IE812640L - Indolinone derivatives. - Google Patents
Indolinone derivatives.Info
- Publication number
- IE812640L IE812640L IE812640A IE264081A IE812640L IE 812640 L IE812640 L IE 812640L IE 812640 A IE812640 A IE 812640A IE 264081 A IE264081 A IE 264081A IE 812640 L IE812640 L IE 812640L
- Authority
- IE
- Ireland
- Prior art keywords
- carbon atoms
- group
- substituted
- phenyl
- aryl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/34—Oxygen atoms in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
Abstract
The present invention relates to novel indolinones of the general formula <IMAGE> wherein R represents an aryl group having from 6 to 10 carbon atoms, unsubstituted or mono- or disubstituted by alkyl groups having from 1 to 5 carbon atoms, hydroxyl groups, alkoxy groups having from 1 to 3 carbon atoms, or halogen atoms, whereby the substituents may be the same or different and whereby the phenyl nucleus of the aryl group may also be substituted by an amino group, a hydroxyl group, or an alkanoylamino group with altogether from 1 to 3 carbon atoms; an aryl group having from 6 to 10 carbon atoms, substituted by 3 or 4 alkyl groups having from 1 to 5 carbon atoms each; a phenyl group substituted by a phenyl, halogenphenyl, or cycloalkyl group with 5 to 7 carbon atoms; an aralkyl group having from 7 to 11 carbon atoms; or a pentamethylphenyl, pyridyl, or quinolyl group; m represents the number 0, 1, or 2; and n represents the number 2, 3, 4, 5, or 6.
[US4629733A]
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3042632 | 1980-11-12 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE812640L true IE812640L (en) | 1982-05-12 |
| IE52107B1 IE52107B1 (en) | 1987-06-24 |
Family
ID=6116579
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE2640/81A IE52107B1 (en) | 1980-11-12 | 1981-11-11 | Indolinone derivatives |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US4629733A (en) |
| JP (1) | JPS57114569A (en) |
| KR (1) | KR880002227B1 (en) |
| AT (1) | AT375923B (en) |
| AU (1) | AU547929B2 (en) |
| BE (1) | BE891103A (en) |
| CA (1) | CA1183848A (en) |
| CH (1) | CH652120A5 (en) |
| DD (1) | DD201889A5 (en) |
| DK (1) | DK154138C (en) |
| ES (2) | ES8206470A1 (en) |
| FI (1) | FI75806C (en) |
| FR (1) | FR2493841A1 (en) |
| GB (1) | GB2098595B (en) |
| GR (1) | GR81330B (en) |
| HU (1) | HU183680B (en) |
| IE (1) | IE52107B1 (en) |
| IL (1) | IL64252A (en) |
| IT (1) | IT1171624B (en) |
| LU (1) | LU83744A1 (en) |
| NL (1) | NL8105100A (en) |
| NO (1) | NO156167C (en) |
| NZ (1) | NZ198941A (en) |
| PL (1) | PL134525B1 (en) |
| PT (1) | PT73969B (en) |
| SE (1) | SE452156B (en) |
| SU (1) | SU1107759A3 (en) |
| YU (1) | YU41995B (en) |
| ZA (1) | ZA817787B (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0089394A1 (en) * | 1982-03-23 | 1983-09-28 | Sterling Drug Inc. | 1-H-Indole-2,3-dione derivatives and preparation thereof |
| US5272145A (en) * | 1989-08-22 | 1993-12-21 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| US5204344A (en) * | 1989-08-22 | 1993-04-20 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| GB9008605D0 (en) * | 1990-04-17 | 1990-06-13 | Smith Kline French Lab | Process |
| US5290798A (en) * | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5190968A (en) * | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5308850A (en) * | 1991-09-30 | 1994-05-03 | Merck Frosst Canada, Inc. | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5389650A (en) * | 1991-09-30 | 1995-02-14 | Merck Frosst Canada, Inc. | (Azaarylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5374635A (en) * | 1993-03-29 | 1994-12-20 | Merck Frosst Canada, Inc. | Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT330169B (en) * | 1971-06-24 | 1976-06-25 | Sandoz Ag | Process for the preparation of new oxindoles and their salts |
| DE2853314A1 (en) * | 1978-12-09 | 1980-06-26 | Thomae Gmbh Dr K | Substd. alkoxy carbostyril, di:hydro-carbostyril and oxindole derivs. - with positive inotropic and antithrombotic activity |
