KR880002227B1 - 인돌리논의 제조방법 - Google Patents

인돌리논의 제조방법 Download PDF

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Publication number
KR880002227B1
KR880002227B1 KR1019810004409A KR810004409A KR880002227B1 KR 880002227 B1 KR880002227 B1 KR 880002227B1 KR 1019810004409 A KR1019810004409 A KR 1019810004409A KR 810004409 A KR810004409 A KR 810004409A KR 880002227 B1 KR880002227 B1 KR 880002227B1
Authority
KR
South Korea
Prior art keywords
dimethyl
group
carbon atoms
butoxy
indolinone
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019810004409A
Other languages
English (en)
Korean (ko)
Other versions
KR830007554A (ko
Inventor
뮐러 에르리히
니클 죠세프
로호 죠세프
나르 베르톨드
하아르만 발터
맥시 밀리안 바이젠 버거 요하네스
Original Assignee
닥터 칼 토매 게젤샤프트 미트 베슈랭크터 하프퉁
요하네스켁, 프리쯔 좀머
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 닥터 칼 토매 게젤샤프트 미트 베슈랭크터 하프퉁, 요하네스켁, 프리쯔 좀머 filed Critical 닥터 칼 토매 게젤샤프트 미트 베슈랭크터 하프퉁
Publication of KR830007554A publication Critical patent/KR830007554A/ko
Application granted granted Critical
Publication of KR880002227B1 publication Critical patent/KR880002227B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1019810004409A 1980-11-12 1981-11-12 인돌리논의 제조방법 Expired KR880002227B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3042632.5 1980-11-12
DE3042632 1980-11-12

Publications (2)

Publication Number Publication Date
KR830007554A KR830007554A (ko) 1983-10-21
KR880002227B1 true KR880002227B1 (ko) 1988-10-20

Family

ID=6116579

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019810004409A Expired KR880002227B1 (ko) 1980-11-12 1981-11-12 인돌리논의 제조방법

Country Status (29)

Country Link
US (1) US4629733A (https=)
JP (1) JPS57114569A (https=)
KR (1) KR880002227B1 (https=)
AT (1) AT375923B (https=)
AU (1) AU547929B2 (https=)
BE (1) BE891103A (https=)
CA (1) CA1183848A (https=)
CH (1) CH652120A5 (https=)
DD (1) DD201889A5 (https=)
DK (1) DK154138C (https=)
ES (2) ES8206470A1 (https=)
FI (1) FI75806C (https=)
FR (1) FR2493841A1 (https=)
GB (1) GB2098595B (https=)
GR (1) GR81330B (https=)
HU (1) HU183680B (https=)
IE (1) IE52107B1 (https=)
IL (1) IL64252A (https=)
IT (1) IT1171624B (https=)
LU (1) LU83744A1 (https=)
NL (1) NL8105100A (https=)
NO (1) NO156167C (https=)
NZ (1) NZ198941A (https=)
PL (1) PL134525B1 (https=)
PT (1) PT73969B (https=)
SE (1) SE452156B (https=)
SU (1) SU1107759A3 (https=)
YU (1) YU41995B (https=)
ZA (1) ZA817787B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0089394A1 (en) * 1982-03-23 1983-09-28 Sterling Drug Inc. 1-H-Indole-2,3-dione derivatives and preparation thereof
US5204344A (en) * 1989-08-22 1993-04-20 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
US5272145A (en) * 1989-08-22 1993-12-21 Merck Frosst Canada, Inc. (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes
GB9008605D0 (en) * 1990-04-17 1990-06-13 Smith Kline French Lab Process
US5389650A (en) * 1991-09-30 1995-02-14 Merck Frosst Canada, Inc. (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5308850A (en) * 1991-09-30 1994-05-03 Merck Frosst Canada, Inc. (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5290798A (en) * 1991-09-30 1994-03-01 Merck Frosst Canada, Inc. (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis
US5190968A (en) * 1991-09-30 1993-03-02 Merck Frosst Canada, Inc. (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis
US5374635A (en) * 1993-03-29 1994-12-20 Merck Frosst Canada, Inc. Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT330169B (de) * 1971-06-24 1976-06-25 Sandoz Ag Verfahren zur herstellung neuer oxindole und ihrer salze
DE2853314A1 (de) * 1978-12-09 1980-06-26 Thomae Gmbh Dr K Neue carbostyril- und oxindolderivate, ihre herstellung und ihre verwendung als arzneimittel
US4329347A (en) * 1978-02-17 1982-05-11 Boehringer Ingelheim Gmbh Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril
SU843739A3 (ru) * 1978-02-17 1981-06-30 Карл Томэ Гмбх (Фирма) Способ получени карбостириловыхили ОКСиНдОлОВыХ пРОизВОдНыХ
US4442111A (en) * 1981-07-25 1984-04-10 Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung Antithrombotic sulfimino and sulfoximino indolinones-2

Also Published As

Publication number Publication date
PT73969A (de) 1981-12-01
ES507015A0 (es) 1982-08-16
PL134525B1 (en) 1985-08-31
IT1171624B (it) 1987-06-10
IL64252A0 (en) 1982-02-28
NO156167B (no) 1987-04-27
GR81330B (https=) 1984-12-11
NO813821L (no) 1982-05-13
AT375923B (de) 1984-09-25
NL8105100A (nl) 1982-06-01
AU547929B2 (en) 1985-11-14
ES8304081A1 (es) 1983-02-16
SE8106704L (sv) 1982-05-13
CH652120A5 (de) 1985-10-31
LU83744A1 (de) 1983-04-13
SE452156B (sv) 1987-11-16
GB2098595B (en) 1984-09-05
DK154138B (da) 1988-10-17
NO156167C (no) 1987-08-05
NZ198941A (en) 1984-10-19
YU41995B (en) 1988-04-30
JPS57114569A (en) 1982-07-16
IE52107B1 (en) 1987-06-24
ZA817787B (en) 1983-07-27
DK496781A (da) 1982-05-13
HU183680B (en) 1984-05-28
SU1107759A3 (ru) 1984-08-07
ATA478981A (de) 1984-02-15
DK154138C (da) 1989-04-17
AU7739081A (en) 1982-05-20
IE812640L (en) 1982-05-12
FI75806C (fi) 1988-08-08
FR2493841B1 (https=) 1984-03-30
IT8149602A0 (it) 1981-10-30
ES8206470A1 (es) 1982-08-16
GB2098595A (en) 1982-11-24
FI813561L (fi) 1982-05-13
ES511834A0 (es) 1983-02-16
CA1183848A (en) 1985-03-12
PL233774A1 (https=) 1982-12-20
FR2493841A1 (fr) 1982-05-14
IT8149602A1 (it) 1983-04-30
IL64252A (en) 1985-02-28
YU266681A (en) 1983-10-31
US4629733A (en) 1986-12-16
BE891103A (fr) 1982-05-12
FI75806B (fi) 1988-04-29
PT73969B (de) 1983-11-23
KR830007554A (ko) 1983-10-21
DD201889A5 (de) 1983-08-17

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Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19811112

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Patent event code: PA02012R01D

Patent event date: 19860830

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19811112

Comment text: Patent Application

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Comment text: Notification of reason for refusal

Patent event date: 19880623

Patent event code: PE09021S01D

PG1605 Publication of application before grant of patent

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Patent event code: PG16051S01I

Patent event date: 19880922

PE0701 Decision of registration

Patent event code: PE07011S01D

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Patent event date: 19881230

PC1904 Unpaid initial registration fee