000

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301

PN2301 Change of applicant

St.27 status event code: A-5-5-R10-R13-asn-PN2301

St.27 status event code: A-5-5-R10-R11-asn-PN2301