| SU843739A3 (en) * | 1978-02-17 | 1981-06-30 | Карл Томэ Гмбх (Фирма) | Method of preparing carbostyryl or oxyindole derivatives |
| US4329347A (en) * | 1978-02-17 | 1982-05-11 | Boehringer Ingelheim Gmbh | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril |
| US4442111A (en) * | 1981-07-25 | 1984-04-10 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Antithrombotic sulfimino and sulfoximino indolinones-2 |
-
1981
- 1981-10-30 IT IT49602/81A patent/IT1171624B/en active
- 1981-11-03 SU SU813349304A patent/SU1107759A3/en active
- 1981-11-04 FR FR8120697A patent/FR2493841A1/en active Granted
- 1981-11-09 CH CH7183/81A patent/CH652120A5/en not_active IP Right Cessation
- 1981-11-09 AT AT0478981A patent/AT375923B/en not_active IP Right Cessation
- 1981-11-10 DD DD81234742A patent/DD201889A5/en unknown
- 1981-11-10 FI FI813561A patent/FI75806C/en not_active IP Right Cessation
- 1981-11-10 IL IL64252A patent/IL64252A/en unknown
- 1981-11-10 DK DK496781A patent/DK154138C/en not_active IP Right Cessation
- 1981-11-10 LU LU83744A patent/LU83744A1/en unknown
- 1981-11-10 GR GR66488A patent/GR81330B/el unknown
- 1981-11-11 IE IE2640/81A patent/IE52107B1/en unknown
- 1981-11-11 NL NL8105100A patent/NL8105100A/en not_active Application Discontinuation
- 1981-11-11 ES ES507015A patent/ES8206470A1/en not_active Expired
- 1981-11-11 PL PL1981233774A patent/PL134525B1/en unknown
- 1981-11-11 GB GB8134003A patent/GB2098595B/en not_active Expired
- 1981-11-11 SE SE8106704A patent/SE452156B/en not_active IP Right Cessation
- 1981-11-11 PT PT73969A patent/PT73969B/en unknown
- 1981-11-11 ZA ZA817787A patent/ZA817787B/en unknown
- 1981-11-11 JP JP56180923A patent/JPS57114569A/en active Pending
- 1981-11-11 AU AU77390/81A patent/AU547929B2/en not_active Ceased
- 1981-11-11 HU HU813373A patent/HU183680B/en unknown
- 1981-11-11 YU YU2666/81A patent/YU41995B/en unknown
- 1981-11-11 NO NO813821A patent/NO156167C/en unknown
- 1981-11-11 NZ NZ198941A patent/NZ198941A/en unknown
- 1981-11-12 BE BE0/206533A patent/BE891103A/en not_active IP Right Cessation
- 1981-11-12 CA CA000389873A patent/CA1183848A/en not_active Expired
- 1981-11-12 KR KR1019810004409A patent/KR880002227B1/en active
-
1982
- 1982-04-30 ES ES511834A patent/ES511834A0/en active Granted
-
1984
- 1984-07-27 US US06/625,020 patent/US4629733A/en not_active Expired - Fee Related
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR960704919A (en) | NOVEL PEPTIDE DERIVATIVE | |
| IE812640L (en) | Indolinone derivatives. | |
| ES463803A1 (en) | O-[3-(4-Substituted-piperazin-1-yl)-2-hydroxypropyl]-hydroxylamines | |
| GB1476797A (en) | Cyanamide derivatives | |
| GB1229082A (en) | ||
| ES8105976A1 (en) | Acylurea insecticides | |
| JPS51125390A (en) | A process for preparing carbostyril derivatives | |
| GB1437815A (en) | ||
| GB1326875A (en) | Acylated phenylene diamines | |
| GB1496297A (en) | Chromogenic compounds | |
| GB1360142A (en) | Styryl derivatives | |
| GB1237658A (en) | Substituted 1-oxy-1-thiono-3-halogen- or -3-alkyl phospholines | |
| IE810004L (en) | Rifamycin derivatives | |
| GB2015515A (en) | 3-Azabicyclo[3.1.0]hexane derivatives | |
| GB1499193A (en) | Indolino-spiropyran compounds useful as colour formers | |
| GB1131467A (en) | New basic derivatives of benzoxazine and methods for their production | |
| GB1509386A (en) | Cationic coumarin and coumarinimide derivatives | |
| IE44950L (en) | Spirocyclic 3-amino-2-hydroxypropoxy-phenyl derivatives | |
| GB1378403A (en) | Process for the preparation of 3-2h-isoquinolones | |
| GB1432736A (en) | Substituted 2-pyrones and process for their preparation | |
| GB1321528A (en) | Basic compounds their manufacture and their use | |
| GB1233118A (en) | ||
| GB1439092A (en) | Hindered phenol pentaerythritol phosphonate | |
| GB1409987A (en) | Beta-amino-beta-imino-propionic acid esters | |
| GB1270107A (en) | Anthraquinone dyestuffs |