KR880002209B1 - 치환된 3,4-디아미노-1,2,5-티아디아졸류 및 그의 제조방법 - Google Patents

치환된 3,4-디아미노-1,2,5-티아디아졸류 및 그의 제조방법 Download PDF

Info

Publication number
KR880002209B1
KR880002209B1 KR1019830001283A KR830001283A KR880002209B1 KR 880002209 B1 KR880002209 B1 KR 880002209B1 KR 1019830001283 A KR1019830001283 A KR 1019830001283A KR 830001283 A KR830001283 A KR 830001283A KR 880002209 B1 KR880002209 B1 KR 880002209B1
Authority
KR
South Korea
Prior art keywords
thiadiazole
amino
pharmaceutically acceptable
propylamino
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
KR1019830001283A
Other languages
English (en)
Korean (ko)
Other versions
KR840004095A (ko
Inventor
안토니오 알지에리 알도
레이 크렌셔 로니
Original Assignee
브리스톨-마이어스 컴페니
아이쟉 쟈코브스키
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 브리스톨-마이어스 컴페니, 아이쟉 쟈코브스키 filed Critical 브리스톨-마이어스 컴페니
Publication of KR840004095A publication Critical patent/KR840004095A/ko
Priority to KR1019880010574A priority Critical patent/KR880002530B1/ko
Application granted granted Critical
Publication of KR880002209B1 publication Critical patent/KR880002209B1/ko
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/06—1,2,3-Thiadiazoles; Hydrogenated 1,2,3-thiadiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/10—1,2,5-Thiadiazoles; Hydrogenated 1,2,5-thiadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Furan Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1019830001283A 1982-03-29 1983-03-29 치환된 3,4-디아미노-1,2,5-티아디아졸류 및 그의 제조방법 Expired KR880002209B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1019880010574A KR880002530B1 (ko) 1982-03-29 1988-08-18 치환된 에탄디이미드 아미드 및 그의 제조방법

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36320782A 1982-03-29 1982-03-29
US363,207 1982-03-29

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019880010574A Division KR880002530B1 (ko) 1982-03-29 1988-08-18 치환된 에탄디이미드 아미드 및 그의 제조방법

Publications (2)

Publication Number Publication Date
KR840004095A KR840004095A (ko) 1984-10-06
KR880002209B1 true KR880002209B1 (ko) 1988-10-18

Family

ID=23429274

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019830001283A Expired KR880002209B1 (ko) 1982-03-29 1983-03-29 치환된 3,4-디아미노-1,2,5-티아디아졸류 및 그의 제조방법

Country Status (30)

Country Link
JP (2) JPS58180477A (enExample)
KR (1) KR880002209B1 (enExample)
AT (1) AT386599B (enExample)
AU (2) AU557577B2 (enExample)
BE (1) BE896291A (enExample)
CH (2) CH660880A5 (enExample)
CS (2) CS250229B2 (enExample)
DD (2) DD219768A5 (enExample)
DE (1) DE3311281A1 (enExample)
DK (2) DK166677B1 (enExample)
ES (3) ES520982A0 (enExample)
FR (2) FR2542741B1 (enExample)
GB (2) GB2117769B (enExample)
GR (1) GR78524B (enExample)
HU (2) HU188742B (enExample)
IE (1) IE55596B1 (enExample)
IL (1) IL68259A0 (enExample)
IT (1) IT1164633B (enExample)
LU (1) LU84716A1 (enExample)
MY (1) MY8700942A (enExample)
NL (1) NL8301063A (enExample)
NO (1) NO163055C (enExample)
NZ (1) NZ203726A (enExample)
OA (1) OA07356A (enExample)
PT (1) PT76459B (enExample)
SE (2) SE461040B (enExample)
SU (2) SU1419518A3 (enExample)
YU (1) YU44849B (enExample)
ZA (1) ZA832154B (enExample)
ZW (1) ZW7683A1 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2222083A (en) * 1982-12-14 1984-06-21 Smith Kline & French Laboratories Limited Pyridine derivatives
US4593039A (en) * 1984-04-02 1986-06-03 Merck & Co., Inc. 1-aryloxy-3-(substituted aminoalkylamino)-2-propanols
US4644006A (en) * 1984-06-22 1987-02-17 Bristol-Myers Company Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
JPH0622828B2 (ja) * 1986-06-30 1994-03-30 フアナツク株式会社 直圧式型締機構
WO2022034121A1 (en) 2020-08-11 2022-02-17 Université De Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3018289A (en) * 1960-02-10 1962-01-23 Wyandotte Chemicals Corp Process for preparing oxamidines
GB1595291A (en) * 1976-09-21 1981-08-12 Smith Kline French Lab Pyrimidone and thiopyrimidone derivatives
NL189197C (nl) * 1979-09-04 1993-02-01 Bristol Myers Squibb Co 3,4-digesubstitueerde-1,2,5-thiadiazool-1-oxiden en 1,1-dioxiden, bereiding daarvan alsmede farmaceutische preparaten.
DE3175201D1 (en) * 1980-04-30 1986-10-02 Merck & Co Inc Aminothiadiazoles as gastric secretion inhibitors
AU2222083A (en) * 1982-12-14 1984-06-21 Smith Kline & French Laboratories Limited Pyridine derivatives

Also Published As

Publication number Publication date
GB2149406A (en) 1985-06-12
BE896291A (fr) 1983-09-28
AU1290783A (en) 1983-10-06
SE464302B (sv) 1991-04-08
GB2117769B (en) 1985-08-29
ES8505978A1 (es) 1985-06-16
IE830686L (en) 1983-09-29
SE8301725L (sv) 1983-11-25
NO831100L (no) 1983-09-30
ES8404683A1 (es) 1984-05-16
NO163055C (no) 1990-03-28
SE8704689L (sv) 1987-11-25
JPH0568472B2 (enExample) 1993-09-29
ATA111083A (de) 1988-02-15
SE8301725D0 (sv) 1983-03-28
JPS58180477A (ja) 1983-10-21
CH660880A5 (de) 1987-05-29
DK141383D0 (da) 1983-03-28
NL8301063A (nl) 1983-10-17
IL68259A0 (en) 1983-06-15
DE3311281A1 (de) 1983-11-24
YU44849B (en) 1991-04-30
ZW7683A1 (en) 1984-01-04
SU1355123A3 (ru) 1987-11-23
MY8700942A (en) 1987-12-31
PT76459B (en) 1986-03-11
ES8505977A1 (es) 1985-06-16
DD219768A5 (de) 1985-03-13
GB2117769A (en) 1983-10-19
GR78524B (enExample) 1984-09-27
DK81192A (da) 1992-06-18
DK141383A (da) 1983-09-30
OA07356A (fr) 1984-08-31
HU196386B (en) 1988-11-28
NZ203726A (en) 1986-05-09
HU188742B (en) 1986-05-28
ES527686A0 (es) 1985-06-16
JPH06135925A (ja) 1994-05-17
GB2149406B (en) 1986-01-02
ZA832154B (en) 1983-12-28
ES520982A0 (es) 1984-05-16
AT386599B (de) 1988-09-12
IT8348005A0 (it) 1983-03-28
PT76459A (en) 1983-04-01
FR2597867B1 (fr) 1989-12-08
LU84716A1 (fr) 1983-12-05
AU586037B2 (en) 1989-06-29
FR2542741A1 (fr) 1984-09-21
AU6327286A (en) 1987-01-08
ES527685A0 (es) 1985-06-16
GB8432809D0 (en) 1985-02-06
YU74483A (en) 1986-02-28
DK166677B1 (da) 1993-06-28
SU1419518A3 (ru) 1988-08-23
FR2542741B1 (fr) 1989-12-08
IE55596B1 (en) 1990-11-21
FR2597867A1 (fr) 1987-10-30
CS250229B2 (en) 1987-04-16
CH655111A5 (de) 1986-03-27
SE8704689D0 (sv) 1987-11-25
KR840004095A (ko) 1984-10-06
NO163055B (no) 1989-12-18
DD210909A5 (de) 1984-06-27
DK81192D0 (da) 1992-06-18
AU557577B2 (en) 1986-12-24
GB8308518D0 (en) 1983-05-05
IT1164633B (it) 1987-04-15
CS250240B2 (en) 1987-04-16
SE461040B (sv) 1989-12-18

Similar Documents

Publication Publication Date Title
KR880000968B1 (ko) 1, 2-디아미노 시클로부텐-3, 4-디온 및 그의 제조방법
KR860002036B1 (ko) 히스타민 h₂-길항제의 제조방법
KR880002209B1 (ko) 치환된 3,4-디아미노-1,2,5-티아디아졸류 및 그의 제조방법
US4522943A (en) Chemical compounds
US4528375A (en) Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
EP0099122B1 (en) Compositions comprising pepstatin and an histamine h2-receptor antagonist having an enhanced antiulcer activity
US4503051A (en) Substituted 3-cyclobutene-1,2-diones, pharmaceutical compositions thereof and methods of use
US4528377A (en) Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
US4528378A (en) Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
US4600779A (en) Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H2 -receptor antagonist activity
KR880002530B1 (ko) 치환된 에탄디이미드 아미드 및 그의 제조방법
US4588826A (en) Ethanediimidamide intermediates
US4539316A (en) Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones
US4578471A (en) Substituted amino alkyl pyridyl ethanediimidamides
US4595758A (en) Ethanediimidamide intermediates
US4517366A (en) Intermediates for preparing 3,4-diamino-1,2,5-thiadiazoles
US4546188A (en) Substituted 1,2-diaminocyclobutene-3,4-diones
US4788184A (en) Substituted 3-cyclobutene-1,2-diones as anti-ulcer agents
KR900004321B1 (ko) 히스타민 h_2-섭수체 길항작용을 가진 치환 3,4-디아미노-1,2,5-티아디아졸류 및 그 제조방법
CA1253144A (en) Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine h.sub.2-receptor antagonist activity
CY1448A (en) Chemical intermediates derived from cyclobutene
NO880872L (no) Fremgangsmaate til fremstilling av en kjemisk forbindelse.

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

G160 Decision to publish patent application
PG1605 Publication of application before grant of patent

St.27 status event code: A-2-2-Q10-Q13-nap-PG1605

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

FPAY Annual fee payment

Payment date: 19941012

Year of fee payment: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 19951019

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 19951019